The load of short telomeres, estimated by a new method, Universal STELA, correlates with number of senescent cells.

abstract：:The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (gamma-H2A.X) at either un...

journal_title：Aging cell

authors： Wang C,Jurk D,Maddick M,Nelson G,Martin-Ruiz C,von Zglinicki T

更新日期：2009-06-01 00:00:00

abstract：:ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimer's disease. Surprisingly, checkpoint attenuation poten...

journal_title：Aging cell

authors： Khurana V,Merlo P,DuBoff B,Fulga TA,Sharp KA,Campbell SD,Götz J,Feany MB

更新日期：2012-04-01 00:00:00

abstract：:The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation init...

journal_title：Aging cell

authors： Rousakis A,Vlassis A,Vlanti A,Patera S,Thireos G,Syntichaki P

更新日期：2013-10-01 00:00:00

abstract：:One of the hallmarks of aging is the progressive accumulation of senescent cells in organisms, which has been proposed to be a contributing factor to age-dependent organ dysfunction. We recently reported that Bruton's tyrosine kinase (BTK) is an upstream component of the p53 responses to DNA damage. BTK binds to and p...

journal_title：Aging cell

authors： Ekpenyong-Akiba AE,Poblocka M,Althubiti M,Rada M,Jurk D,Germano S,Kocsis-Fodor G,Shi Y,Canales JJ,Macip S

更新日期：2020-01-01 00:00:00

abstract：:In a previous study, we reported that a deficiency in MnSOD activity (approximately 80% reduction) targeted to type IIB skeletal muscle fibers was sufficient to elevate oxidative stress and to reduce muscle function in young adult mice (TnIFastCreSod2(fl/fl) mice). In this study, we used TnIFastCreSod2(fl/fl) mice to ...

journal_title：Aging cell

authors： Lustgarten MS,Jang YC,Liu Y,Qi W,Qin Y,Dahia PL,Shi Y,Bhattacharya A,Muller FL,Shimizu T,Shirasawa T,Richardson A,Van Remmen H

更新日期：2011-06-01 00:00:00

abstract：:Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators ...

journal_title：Aging cell

authors： Pan KZ,Palter JE,Rogers AN,Olsen A,Chen D,Lithgow GJ,Kapahi P

更新日期：2007-02-01 00:00:00

abstract：:The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more ...

journal_title：Aging cell

authors： Fridovich I

更新日期：2004-02-01 00:00:00

abstract：:Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processe...

journal_title：Aging cell

authors： Trujillo-Estrada L,Nguyen C,da Cunha C,Cai L,Forner S,Martini AC,Ager RR,Prieto GA,Cotman CW,Baglietto-Vargas D,LaFerla FM

更新日期：2019-06-01 00:00:00

abstract：:The discovery of treatments to prevent or delay dementia and Alzheimer's disease is a priority. The gene APOE is associated with cognitive change and late-onset Alzheimer's disease, and epidemiological studies have provided strong evidence that the e2 allele of APOE has a neuroprotective effect, it is associated with ...

journal_title：Aging cell

authors： Sebastiani P,Monti S,Morris M,Gurinovich A,Toshiko T,Andersen SL,Sweigart B,Ferrucci L,Jennings LL,Glass DJ,Perls TT

更新日期：2019-12-01 00:00:00

abstract：:Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia-inducible factor (HIF)-1α is largely unknown. In this study, we investigated whether HIF-1α could be a deacetylation target of Sirt1 and the effect of their interact...

journal_title：Aging cell

authors： Ryu DR,Yu MR,Kong KH,Kim H,Kwon SH,Jeon JS,Han DC,Noh H

更新日期：2019-04-01 00:00:00

abstract：:While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely unknown. During aging, many alterations occur in the organism, which are associated with progressive impairment of metabolic pathways related to insulin resistance, autophagy dysfunction, and inf...

journal_title：Aging cell

authors： Marín-Aguilar F,Lechuga-Vieco AV,Alcocer-Gómez E,Castejón-Vega B,Lucas J,Garrido C,Peralta-Garcia A,Pérez-Pulido AJ,Varela-López A,Quiles JL,Ryffel B,Flores I,Bullón P,Ruiz-Cabello J,Cordero MD

更新日期：2020-01-01 00:00:00

abstract：:Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generations of telomerase-def...

journal_title：Aging cell

authors： García-Beccaria M,Martínez P,Flores JM,Blasco MA

更新日期：2014-10-01 00:00:00

abstract：:Replicative senescence has a major impact on function and integrity of cell preparations. This process is reflected by continuous DNA methylation (DNAm) changes at specific CpG dinucleotides in the course of in vitro culture, and such modifications can be used to estimate the state of cellular senescence for quality c...

journal_title：Aging cell

authors： Franzen J,Zirkel A,Blake J,Rath B,Benes V,Papantonis A,Wagner W

更新日期：2017-02-01 00:00:00

abstract：:Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...

journal_title：Aging cell

authors： Zhang B,Podolskiy DI,Mariotti M,Seravalli J,Gladyshev VN

更新日期：2020-05-01 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest activated in response to damaging stimuli. Many hallmarks associated with senescent cells are measured by quantitative real-time PCR (qPCR). As the selection of stable reference genes for interpretation of qPCR data is often overlooked, we performed a syste...

journal_title：Aging cell

authors： Hernandez-Segura A,Rubingh R,Demaria M

更新日期：2019-04-01 00:00:00

abstract：:Naked mole-rats (Heterocephalus glaber), the longest-lived rodents, live 7-10 times longer than similarly sized mice and exhibit normal activities for approximately 75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long. Neuregulin-1 (NRG-1) signaling is cr...

