Ambient temperature influences aging in an annual fish (Nothobranchius rachovii).

abstract：:Little is known about the types and numbers of mutations that may accumulate in normal human cells with age. Such information would require obtaining enough DNA from a single cell to accurately carry out reliable analysis despite extensive amplification; and complete genomic coverage under these circumstances is diffi...

journal_title：Aging cell

authors： Hsieh JC,Van Den Berg D,Kang H,Hsieh CL,Lieber MR

更新日期：2013-04-01 00:00:00

abstract：:The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of the cytoplasm, i.e., the myonuclear domain (MND). We analysed aging- and gender-related effects on myonuclei organization and the MND size in single muscle fibres from six young (21-31 years) and nine old m...

journal_title：Aging cell

authors： Cristea A,Qaisar R,Edlund PK,Lindblad J,Bengtsson E,Larsson L

更新日期：2010-10-01 00:00:00

abstract：:Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotyp...

journal_title：Aging cell

authors： Umehara T,Kawai T,Kawashima I,Tanaka K,Okuda S,Kitasaka H,Richards JS,Shimada M

更新日期：2017-12-01 00:00:00

abstract：:The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of d...

journal_title：Aging cell

authors： Zhu Y,Tchkonia T,Pirtskhalava T,Gower AC,Ding H,Giorgadze N,Palmer AK,Ikeno Y,Hubbard GB,Lenburg M,O'Hara SP,LaRusso NF,Miller JD,Roos CM,Verzosa GC,LeBrasseur NK,Wren JD,Farr JN,Khosla S,Stout MB,McGowan SJ,Fuh

更新日期：2015-08-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is regarded as one of the serious risk factors for age-related cognitive impairment; however, a causal link between these two diseases has so far not been established. It was recently discovered that, apart from high D-glucose levels, T2DM patients also display abnormally high concentra...

journal_title：Aging cell

authors： Wei Y,Han C,Wang Y,Wu B,Su T,Liu Y,He R

更新日期：2015-10-01 00:00:00

abstract：:Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair-deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamycin, while significantly lowering mTOR signaling, failed to improve lif...

journal_title：Aging cell

authors： Birkisdóttir MB,Jaarsma D,Brandt RMC,Barnhoorn S,van Vliet N,Imholz S,van Oostrom CT,Nagarajah B,Portilla Fernández E,Roks AJM,Elgersma Y,van Steeg H,Ferreira JA,Pennings JLA,Hoeijmakers JHJ,Vermeij WP,Dollé MET

更新日期：2021-01-23 00:00:00

abstract：:The decrease in skeletal muscle mitochondrial oxidative capacity with age adversely affects muscle strength and physical performance. Factors that are associated with this decrease have not been well characterized. Low plasma lysophosphatidylcholines (LPC), a major class of systemic bioactive lipids, are predictive of...

journal_title：Aging cell

authors： Semba RD,Zhang P,Adelnia F,Sun K,Gonzalez-Freire M,Salem N Jr,Brennan N,Spencer RG,Fishbein K,Khadeer M,Shardell M,Moaddel R,Ferrucci L

更新日期：2019-04-01 00:00:00

abstract：:We used DNA microarrays to identify panels of transcriptional markers of aging that are differentially expressed in young (5 month) and old (25 month) mice of multiple inbred strains (129sv, BALB/c, CBA, DBA, B6, C3H and B6C3F(1)). In the heart, age-related changes of five genes were studied throughout the mouse lifes...

journal_title：Aging cell

authors： Park SK,Kim K,Page GP,Allison DB,Weindruch R,Prolla TA

更新日期：2009-08-01 00:00:00

abstract：:Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome dysfunction to cell degeneration are poorly understood. We examined in young and aged rat hippocampu...

journal_title：Aging cell

authors： Gavilán MP,Pintado C,Gavilán E,Jiménez S,Ríos RM,Vitorica J,Castaño A,Ruano D

更新日期：2009-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...

journal_title：Aging cell

authors： Xie S,Jin N,Gu J,Shi J,Sun J,Chu D,Zhang L,Dai CL,Gu JH,Gong CX,Iqbal K,Liu F

