A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans.

abstract：:Most human tissues express low levels of telomerase and undergo telomere shortening and eventual senescence; the resulting limitation on tissue renewal can lead to a wide range of age-dependent pathophysiologies. Increasing evidence indicates that the decline in cell division capacity in cells that lack telomerase can...

journal_title：Aging cell

authors： Ballew BJ,Lundblad V

更新日期：2013-08-01 00:00:00

abstract：:Lactic-acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic-acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the be...

journal_title：Aging cell

authors： Nakagawa H,Shiozaki T,Kobatake E,Hosoya T,Moriya T,Sakai F,Taru H,Miyazaki T

更新日期：2016-04-01 00:00:00

abstract：:Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in the pathogenesis of several aging-related pathologies including sarcopenia and type 2 diabetes an...

journal_title：Aging cell

authors： Zhang N,Valentine JM,Zhou Y,Li ME,Zhang Y,Bhattacharya A,Walsh ME,Fischer KE,Austad SN,Osmulski P,Gaczynska M,Shoelson SE,Van Remmen H,Chen HI,Chen Y,Liang H,Musi N

更新日期：2017-08-01 00:00:00

abstract：:Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5(+) cells are generated at late stages of retinal development and exh...

journal_title：Aging cell

authors： Chen M,Tian S,Glasgow NG,Gibson G,Yang X,Shiber CE,Funderburgh J,Watkins S,Johnson JW,Schuman JS,Liu H

更新日期：2015-08-01 00:00:00

abstract：:Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline ...

journal_title：Aging cell

authors： Tarantini S,Valcarcel-Ares NM,Yabluchanskiy A,Fulop GA,Hertelendy P,Gautam T,Farkas E,Perz A,Rabinovitch PS,Sonntag WE,Csiszar A,Ungvari Z

更新日期：2018-04-01 00:00:00

abstract：:We used DNA microarrays to identify panels of transcriptional markers of aging that are differentially expressed in young (5 month) and old (25 month) mice of multiple inbred strains (129sv, BALB/c, CBA, DBA, B6, C3H and B6C3F(1)). In the heart, age-related changes of five genes were studied throughout the mouse lifes...

journal_title：Aging cell

authors： Park SK,Kim K,Page GP,Allison DB,Weindruch R,Prolla TA

更新日期：2009-08-01 00:00:00

abstract：:Dietary restriction extends lifespan and inhibits reproduction in many species. In Caenorhabditis elegans, inhibiting reproduction by germline removal extends lifespan. Therefore, we asked whether the effect of dietary restriction on lifespan might proceed via changes in the activity of the germline. We found that die...

journal_title：Aging cell

authors： Crawford D,Libina N,Kenyon C

更新日期：2007-10-01 00:00:00

abstract：:Age-related increase in L-type Ca(2+) channel (LTCC) expression in hippocampal pyramidal neurons has been hypothesized to underlie the increased Ca(2+) influx and subsequent reduced intrinsic neuronal excitability of these neurons that lead to age-related cognitive deficits. Here, using specific antibodies against Cav...

journal_title：Aging cell

authors： Núñez-Santana FL,Oh MM,Antion MD,Lee A,Hell JW,Disterhoft JF

更新日期：2014-02-01 00:00:00

abstract：:The nematode Caenorhabditis elegans has become one of the most widely used model systems for the study of aging, yet very little is known about how C. elegans age. The development of the worm, from egg to young adult has been completely mapped at the cellular level, but such detailed studies have not been extended thr...

journal_title：Aging cell

authors： Golden TR,Beckman KB,Lee AH,Dudek N,Hubbard A,Samper E,Melov S

更新日期：2007-04-01 00:00:00

abstract：:Neurogenesis, which may contribute to the ability of the adult brain to function normally and adapt to disease, nevertheless declines with advancing age. Adult neurogenesis can be enhanced by administration of growth factors, but whether the aged brain remains responsive to these factors is unknown. We compared the ef...

