Characterization of the direct targets of FOXO transcription factors throughout evolution.

abstract：:Long-term calorie restriction (CR) has numerous benefits; however, effects of CR on susceptibility to intact pathogens are not well understood. Because CR enhances immune function of laboratory mice (Mus musculus), it was hypothesized that mice subjected to CR would be less susceptible to experimental infections of th...

journal_title：Aging cell

authors： Kristan DM

更新日期：2007-12-01 00:00:00

abstract：:Growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and have improved glucose homeostasis along with altered energy metabolism which manifests through decreased respiratory quotient (RQ) and increased oxygen consumption (VO2 ). Short-term exposure of these animals to increased environmental tempera...

journal_title：Aging cell

authors： Fang Y,McFadden S,Darcy J,Hascup ER,Hascup KN,Bartke A

更新日期：2020-05-01 00:00:00

abstract：:The susceptibility of human CD4+ and CD8+ T cells to senesce differs, with CD8+ T cells acquiring an immunosenescent phenotype faster than the CD4+ T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD4+ T cells displaying a hig...

journal_title：Aging cell

authors： Callender LA,Carroll EC,Bober EA,Akbar AN,Solito E,Henson SM

更新日期：2020-02-01 00:00:00

abstract：:Oxidative modification of cellular components may contribute to tissue dysfunction during aging. In skeletal muscle, contractile activity increases the generation of reactive oxygen and nitrogen species (ROS). The question of whether contraction-induced ROS generation is further increased in skeletal muscle of the eld...

journal_title：Aging cell

authors： Vasilaki A,Mansouri A,Van Remmen H,van der Meulen JH,Larkin L,Richardson AG,McArdle A,Faulkner JA,Jackson MJ

更新日期：2006-04-01 00:00:00

abstract：:The COVID-19 coronavirus is now spreading worldwide. Its pathogen, SARS-CoV-2, has been shown to use angiotensin-converting enzyme 2 (ACE2) as its host cell receptor, same as the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003. Epidemiology studies found males although only slightly more likely to be ...

journal_title：Aging cell

authors： Chen J,Jiang Q,Xia X,Liu K,Yu Z,Tao W,Gong W,Han JJ

更新日期：2020-07-01 00:00:00

abstract：:Lactic-acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic-acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the be...

journal_title：Aging cell

authors： Nakagawa H,Shiozaki T,Kobatake E,Hosoya T,Moriya T,Sakai F,Taru H,Miyazaki T

更新日期：2016-04-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is regarded as one of the serious risk factors for age-related cognitive impairment; however, a causal link between these two diseases has so far not been established. It was recently discovered that, apart from high D-glucose levels, T2DM patients also display abnormally high concentra...

journal_title：Aging cell

authors： Wei Y,Han C,Wang Y,Wu B,Su T,Liu Y,He R

更新日期：2015-10-01 00:00:00

abstract：:While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called 'fenestrations' are...

journal_title：Aging cell

authors： Mohamad M,Mitchell SJ,Wu LE,White MY,Cordwell SJ,Mach J,Solon-Biet SM,Boyer D,Nines D,Das A,Catherine Li SY,Warren A,Hilmer SN,Fraser R,Sinclair DA,Simpson SJ,de Cabo R,Le Couteur DG,Cogger VC

更新日期：2016-08-01 00:00:00

abstract：:Frailty is a state of decreased physiological reserve and increased vulnerability to adverse outcomes in aging, and is characterized by dysregulation across various biological pathways. Frailty may manifest biologically as alteration in protein expression, possibly regulated at genetic, transcriptional and epigenetic ...

journal_title：Aging cell

authors： Sathyan S,Ayers E,Gao T,Milman S,Barzilai N,Verghese J

更新日期：2020-09-01 00:00:00

abstract：:With aging, the kidney develops a progressive deterioration of several structures and functions. Proximal tubular acidification is impaired in old rats with a decrease in the activity of brush border Na+/H+ exchange and a fall of H-ion flux measured with micropuncture experiments. In the present work we evaluate the c...

journal_title：Aging cell

authors： Fiori M,Radrizzani M,Díaz-Sylvester P,Müller A,Corti T,Monserrat A,Amorena C

