Alogliptin improves survival and health of mice on a high-fat diet.

abstract：:Although dietary restriction (DR) is known to extend lifespan across species, from yeast to mammals, the signalling events downstream of food/nutrient perception are not well understood. In Caenorhabditis elegans, DR is typically attained either by using the eat-2 mutants that have reduced pharyngeal pumping leading t...

journal_title：Aging cell

authors： Chamoli M,Singh A,Malik Y,Mukhopadhyay A

更新日期：2014-08-01 00:00:00

abstract：:Aging impairs arterial function through oxidative stress and diminished nitric oxide (NO) bioavailability. Life-long caloric restriction (CR) reduces oxidative stress, but its impact on arterial aging is incompletely understood. We tested the hypothesis that life-long CR attenuates key features of arterial aging. Bloo...

journal_title：Aging cell

authors： Donato AJ,Walker AE,Magerko KA,Bramwell RC,Black AD,Henson GD,Lawson BR,Lesniewski LA,Seals DR

更新日期：2013-10-01 00:00:00

abstract：:While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called 'fenestrations' are...

journal_title：Aging cell

authors： Mohamad M,Mitchell SJ,Wu LE,White MY,Cordwell SJ,Mach J,Solon-Biet SM,Boyer D,Nines D,Das A,Catherine Li SY,Warren A,Hilmer SN,Fraser R,Sinclair DA,Simpson SJ,de Cabo R,Le Couteur DG,Cogger VC

更新日期：2016-08-01 00:00:00

abstract：:We test the 'free radical theory of aging' using six species of colubrid snakes (numerous, widely distributed, non-venomous snakes of the family Colubridae) that exhibit long (> 15 years) or short (< 10 years) lifespans. Because the 'rate of living theory' predicts metabolic rates to be correlated with rates of aging ...

journal_title：Aging cell

authors： Robert KA,Brunet-Rossinni A,Bronikowski AM

更新日期：2007-06-01 00:00:00

abstract：:Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging. We examined the state of chromatin structure and its effect on gene expression during aging in Drosophila at the whole g...

journal_title：Aging cell

authors： Wood JG,Hillenmeyer S,Lawrence C,Chang C,Hosier S,Lightfoot W,Mukherjee E,Jiang N,Schorl C,Brodsky AS,Neretti N,Helfand SL

更新日期：2010-12-01 00:00:00

abstract：:Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here, we demonstrate that a single treatment with the mitochondrial-tar...

journal_title：Aging cell

authors： Siegel MP,Kruse SE,Percival JM,Goh J,White CC,Hopkins HC,Kavanagh TJ,Szeto HH,Rabinovitch PS,Marcinek DJ

更新日期：2013-10-01 00:00:00

abstract：:Ubiquitously reduced signaling via Methuselah (MTH), a G-protein-coupled receptor (GPCR) required for neurosecretion, has previously been reported to extend life and enhance stress resistance in flies. Whether these effects are due to reduced MTH signalling in specific tissues remains unknown. We determined that reduc...

journal_title：Aging cell

authors： Gimenez LE,Ghildyal P,Fischer KE,Hu H,Ja WW,Eaton BA,Wu Y,Austad SN,Ranjan R

更新日期：2013-02-01 00:00:00

abstract：:Aging is associated with a progressive loss of tissue and metabolic homeostasis. This loss can be delayed by single-gene perturbations, increasing lifespan. How such perturbations affect metabolic and proteostatic networks to extend lifespan remains unclear. Here, we address this question by comprehensively characteri...

journal_title：Aging cell

authors： Wang L,Davis SS,Borch Jensen M,Rodriguez-Fernandez IA,Apaydin C,Juhasz G,Gibson BW,Schilling B,Ramanathan A,Ghaemmaghami S,Jasper H

更新日期：2019-06-01 00:00:00

abstract：:Cardiac performance decreases with age, which is a major risk factor for cardiovascular disease and mortality in the aging human population, but the molecular mechanisms underlying cardiac aging are still poorly understood. Investigating the role of integrin-linked kinase (ilk) and β1-integrin (myospheroid, mys) in Dr...

journal_title：Aging cell

authors： Nishimura M,Kumsta C,Kaushik G,Diop SB,Ding Y,Bisharat-Kernizan J,Catan H,Cammarato A,Ross RS,Engler AJ,Bodmer R,Hansen M,Ocorr K

