Abstract:
:Nutrient availability influences an organism's life history with profound effects on metabolism and lifespan. The association between a healthy lifespan and metabolism is incompletely understood, but a central factor is glucose metabolism. Although glucose is an important cellular energy source, glucose restriction is associated with extended lifespan in simple animals and a reduced incidence of age-dependent pathologies in humans. We report here that glucose enrichment delays mutant polyglutamine, TDP-43, FUS, and amyloid-β toxicity in Caenorhabditis elegans models of neurodegeneration by reducing protein misfolding. Dysregulated metabolism is common to neurodegeneration and we show that glucose enrichment is broadly protective against proteotoxicity.
journal_name
Aging Celljournal_title
Aging cellauthors
Tauffenberger A,Vaccaro A,Aulas A,Vande Velde C,Parker JAdoi
10.1111/j.1474-9726.2012.00855.xsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
856-66issue
5eissn
1474-9718issn
1474-9726journal_volume
11pub_type
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