Abstract:
:Summary We address the problem of establishing a survival schedule for wild populations. A demographic key identity is established, leading to a method whereby age-specific survival and mortality can be deduced from a marked cohort life table established for individuals that are randomly sampled at unknown age and marked, with subsequent recording of time-to-death. This identity permits the construction of life tables from data where the birth date of subjects is unknown. An analogous key identity is established for the continuous case in which the survival schedule of the wild population is related to the density of the survival distribution in the marked cohort. These identities are explored for both life tables and continuous lifetime data. For the continuous case, they are implemented with statistical methods using non-parametric density estimation methods to obtain flexible estimates for the unknown survival distribution of the wild population. The analytical model provided here serves as a starting point to develop more complex models for residual demography, i.e. models for estimating survival of wild populations in which age-at-entry is unknown and using remaining information in randomly encountered individuals. This is a first step towards a broad new concept of 'expressed demographic information content of marked or captured individuals'.
journal_name
Aging Celljournal_title
Aging cellauthors
Müller HG,Wang JL,Carey JR,Caswell-Chen EP,Chen C,Papadopoulos N,Yao Fdoi
10.1111/j.1474-9728.2004.00096.xkeywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
125-31issue
3eissn
1474-9718issn
1474-9726pii
ACE096journal_volume
3pub_type
杂志文章相关文献
AGING CELL文献大全abstract::Aging causes cardiac dysfunction, often leading to heart failure and death. The molecular basis of age-associated changes in cardiac structure and function is largely unknown. The fruit fly, Drosophila melanogaster, is well-suited to investigate the genetics of cardiac aging. Flies age rapidly over the course of weeks...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12559
更新日期:2017-02-01 00:00:00
abstract::Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mu...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/j.1474-9726.2010.00608.x
更新日期:2010-10-01 00:00:00
abstract::Most mammalian cells when placed in culture will undergo a limited number of cell divisions before entering an unresponsive non-proliferating state termed senescence. However, several pathways that are activated singly or in concert can allow cells to bypass senescence at least for limited periods. These include the t...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/j.1474-9728.2004.00134.x
更新日期:2004-12-01 00:00:00
abstract::Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age-dependent metabolic changes, but the mechanism is unknown. Here, we profile lamina-associated domains (LADs) using lamin B1 ChIP-Seq in young and old hepatocytes and find that, alt...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12742
更新日期:2018-06-01 00:00:00
abstract::Age-associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13261
更新日期:2020-11-01 00:00:00
abstract::Accumulating evidence suggests a role for microRNAs (miRNAs) in regulating various processes of mammalian postnatal development and aging. To investigate the changes in blood-based miRNA expression from preterm infants to adulthood, we compared 365 miRNA expression profiles in a screening set of preterm infants and ad...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12225
更新日期:2014-08-01 00:00:00
abstract::Frailty is a state of decreased physiological reserve and increased vulnerability to adverse outcomes in aging, and is characterized by dysregulation across various biological pathways. Frailty may manifest biologically as alteration in protein expression, possibly regulated at genetic, transcriptional and epigenetic ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13193
更新日期:2020-09-01 00:00:00
abstract::Cellular senescence is a cellular program that prevents the proliferation of cells at risk of neoplastic transformation. On the other hand, age-related accumulation of senescent cells promotes aging at least partially due to the senescence-associated secretory phenotype, whereby cells secrete high levels of inflammato...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/acel.12734
更新日期:2018-04-01 00:00:00
abstract::Studies in the nematode Caenorhabditis elegans have been instrumental in defining genetic pathways that are involved in modulating lifespan. Multiple processes such as endocrine signaling, nutritional sensing and mitochondrial function play a role in determining lifespan in the worm and these mechanisms appear to be c...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/j.1474-9726.2006.00186.x
更新日期:2006-02-01 00:00:00
abstract::Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence, a stable proliferative arrest that promotes aging-associated disorders in some mammals. The budding yeast CST complex, comprising Cdc13, Stn1, and Ctc1, is critical for telomere replication, length regulation, and end prot...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12289
更新日期:2015-06-01 00:00:00
abstract::Age-related thymic involution is characterized by reduction in T cell production together with ectopic adipocyte development within the hematopoietic and thymic niches. Peroxisome proliferator-activated receptor gamma (PPARgamma) is required for adipocyte development, glucose homeostasis and is a target for several in...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2010.00574.x
更新日期:2010-08-01 00:00:00
abstract::In this, the fourth installment of our annual Hot Topics review on mRNA translation and aging, we have decided to expand our scope to include recent findings related to the role of TOR signaling in aging. As new data emerge, it is clear that TOR signaling acts upstream of mRNA translation, as well as a variety of othe...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2010.00665.x
