Abstract:
:ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimer's disease. Surprisingly, checkpoint attenuation potently increases neurodegeneration through aberrant cell cycle re-entry of postmitotic neurons. These data suggest an unexpected neuroprotective role for the DNA damage checkpoint in tauopathies.
journal_name
Aging Celljournal_title
Aging cellauthors
Khurana V,Merlo P,DuBoff B,Fulga TA,Sharp KA,Campbell SD,Götz J,Feany MBdoi
10.1111/j.1474-9726.2011.00778.xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
360-2issue
2eissn
1474-9718issn
1474-9726journal_volume
11pub_type
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