Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants.

abstract：:Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during cellular senescence are not known. We used formaldehyde assisted isolation of regul...

journal_title：Aging cell

authors： De Cecco M,Criscione SW,Peckham EJ,Hillenmeyer S,Hamm EA,Manivannan J,Peterson AL,Kreiling JA,Neretti N,Sedivy JM

更新日期：2013-04-01 00:00:00

abstract：:Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central ...

journal_title：Aging cell

authors： Cohen J,Torres C

更新日期：2019-06-01 00:00:00

abstract：:General locomotor activity decreases with normal aging in animals and could be partially explained by decreases in neuronal function. Voltage-gated Na(+) channels are essential in initiating and propagating rapid electrical impulses underlying normal locomotor activity and behavior in animals. Isolation of mutations c...

journal_title：Aging cell

authors： Reenan RA,Rogina B

更新日期：2008-03-01 00:00:00

abstract：:Age-associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute to progressive ventricular expansion. By directly linking postmortem human MRI sequences with histological features of periventricular tissue, we show that substantial lateral ventricl...

journal_title：Aging cell

authors： Shook BA,Lennington JB,Acabchuk RL,Halling M,Sun Y,Peters J,Wu Q,Mahajan A,Fellows DW,Conover JC

更新日期：2014-04-01 00:00:00

abstract：:The ING family of tumor suppressor proteins affects cell growth, apoptosis and response to DNA damage by modulating chromatin structure through association with different HAT and HDAC complexes. The major splicing isoforms of the ING1 locus are ING1a and INGlb. While INGlb plays a role in inducing apoptosis, the funct...

journal_title：Aging cell

authors： Soliman MA,Berardi P,Pastyryeva S,Bonnefin P,Feng X,Colina A,Young D,Riabowol K

更新日期：2008-12-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model o...

journal_title：Aging cell

authors： Elhaik Goldman S,Goez D,Last D,Naor S,Liraz Zaltsman S,Sharvit-Ginon I,Atrakchi-Baranes D,Shemesh C,Twitto-Greenberg R,Tsach S,Lotan R,Leikin-Frenkel A,Shish A,Mardor Y,Schnaider Beeri M,Cooper I

更新日期：2018-10-01 00:00:00

abstract：:Calorie restriction (CR) without malnutrition slows aging in animal models. Oxidative stress reduction was proposed to mediate CR effects. CR effect on urinary F2-isoprostanes, validated oxidative stress markers, was assessed in CALERIE, a two-year randomized controlled trial. Healthy volunteers (n = 218) were randomi...

journal_title：Aging cell

authors： Il'yasova D,Fontana L,Bhapkar M,Pieper CF,Spasojevic I,Redman LM,Das SK,Huffman KM,Kraus WE,CALERIE Study Investigators.

更新日期：2018-04-01 00:00:00

abstract：:Cardiac performance decreases with age, which is a major risk factor for cardiovascular disease and mortality in the aging human population, but the molecular mechanisms underlying cardiac aging are still poorly understood. Investigating the role of integrin-linked kinase (ilk) and β1-integrin (myospheroid, mys) in Dr...

journal_title：Aging cell

authors： Nishimura M,Kumsta C,Kaushik G,Diop SB,Ding Y,Bisharat-Kernizan J,Catan H,Cammarato A,Ross RS,Engler AJ,Bodmer R,Hansen M,Ocorr K

更新日期：2014-06-01 00:00:00

abstract：:Mitochondrial malfunction is a universal and critical step in the pathogenesis of many neurodegenerative diseases including prion diseases. Dynamin-like protein 1 (DLP1) is one of the key regulators of mitochondrial fission. In this study, we investigated the role of DLP1 in mitochondrial fragmentation and dysfunction...

journal_title：Aging cell

authors： Li C,Wang D,Wu W,Yang W,Ali Shah SZ,Zhao Y,Duan Y,Wang L,Zhou X,Zhao D,Yang L

更新日期：2018-02-01 00:00:00

abstract：:Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...

journal_title：Aging cell

authors： Zhang B,Podolskiy DI,Mariotti M,Seravalli J,Gladyshev VN

更新日期：2020-05-01 00:00:00

abstract：:The discovery of treatments to prevent or delay dementia and Alzheimer's disease is a priority. The gene APOE is associated with cognitive change and late-onset Alzheimer's disease, and epidemiological studies have provided strong evidence that the e2 allele of APOE has a neuroprotective effect, it is associated with ...

journal_title：Aging cell

authors： Sebastiani P,Monti S,Morris M,Gurinovich A,Toshiko T,Andersen SL,Sweigart B,Ferrucci L,Jennings LL,Glass DJ,Perls TT

更新日期：2019-12-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:The nematode Caenorhabditis elegans has become one of the most widely used model systems for the study of aging, yet very little is known about how C. elegans age. The development of the worm, from egg to young adult has been completely mapped at the cellular level, but such detailed studies have not been extended thr...

journal_title：Aging cell

authors： Golden TR,Beckman KB,Lee AH,Dudek N,Hubbard A,Samper E,Melov S

更新日期：2007-04-01 00:00:00

abstract：:Although dietary restriction (DR) is known to extend lifespan across species, from yeast to mammals, the signalling events downstream of food/nutrient perception are not well understood. In Caenorhabditis elegans, DR is typically attained either by using the eat-2 mutants that have reduced pharyngeal pumping leading t...

