Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity.

abstract：:Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5(+) cells are generated at late stages of retinal development and exh...

journal_title：Aging cell

authors： Chen M,Tian S,Glasgow NG,Gibson G,Yang X,Shiber CE,Funderburgh J,Watkins S,Johnson JW,Schuman JS,Liu H

更新日期：2015-08-01 00:00:00

abstract：:Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long-term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high-fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin...

journal_title：Aging cell

authors： Zhu B,Li Y,Xiang L,Zhang J,Wang L,Guo B,Liang M,Chen L,Xiang L,Dong J,Liu M,Mei W,Li H,Xiang G

更新日期：2019-04-01 00:00:00

abstract：:Endothelial oxidative stress develops with aging and reactive oxygen species impair endothelium-dependent relaxation (EDR) by decreasing nitric oxide (NO) availability. Endothelial KCa 3.1, which contributes to EDR, is upregulated by H2 O2 . We investigated whether KCa 3.1 upregulation compensates for diminished EDR t...

journal_title：Aging cell

authors： Choi S,Kim JA,Li HY,Shin KO,Oh GT,Lee YM,Oh S,Pewzner-Jung Y,Futerman AH,Suh SH

更新日期：2016-10-01 00:00:00

abstract：:Cellular senescence plays both beneficial and detrimental roles in embryonic development and tissue regeneration, while the underlying mechanism remains elusive. Recent studies disclosed the emerging roles of heat-shock proteins in regulating muscle regeneration and homeostasis. Here, we found that Hsp90β, but not Hsp...

journal_title：Aging cell

authors： He MY,Xu SB,Qu ZH,Guo YM,Liu XC,Cong XX,Wang JF,Low BC,Li L,Wu Q,Lin P,Yan SG,Bao Z,Zhou YT,Zheng LL

更新日期：2019-10-01 00:00:00

abstract：:Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of age-related degenerative diseases is termed 'laminopathies'. Here, we show that mature lamin A has an essential role in cellular fitness and that oxidative damage to lamin A is involved in cellular senescence. Primary human dermal f...

journal_title：Aging cell

authors： Pekovic V,Gibbs-Seymour I,Markiewicz E,Alzoghaibi F,Benham AM,Edwards R,Wenhert M,von Zglinicki T,Hutchison CJ

更新日期：2011-12-01 00:00:00

abstract：:Immunosenescence, the age-related decline in immune response, is a well-known consequence of aging. To date, most studies of age-related changes in immune response focused on the cellular and physiological bases of this decline; we have virtually no understanding of the genetic basis of age-related changes in the immu...

journal_title：Aging cell

authors： Lesser KJ,Paiusi IC,Leips J

更新日期：2006-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density that occurs early in the disease process seems to be partially due to the overactivation of N-methyl-d-aspartate receptors (NMDARs) leading to excitotoxicity. Recently, ...

journal_title：Aging cell

authors： Costa RO,Lacor PN,Ferreira IL,Resende R,Auberson YP,Klein WL,Oliveira CR,Rego AC,Pereira CM

更新日期：2012-10-01 00:00:00

abstract：:Aging is associated with a large number of both phenotypic and molecular changes, but for most of these, it is not known whether these changes are detrimental, neutral, or protective. We have identified a conserved Caenorhabditis elegans GATA transcription factor/MTA-1 homolog egr-1 (lin-40) that extends lifespan and ...

journal_title：Aging cell

authors： Zimmerman SM,Kim SK

更新日期：2014-04-01 00:00:00

abstract：:Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isol...

journal_title：Aging cell

authors： Rittié L,Stoll SW,Kang S,Voorhees JJ,Fisher GJ

更新日期：2009-12-01 00:00:00

abstract：:Brain lesions in Alzheimer's disease (AD) include amyloid plaques made of Aβ peptides and neurofibrillary tangles composed of hyperphosphorylated tau protein with synaptic and neuronal loss and neuroinflammation. Aβ oligomers can trigger tau phosphorylation and neuronal alterations through activation of neuronal kinas...

