Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice.

abstract：:Neurodegeneration resulting in cognitive and motor impairment is an inevitable consequence of aging. Little is known about the genetic regulation of this process despite its overriding importance in normal aging. Here, we identify the Forkhead Box O (FOXO) transcription factor 1, 3, and 4 isoforms as a guardian of neu...

journal_title：Aging cell

authors： Hwang I,Oh H,Santo E,Kim DY,Chen JW,Bronson RT,Locasale JW,Na Y,Lee J,Reed S,Toth M,Yu WH,Muller FL,Paik J

更新日期：2018-02-01 00:00:00

abstract：:Impairments of dendritic trees and spines have been found in many neurodegenerative diseases, including Alzheimer's disease (AD), in which the deficits of melatonin signal pathway were reported. Melatonin receptor 2 (MT2) is widely expressed in the hippocampus and mediates the biological functions of melatonin. It is ...

journal_title：Aging cell

authors： Tang H,Ma M,Wu Y,Deng MF,Hu F,Almansoub HAMM,Huang HZ,Wang DQ,Zhou LT,Wei N,Man H,Lu Y,Liu D,Zhu LQ

更新日期：2019-04-01 00:00:00

abstract：:Despite its medical, social, and economic significance, understanding what primarily causes aging, that is, the mechanisms of the aging process, remains a fundamental and fascinating problem in biology. Accumulating evidence indicates that a small RNA-based gene regulatory machinery, the Piwi-piRNA pathway, represents...

journal_title：Aging cell

authors： Sturm Á,Perczel A,Ivics Z,Vellai T

更新日期：2017-10-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:Endothelial oxidative stress develops with aging and reactive oxygen species impair endothelium-dependent relaxation (EDR) by decreasing nitric oxide (NO) availability. Endothelial KCa 3.1, which contributes to EDR, is upregulated by H2 O2 . We investigated whether KCa 3.1 upregulation compensates for diminished EDR t...

journal_title：Aging cell

authors： Choi S,Kim JA,Li HY,Shin KO,Oh GT,Lee YM,Oh S,Pewzner-Jung Y,Futerman AH,Suh SH

更新日期：2016-10-01 00:00:00

abstract：:This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases esp...

journal_title：Aging cell

authors： Conover CA

更新日期：2010-12-01 00:00:00

abstract：:Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central ...

journal_title：Aging cell

authors： Cohen J,Torres C

更新日期：2019-06-01 00:00:00

abstract：:The inhibitor of differentiation or DNA binding (Id) family of transcription regulators plays an important role in cell proliferation, differentiation, and senescence. However, regulation of Id expression during these processes is poorly understood. Id proteins are known to undergo rapid turnover mediated by the ubiqu...

journal_title：Aging cell

authors： Kong Y,Cui H,Zhang H

更新日期：2011-12-01 00:00:00

abstract：:Age-related thymic involution is characterized by reduction in T cell production together with ectopic adipocyte development within the hematopoietic and thymic niches. Peroxisome proliferator-activated receptor gamma (PPARgamma) is required for adipocyte development, glucose homeostasis and is a target for several in...

journal_title：Aging cell

authors： Youm YH,Yang H,Amin R,Smith SR,Leff T,Dixit VD

更新日期：2010-08-01 00:00:00

abstract：:Previously, we reported that persistent DNA damage accelerates ageing of the spine, but the mechanisms behind this process are not well understood. Ataxia telangiectasia mutated (ATM) is a protein kinase involved in the DNA damage response, which controls cell fate, including cell death. To test the role of ATM in the...

journal_title：Aging cell

authors： Han Y,Zhou CM,Shen H,Tan J,Dong Q,Zhang L,McGowan SJ,Zhao J,Sowa GA,Kang JD,Niedernhofer LJ,Robbins PD,Vo NN

更新日期：2020-07-01 00:00:00

abstract：:Summary We address the problem of establishing a survival schedule for wild populations. A demographic key identity is established, leading to a method whereby age-specific survival and mortality can be deduced from a marked cohort life table established for individuals that are randomly sampled at unknown age and mar...

