Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging.

abstract：:The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amy...

journal_title：Aging cell

authors： Schultz N,Brännström K,Byman E,Moussaud S,Nielsen HM,Netherlands Brain Bank.,Olofsson A,Wennström M

更新日期：2018-06-01 00:00:00

abstract：:Age-associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial...

journal_title：Aging cell

authors： Bose C,Alves I,Singh P,Palade PT,Carvalho E,Børsheim E,Jun SR,Cheema A,Boerma M,Awasthi S,Singh SP

更新日期：2020-11-01 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest activated in response to damaging stimuli. Many hallmarks associated with senescent cells are measured by quantitative real-time PCR (qPCR). As the selection of stable reference genes for interpretation of qPCR data is often overlooked, we performed a syste...

journal_title：Aging cell

authors： Hernandez-Segura A,Rubingh R,Demaria M

更新日期：2019-04-01 00:00:00

abstract：:In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolong the chronological aging of yeast cells during the stationary phase. Lifespan extension is significantly reduced in yca1 mutants as well in rho(0) strains, suggesting that the protective effects pass through the Yca1 cas...

journal_title：Aging cell

authors： Palermo V,Falcone C,Calvani M,Mazzoni C

更新日期：2010-08-01 00:00:00

abstract：:Frailty is a state of decreased physiological reserve and increased vulnerability to adverse outcomes in aging, and is characterized by dysregulation across various biological pathways. Frailty may manifest biologically as alteration in protein expression, possibly regulated at genetic, transcriptional and epigenetic ...

journal_title：Aging cell

authors： Sathyan S,Ayers E,Gao T,Milman S,Barzilai N,Verghese J

更新日期：2020-09-01 00:00:00

abstract：:Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generations of telomerase-def...

journal_title：Aging cell

authors： García-Beccaria M,Martínez P,Flores JM,Blasco MA

更新日期：2014-10-01 00:00:00

abstract：:Cellular senescence plays both beneficial and detrimental roles in embryonic development and tissue regeneration, while the underlying mechanism remains elusive. Recent studies disclosed the emerging roles of heat-shock proteins in regulating muscle regeneration and homeostasis. Here, we found that Hsp90β, but not Hsp...

journal_title：Aging cell

authors： He MY,Xu SB,Qu ZH,Guo YM,Liu XC,Cong XX,Wang JF,Low BC,Li L,Wu Q,Lin P,Yan SG,Bao Z,Zhou YT,Zheng LL

更新日期：2019-10-01 00:00:00

abstract：:Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effect of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. Here, we describe a large-scale effort to define molecular mechanisms that underlie genotype-spe...

journal_title：Aging cell

authors： Schleit J,Johnson SC,Bennett CF,Simko M,Trongtham N,Castanza A,Hsieh EJ,Moller RM,Wasko BM,Delaney JR,Sutphin GL,Carr D,Murakami CJ,Tocchi A,Xian B,Chen W,Yu T,Goswami S,Higgins S,Holmberg M,Jeong KS,Kim JR,Kl

更新日期：2013-12-01 00:00:00

abstract：:Aging is associated with a large number of both phenotypic and molecular changes, but for most of these, it is not known whether these changes are detrimental, neutral, or protective. We have identified a conserved Caenorhabditis elegans GATA transcription factor/MTA-1 homolog egr-1 (lin-40) that extends lifespan and ...

journal_title：Aging cell

authors： Zimmerman SM,Kim SK

更新日期：2014-04-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions occur sporadically in zygotic and somatic tissues and reach their highest concentration in substantia nigra. Previously, we noted the increase of the adenosine monophosphate (AMP)-activated protein kinase (AMPK) transcript by microarray in multiple cells and tissues bearing deletion...

journal_title：Aging cell

authors： Prigione A,Cortopassi G

更新日期：2007-10-01 00:00:00

abstract：:The aim of this study was to determine the mechanism underlying the association between one-carbon metabolism and DNA methylation during chronic degenerative joint disorder, osteoarthritis (OA). Articular chondrocytes were isolated from human OA cartilage and normal cartilage biopsied, and the degree of cartilage degr...