更新日期：2006-10-01 00:00:00

abstract：:Amyloid-β 1-42 accumulation is the major pathogenetic event in Alzheimer's disease (AD), believed to be responsible for synaptic dysfunction and neuronal cell death. However, the physiologic activity of Aβ peptides remains elusive: Aβ might not only play a toxic role, but also act as a functional signaling intermediat...

journal_title：Aging cell

authors： Guglielmotto M,Monteleone D,Boido M,Piras A,Giliberto L,Borghi R,Vercelli A,Fornaro M,Tabaton M,Tamagno E

更新日期：2012-10-01 00:00:00

abstract：:Studies in the nematode Caenorhabditis elegans have been instrumental in defining genetic pathways that are involved in modulating lifespan. Multiple processes such as endocrine signaling, nutritional sensing and mitochondrial function play a role in determining lifespan in the worm and these mechanisms appear to be c...

journal_title：Aging cell

authors： Gill MS

更新日期：2006-02-01 00:00:00

abstract：:Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO+/- ) or homozygous (PerIR...

journal_title：Aging cell

authors： Merry TL,Kuhlow D,Laube B,Pöhlmann D,Pfeiffer AFH,Kahn CR,Ristow M,Zarse K

更新日期：2017-08-01 00:00:00

abstract：:Methionine restriction (MetR) extends lifespan across different species and exerts beneficial effects on metabolic health and inflammatory responses. In contrast, certain cancer cells exhibit methionine auxotrophy that can be exploited for therapeutic treatment, as decreasing dietary methionine selectively suppresses ...

journal_title：Aging cell

authors： Parkhitko AA,Jouandin P,Mohr SE,Perrimon N

更新日期：2019-12-01 00:00:00

abstract：:We analyzed MBL2 gene variants in two cohorts of centenarians, octo-nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity. We also assessed in ...

journal_title：Aging cell

authors： Tomaiuolo R,Ruocco A,Salapete C,Carru C,Baggio G,Franceschi C,Zinellu A,Vaupel J,Bellia C,Lo Sasso B,Ciaccio M,Castaldo G,Deiana L

更新日期：2012-06-01 00:00:00

abstract：:Evidence suggests that muscarinic receptors (MAChRs) are involved in various aspects of neuronal and vascular functioning, and that there is selective oxidative stress sensitivity (OSS) among MAChR subtypes. COS-7 cells transfected with M1, M2 and M4 subtypes show greater OSS than the M1 and M3 subtypes, as seen by th...

journal_title：Aging cell

authors： Joseph JA,Fisher DR,Carey A,Szprengiel A

更新日期：2004-10-01 00:00:00

abstract：:The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor 5 (TLR5), unlike th...

journal_title：Aging cell

authors： Lim JS,Nguyen KC,Nguyen CT,Jang IS,Han JM,Fabian C,Lee SE,Rhee JH,Cho KA

更新日期：2015-10-01 00:00:00

abstract：:The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age-associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirmed that specific depletion of Sirt2 disrupts maturational progression and spindle/chromos...

journal_title：Aging cell

authors： Qiu D,Hou X,Han L,Li X,Ge J,Wang Q

更新日期：2018-02-01 00:00:00

abstract：:Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here, we demonstrate that a single treatment with the mitochondrial-tar...

journal_title：Aging cell

authors： Siegel MP,Kruse SE,Percival JM,Goh J,White CC,Hopkins HC,Kavanagh TJ,Szeto HH,Rabinovitch PS,Marcinek DJ

更新日期：2013-10-01 00:00:00

abstract：:Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effect of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. Here, we describe a large-scale effort to define molecular mechanisms that underlie genotype-spe...

journal_title：Aging cell

authors： Schleit J,Johnson SC,Bennett CF,Simko M,Trongtham N,Castanza A,Hsieh EJ,Moller RM,Wasko BM,Delaney JR,Sutphin GL,Carr D,Murakami CJ,Tocchi A,Xian B,Chen W,Yu T,Goswami S,Higgins S,Holmberg M,Jeong KS,Kim JR,Kl

更新日期：2013-12-01 00:00:00

abstract：:Epidemiological studies of human longevity found two interesting features, robust advantage of female lifespan and consistent reduction of lifespan variation. To help understand the genetic aspects of these phenomena, the current study examined sex differences and variation of longevity using previously published mous...

journal_title：Aging cell

authors： Yuan R,Musters CJM,Zhu Y,Evans TR,Sun Y,Chesler EJ,Peters LL,Harrison DE,Bartke A

更新日期：2020-11-01 00:00:00

abstract：:We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in...

journal_title：Aging cell

authors： Sutphin GL,Backer G,Sheehan S,Bean S,Corban C,Liu T,Peters MJ,van Meurs JBJ,Murabito JM,Johnson AD,Korstanje R,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group.

