Molecular mechanisms underlying genotype-dependent responses to dietary restriction.

abstract：:Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isol...

journal_title：Aging cell

authors： Rittié L,Stoll SW,Kang S,Voorhees JJ,Fisher GJ

更新日期：2009-12-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in multiple species from various taxa. This effect can arise via two distinct but not mutually exclusive ways: a change in aging rate and/or vulnerability to the aging process (i.e. initial mortality rate). When DR affects vulnerability, this lowers mortality instantly, wherea...

journal_title：Aging cell

authors： Simons MJ,Koch W,Verhulst S

更新日期：2013-06-01 00:00:00

abstract：:Cellular senescence plays both beneficial and detrimental roles in embryonic development and tissue regeneration, while the underlying mechanism remains elusive. Recent studies disclosed the emerging roles of heat-shock proteins in regulating muscle regeneration and homeostasis. Here, we found that Hsp90β, but not Hsp...

journal_title：Aging cell

authors： He MY,Xu SB,Qu ZH,Guo YM,Liu XC,Cong XX,Wang JF,Low BC,Li L,Wu Q,Lin P,Yan SG,Bao Z,Zhou YT,Zheng LL

更新日期：2019-10-01 00:00:00

abstract：:The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amy...

journal_title：Aging cell

authors： Schultz N,Brännström K,Byman E,Moussaud S,Nielsen HM,Netherlands Brain Bank.,Olofsson A,Wennström M

更新日期：2018-06-01 00:00:00

abstract：:Aging is associated with a progressive loss of tissue and metabolic homeostasis. This loss can be delayed by single-gene perturbations, increasing lifespan. How such perturbations affect metabolic and proteostatic networks to extend lifespan remains unclear. Here, we address this question by comprehensively characteri...

journal_title：Aging cell

authors： Wang L,Davis SS,Borch Jensen M,Rodriguez-Fernandez IA,Apaydin C,Juhasz G,Gibson BW,Schilling B,Ramanathan A,Ghaemmaghami S,Jasper H

更新日期：2019-06-01 00:00:00

abstract：:Dietary restriction (DR) is the most universal intervention known to extend animal lifespan. DR also prevents tumor development in mammals, and this effect requires the tumor suppressor PTEN. However, the metabolic and cellular processes that underly the beneficial effects of DR are poorly understood. We identified sl...

journal_title：Aging cell

authors： Mouchiroud L,Molin L,Kasturi P,Triba MN,Dumas ME,Wilson MC,Halestrap AP,Roussel D,Masse I,Dallière N,Ségalat L,Billaud M,Solari F

更新日期：2011-02-01 00:00:00

abstract：:Recent reports highlight regulatory functions of long noncoding RNAs (lncRNAs) in neurodegeneration and aging, but biomedical implications remain limited. Here, we report an rRNA-depletion-based long RNA-Sequencing Resource of 65 substantia nigra, amygdala, and medial temporal gyrus samples from Parkinson's disease (P...

journal_title：Aging cell

authors： Simchovitz A,Hanan M,Yayon N,Lee S,Bennett ER,Greenberg DS,Kadener S,Soreq H

更新日期：2020-03-01 00:00:00

abstract：:Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the unknown etiol...

journal_title：Aging cell

authors： Kreienkamp R,Billon C,Bedia-Diaz G,Albert CJ,Toth Z,Butler AA,McBride-Gagyi S,Ford DA,Baldan A,Burris TP,Gonzalo S

更新日期：2019-02-01 00:00:00

abstract：:Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has r...

journal_title：Aging cell

authors： Mendenhall A,Driscoll M,Brent R

更新日期：2016-02-01 00:00:00

abstract：:The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of d...

journal_title：Aging cell

authors： Zhu Y,Tchkonia T,Pirtskhalava T,Gower AC,Ding H,Giorgadze N,Palmer AK,Ikeno Y,Hubbard GB,Lenburg M,O'Hara SP,LaRusso NF,Miller JD,Roos CM,Verzosa GC,LeBrasseur NK,Wren JD,Farr JN,Khosla S,Stout MB,McGowan SJ,Fuh