journal_title：Aging cell

authors： Edrey YH,Casper D,Huchon D,Mele J,Gelfond JA,Kristan DM,Nevo E,Buffenstein R

更新日期：2012-04-01 00:00:00

abstract：:Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would ...

journal_title：Aging cell

authors： Walton RG,Dungan CM,Long DE,Tuggle SC,Kosmac K,Peck BD,Bush HM,Villasante Tezanos AG,McGwin G,Windham ST,Ovalle F,Bamman MM,Kern PA,Peterson CA

更新日期：2019-12-01 00:00:00

abstract：:Most mammalian cells when placed in culture will undergo a limited number of cell divisions before entering an unresponsive non-proliferating state termed senescence. However, several pathways that are activated singly or in concert can allow cells to bypass senescence at least for limited periods. These include the t...

journal_title：Aging cell

authors： Miura T,Mattson MP,Rao MS

更新日期：2004-12-01 00:00:00

abstract：:Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during cellular senescence are not known. We used formaldehyde assisted isolation of regul...

journal_title：Aging cell

authors： De Cecco M,Criscione SW,Peckham EJ,Hillenmeyer S,Hamm EA,Manivannan J,Peterson AL,Kreiling JA,Neretti N,Sedivy JM

更新日期：2013-04-01 00:00:00

abstract：:General locomotor activity decreases with normal aging in animals and could be partially explained by decreases in neuronal function. Voltage-gated Na(+) channels are essential in initiating and propagating rapid electrical impulses underlying normal locomotor activity and behavior in animals. Isolation of mutations c...

journal_title：Aging cell

authors： Reenan RA,Rogina B

更新日期：2008-03-01 00:00:00

abstract：:Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...

journal_title：Aging cell

authors： Murchison D,Griffith WH

更新日期：2007-06-01 00:00:00

abstract：:The G protein-coupled receptor (GPCR) encoding family of genes constitutes more than 6% of genes in Caenorhabditis elegans genome. GPCRs control behavior, innate immunity, chemotaxis, and food search behavior. Here, we show that C. elegans longevity is regulated by a chemosensory GPCR STR-2, expressed in AWC and ASI a...

journal_title：Aging cell

authors： Dixit A,Sandhu A,Modi S,Shashikanth M,Koushika SP,Watts JL,Singh V

更新日期：2020-06-01 00:00:00

abstract：:Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age-related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age-related arterial dysfunction. To explore this, young (3.8 ± 0.6 months) and old (30.3 ± 0....

journal_title：Aging cell

authors： Lesniewski LA,Seals DR,Walker AE,Henson GD,Blimline MW,Trott DW,Bosshardt GC,LaRocca TJ,Lawson BR,Zigler MC,Donato AJ

更新日期：2017-02-01 00:00:00

abstract：:Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a promising therapeutic tool for many diseases, including aged tissues and organs at high risk of failure. However, the intrinsic self-renewal and pluripotency of ES and iPS cells make them tumorigenic, and hence, the risk of tumor developmen...

journal_title：Aging cell

authors： Menendez S,Camus S,Herreria A,Paramonov I,Morera LB,Collado M,Pekarik V,Maceda I,Edel M,Consiglio A,Sanchez A,Li H,Serrano M,Belmonte JC

更新日期：2012-02-01 00:00:00

abstract：:Maternal age-related decline in oocyte quality is associated with meiotic defects, but the underlying mechanisms remain to be explored. Histone deacetylase 3 (HDAC3) has been shown to govern multiple cellular events via deacetylating diverse substrates. We previously found that HDAC3 could promote meiotic apparatus as...

journal_title：Aging cell

authors： He Y,Li X,Gao M,Liu H,Gu L

更新日期：2019-12-01 00:00:00

abstract：:The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor 5 (TLR5), unlike th...

journal_title：Aging cell

authors： Lim JS,Nguyen KC,Nguyen CT,Jang IS,Han JM,Fabian C,Lee SE,Rhee JH,Cho KA

更新日期：2015-10-01 00:00:00

abstract：:Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death rate, which is thought to reflect the rate of age-related damage accumulation....

journal_title：Aging cell

authors： Valenzano DR,Terzibasi E,Cattaneo A,Domenici L,Cellerino A

更新日期：2006-06-01 00:00:00

abstract：:Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is...

journal_title：Aging cell

authors： Tauffenberger A,Vaccaro A,Aulas A,Vande Velde C,Parker JA

更新日期：2012-10-01 00:00:00

abstract：:Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve lif...

journal_title：Aging cell

authors： Birkisdóttir MB,Jaarsma D,Brandt RMC,Barnhoorn S,van Vliet N,Imholz S,van Oostrom CT,Nagarajah B,Portilla Fernández E,Roks AJM,Elgersma Y,van Steeg H,Ferreira JA,Pennings JLA,Hoeijmakers JHJ,Vermeij WP,Dollé MET

更新日期：2021-01-23 00:00:00

abstract：:Fetal cardiomyocytes have been proposed as a potential source of cell-based therapy for heart failure. This study examined cellular senescence in cultured human fetal ventricular cardiomyocytes (HFCs). HFCs were isolated and identified by immunocytochemistry and RT-PCR. Cells were found to senesce after 20-25 populati...

journal_title：Aging cell

authors： Ball AJ,Levine F

更新日期：2005-02-01 00:00:00