Abstract:
:Studies in the nematode Caenorhabditis elegans have been instrumental in defining genetic pathways that are involved in modulating lifespan. Multiple processes such as endocrine signaling, nutritional sensing and mitochondrial function play a role in determining lifespan in the worm and these mechanisms appear to be conserved across species. These discoveries have identified a range of novel targets for pharmacological manipulation of lifespan and it is likely that the nematode model will now prove useful in the discovery of compounds that slow aging. This review will focus on the endocrine targets for intervention in aging and the use of C. elegans as a system for high throughput screens of compounds for their effects on aging.
journal_name
Aging Celljournal_title
Aging cellauthors
Gill MSdoi
10.1111/j.1474-9726.2006.00186.xkeywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
23-30issue
1eissn
1474-9718issn
1474-9726pii
ACE186journal_volume
5pub_type
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