journal_title：Aging cell

authors： Song J,Kim D,Chun CH,Jin EJ

更新日期：2015-10-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are formed when glucose reacts nonenzymatically with proteins; these modifications are implicated in aging and pathogenesis of many age-related diseases including type II diabetes, atherosclerosis, and neurodegenerative disorders. Thus, pharmaceutical interventions that can reduc...

journal_title：Aging cell

authors： Golegaonkar S,Tabrez SS,Pandit A,Sethurathinam S,Jagadeeshaprasad MG,Bansode S,Sampathkumar SG,Kulkarni MJ,Mukhopadhyay A

更新日期：2015-06-01 00:00:00

abstract：:Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) su...

journal_title：Aging cell

authors： Johnson ML,Lalia AZ,Dasari S,Pallauf M,Fitch M,Hellerstein MK,Lanza IR

更新日期：2015-10-01 00:00:00

abstract：:A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. H...

journal_title：Aging cell

authors： Yousefzadeh MJ,Schafer MJ,Noren Hooten N,Atkinson EJ,Evans MK,Baker DJ,Quarles EK,Robbins PD,Ladiges WC,LeBrasseur NK,Niedernhofer LJ

更新日期：2018-04-01 00:00:00

abstract：:The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, ...

journal_title：Aging cell

authors： Garagnani P,Bacalini MG,Pirazzini C,Gori D,Giuliani C,Mari D,Di Blasio AM,Gentilini D,Vitale G,Collino S,Rezzi S,Castellani G,Capri M,Salvioli S,Franceschi C

更新日期：2012-12-01 00:00:00

abstract：:Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...

journal_title：Aging cell

authors： Murchison D,Griffith WH

更新日期：2007-06-01 00:00:00

abstract：:Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death rate, which is thought to reflect the rate of age-related damage accumulation....

journal_title：Aging cell

authors： Valenzano DR,Terzibasi E,Cattaneo A,Domenici L,Cellerino A

更新日期：2006-06-01 00:00:00

abstract：:Adipose tissue inflammation and dysfunction are associated with obesity-related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the development of dia...

journal_title：Aging cell

authors： Palmer AK,Xu M,Zhu Y,Pirtskhalava T,Weivoda MM,Hachfeld CM,Prata LG,van Dijk TH,Verkade E,Casaclang-Verzosa G,Johnson KO,Cubro H,Doornebal EJ,Ogrodnik M,Jurk D,Jensen MD,Chini EN,Miller JD,Matveyenko A,Stout MB,Sc

更新日期：2019-06-01 00:00:00

abstract：:Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks...

journal_title：Aging cell

authors： Cannon L,Zambon AC,Cammarato A,Zhang Z,Vogler G,Munoz M,Taylor E,Cartry J,Bernstein SI,Melov S,Bodmer R

更新日期：2017-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a terminal age-associated dementia characterized by early synaptic dysfunction and late neurodegeneration. Although the presence of plaques of fibrillar aggregates of the amyloid beta peptide (Abeta) is a signature of AD, evidence suggests that the preplaque small oligomeric Abeta promotes ...

journal_title：Aging cell

authors： Reese LC,Zhang W,Dineley KT,Kayed R,Taglialatela G

更新日期：2008-12-01 00:00:00

abstract：:We analyzed MBL2 gene variants in two cohorts of centenarians, octo-nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity. We also assessed in ...

journal_title：Aging cell

authors： Tomaiuolo R,Ruocco A,Salapete C,Carru C,Baggio G,Franceschi C,Zinellu A,Vaupel J,Bellia C,Lo Sasso B,Ciaccio M,Castaldo G,Deiana L

更新日期：2012-06-01 00:00:00

abstract：:Sarcopenia, loss of skeletal muscle mass, is a hallmark of aging commonly attributed to a decreased capacity to maintain muscle tissue in senescence, yet the mechanism behind the muscle wasting remains unresolved. To address these issues we have explored a rodent model of sarcopenia and age-related sensorimotor impair...

