Expression patterns of cardiac aging in Drosophila.

abstract：:In a previous study, we reported that a deficiency in MnSOD activity (approximately 80% reduction) targeted to type IIB skeletal muscle fibers was sufficient to elevate oxidative stress and to reduce muscle function in young adult mice (TnIFastCreSod2(fl/fl) mice). In this study, we used TnIFastCreSod2(fl/fl) mice to ...

journal_title：Aging cell

authors： Lustgarten MS,Jang YC,Liu Y,Qi W,Qin Y,Dahia PL,Shi Y,Bhattacharya A,Muller FL,Shimizu T,Shirasawa T,Richardson A,Van Remmen H

更新日期：2011-06-01 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest activated in response to damaging stimuli. Many hallmarks associated with senescent cells are measured by quantitative real-time PCR (qPCR). As the selection of stable reference genes for interpretation of qPCR data is often overlooked, we performed a syste...

journal_title：Aging cell

authors： Hernandez-Segura A,Rubingh R,Demaria M

更新日期：2019-04-01 00:00:00

abstract：:Dietary restriction extends lifespan and inhibits reproduction in many species. In Caenorhabditis elegans, inhibiting reproduction by germline removal extends lifespan. Therefore, we asked whether the effect of dietary restriction on lifespan might proceed via changes in the activity of the germline. We found that die...

journal_title：Aging cell

authors： Crawford D,Libina N,Kenyon C

更新日期：2007-10-01 00:00:00

abstract：:Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG) mice with increased skeletal muscle mitochondrial uncoupling (HSA-mUCP1 mice) were fed one of three different semisyn...

journal_title：Aging cell

authors： Keipert S,Voigt A,Klaus S

更新日期：2011-02-01 00:00:00

abstract：:Methionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where ...

journal_title：Aging cell

authors： Aledo JC,Li Y,de Magalhães JP,Ruíz-Camacho M,Pérez-Claros JA

更新日期：2011-04-01 00:00:00

abstract：:The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of d...

journal_title：Aging cell

authors： Zhu Y,Tchkonia T,Pirtskhalava T,Gower AC,Ding H,Giorgadze N,Palmer AK,Ikeno Y,Hubbard GB,Lenburg M,O'Hara SP,LaRusso NF,Miller JD,Roos CM,Verzosa GC,LeBrasseur NK,Wren JD,Farr JN,Khosla S,Stout MB,McGowan SJ,Fuh

更新日期：2015-08-01 00:00:00

abstract：:The 'rate of living' theory predicts that longevity should be inversely correlated with the rate of mitochondrial respiration. However, recent studies in a number of model organisms, including mice, have reported that interventions that retard the aging process are, in fact, associated with an increase in mitochondria...

journal_title：Aging cell

authors： Bahadorani S,Cho J,Lo T,Contreras H,Lawal HO,Krantz DE,Bradley TJ,Walker DW

更新日期：2010-04-01 00:00:00

abstract：:FOXO transcription factors (FOXOs) are central regulators of lifespan across species, yet they also have cell-specific functions, including adult stem cell homeostasis and immune function. Direct targets of FOXOs have been identified genome-wide in several species and cell types. However, whether FOXO targets are spec...

journal_title：Aging cell

authors： Webb AE,Kundaje A,Brunet A

更新日期：2016-08-01 00:00:00

abstract：:The inhibitor of differentiation or DNA binding (Id) family of transcription regulators plays an important role in cell proliferation, differentiation, and senescence. However, regulation of Id expression during these processes is poorly understood. Id proteins are known to undergo rapid turnover mediated by the ubiqu...

journal_title：Aging cell

authors： Kong Y,Cui H,Zhang H

更新日期：2011-12-01 00:00:00

abstract：:Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancem...

journal_title：Aging cell

authors： Liu YL,Lu WC,Brummel TJ,Yuh CH,Lin PT,Kao TY,Li FY,Liao PC,Benzer S,Wang HD

更新日期：2009-08-01 00:00:00

abstract：:Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...