journal_title：Aging cell

authors： Jin K,Sun Y,Xie L,Batteur S,Mao XO,Smelick C,Logvinova A,Greenberg DA

更新日期：2003-06-01 00:00:00

abstract：:The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more ...

journal_title：Aging cell

authors： Fridovich I

更新日期：2004-02-01 00:00:00

abstract：:Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancem...

journal_title：Aging cell

authors： Liu YL,Lu WC,Brummel TJ,Yuh CH,Lin PT,Kao TY,Li FY,Liao PC,Benzer S,Wang HD

更新日期：2009-08-01 00:00:00

abstract：:Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains incompletely understo...

journal_title：Aging cell

authors： Metcalf TU,Cubas RA,Ghneim K,Cartwright MJ,Grevenynghe JV,Richner JM,Olagnier DP,Wilkinson PA,Cameron MJ,Park BS,Hiscott JB,Diamond MS,Wertheimer AM,Nikolich-Zugich J,Haddad EK

更新日期：2015-06-01 00:00:00

abstract：:Previously, we reported that persistent DNA damage accelerates ageing of the spine, but the mechanisms behind this process are not well understood. Ataxia telangiectasia mutated (ATM) is a protein kinase involved in the DNA damage response, which controls cell fate, including cell death. To test the role of ATM in the...

journal_title：Aging cell

authors： Han Y,Zhou CM,Shen H,Tan J,Dong Q,Zhang L,McGowan SJ,Zhao J,Sowa GA,Kang JD,Niedernhofer LJ,Robbins PD,Vo NN

更新日期：2020-07-01 00:00:00

abstract：:The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor 5 (TLR5), unlike th...

journal_title：Aging cell

authors： Lim JS,Nguyen KC,Nguyen CT,Jang IS,Han JM,Fabian C,Lee SE,Rhee JH,Cho KA

更新日期：2015-10-01 00:00:00

abstract：:The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age-associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirmed that specific depletion of Sirt2 disrupts maturational progression and spindle/chromos...

journal_title：Aging cell

authors： Qiu D,Hou X,Han L,Li X,Ge J,Wang Q

更新日期：2018-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density that occurs early in the disease process seems to be partially due to the overactivation of N-methyl-d-aspartate receptors (NMDARs) leading to excitotoxicity. Recently, ...

journal_title：Aging cell

authors： Costa RO,Lacor PN,Ferreira IL,Resende R,Auberson YP,Klein WL,Oliveira CR,Rego AC,Pereira CM

更新日期：2012-10-01 00:00:00

abstract：:SIRT4 modulates energy homeostasis in multiple cell types and tissues. However, its role in meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT4 are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reac...

journal_title：Aging cell

authors： Zeng J,Jiang M,Wu X,Diao F,Qiu D,Hou X,Wang H,Li L,Li C,Ge J,Liu J,Ou X,Wang Q

更新日期：2018-08-01 00:00:00

abstract：:Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome...

journal_title：Aging cell

authors： Chung KW,Lee EK,Kim DH,An HJ,Kim ND,Im DS,Lee J,Yu BP,Chung HY

更新日期：2015-08-01 00:00:00

abstract：:Accumulating evidence suggests a role for microRNAs (miRNAs) in regulating various processes of mammalian postnatal development and aging. To investigate the changes in blood-based miRNA expression from preterm infants to adulthood, we compared 365 miRNA expression profiles in a screening set of preterm infants and ad...

journal_title：Aging cell

authors： Lai CY,Wu YT,Yu SL,Yu YH,Lee SY,Liu CM,Hsieh WS,Hwu HG,Chen PC,Jeng SF,Chen WJ

更新日期：2014-08-01 00:00:00

abstract：:Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processe...

journal_title：Aging cell

authors： Trujillo-Estrada L,Nguyen C,da Cunha C,Cai L,Forner S,Martini AC,Ager RR,Prieto GA,Cotman CW,Baglietto-Vargas D,LaFerla FM