更新日期:2011-04-01 00:00:00
abstract::FOXO transcription factors (FOXOs) are central regulators of lifespan across species, yet they also have cell-specific functions, including adult stem cell homeostasis and immune function. Direct targets of FOXOs have been identified genome-wide in several species and cell types. However, whether FOXO targets are spec...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12479
更新日期:2016-08-01 00:00:00
abstract::The progressively increasing frailty, morbidity and mortality of aging organisms coincides with, and may be causally related to, their waning ability to adapt to environmental perturbations. Transcriptional responses to challenges, such as oxidative stress or pathogens, diminish with age. This effect is manifest in th...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13297
更新日期:2021-01-20 00:00:00
abstract::We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear. In the present study, we identified distinct contributions of lung endothelial cells (Ec) and ep...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12914
更新日期:2019-06-01 00:00:00
abstract::Amyloid-β 1-42 accumulation is the major pathogenetic event in Alzheimer's disease (AD), believed to be responsible for synaptic dysfunction and neuronal cell death. However, the physiologic activity of Aβ peptides remains elusive: Aβ might not only play a toxic role, but also act as a functional signaling intermediat...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2012.00854.x
更新日期:2012-10-01 00:00:00
abstract::Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest, or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies determined the mutation...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12036
更新日期:2013-04-01 00:00:00
abstract::We analyzed MBL2 gene variants in two cohorts of centenarians, octo-nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity. We also assessed in ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2012.00793.x
更新日期:2012-06-01 00:00:00
abstract::Wnt signaling is a major and highly conserved developmental pathway that guides many important events during embryonic and larval development. In adulthood, misregulation of Wnt signaling has been implicated in tumorigenesis and various age-related diseases. These effects occur through highly complicated cell-to-cell ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12141
更新日期:2014-02-01 00:00:00
abstract::Methionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2010.00657.x
更新日期:2011-04-01 00:00:00
abstract::This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for in-depth analysis. This year, the first quantitative estimate of evolutionary conservation of genetic effects on lifespan has pointed to the key importance of genes involved in prot...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/j.1474-9726.2008.00415.x
更新日期:2008-10-01 00:00:00
abstract::Aging is the largest risk factor for a variety of noncommunicable diseases. Model organism studies have shown that genetic and chemical perturbations can extend both lifespan and healthspan. Aging is a complex process, with parallel and interacting mechanisms contributing to its aetiology, posing a challenge for the d...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12819
更新日期:2018-10-01 00:00:00
abstract::Impaired osteoblast function is involved in osteoporosis, and microRNA (miRNA) dysregulation may cause abnormal osteoblast osteogenic activity. However, the influence of miRNA on osteoblast activity and the underlying mechanisms remain elusive. In this study, miR-103-3p was found to be negatively correlated with bone ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13298
更新日期:2021-01-13 00:00:00
abstract::The cerebral amyloid-β accumulation that begins in middle age is considered the critical triggering event in the pathogenesis of late-onset Alzheimer's disease (LOAD). However, the molecular mechanism remains elusive. The Shugoshin 1 (Sgo1-/+ ) mouse model, a model for mitotic cohesinopathy-genomic instability that is...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13221
更新日期:2020-10-01 00:00:00
abstract::Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/j.1474-9726.2007.00293.x
更新日期:2007-06-01 00:00:00
abstract::Cellular senescence is a state of permanent cell cycle arrest activated in response to damaging stimuli. Many hallmarks associated with senescent cells are measured by quantitative real-time PCR (qPCR). As the selection of stable reference genes for interpretation of qPCR data is often overlooked, we performed a syste...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12911
更新日期:2019-04-01 00:00:00
abstract::Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy to slow aging. However, recent evidence indicates that adding metformin to exercise antagonizes the exercise-induced improvement in insulin sensitivity and car...
journal_title:Aging cell
pub_type: 杂志文章,随机对照试验
doi:10.1111/acel.12880
更新日期:2019-02-01 00:00:00
abstract::Deficits in learning and memory accompanied by age-related neurodegenerative diseases are closely related to the impairment of synaptic plasticity. In this study, we investigated the role of thiol redox status in the modulation of the N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) in CA1 ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2010.00595.x
更新日期:2010-10-01 00:00:00
abstract::Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO+/- ) or homozygous (PerIR...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12610
更新日期:2017-08-01 00:00:00
abstract::The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...
journal_title:Aging cell
pub_type: 杂志文章,meta分析
doi:10.1111/acel.12160
更新日期:2014-04-01 00:00:00