journal_title：Aging cell

authors： Edström E,Ulfhake B

更新日期：2005-04-01 00:00:00

abstract：:Werner syndrome (WS) is an autosomal recessive disorder, the hallmarks of which are premature aging and early onset of neoplastic diseases (Orren, 2006; Bohr, 2008). The gene, whose mutation underlies the WS phenotype, is called WRN. The protein encoded by the WRN gene, WRNp, has DNA helicase activity (Gray et al., 19...

journal_title：Aging cell

authors： Smith JA,Ndoye AM,Geary K,Lisanti MP,Igoucheva O,Daniel R

更新日期：2010-08-01 00:00:00

abstract：:Although the link between altered stem cell properties and tissue aging has been recognized, the molecular and cellular processes of tendon aging have not been elucidated. As tendons contain stem/progenitor cells (TSPC), we investigated whether the molecular and cellular attributes of TSPC alter during tendon aging an...

journal_title：Aging cell

authors： Kohler J,Popov C,Klotz B,Alberton P,Prall WC,Haasters F,Müller-Deubert S,Ebert R,Klein-Hitpass L,Jakob F,Schieker M,Docheva D

更新日期：2013-12-01 00:00:00

abstract：:Hutchinson-Gilford progeria syndrome (HGPS) is caused by the accumulation of mutant prelamin A (progerin) in the nuclear lamina, resulting in increased nuclear stiffness and abnormal nuclear architecture. Nuclear mechanics are tightly coupled to cytoskeletal mechanics via lamin A/C. However, the role of cytoskeletal/n...

journal_title：Aging cell

authors： Mu X,Tseng C,Hambright WS,Matre P,Lin CY,Chanda P,Chen W,Gu J,Ravuri S,Cui Y,Zhong L,Cooke JP,Niedernhofer LJ,Robbins PD,Huard J

更新日期：2020-08-01 00:00:00

abstract：:SARS-CoV-2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID-19), a complex respiratory distress syndrome. Epidemiological data show that COVID-19 has a rising mortality particularly in individuals with advanced age. Identifying a functional association ...

journal_title：Aging cell

authors： Nehme J,Borghesan M,Mackedenski S,Bird TG,Demaria M

更新日期：2020-10-01 00:00:00

abstract：:FOXO transcription factors (FOXOs) are central regulators of lifespan across species, yet they also have cell-specific functions, including adult stem cell homeostasis and immune function. Direct targets of FOXOs have been identified genome-wide in several species and cell types. However, whether FOXO targets are spec...

journal_title：Aging cell

authors： Webb AE,Kundaje A,Brunet A

更新日期：2016-08-01 00:00:00

abstract：:Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life-history traits and transcriptomes of 14 Drosophila species d...

journal_title：Aging cell

authors： Ma S,Avanesov AS,Porter E,Lee BC,Mariotti M,Zemskaya N,Guigo R,Moskalev AA,Gladyshev VN

更新日期：2018-08-01 00:00:00

abstract：:Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during cellular senescence are not known. We used formaldehyde assisted isolation of regul...

journal_title：Aging cell

authors： De Cecco M,Criscione SW,Peckham EJ,Hillenmeyer S,Hamm EA,Manivannan J,Peterson AL,Kreiling JA,Neretti N,Sedivy JM

更新日期：2013-04-01 00:00:00

abstract：:Age-related increase in L-type Ca(2+) channel (LTCC) expression in hippocampal pyramidal neurons has been hypothesized to underlie the increased Ca(2+) influx and subsequent reduced intrinsic neuronal excitability of these neurons that lead to age-related cognitive deficits. Here, using specific antibodies against Cav...

journal_title：Aging cell

authors： Núñez-Santana FL,Oh MM,Antion MD,Lee A,Hell JW,Disterhoft JF

更新日期：2014-02-01 00:00:00