journal_title：Aging cell

authors： Chamoli M,Singh A,Malik Y,Mukhopadhyay A

更新日期：2014-08-01 00:00:00

abstract：:Accumulation of DNA damage may play an essential role in both cellular senescence and organismal aging. The ability of cells to sense and repair DNA damage declines with age. However, the underlying molecular mechanism for this age-dependent decline is still elusive. To understand quantitative and qualitative changes ...

journal_title：Aging cell

authors： Sedelnikova OA,Horikawa I,Redon C,Nakamura A,Zimonjic DB,Popescu NC,Bonner WM

更新日期：2008-01-01 00:00:00

abstract：:We analyzed MBL2 gene variants in two cohorts of centenarians, octo-nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity. We also assessed in ...

journal_title：Aging cell

authors： Tomaiuolo R,Ruocco A,Salapete C,Carru C,Baggio G,Franceschi C,Zinellu A,Vaupel J,Bellia C,Lo Sasso B,Ciaccio M,Castaldo G,Deiana L

更新日期：2012-06-01 00:00:00

abstract：:Dietary restriction (DR) is the most universal intervention known to extend animal lifespan. DR also prevents tumor development in mammals, and this effect requires the tumor suppressor PTEN. However, the metabolic and cellular processes that underly the beneficial effects of DR are poorly understood. We identified sl...

journal_title：Aging cell

authors： Mouchiroud L,Molin L,Kasturi P,Triba MN,Dumas ME,Wilson MC,Halestrap AP,Roussel D,Masse I,Dallière N,Ségalat L,Billaud M,Solari F

更新日期：2011-02-01 00:00:00

abstract：:Wnt signaling is a major and highly conserved developmental pathway that guides many important events during embryonic and larval development. In adulthood, misregulation of Wnt signaling has been implicated in tumorigenesis and various age-related diseases. These effects occur through highly complicated cell-to-cell ...

journal_title：Aging cell

authors： Lezzerini M,Budovskaya Y

更新日期：2014-02-01 00:00:00

abstract：:Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotyp...

journal_title：Aging cell

authors： Umehara T,Kawai T,Kawashima I,Tanaka K,Okuda S,Kitasaka H,Richards JS,Shimada M

更新日期：2017-12-01 00:00:00

abstract：:Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mu...

journal_title：Aging cell

authors： Tchkonia T,Morbeck DE,Von Zglinicki T,Van Deursen J,Lustgarten J,Scrable H,Khosla S,Jensen MD,Kirkland JL

更新日期：2010-10-01 00:00:00

abstract：:This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for both genome-wide and in-depth analysis. This year, protein interaction networks have been used in a new bioinformatic approach to identify novel genes that extend replicative lifesp...

journal_title：Aging cell

authors： Partridge L

更新日期：2009-09-01 00:00:00

abstract：:Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks...

journal_title：Aging cell

authors： Cannon L,Zambon AC,Cammarato A,Zhang Z,Vogler G,Munoz M,Taylor E,Cartry J,Bernstein SI,Melov S,Bodmer R

更新日期：2017-02-01 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest activated in response to damaging stimuli. Many hallmarks associated with senescent cells are measured by quantitative real-time PCR (qPCR). As the selection of stable reference genes for interpretation of qPCR data is often overlooked, we performed a syste...

journal_title：Aging cell

authors： Hernandez-Segura A,Rubingh R,Demaria M

更新日期：2019-04-01 00:00:00

abstract：:SIRT4 modulates energy homeostasis in multiple cell types and tissues. However, its role in meiotic oocytes remains unknown. Here, we report that mouse oocytes overexpressing SIRT4 are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reac...

journal_title：Aging cell

authors： Zeng J,Jiang M,Wu X,Diao F,Qiu D,Hou X,Wang H,Li L,Li C,Ge J,Liu J,Ou X,Wang Q

更新日期：2018-08-01 00:00:00

abstract：:Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has r...

journal_title：Aging cell

authors： Mendenhall A,Driscoll M,Brent R

更新日期：2016-02-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is characterized by the formation of drusen, extracellular deposits associated with atrophy of the retinal pigmented epithelium (RPE), disturbance of the transepithelial barrier and photoreceptor death. Amyloid-beta (Abeta) is present in drusen but its role during AMD remains unk...

journal_title：Aging cell

authors： Bruban J,Glotin AL,Dinet V,Chalour N,Sennlaub F,Jonet L,An N,Faussat AM,Mascarelli F

更新日期：2009-04-01 00:00:00

abstract：:The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely to be ...

journal_title：Aging cell

authors： Chen J,Jiang Q,Xia X,Liu K,Yu Z,Tao W,Gong W,Han JJ

更新日期：2020-07-01 00:00:00

abstract：:Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...

journal_title：Aging cell

authors： Murchison D,Griffith WH

更新日期：2007-06-01 00:00:00

abstract：:Immunosenescence, the age-related decline in immune response, is a well-known consequence of aging. To date, most studies of age-related changes in immune response focused on the cellular and physiological bases of this decline; we have virtually no understanding of the genetic basis of age-related changes in the immu...

journal_title：Aging cell

authors： Lesser KJ,Paiusi IC,Leips J

更新日期：2006-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...

journal_title：Aging cell

authors： Xie S,Jin N,Gu J,Shi J,Sun J,Chu D,Zhang L,Dai CL,Gu JH,Gong CX,Iqbal K,Liu F

更新日期：2016-06-01 00:00:00