更新日期：2019-06-01 00:00:00

abstract：:Neurodegenerative diseases (ND) have been linked to the critical process in aging-cellular senescence. However, the temporal dynamics of cellular senescence in ND conditions is unresolved. Here, we show senescence features develop in human Huntington's disease (HD) neural stem cells (NSCs) and medium spiny neurons (MS...

journal_title：Aging cell

authors： Voisin J,Farina F,Naphade S,Fontaine M,Tshilenge KT,Galicia Aguirre C,Lopez-Ramirez A,Dancourt J,Ginisty A,Sasidharan Nair S,Lakshika Madushani K,Zhang N,Lejeune FX,Verny M,Campisi J,Ellerby LM,Neri C

更新日期：2020-11-01 00:00:00

abstract：:While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely unknown. During aging, many alterations occur in the organism, which are associated with progressive impairment of metabolic pathways related to insulin resistance, autophagy dysfunction, and inf...

journal_title：Aging cell

authors： Marín-Aguilar F,Lechuga-Vieco AV,Alcocer-Gómez E,Castejón-Vega B,Lucas J,Garrido C,Peralta-Garcia A,Pérez-Pulido AJ,Varela-López A,Quiles JL,Ryffel B,Flores I,Bullón P,Ruiz-Cabello J,Cordero MD

更新日期：2020-01-01 00:00:00

abstract：:The mitochondrial theory of aging is based around the idea of a vicious cycle, in which somatic mutation of mtDNA engenders respiratory chain dysfunction, enhancing the production of DNA-damaging oxygen radicals. In turn, this is proposed to result in the accumulation of further mtDNA mutations. Finally, a bioenergeti...

journal_title：Aging cell

authors： Jacobs HT

更新日期：2003-02-01 00:00:00

abstract：:Long-term calorie restriction (CR) has numerous benefits; however, effects of CR on susceptibility to intact pathogens are not well understood. Because CR enhances immune function of laboratory mice (Mus musculus), it was hypothesized that mice subjected to CR would be less susceptible to experimental infections of th...

journal_title：Aging cell

authors： Kristan DM

更新日期：2007-12-01 00:00:00

abstract：:We test the 'free radical theory of aging' using six species of colubrid snakes (numerous, widely distributed, non-venomous snakes of the family Colubridae) that exhibit long (> 15 years) or short (< 10 years) lifespans. Because the 'rate of living theory' predicts metabolic rates to be correlated with rates of aging ...

journal_title：Aging cell

authors： Robert KA,Brunet-Rossinni A,Bronikowski AM

更新日期：2007-06-01 00:00:00

abstract：:Aging impairs arterial function through oxidative stress and diminished nitric oxide (NO) bioavailability. Life-long caloric restriction (CR) reduces oxidative stress, but its impact on arterial aging is incompletely understood. We tested the hypothesis that life-long CR attenuates key features of arterial aging. Bloo...

journal_title：Aging cell

authors： Donato AJ,Walker AE,Magerko KA,Bramwell RC,Black AD,Henson GD,Lawson BR,Lesniewski LA,Seals DR

更新日期：2013-10-01 00:00:00

abstract：:Summary We address the problem of establishing a survival schedule for wild populations. A demographic key identity is established, leading to a method whereby age-specific survival and mortality can be deduced from a marked cohort life table established for individuals that are randomly sampled at unknown age and mar...

journal_title：Aging cell

authors： Müller HG,Wang JL,Carey JR,Caswell-Chen EP,Chen C,Papadopoulos N,Yao F

更新日期：2004-06-01 00:00:00

abstract：:We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in...

journal_title：Aging cell

authors： Sutphin GL,Backer G,Sheehan S,Bean S,Corban C,Liu T,Peters MJ,van Meurs JBJ,Murabito JM,Johnson AD,Korstanje R,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group.

更新日期：2017-08-01 00:00:00

abstract：:Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a benefici...

journal_title：Aging cell

authors： Yang CC,Chen D,Lee SS,Walter L

更新日期：2011-08-01 00:00:00