journal_title：Aging cell

authors： Tible M,Mouton Liger F,Schmitt J,Giralt A,Farid K,Thomasseau S,Gourmaud S,Paquet C,Rondi Reig L,Meurs E,Girault JA,Hugon J

更新日期：2019-06-01 00:00:00

abstract：:Methionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where ...

journal_title：Aging cell

authors： Aledo JC,Li Y,de Magalhães JP,Ruíz-Camacho M,Pérez-Claros JA

更新日期：2011-04-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:Aging is inevitably accompanied by gradual and irreversible innate endothelial dysfunction. In this study, we tested the hypothesis that accentuation of glucose metabolism via the aldose reductase (AR) pathway contributes to age-related vascular dysfunction. AR protein and activity levels were significantly increased ...

journal_title：Aging cell

authors： Hallam KM,Li Q,Ananthakrishnan R,Kalea A,Zou YS,Vedantham S,Schmidt AM,Yan SF,Ramasamy R

更新日期：2010-10-01 00:00:00

abstract：:The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide...

journal_title：Aging cell

authors： Teumer A,Qi Q,Nethander M,Aschard H,Bandinelli S,Beekman M,Berndt SI,Bidlingmaier M,Broer L,CHARGE Longevity Working Group.,Cappola A,Ceda GP,Chanock S,Chen MH,Chen TC,Chen YD,Chung J,Del Greco Miglianico F,Eriksson J

更新日期：2016-10-01 00:00:00

abstract：:Here I comment on the recent contribution by Barrientos et al. J. Neurosci. 32, 14641-14648 (2012) addressing treatment possibilities for surgery-induced cognitive dysfunction. It has been over 15 years since the publication of a landmark study that indicated age as a major risk factor for postoperative cognitive dysf...

journal_title：Aging cell

authors： Fidalgo AR

更新日期：2013-06-01 00:00:00

abstract：:Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators ...

journal_title：Aging cell

authors： Pan KZ,Palter JE,Rogers AN,Olsen A,Chen D,Lithgow GJ,Kapahi P

更新日期：2007-02-01 00:00:00

abstract：:Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effect of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. Here, we describe a large-scale effort to define molecular mechanisms that underlie genotype-spe...

journal_title：Aging cell

authors： Schleit J,Johnson SC,Bennett CF,Simko M,Trongtham N,Castanza A,Hsieh EJ,Moller RM,Wasko BM,Delaney JR,Sutphin GL,Carr D,Murakami CJ,Tocchi A,Xian B,Chen W,Yu T,Goswami S,Higgins S,Holmberg M,Jeong KS,Kim JR,Kl

更新日期：2013-12-01 00:00:00

abstract：:While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called 'fenestrations' are...

journal_title：Aging cell

authors： Mohamad M,Mitchell SJ,Wu LE,White MY,Cordwell SJ,Mach J,Solon-Biet SM,Boyer D,Nines D,Das A,Catherine Li SY,Warren A,Hilmer SN,Fraser R,Sinclair DA,Simpson SJ,de Cabo R,Le Couteur DG,Cogger VC

更新日期：2016-08-01 00:00:00

abstract：:Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generations of telomerase-def...

journal_title：Aging cell

authors： García-Beccaria M,Martínez P,Flores JM,Blasco MA

更新日期：2014-10-01 00:00:00

abstract：:Adequate energy stores are essential for survival, and sophisticated neuroendocrine mechanisms evolved to stimulate foraging in response to nutrient deprivation. Food search behavior is usually investigated in young animals, and it is not known how aging alters this behavior. To address this question in Drosophila mel...

