Abstract:
:This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
journal_name
Aging Celljournal_title
Aging cellauthors
Conover CAdoi
10.1111/j.1474-9726.2010.00630.xsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
942-6issue
6eissn
1474-9718issn
1474-9726journal_volume
9pub_type
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