journal_title：Aging cell

authors： Zhang B,Podolskiy DI,Mariotti M,Seravalli J,Gladyshev VN

更新日期：2020-05-01 00:00:00

abstract：:Short telomeres are thought to trigger senescence, most likely through a single - or a group of few - critically shortened telomeres. Such short telomeres are thought to result from a combination of gradual linear shortening resulting from the end replication problem, reflecting the division history of the cell, super...

journal_title：Aging cell

authors： Bendix L,Horn PB,Jensen UB,Rubelj I,Kolvraa S

更新日期：2010-06-01 00:00:00

abstract：:The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor 5 (TLR5), unlike th...

journal_title：Aging cell

authors： Lim JS,Nguyen KC,Nguyen CT,Jang IS,Han JM,Fabian C,Lee SE,Rhee JH,Cho KA

更新日期：2015-10-01 00:00:00

abstract：:mTOR signalling is implicated in the development of disease and in lifespan extension in model organisms. This pathway has been associated with human diseases such as diabetes and cancer, but has not been investigated for its impact on longevity per se. Here, we investigated whether transcriptional variation within th...

journal_title：Aging cell

authors： Passtoors WM,Beekman M,Deelen J,van der Breggen R,Maier AB,Guigas B,Derhovanessian E,van Heemst D,de Craen AJ,Gunn DA,Pawelec G,Slagboom PE

更新日期：2013-02-01 00:00:00

abstract：:Adequate energy stores are essential for survival, and sophisticated neuroendocrine mechanisms evolved to stimulate foraging in response to nutrient deprivation. Food search behavior is usually investigated in young animals, and it is not known how aging alters this behavior. To address this question in Drosophila mel...

journal_title：Aging cell

authors： Egenriether SM,Chow ES,Krauth N,Giebultowicz JM

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to investigate changes in astrocyte density, morphology, proliferation and apoptosis occurring in the central nervous system during physiological aging. Astrocytes in retinal whole-mount preparations from Wistar rats aged 3 (young adult) to 25 months (aged) were investigated qualitatively and...

journal_title：Aging cell

authors： Mansour H,Chamberlain CG,Weible MW 2nd,Hughes S,Chu Y,Chan-Ling T

更新日期：2008-08-01 00:00:00

abstract：:In this, the fourth installment of our annual Hot Topics review on mRNA translation and aging, we have decided to expand our scope to include recent findings related to the role of TOR signaling in aging. As new data emerge, it is clear that TOR signaling acts upstream of mRNA translation, as well as a variety of othe...

journal_title：Aging cell

authors： Kaeberlein M,Kennedy BK

更新日期：2011-04-01 00:00:00

abstract：:The transcription of ribosomal RNA genes (rDNA) is subject to epigenetic regulation, as it is abrogated by the methylation of CpG dinucleotides within their promoter region. Here, we investigated, through Sequenom platform, the age-related methylation status of the CpG island falling into the rDNA promoter in 472 bloo...

journal_title：Aging cell

authors： D'Aquila P,Montesanto A,Mandalà M,Garasto S,Mari V,Corsonello A,Bellizzi D,Passarino G

更新日期：2017-10-01 00:00:00

abstract：:Werner syndrome (WS) is an autosomal recessive disorder, the hallmarks of which are premature aging and early onset of neoplastic diseases (Orren, 2006; Bohr, 2008). The gene, whose mutation underlies the WS phenotype, is called WRN. The protein encoded by the WRN gene, WRNp, has DNA helicase activity (Gray et al., 19...

journal_title：Aging cell

authors： Smith JA,Ndoye AM,Geary K,Lisanti MP,Igoucheva O,Daniel R

更新日期：2010-08-01 00:00:00

abstract：:Oxidative modification of cellular components may contribute to tissue dysfunction during aging. In skeletal muscle, contractile activity increases the generation of reactive oxygen and nitrogen species (ROS). The question of whether contraction-induced ROS generation is further increased in skeletal muscle of the eld...

journal_title：Aging cell

authors： Vasilaki A,Mansouri A,Van Remmen H,van der Meulen JH,Larkin L,Richardson AG,McArdle A,Faulkner JA,Jackson MJ