更新日期：2016-06-01 00:00:00

abstract：:Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks...

journal_title：Aging cell

authors： Cannon L,Zambon AC,Cammarato A,Zhang Z,Vogler G,Munoz M,Taylor E,Cartry J,Bernstein SI,Melov S,Bodmer R

更新日期：2017-02-01 00:00:00

abstract：:Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a promising therapeutic tool for many diseases, including aged tissues and organs at high risk of failure. However, the intrinsic self-renewal and pluripotency of ES and iPS cells make them tumorigenic, and hence, the risk of tumor developmen...

journal_title：Aging cell

authors： Menendez S,Camus S,Herreria A,Paramonov I,Morera LB,Collado M,Pekarik V,Maceda I,Edel M,Consiglio A,Sanchez A,Li H,Serrano M,Belmonte JC

更新日期：2012-02-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model o...

journal_title：Aging cell

authors： Elhaik Goldman S,Goez D,Last D,Naor S,Liraz Zaltsman S,Sharvit-Ginon I,Atrakchi-Baranes D,Shemesh C,Twitto-Greenberg R,Tsach S,Lotan R,Leikin-Frenkel A,Shish A,Mardor Y,Schnaider Beeri M,Cooper I

更新日期：2018-10-01 00:00:00

abstract：:Although the link between altered stem cell properties and tissue aging has been recognized, the molecular and cellular processes of tendon aging have not been elucidated. As tendons contain stem/progenitor cells (TSPC), we investigated whether the molecular and cellular attributes of TSPC alter during tendon aging an...

journal_title：Aging cell

authors： Kohler J,Popov C,Klotz B,Alberton P,Prall WC,Haasters F,Müller-Deubert S,Ebert R,Klein-Hitpass L,Jakob F,Schieker M,Docheva D

更新日期：2013-12-01 00:00:00

abstract：:The aim of this study was to determine the mechanism underlying the association between one-carbon metabolism and DNA methylation during chronic degenerative joint disorder, osteoarthritis (OA). Articular chondrocytes were isolated from human OA cartilage and normal cartilage biopsied, and the degree of cartilage degr...

journal_title：Aging cell

authors： Song J,Kim D,Chun CH,Jin EJ

更新日期：2015-10-01 00:00:00

abstract：:Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains incompletely understo...

journal_title：Aging cell

authors： Metcalf TU,Cubas RA,Ghneim K,Cartwright MJ,Grevenynghe JV,Richner JM,Olagnier DP,Wilkinson PA,Cameron MJ,Park BS,Hiscott JB,Diamond MS,Wertheimer AM,Nikolich-Zugich J,Haddad EK

更新日期：2015-06-01 00:00:00

abstract：:This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases esp...

journal_title：Aging cell

authors： Conover CA

更新日期：2010-12-01 00:00:00

abstract：:With aging, the kidney develops a progressive deterioration of several structures and functions. Proximal tubular acidification is impaired in old rats with a decrease in the activity of brush border Na+/H+ exchange and a fall of H-ion flux measured with micropuncture experiments. In the present work we evaluate the c...

journal_title：Aging cell

authors： Fiori M,Radrizzani M,Díaz-Sylvester P,Müller A,Corti T,Monserrat A,Amorena C

更新日期：2006-10-01 00:00:00

abstract：:This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for in-depth analysis. This year, the first quantitative estimate of evolutionary conservation of genetic effects on lifespan has pointed to the key importance of genes involved in prot...

journal_title：Aging cell

authors： Partridge L

更新日期：2008-10-01 00:00:00

abstract：:Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age-dependent metabolic changes, but the mechanism is unknown. Here, we profile lamina-associated domains (LADs) using lamin B1 ChIP-Seq in young and old hepatocytes and find that, alt...

journal_title：Aging cell

authors： Whitton H,Singh LN,Patrick MA,Price AJ,Osorio FG,López-Otín C,Bochkis IM

