Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration.

abstract：:Alzheimer's disease (AD) is a terminal age-associated dementia characterized by early synaptic dysfunction and late neurodegeneration. Although the presence of plaques of fibrillar aggregates of the amyloid beta peptide (Abeta) is a signature of AD, evidence suggests that the preplaque small oligomeric Abeta promotes ...

journal_title：Aging cell

authors： Reese LC,Zhang W,Dineley KT,Kayed R,Taglialatela G

更新日期：2008-12-01 00:00:00

abstract：:Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that ha...

journal_title：Aging cell

authors： Beekman M,Blanché H,Perola M,Hervonen A,Bezrukov V,Sikora E,Flachsbart F,Christiansen L,De Craen AJ,Kirkwood TB,Rea IM,Poulain M,Robine JM,Valensin S,Stazi MA,Passarino G,Deiana L,Gonos ES,Paternoster L,Sørensen TI

更新日期：2013-04-01 00:00:00

abstract：:Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains incompletely understo...

journal_title：Aging cell

authors： Metcalf TU,Cubas RA,Ghneim K,Cartwright MJ,Grevenynghe JV,Richner JM,Olagnier DP,Wilkinson PA,Cameron MJ,Park BS,Hiscott JB,Diamond MS,Wertheimer AM,Nikolich-Zugich J,Haddad EK

更新日期：2015-06-01 00:00:00

abstract：:Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...

journal_title：Aging cell

authors： Murchison D,Griffith WH

更新日期：2007-06-01 00:00:00

abstract：:Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a promising therapeutic tool for many diseases, including aged tissues and organs at high risk of failure. However, the intrinsic self-renewal and pluripotency of ES and iPS cells make them tumorigenic, and hence, the risk of tumor developmen...

journal_title：Aging cell

authors： Menendez S,Camus S,Herreria A,Paramonov I,Morera LB,Collado M,Pekarik V,Maceda I,Edel M,Consiglio A,Sanchez A,Li H,Serrano M,Belmonte JC

更新日期：2012-02-01 00:00:00

abstract：:The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a genome protective barrier and mechanotransduction interface between the cytoplasm and the nucleus. The NE is mainly composed of a nuclear lamina and a double membrane connected at specific points where the nuclear pore complex...

journal_title：Aging cell

authors： Martins F,Sousa J,Pereira CD,da Cruz E Silva OAB,Rebelo S

更新日期：2020-05-01 00:00:00

abstract：:The mitochondrial theory of aging is based around the idea of a vicious cycle, in which somatic mutation of mtDNA engenders respiratory chain dysfunction, enhancing the production of DNA-damaging oxygen radicals. In turn, this is proposed to result in the accumulation of further mtDNA mutations. Finally, a bioenergeti...

journal_title：Aging cell

authors： Jacobs HT

更新日期：2003-02-01 00:00:00

abstract：:Neurodegenerative diseases (ND) have been linked to the critical process in aging-cellular senescence. However, the temporal dynamics of cellular senescence in ND conditions is unresolved. Here, we show senescence features develop in human Huntington's disease (HD) neural stem cells (NSCs) and medium spiny neurons (MS...

journal_title：Aging cell

authors： Voisin J,Farina F,Naphade S,Fontaine M,Tshilenge KT,Galicia Aguirre C,Lopez-Ramirez A,Dancourt J,Ginisty A,Sasidharan Nair S,Lakshika Madushani K,Zhang N,Lejeune FX,Verny M,Campisi J,Ellerby LM,Neri C

更新日期：2020-11-01 00:00:00

abstract：:Long-term calorie restriction (CR) has numerous benefits; however, effects of CR on susceptibility to intact pathogens are not well understood. Because CR enhances immune function of laboratory mice (Mus musculus), it was hypothesized that mice subjected to CR would be less susceptible to experimental infections of th...

journal_title：Aging cell

authors： Kristan DM

更新日期：2007-12-01 00:00:00

abstract：:The nematode Caenorhabditis elegans has become one of the most widely used model systems for the study of aging, yet very little is known about how C. elegans age. The development of the worm, from egg to young adult has been completely mapped at the cellular level, but such detailed studies have not been extended thr...