更新日期：2014-06-01 00:00:00

abstract：:Werner syndrome (WS) is an autosomal recessive disorder, the hallmarks of which are premature aging and early onset of neoplastic diseases (Orren, 2006; Bohr, 2008). The gene, whose mutation underlies the WS phenotype, is called WRN. The protein encoded by the WRN gene, WRNp, has DNA helicase activity (Gray et al., 19...

journal_title：Aging cell

authors： Smith JA,Ndoye AM,Geary K,Lisanti MP,Igoucheva O,Daniel R

更新日期：2010-08-01 00:00:00

abstract：:The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...

journal_title：Aging cell

authors： van den Akker EB,Passtoors WM,Jansen R,van Zwet EW,Goeman JJ,Hulsman M,Emilsson V,Perola M,Willemsen G,Penninx BW,Heijmans BT,Maier AB,Boomsma DI,Kok JN,Slagboom PE,Reinders MJ,Beekman M

更新日期：2014-04-01 00:00:00

abstract：:Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) su...

journal_title：Aging cell

authors： Johnson ML,Lalia AZ,Dasari S,Pallauf M,Fitch M,Hellerstein MK,Lanza IR

更新日期：2015-10-01 00:00:00

abstract：:Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in the pathogenesis of several aging-related pathologies including sarcopenia and type 2 diabetes an...

journal_title：Aging cell

authors： Zhang N,Valentine JM,Zhou Y,Li ME,Zhang Y,Bhattacharya A,Walsh ME,Fischer KE,Austad SN,Osmulski P,Gaczynska M,Shoelson SE,Van Remmen H,Chen HI,Chen Y,Liang H,Musi N

更新日期：2017-08-01 00:00:00

abstract：:ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimer's disease. Surprisingly, checkpoint attenuation poten...

journal_title：Aging cell

authors： Khurana V,Merlo P,DuBoff B,Fulga TA,Sharp KA,Campbell SD,Götz J,Feany MB

更新日期：2012-04-01 00:00:00

abstract：:Intron retention (IR) is the least well-understood alternative splicing type in animals, and its prevalence and function in physiological and pathological processes have long been underestimated. Cellular senescence contributes to individual aging and age-related diseases and can also serve as an important cancer prev...

journal_title：Aging cell

authors： Yao J,Ding D,Li X,Shen T,Fu H,Zhong H,Wei G,Ni T

更新日期：2020-12-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to improving functional outcomes in this age-related disease. The molecula...

journal_title：Aging cell

authors： Roh JD,Houstis N,Yu A,Chang B,Yeri A,Li H,Hobson R,Lerchenmüller C,Vujic A,Chaudhari V,Damilano F,Platt C,Zlotoff D,Lee RT,Shah R,Jerosch-Herold M,Rosenzweig A

更新日期：2020-06-01 00:00:00

abstract：:Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve lif...

journal_title：Aging cell

authors： Birkisdóttir MB,Jaarsma D,Brandt RMC,Barnhoorn S,van Vliet N,Imholz S,van Oostrom CT,Nagarajah B,Portilla Fernández E,Roks AJM,Elgersma Y,van Steeg H,Ferreira JA,Pennings JLA,Hoeijmakers JHJ,Vermeij WP,Dollé MET

更新日期：2021-01-23 00:00:00

abstract：:Neuropeptide Y (NPY) is an orexigenic peptide that plays an essential role in caloric restriction (CR)-mediated lifespan extension. However, the mechanisms underlying the NPY-mediated effects in CR are poorly defined. Here, we report that NPY deficiency in male mice during CR increases mortality in association with li...

journal_title：Aging cell

authors： Park S,Komatsu T,Kim SE,Tanaka K,Hayashi H,Mori R,Shimokawa I

更新日期：2017-04-01 00:00:00

abstract：:SARS-CoV-2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID-19), a complex respiratory distress syndrome. Epidemiological data show that COVID-19 has a rising mortality particularly in individuals with advanced age. Identifying a functional association ...

journal_title：Aging cell

authors： Nehme J,Borghesan M,Mackedenski S,Bird TG,Demaria M

更新日期：2020-10-01 00:00:00

abstract：:Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processe...

journal_title：Aging cell

authors： Trujillo-Estrada L,Nguyen C,da Cunha C,Cai L,Forner S,Martini AC,Ager RR,Prieto GA,Cotman CW,Baglietto-Vargas D,LaFerla FM

