Abstract:
:Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
journal_name
Aging Celljournal_title
Aging cellauthors
Yang CC,Chen D,Lee SS,Walter Ldoi
10.1111/j.1474-9726.2011.00711.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
724-8issue
4eissn
1474-9718issn
1474-9726journal_volume
10pub_type
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