journal_title：Aging cell

authors： Egenriether SM,Chow ES,Krauth N,Giebultowicz JM

更新日期：2015-10-01 00:00:00

abstract：:In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolong the chronological aging of yeast cells during the stationary phase. Lifespan extension is significantly reduced in yca1 mutants as well in rho(0) strains, suggesting that the protective effects pass through the Yca1 cas...

journal_title：Aging cell

authors： Palermo V,Falcone C,Calvani M,Mazzoni C

更新日期：2010-08-01 00:00:00

abstract：:Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest, or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies determined the mutation...

journal_title：Aging cell

authors： Beltrami E,Ruggiero A,Busuttil R,Migliaccio E,Pelicci PG,Vijg J,Giorgio M

更新日期：2013-04-01 00:00:00

abstract：:Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mu...

journal_title：Aging cell

authors： Tchkonia T,Morbeck DE,Von Zglinicki T,Van Deursen J,Lustgarten J,Scrable H,Khosla S,Jensen MD,Kirkland JL

更新日期：2010-10-01 00:00:00

abstract：:The 'rate of living' theory predicts that longevity should be inversely correlated with the rate of mitochondrial respiration. However, recent studies in a number of model organisms, including mice, have reported that interventions that retard the aging process are, in fact, associated with an increase in mitochondria...

journal_title：Aging cell

authors： Bahadorani S,Cho J,Lo T,Contreras H,Lawal HO,Krantz DE,Bradley TJ,Walker DW

更新日期：2010-04-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is regarded as one of the serious risk factors for age-related cognitive impairment; however, a causal link between these two diseases has so far not been established. It was recently discovered that, apart from high D-glucose levels, T2DM patients also display abnormally high concentra...

journal_title：Aging cell

authors： Wei Y,Han C,Wang Y,Wu B,Su T,Liu Y,He R

更新日期：2015-10-01 00:00:00

abstract：:Dietary restriction (DR) is the most universal intervention known to extend animal lifespan. DR also prevents tumor development in mammals, and this effect requires the tumor suppressor PTEN. However, the metabolic and cellular processes that underly the beneficial effects of DR are poorly understood. We identified sl...

journal_title：Aging cell

authors： Mouchiroud L,Molin L,Kasturi P,Triba MN,Dumas ME,Wilson MC,Halestrap AP,Roussel D,Masse I,Dallière N,Ségalat L,Billaud M,Solari F

更新日期：2011-02-01 00:00:00

abstract：:We test the 'free radical theory of aging' using six species of colubrid snakes (numerous, widely distributed, non-venomous snakes of the family Colubridae) that exhibit long (> 15 years) or short (< 10 years) lifespans. Because the 'rate of living theory' predicts metabolic rates to be correlated with rates of aging ...

journal_title：Aging cell

authors： Robert KA,Brunet-Rossinni A,Bronikowski AM

更新日期：2007-06-01 00:00:00

abstract：:With reduced thymic activity, the population of naïve T cells in humans is maintained by homeostatic proliferation throughout adult life. In young adults, naïve CD4 T cells have enormous proliferative potential and plasticity to differentiate into different lineages. Here, we explored whether naïve CD4 T-cell aging is...

journal_title：Aging cell

authors： Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ

更新日期：2019-08-01 00:00:00

abstract：:Long-term calorie restriction (CR) has numerous benefits; however, effects of CR on susceptibility to intact pathogens are not well understood. Because CR enhances immune function of laboratory mice (Mus musculus), it was hypothesized that mice subjected to CR would be less susceptible to experimental infections of th...

journal_title：Aging cell

authors： Kristan DM

更新日期：2007-12-01 00:00:00

abstract：:Most human tissues express low levels of telomerase and undergo telomere shortening and eventual senescence; the resulting limitation on tissue renewal can lead to a wide range of age-dependent pathophysiologies. Increasing evidence indicates that the decline in cell division capacity in cells that lack telomerase can...

journal_title：Aging cell

authors： Ballew BJ,Lundblad V

更新日期：2013-08-01 00:00:00