更新日期：2015-08-01 00:00:00

abstract：:Most human tissues express low levels of telomerase and undergo telomere shortening and eventual senescence; the resulting limitation on tissue renewal can lead to a wide range of age-dependent pathophysiologies. Increasing evidence indicates that the decline in cell division capacity in cells that lack telomerase can...

journal_title：Aging cell

authors： Ballew BJ,Lundblad V

更新日期：2013-08-01 00:00:00

abstract：:The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (gamma-H2A.X) at either un...

journal_title：Aging cell

authors： Wang C,Jurk D,Maddick M,Nelson G,Martin-Ruiz C,von Zglinicki T

更新日期：2009-06-01 00:00:00

abstract：:The decrease in skeletal muscle mitochondrial oxidative capacity with age adversely affects muscle strength and physical performance. Factors that are associated with this decrease have not been well characterized. Low plasma lysophosphatidylcholines (LPC), a major class of systemic bioactive lipids, are predictive of...

journal_title：Aging cell

authors： Semba RD,Zhang P,Adelnia F,Sun K,Gonzalez-Freire M,Salem N Jr,Brennan N,Spencer RG,Fishbein K,Khadeer M,Shardell M,Moaddel R,Ferrucci L

更新日期：2019-04-01 00:00:00

abstract：:Methionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where ...

journal_title：Aging cell

authors： Aledo JC,Li Y,de Magalhães JP,Ruíz-Camacho M,Pérez-Claros JA

更新日期：2011-04-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model o...

journal_title：Aging cell

authors： Elhaik Goldman S,Goez D,Last D,Naor S,Liraz Zaltsman S,Sharvit-Ginon I,Atrakchi-Baranes D,Shemesh C,Twitto-Greenberg R,Tsach S,Lotan R,Leikin-Frenkel A,Shish A,Mardor Y,Schnaider Beeri M,Cooper I

更新日期：2018-10-01 00:00:00

abstract：:One of the hallmarks of aging is the progressive accumulation of senescent cells in organisms, which has been proposed to be a contributing factor to age-dependent organ dysfunction. We recently reported that Bruton's tyrosine kinase (BTK) is an upstream component of the p53 responses to DNA damage. BTK binds to and p...

journal_title：Aging cell

authors： Ekpenyong-Akiba AE,Poblocka M,Althubiti M,Rada M,Jurk D,Germano S,Kocsis-Fodor G,Shi Y,Canales JJ,Macip S

更新日期：2020-01-01 00:00:00

abstract：:We used DNA microarrays to identify panels of transcriptional markers of aging that are differentially expressed in young (5 month) and old (25 month) mice of multiple inbred strains (129sv, BALB/c, CBA, DBA, B6, C3H and B6C3F(1)). In the heart, age-related changes of five genes were studied throughout the mouse lifes...

journal_title：Aging cell

authors： Park SK,Kim K,Page GP,Allison DB,Weindruch R,Prolla TA

更新日期：2009-08-01 00:00:00

abstract：:This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for in-depth analysis. This year, the first quantitative estimate of evolutionary conservation of genetic effects on lifespan has pointed to the key importance of genes involved in prot...

journal_title：Aging cell

authors： Partridge L

更新日期：2008-10-01 00:00:00

abstract：:Small body size has been associated with long life span in four stocks of mutant dwarf mice, and in two varieties of dietary restriction in rodents. In this study, small body size at ages 2-24 months was shown to be a significant predictor of life span in a genetically heterogeneous mouse population derived from four ...

journal_title：Aging cell

authors： Miller RA,Harper JM,Galecki A,Burke DT

更新日期：2002-10-01 00:00:00

abstract：:One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To inves...

journal_title：Aging cell

authors： Ye X,Linton JM,Schork NJ,Buck LB,Petrascheck M

更新日期：2014-04-01 00:00:00

abstract：:The epidermis of the skin, acting as the primary physical barrier between self and environment, is a dynamic tissue whose maintenance is critical to the survival of an organism. Like most other tissues and organs, the epidermis is maintained and repaired by a population of resident somatic stem cells. The epidermal st...