journal_title：Aging cell

authors： Golden TR,Beckman KB,Lee AH,Dudek N,Hubbard A,Samper E,Melov S

更新日期：2007-04-01 00:00:00

abstract：:We used DNA microarrays to identify panels of transcriptional markers of aging that are differentially expressed in young (5 month) and old (25 month) mice of multiple inbred strains (129sv, BALB/c, CBA, DBA, B6, C3H and B6C3F(1)). In the heart, age-related changes of five genes were studied throughout the mouse lifes...

journal_title：Aging cell

authors： Park SK,Kim K,Page GP,Allison DB,Weindruch R,Prolla TA

更新日期：2009-08-01 00:00:00

abstract：:The hypoxia-inducible factor HIF-1 has recently been identified as an important modifier of longevity in the roundworm Caenorhabditis elegans. Studies have reported that HIF-1 can function as both a positive and negative regulator of life span, and several disparate models have been proposed for the role of HIF in agi...

journal_title：Aging cell

authors： Leiser SF,Begun A,Kaeberlein M

更新日期：2011-04-01 00:00:00

abstract：:Methionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where ...

journal_title：Aging cell

authors： Aledo JC,Li Y,de Magalhães JP,Ruíz-Camacho M,Pérez-Claros JA

更新日期：2011-04-01 00:00:00

abstract：:Endothelial oxidative stress develops with aging and reactive oxygen species impair endothelium-dependent relaxation (EDR) by decreasing nitric oxide (NO) availability. Endothelial KCa 3.1, which contributes to EDR, is upregulated by H2 O2 . We investigated whether KCa 3.1 upregulation compensates for diminished EDR t...

journal_title：Aging cell

authors： Choi S,Kim JA,Li HY,Shin KO,Oh GT,Lee YM,Oh S,Pewzner-Jung Y,Futerman AH,Suh SH

更新日期：2016-10-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in multiple species from various taxa. This effect can arise via two distinct but not mutually exclusive ways: a change in aging rate and/or vulnerability to the aging process (i.e. initial mortality rate). When DR affects vulnerability, this lowers mortality instantly, wherea...

journal_title：Aging cell

authors： Simons MJ,Koch W,Verhulst S

更新日期：2013-06-01 00:00:00

abstract：:Extending lifespan by lowering ambient temperature in the habitat has been shown in a variety of organisms. Its mechanism, however, remains elusive. In this study, we examined the survivorship and the aging process of the annual fish (Nothobranchius rachovii) reared under high (30 degrees C), moderate (25 degrees C) a...

journal_title：Aging cell

authors： Hsu CY,Chiu YC

更新日期：2009-12-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is characterized by the formation of drusen, extracellular deposits associated with atrophy of the retinal pigmented epithelium (RPE), disturbance of the transepithelial barrier and photoreceptor death. Amyloid-beta (Abeta) is present in drusen but its role during AMD remains unk...

journal_title：Aging cell

authors： Bruban J,Glotin AL,Dinet V,Chalour N,Sennlaub F,Jonet L,An N,Faussat AM,Mascarelli F

更新日期：2009-04-01 00:00:00

abstract：:Aging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefit...

journal_title：Aging cell

authors： Crane JD,MacNeil LG,Lally JS,Ford RJ,Bujak AL,Brar IK,Kemp BE,Raha S,Steinberg GR,Tarnopolsky MA

更新日期：2015-08-01 00:00:00

abstract：:A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. H...

journal_title：Aging cell

authors： Yousefzadeh MJ,Schafer MJ,Noren Hooten N,Atkinson EJ,Evans MK,Baker DJ,Quarles EK,Robbins PD,Ladiges WC,LeBrasseur NK,Niedernhofer LJ

更新日期：2018-04-01 00:00:00

abstract：:Immunosenescence, the age-related decline in immune response, is a well-known consequence of aging. To date, most studies of age-related changes in immune response focused on the cellular and physiological bases of this decline; we have virtually no understanding of the genetic basis of age-related changes in the immu...