更新日期：2019-06-01 00:00:00

abstract：:The IGF-1 signaling pathway plays an important role in regulating longevity. To identify the genetic loci and genes that regulate plasma IGF-1 levels, we intercrossed MRL/MpJ and SM/J, inbred mouse strains that differ in IGF-1 levels. Quantitative trait loci (QTL) analysis of IGF-1 levels of these F2 mice detected fou...

journal_title：Aging cell

authors： Leduc MS,Hageman RS,Meng Q,Verdugo RA,Tsaih SW,Churchill GA,Paigen B,Yuan R

更新日期：2010-10-01 00:00:00

abstract：:The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amy...

journal_title：Aging cell

authors： Schultz N,Brännström K,Byman E,Moussaud S,Nielsen HM,Netherlands Brain Bank.,Olofsson A,Wennström M

更新日期：2018-06-01 00:00:00

abstract：:Dietary restriction (DR) is the most universal intervention known to extend animal lifespan. DR also prevents tumor development in mammals, and this effect requires the tumor suppressor PTEN. However, the metabolic and cellular processes that underly the beneficial effects of DR are poorly understood. We identified sl...

journal_title：Aging cell

authors： Mouchiroud L,Molin L,Kasturi P,Triba MN,Dumas ME,Wilson MC,Halestrap AP,Roussel D,Masse I,Dallière N,Ségalat L,Billaud M,Solari F

更新日期：2011-02-01 00:00:00

abstract：:Oestrogenic compounds have been postulated as neuroprotective agents. This prompted us to investigate their mechanism action in neurons in primary culture. Cells were pretreated with physiological concentrations of 17-beta estradiol (0.2 nm) or with nutritionally relevant concentrations of genistein (0.5 microm), and ...

journal_title：Aging cell

authors： Vallés SL,Borrás C,Gambini J,Furriol J,Ortega A,Sastre J,Pallardó FV,Viña J

更新日期：2008-01-01 00:00:00

abstract：:Older adults often show signs of impaired CD8+ T-cell immunity, reflected by weaker responses against new infections and vaccinations, and decreased protection against reinfection. This immune impairment is in part thought to be the consequence of a decrease in both T-cell numbers and repertoire diversity. If this is ...

journal_title：Aging cell

authors： Lanfermeijer J,Borghans JAM,van Baarle D

更新日期：2020-11-01 00:00:00

abstract：:We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in...

journal_title：Aging cell

authors： Sutphin GL,Backer G,Sheehan S,Bean S,Corban C,Liu T,Peters MJ,van Meurs JBJ,Murabito JM,Johnson AD,Korstanje R,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group.

更新日期：2017-08-01 00:00:00

abstract：:Cross-sectional studies have repeatedly suggested peripheral blood monocyte telomere length as a biomarker of aging. To test this suggestion in a large population-based follow-up study of the oldest old, we measured telomere length at baseline in 598 participants of the Leiden 85-plus Study (mean age at baseline 89.8 ...

journal_title：Aging cell

authors： Martin-Ruiz CM,Gussekloo J,van Heemst D,von Zglinicki T,Westendorp RG

更新日期：2005-12-01 00:00:00

abstract：:Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the elderly. Previous studies found a protective effect of reduced histone deacetylase activity in models of neurogenic muscle atrophy. Because loss of muscle mass during aging is associated with...

journal_title：Aging cell

authors： Walsh ME,Bhattacharya A,Sataranatarajan K,Qaisar R,Sloane L,Rahman MM,Kinter M,Van Remmen H

更新日期：2015-12-01 00:00:00

abstract：:Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a promising therapeutic tool for many diseases, including aged tissues and organs at high risk of failure. However, the intrinsic self-renewal and pluripotency of ES and iPS cells make them tumorigenic, and hence, the risk of tumor developmen...

journal_title：Aging cell

authors： Menendez S,Camus S,Herreria A,Paramonov I,Morera LB,Collado M,Pekarik V,Maceda I,Edel M,Consiglio A,Sanchez A,Li H,Serrano M,Belmonte JC

更新日期：2012-02-01 00:00:00

abstract：:The goal of this study is to test the role of mitochondria and of mitochondrial metabolism in determining the processes that influence aging of female and male Drosophila. We observe that Drosophila simulans females tended to have shorter lifespan, higher levels of hydrogen peroxide production and significantly lower ...

journal_title：Aging cell

authors： Ballard JW,Melvin RG,Miller JT,Katewa SD

更新日期：2007-10-01 00:00:00