Abstract:
:Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5(+) cells are generated at late stages of retinal development and exhibit properties of differentiated amacrine interneurons (amacrine cells). Nevertheless, Lgr5(+) amacrine cells contribute to regeneration of new retinal cells in the adult stage. The generation of new retinal cells, including retinal neurons and Müller glia from Lgr5(+) amacrine cells, begins in early adulthood and continues as the animal ages. Together, these findings suggest that the mammalian retina is not devoid of regeneration as previously thought. It is rather dynamic, and Lgr5(+) amacrine cells function as an endogenous regenerative source. The identification of such cells in the mammalian retina may provide new insights into neuronal regeneration and point to therapeutic opportunities for age-related retinal degenerative diseases.
journal_name
Aging Celljournal_title
Aging cellauthors
Chen M,Tian S,Glasgow NG,Gibson G,Yang X,Shiber CE,Funderburgh J,Watkins S,Johnson JW,Schuman JS,Liu Hdoi
10.1111/acel.12346subject
Has Abstractpub_date
2015-08-01 00:00:00pages
635-43issue
4eissn
1474-9718issn
1474-9726journal_volume
14pub_type
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