journal_title：Aging cell

authors： Müller HG,Wang JL,Carey JR,Caswell-Chen EP,Chen C,Papadopoulos N,Yao F

更新日期：2004-06-01 00:00:00

abstract：:Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generations of telomerase-def...

journal_title：Aging cell

authors： García-Beccaria M,Martínez P,Flores JM,Blasco MA

更新日期：2014-10-01 00:00:00

abstract：:Aging is inevitably accompanied by gradual and irreversible innate endothelial dysfunction. In this study, we tested the hypothesis that accentuation of glucose metabolism via the aldose reductase (AR) pathway contributes to age-related vascular dysfunction. AR protein and activity levels were significantly increased ...

journal_title：Aging cell

authors： Hallam KM,Li Q,Ananthakrishnan R,Kalea A,Zou YS,Vedantham S,Schmidt AM,Yan SF,Ramasamy R

更新日期：2010-10-01 00:00:00

abstract：:The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of the cytoplasm, i.e., the myonuclear domain (MND). We analysed aging- and gender-related effects on myonuclei organization and the MND size in single muscle fibres from six young (21-31 years) and nine old m...

journal_title：Aging cell

authors： Cristea A,Qaisar R,Edlund PK,Lindblad J,Bengtsson E,Larsson L

更新日期：2010-10-01 00:00:00

abstract：:While NLRP3-inflammasome has been implicated in cardiovascular diseases, its role in physiological cardiac aging is largely unknown. During aging, many alterations occur in the organism, which are associated with progressive impairment of metabolic pathways related to insulin resistance, autophagy dysfunction, and inf...

journal_title：Aging cell

authors： Marín-Aguilar F,Lechuga-Vieco AV,Alcocer-Gómez E,Castejón-Vega B,Lucas J,Garrido C,Peralta-Garcia A,Pérez-Pulido AJ,Varela-López A,Quiles JL,Ryffel B,Flores I,Bullón P,Ruiz-Cabello J,Cordero MD

更新日期：2020-01-01 00:00:00

abstract：:Neuropeptide Y (NPY) is an orexigenic peptide that plays an essential role in caloric restriction (CR)-mediated lifespan extension. However, the mechanisms underlying the NPY-mediated effects in CR are poorly defined. Here, we report that NPY deficiency in male mice during CR increases mortality in association with li...

journal_title：Aging cell

authors： Park S,Komatsu T,Kim SE,Tanaka K,Hayashi H,Mori R,Shimokawa I

更新日期：2017-04-01 00:00:00

abstract：:Klotho is a recently discovered anti-aging gene. The purpose of this study was to investigate whether klotho gene transfer attenuates superoxide production and oxidative stress in rat aorta smooth muscle (RASM) cells. RASM cells were transfected with AAV plasmids carrying mouse klotho full-length cDNA (mKL) or LacZ as...

journal_title：Aging cell

authors： Wang Y,Kuro-o M,Sun Z

更新日期：2012-06-01 00:00:00

abstract：:Dietary restriction extends lifespan and inhibits reproduction in many species. In Caenorhabditis elegans, inhibiting reproduction by germline removal extends lifespan. Therefore, we asked whether the effect of dietary restriction on lifespan might proceed via changes in the activity of the germline. We found that die...

journal_title：Aging cell

authors： Crawford D,Libina N,Kenyon C

更新日期：2007-10-01 00:00:00

abstract：:Evidence suggests that muscarinic receptors (MAChRs) are involved in various aspects of neuronal and vascular functioning, and that there is selective oxidative stress sensitivity (OSS) among MAChR subtypes. COS-7 cells transfected with M1, M2 and M4 subtypes show greater OSS than the M1 and M3 subtypes, as seen by th...

journal_title：Aging cell

authors： Joseph JA,Fisher DR,Carey A,Szprengiel A

更新日期：2004-10-01 00:00:00

abstract：:Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to a...

journal_title：Aging cell

authors： Rocha LR,Nguyen Huu VA,Palomino La Torre C,Xu Q,Jabari M,Krawczyk M,Weinreb RN,Skowronska-Krawczyk D

更新日期：2020-02-01 00:00:00

abstract：:Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mu...

