Abstract:
:Most mammalian cells when placed in culture will undergo a limited number of cell divisions before entering an unresponsive non-proliferating state termed senescence. However, several pathways that are activated singly or in concert can allow cells to bypass senescence at least for limited periods. These include the telomerase pathway required to maintain telomere ends, the p53 and Rb pathways required to direct senescence in response to DNA damage, telomere shortening and mitogenic signals, and the insulin-like growth factor--Akt pathway that may regulate lifespan and cell proliferation. In this review, we summarize recent findings related to these pathways in embryonic stem (ES) cells and suggest that ES cells are immortal because these pathways are tightly regulated.
journal_name
Aging Celljournal_title
Aging cellauthors
Miura T,Mattson MP,Rao MSdoi
10.1111/j.1474-9728.2004.00134.xkeywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
333-43issue
6eissn
1474-9718issn
1474-9726pii
ACE134journal_volume
3pub_type
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