更新日期：2006-04-01 00:00:00

abstract：:Replicative senescence has a major impact on function and integrity of cell preparations. This process is reflected by continuous DNA methylation (DNAm) changes at specific CpG dinucleotides in the course of in vitro culture, and such modifications can be used to estimate the state of cellular senescence for quality c...

journal_title：Aging cell

authors： Franzen J,Zirkel A,Blake J,Rath B,Benes V,Papantonis A,Wagner W

更新日期：2017-02-01 00:00:00

abstract：:Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would ...

journal_title：Aging cell

authors： Walton RG,Dungan CM,Long DE,Tuggle SC,Kosmac K,Peck BD,Bush HM,Villasante Tezanos AG,McGwin G,Windham ST,Ovalle F,Bamman MM,Kern PA,Peterson CA

更新日期：2019-12-01 00:00:00

abstract：:The cell cycle and its regulators are validated targets for cancer drugs. Reagents that target cells in a specific cell cycle phase (e.g., antimitotics or DNA synthesis inhibitors/replication stress inducers) have demonstrated success as broad-spectrum anticancer drugs. Cyclin-dependent kinases (CDKs) are drivers of c...

journal_title：Aging cell

authors： Rao CV,Asch AS,Carr DJJ,Yamada HY

更新日期：2020-03-01 00:00:00

abstract：:Downregulation of insulin-like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF-I receptor (IGF-1R) in adult stem ...

journal_title：Aging cell

authors： Chaker Z,Aïd S,Berry H,Holzenberger M

更新日期：2015-10-01 00:00:00

abstract：:Klotho is a recently discovered anti-aging gene. The purpose of this study was to investigate whether klotho gene transfer attenuates superoxide production and oxidative stress in rat aorta smooth muscle (RASM) cells. RASM cells were transfected with AAV plasmids carrying mouse klotho full-length cDNA (mKL) or LacZ as...

journal_title：Aging cell

authors： Wang Y,Kuro-o M,Sun Z

更新日期：2012-06-01 00:00:00

abstract：:Previously, we reported that persistent DNA damage accelerates ageing of the spine, but the mechanisms behind this process are not well understood. Ataxia telangiectasia mutated (ATM) is a protein kinase involved in the DNA damage response, which controls cell fate, including cell death. To test the role of ATM in the...

journal_title：Aging cell

authors： Han Y,Zhou CM,Shen H,Tan J,Dong Q,Zhang L,McGowan SJ,Zhao J,Sowa GA,Kang JD,Niedernhofer LJ,Robbins PD,Vo NN

更新日期：2020-07-01 00:00:00

abstract：:Immunosenescence, the age-related decline in immune response, is a well-known consequence of aging. To date, most studies of age-related changes in immune response focused on the cellular and physiological bases of this decline; we have virtually no understanding of the genetic basis of age-related changes in the immu...

journal_title：Aging cell

authors： Lesser KJ,Paiusi IC,Leips J

更新日期：2006-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significant molecular damage. Animals tightly control ROS levels using sophisticated defense mechanisms, yet the transcriptional pathways that induce ROS defense remain incompletely understood. In the nematode Caenorhabditis eleg...

journal_title：Aging cell

authors： Goh GY,Martelli KL,Parhar KS,Kwong AW,Wong MA,Mah A,Hou NS,Taubert S

更新日期：2014-02-01 00:00:00

abstract：:Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline ...

journal_title：Aging cell

authors： Tarantini S,Valcarcel-Ares NM,Yabluchanskiy A,Fulop GA,Hertelendy P,Gautam T,Farkas E,Perz A,Rabinovitch PS,Sonntag WE,Csiszar A,Ungvari Z

更新日期：2018-04-01 00:00:00

abstract：:Cellular senescence plays both beneficial and detrimental roles in embryonic development and tissue regeneration, while the underlying mechanism remains elusive. Recent studies disclosed the emerging roles of heat-shock proteins in regulating muscle regeneration and homeostasis. Here, we found that Hsp90β, but not Hsp...

journal_title：Aging cell

authors： He MY,Xu SB,Qu ZH,Guo YM,Liu XC,Cong XX,Wang JF,Low BC,Li L,Wu Q,Lin P,Yan SG,Bao Z,Zhou YT,Zheng LL

更新日期：2019-10-01 00:00:00