更新日期：2018-06-01 00:00:00

abstract：:In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolong the chronological aging of yeast cells during the stationary phase. Lifespan extension is significantly reduced in yca1 mutants as well in rho(0) strains, suggesting that the protective effects pass through the Yca1 cas...

journal_title：Aging cell

authors： Palermo V,Falcone C,Calvani M,Mazzoni C

更新日期：2010-08-01 00:00:00

abstract：:The ING family of tumor suppressor proteins affects cell growth, apoptosis and response to DNA damage by modulating chromatin structure through association with different HAT and HDAC complexes. The major splicing isoforms of the ING1 locus are ING1a and INGlb. While INGlb plays a role in inducing apoptosis, the funct...

journal_title：Aging cell

authors： Soliman MA,Berardi P,Pastyryeva S,Bonnefin P,Feng X,Colina A,Young D,Riabowol K

更新日期：2008-12-01 00:00:00

abstract：:Cardiac performance decreases with age, which is a major risk factor for cardiovascular disease and mortality in the aging human population, but the molecular mechanisms underlying cardiac aging are still poorly understood. Investigating the role of integrin-linked kinase (ilk) and β1-integrin (myospheroid, mys) in Dr...

journal_title：Aging cell

authors： Nishimura M,Kumsta C,Kaushik G,Diop SB,Ding Y,Bisharat-Kernizan J,Catan H,Cammarato A,Ross RS,Engler AJ,Bodmer R,Hansen M,Ocorr K

更新日期：2014-06-01 00:00:00

abstract：:Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in the pathogenesis of several aging-related pathologies including sarcopenia and type 2 diabetes an...

journal_title：Aging cell

authors： Zhang N,Valentine JM,Zhou Y,Li ME,Zhang Y,Bhattacharya A,Walsh ME,Fischer KE,Austad SN,Osmulski P,Gaczynska M,Shoelson SE,Van Remmen H,Chen HI,Chen Y,Liang H,Musi N

更新日期：2017-08-01 00:00:00

abstract：:Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isol...

journal_title：Aging cell

authors： Rittié L,Stoll SW,Kang S,Voorhees JJ,Fisher GJ

更新日期：2009-12-01 00:00:00

abstract：:The aim of this study was to investigate changes in astrocyte density, morphology, proliferation and apoptosis occurring in the central nervous system during physiological aging. Astrocytes in retinal whole-mount preparations from Wistar rats aged 3 (young adult) to 25 months (aged) were investigated qualitatively and...

journal_title：Aging cell

authors： Mansour H,Chamberlain CG,Weible MW 2nd,Hughes S,Chu Y,Chan-Ling T

更新日期：2008-08-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are formed when glucose reacts nonenzymatically with proteins; these modifications are implicated in aging and pathogenesis of many age-related diseases including type II diabetes, atherosclerosis, and neurodegenerative disorders. Thus, pharmaceutical interventions that can reduc...

journal_title：Aging cell

authors： Golegaonkar S,Tabrez SS,Pandit A,Sethurathinam S,Jagadeeshaprasad MG,Bansode S,Sampathkumar SG,Kulkarni MJ,Mukhopadhyay A

更新日期：2015-06-01 00:00:00

abstract：:Older adults often show signs of impaired CD8+ T-cell immunity, reflected by weaker responses against new infections and vaccinations, and decreased protection against reinfection. This immune impairment is in part thought to be the consequence of a decrease in both T-cell numbers and repertoire diversity. If this is ...

journal_title：Aging cell

authors： Lanfermeijer J,Borghans JAM,van Baarle D

更新日期：2020-11-01 00:00:00

abstract：:Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is...

journal_title：Aging cell

authors： Tauffenberger A,Vaccaro A,Aulas A,Vande Velde C,Parker JA

更新日期：2012-10-01 00:00:00

abstract：:Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia-inducible factor (HIF)-1α is largely unknown. In this study, we investigated whether HIF-1α could be a deacetylation target of Sirt1 and the effect of their interact...

journal_title：Aging cell

authors： Ryu DR,Yu MR,Kong KH,Kim H,Kwon SH,Jeon JS,Han DC,Noh H

更新日期：2019-04-01 00:00:00