journal_title：Aging cell

authors： Lesser KJ,Paiusi IC,Leips J

更新日期：2006-08-01 00:00:00

abstract：:The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor 5 (TLR5), unlike th...

journal_title：Aging cell

authors： Lim JS,Nguyen KC,Nguyen CT,Jang IS,Han JM,Fabian C,Lee SE,Rhee JH,Cho KA

更新日期：2015-10-01 00:00:00

abstract：:Most mammalian cells when placed in culture will undergo a limited number of cell divisions before entering an unresponsive non-proliferating state termed senescence. However, several pathways that are activated singly or in concert can allow cells to bypass senescence at least for limited periods. These include the t...

journal_title：Aging cell

authors： Miura T,Mattson MP,Rao MS

更新日期：2004-12-01 00:00:00

abstract：:Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during cellular senescence are not known. We used formaldehyde assisted isolation of regul...

journal_title：Aging cell

authors： De Cecco M,Criscione SW,Peckham EJ,Hillenmeyer S,Hamm EA,Manivannan J,Peterson AL,Kreiling JA,Neretti N,Sedivy JM

更新日期：2013-04-01 00:00:00

abstract：:The cerebral amyloid-β accumulation that begins in middle age is considered the critical triggering event in the pathogenesis of late-onset Alzheimer's disease (LOAD). However, the molecular mechanism remains elusive. The Shugoshin 1 (Sgo1-/+ ) mouse model, a model for mitotic cohesinopathy-genomic instability that is...

journal_title：Aging cell

authors： Rao CV,Farooqui M,Madhavaram A,Zhang Y,Asch AS,Yamada HY

更新日期：2020-10-01 00:00:00

abstract：:The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of d...

journal_title：Aging cell

authors： Zhu Y,Tchkonia T,Pirtskhalava T,Gower AC,Ding H,Giorgadze N,Palmer AK,Ikeno Y,Hubbard GB,Lenburg M,O'Hara SP,LaRusso NF,Miller JD,Roos CM,Verzosa GC,LeBrasseur NK,Wren JD,Farr JN,Khosla S,Stout MB,McGowan SJ,Fuh

更新日期：2015-08-01 00:00:00

abstract：:Dietary restriction is arguably the most promising nonpharmacological intervention to extend human life and health span. Yet, only few genetic regulators mediating the cellular response to dietary restriction are known, and the question remains which other regulatory factors are involved. Here, we measured at the geno...

journal_title：Aging cell

authors： Campos SE,Avelar-Rivas JA,Garay E,Juárez-Reyes A,DeLuna A

更新日期：2018-06-01 00:00:00

abstract：:Dietary restriction extends lifespan and inhibits reproduction in many species. In Caenorhabditis elegans, inhibiting reproduction by germline removal extends lifespan. Therefore, we asked whether the effect of dietary restriction on lifespan might proceed via changes in the activity of the germline. We found that die...

journal_title：Aging cell

authors： Crawford D,Libina N,Kenyon C

更新日期：2007-10-01 00:00:00

abstract：:The progressively increasing frailty, morbidity and mortality of aging organisms coincides with, and may be causally related to, their waning ability to adapt to environmental perturbations. Transcriptional responses to challenges, such as oxidative stress or pathogens, diminish with age. This effect is manifest in th...

journal_title：Aging cell

authors： Cheng Y,Pitoniak A,Wang J,Bohmann D

更新日期：2021-01-20 00:00:00

abstract：:The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an underlying cause of the aging process. Such mutations are thought to be generated principally through mechanisms involving oxidative stress. Skin is frequently exposed to a potent mutagen in the form of ultraviolet (UV) radiation and mtDNA...

journal_title：Aging cell

authors： Birket MJ,Birch-Machin MA

更新日期：2007-08-01 00:00:00

abstract：:Small body size has been associated with long life span in four stocks of mutant dwarf mice, and in two varieties of dietary restriction in rodents. In this study, small body size at ages 2-24 months was shown to be a significant predictor of life span in a genetically heterogeneous mouse population derived from four ...

journal_title：Aging cell

authors： Miller RA,Harper JM,Galecki A,Burke DT

更新日期：2002-10-01 00:00:00