journal_title：Aging cell

authors： Stern MM,Bickenbach JR

更新日期：2007-08-01 00:00:00

abstract：:Adipose tissue inflammation and dysfunction are associated with obesity-related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the development of dia...

journal_title：Aging cell

authors： Palmer AK,Xu M,Zhu Y,Pirtskhalava T,Weivoda MM,Hachfeld CM,Prata LG,van Dijk TH,Verkade E,Casaclang-Verzosa G,Johnson KO,Cubro H,Doornebal EJ,Ogrodnik M,Jurk D,Jensen MD,Chini EN,Miller JD,Matveyenko A,Stout MB,Sc

更新日期：2019-06-01 00:00:00

abstract：:Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome...

journal_title：Aging cell

authors： Chung KW,Lee EK,Kim DH,An HJ,Kim ND,Im DS,Lee J,Yu BP,Chung HY

更新日期：2015-08-01 00:00:00

abstract：:Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a promising therapeutic tool for many diseases, including aged tissues and organs at high risk of failure. However, the intrinsic self-renewal and pluripotency of ES and iPS cells make them tumorigenic, and hence, the risk of tumor developmen...

journal_title：Aging cell

authors： Menendez S,Camus S,Herreria A,Paramonov I,Morera LB,Collado M,Pekarik V,Maceda I,Edel M,Consiglio A,Sanchez A,Li H,Serrano M,Belmonte JC

更新日期：2012-02-01 00:00:00

abstract：:Aging is inevitably accompanied by gradual and irreversible innate endothelial dysfunction. In this study, we tested the hypothesis that accentuation of glucose metabolism via the aldose reductase (AR) pathway contributes to age-related vascular dysfunction. AR protein and activity levels were significantly increased ...

journal_title：Aging cell

authors： Hallam KM,Li Q,Ananthakrishnan R,Kalea A,Zou YS,Vedantham S,Schmidt AM,Yan SF,Ramasamy R

更新日期：2010-10-01 00:00:00

abstract：:Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest, or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies determined the mutation...

journal_title：Aging cell

authors： Beltrami E,Ruggiero A,Busuttil R,Migliaccio E,Pelicci PG,Vijg J,Giorgio M

更新日期：2013-04-01 00:00:00

abstract：:ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimer's disease. Surprisingly, checkpoint attenuation poten...

journal_title：Aging cell

authors： Khurana V,Merlo P,DuBoff B,Fulga TA,Sharp KA,Campbell SD,Götz J,Feany MB

更新日期：2012-04-01 00:00:00

abstract：:Here I comment on the recent contribution by Barrientos et al. J. Neurosci. 32, 14641-14648 (2012) addressing treatment possibilities for surgery-induced cognitive dysfunction. It has been over 15 years since the publication of a landmark study that indicated age as a major risk factor for postoperative cognitive dysf...

journal_title：Aging cell

authors： Fidalgo AR

更新日期：2013-06-01 00:00:00

abstract：:The discovery of treatments to prevent or delay dementia and Alzheimer's disease is a priority. The gene APOE is associated with cognitive change and late-onset Alzheimer's disease, and epidemiological studies have provided strong evidence that the e2 allele of APOE has a neuroprotective effect, it is associated with ...

journal_title：Aging cell

authors： Sebastiani P,Monti S,Morris M,Gurinovich A,Toshiko T,Andersen SL,Sweigart B,Ferrucci L,Jennings LL,Glass DJ,Perls TT

更新日期：2019-12-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to improving functional outcomes in this age-related disease. The molecula...

journal_title：Aging cell

authors： Roh JD,Houstis N,Yu A,Chang B,Yeri A,Li H,Hobson R,Lerchenmüller C,Vujic A,Chaudhari V,Damilano F,Platt C,Zlotoff D,Lee RT,Shah R,Jerosch-Herold M,Rosenzweig A

更新日期：2020-06-01 00:00:00