journal_title：Aging cell

authors： Tchkonia T,Morbeck DE,Von Zglinicki T,Van Deursen J,Lustgarten J,Scrable H,Khosla S,Jensen MD,Kirkland JL

更新日期：2010-10-01 00:00:00

abstract：:The susceptibility of human CD4+ and CD8+ T cells to senesce differs, with CD8+ T cells acquiring an immunosenescent phenotype faster than the CD4+ T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD4+ T cells displaying a hig...

journal_title：Aging cell

authors： Callender LA,Carroll EC,Bober EA,Akbar AN,Solito E,Henson SM

更新日期：2020-02-01 00:00:00

abstract：:Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of age-related degenerative diseases is termed 'laminopathies'. Here, we show that mature lamin A has an essential role in cellular fitness and that oxidative damage to lamin A is involved in cellular senescence. Primary human dermal f...

journal_title：Aging cell

authors： Pekovic V,Gibbs-Seymour I,Markiewicz E,Alzoghaibi F,Benham AM,Edwards R,Wenhert M,von Zglinicki T,Hutchison CJ

更新日期：2011-12-01 00:00:00

abstract：:With reduced thymic activity, the population of naïve T cells in humans is maintained by homeostatic proliferation throughout adult life. In young adults, naïve CD4 T cells have enormous proliferative potential and plasticity to differentiate into different lineages. Here, we explored whether naïve CD4 T-cell aging is...

journal_title：Aging cell

authors： Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ

更新日期：2019-08-01 00:00:00

abstract：:Ubiquitously reduced signaling via Methuselah (MTH), a G-protein-coupled receptor (GPCR) required for neurosecretion, has previously been reported to extend life and enhance stress resistance in flies. Whether these effects are due to reduced MTH signalling in specific tissues remains unknown. We determined that reduc...

journal_title：Aging cell

authors： Gimenez LE,Ghildyal P,Fischer KE,Hu H,Ja WW,Eaton BA,Wu Y,Austad SN,Ranjan R

更新日期：2013-02-01 00:00:00

abstract：:Growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and have improved glucose homeostasis along with altered energy metabolism which manifests through decreased respiratory quotient (RQ) and increased oxygen consumption (VO2 ). Short-term exposure of these animals to increased environmental tempera...

journal_title：Aging cell

authors： Fang Y,McFadden S,Darcy J,Hascup ER,Hascup KN,Bartke A

更新日期：2020-05-01 00:00:00

abstract：:We tested the hypothesis that supplementation of nicotinamide mononucleotide (NMN), a key NAD(+) intermediate, increases arterial SIRT1 activity and reverses age-associated arterial dysfunction and oxidative stress. Old control mice (OC) had impaired carotid artery endothelium-dependent dilation (EDD) (60 ± 5% vs. 84 ...

journal_title：Aging cell

authors： de Picciotto NE,Gano LB,Johnson LC,Martens CR,Sindler AL,Mills KF,Imai S,Seals DR

更新日期：2016-06-01 00:00:00

abstract：:The cell cycle and its regulators are validated targets for cancer drugs. Reagents that target cells in a specific cell cycle phase (e.g., antimitotics or DNA synthesis inhibitors/replication stress inducers) have demonstrated success as broad-spectrum anticancer drugs. Cyclin-dependent kinases (CDKs) are drivers of c...

journal_title：Aging cell

authors： Rao CV,Asch AS,Carr DJJ,Yamada HY

更新日期：2020-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...

journal_title：Aging cell

authors： Xie S,Jin N,Gu J,Shi J,Sun J,Chu D,Zhang L,Dai CL,Gu JH,Gong CX,Iqbal K,Liu F

更新日期：2016-06-01 00:00:00

abstract：:Age-associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute to progressive ventricular expansion. By directly linking postmortem human MRI sequences with histological features of periventricular tissue, we show that substantial lateral ventricl...

journal_title：Aging cell

authors： Shook BA,Lennington JB,Acabchuk RL,Halling M,Sun Y,Peters J,Wu Q,Mahajan A,Fellows DW,Conover JC

更新日期：2014-04-01 00:00:00