更新日期：2017-08-01 00:00:00

abstract：:One of the hallmarks of aging is the progressive accumulation of senescent cells in organisms, which has been proposed to be a contributing factor to age-dependent organ dysfunction. We recently reported that Bruton's tyrosine kinase (BTK) is an upstream component of the p53 responses to DNA damage. BTK binds to and p...

journal_title：Aging cell

authors： Ekpenyong-Akiba AE,Poblocka M,Althubiti M,Rada M,Jurk D,Germano S,Kocsis-Fodor G,Shi Y,Canales JJ,Macip S

更新日期：2020-01-01 00:00:00

abstract：:The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (gamma-H2A.X) at either un...

journal_title：Aging cell

authors： Wang C,Jurk D,Maddick M,Nelson G,Martin-Ruiz C,von Zglinicki T

更新日期：2009-06-01 00:00:00

abstract：:Cockayne syndrome (CS) is a rare hereditary multisystem disease characterized by neurological and development impairment, and premature aging. Cockayne syndrome cells are hypersensitive to oxidative stress, but the molecular mechanisms involved remain unresolved. Here we provide the first evidence that primary fibrobl...

journal_title：Aging cell

authors： Pascucci B,Lemma T,Iorio E,Giovannini S,Vaz B,Iavarone I,Calcagnile A,Narciso L,Degan P,Podo F,Roginskya V,Janjic BM,Van Houten B,Stefanini M,Dogliotti E,D'Errico M

更新日期：2012-06-01 00:00:00

abstract：:The aim of this study was to investigate changes in astrocyte density, morphology, proliferation and apoptosis occurring in the central nervous system during physiological aging. Astrocytes in retinal whole-mount preparations from Wistar rats aged 3 (young adult) to 25 months (aged) were investigated qualitatively and...

journal_title：Aging cell

authors： Mansour H,Chamberlain CG,Weible MW 2nd,Hughes S,Chu Y,Chan-Ling T

更新日期：2008-08-01 00:00:00

abstract：:We test the 'free radical theory of aging' using six species of colubrid snakes (numerous, widely distributed, non-venomous snakes of the family Colubridae) that exhibit long (> 15 years) or short (< 10 years) lifespans. Because the 'rate of living theory' predicts metabolic rates to be correlated with rates of aging ...

journal_title：Aging cell

authors： Robert KA,Brunet-Rossinni A,Bronikowski AM

更新日期：2007-06-01 00:00:00

abstract：:Oestrogenic compounds have been postulated as neuroprotective agents. This prompted us to investigate their mechanism action in neurons in primary culture. Cells were pretreated with physiological concentrations of 17-beta estradiol (0.2 nm) or with nutritionally relevant concentrations of genistein (0.5 microm), and ...

journal_title：Aging cell

authors： Vallés SL,Borrás C,Gambini J,Furriol J,Ortega A,Sastre J,Pallardó FV,Viña J

更新日期：2008-01-01 00:00:00

abstract：:The deleterious reactive carbonyls released upon oxidation of polyunsaturated fatty acids in biological membranes are believed to foster cellular aging. Comparative studies in mammals and birds have shown that the susceptibility to peroxidation of membrane lipids peroxidation index (PI) is negatively correlated with l...

journal_title：Aging cell

authors： Munro D,Blier PU

更新日期：2012-10-01 00:00:00

abstract：:Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mu...

journal_title：Aging cell

authors： Tchkonia T,Morbeck DE,Von Zglinicki T,Van Deursen J,Lustgarten J,Scrable H,Khosla S,Jensen MD,Kirkland JL

更新日期：2010-10-01 00:00:00