MiR-103-3p targets the m6 A methyltransferase METTL14 to inhibit osteoblastic bone formation.

abstract：:We test the 'free radical theory of aging' using six species of colubrid snakes (numerous, widely distributed, non-venomous snakes of the family Colubridae) that exhibit long (> 15 years) or short (< 10 years) lifespans. Because the 'rate of living theory' predicts metabolic rates to be correlated with rates of aging ...

journal_title：Aging cell

authors： Robert KA,Brunet-Rossinni A,Bronikowski AM

更新日期：2007-06-01 00:00:00

abstract：:Lactic-acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic-acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the be...

journal_title：Aging cell

authors： Nakagawa H,Shiozaki T,Kobatake E,Hosoya T,Moriya T,Sakai F,Taru H,Miyazaki T

更新日期：2016-04-01 00:00:00

abstract：:Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the unknown etiol...

journal_title：Aging cell

authors： Kreienkamp R,Billon C,Bedia-Diaz G,Albert CJ,Toth Z,Butler AA,McBride-Gagyi S,Ford DA,Baldan A,Burris TP,Gonzalo S

更新日期：2019-02-01 00:00:00

abstract：:Dysfunctions of the ubiquitin proteasome system (UPS) have been proposed to be involved in the aetiology and/or progression of several age-related neurodegenerative disorders. However, the mechanisms linking proteasome dysfunction to cell degeneration are poorly understood. We examined in young and aged rat hippocampu...

journal_title：Aging cell

authors： Gavilán MP,Pintado C,Gavilán E,Jiménez S,Ríos RM,Vitorica J,Castaño A,Ruano D

更新日期：2009-12-01 00:00:00

abstract：:Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A variation on the technique, heteroch...

journal_title：Aging cell

authors： Conboy MJ,Conboy IM,Rando TA

更新日期：2013-06-01 00:00:00

abstract：:Disruption of telomere maintenance pathways leads to accelerated entry into cellular senescence, a stable proliferative arrest that promotes aging-associated disorders in some mammals. The budding yeast CST complex, comprising Cdc13, Stn1, and Ctc1, is critical for telomere replication, length regulation, and end prot...

journal_title：Aging cell

authors： Boccardi V,Razdan N,Kaplunov J,Mundra JJ,Kimura M,Aviv A,Herbig U

更新日期：2015-06-01 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest activated in response to damaging stimuli. Many hallmarks associated with senescent cells are measured by quantitative real-time PCR (qPCR). As the selection of stable reference genes for interpretation of qPCR data is often overlooked, we performed a syste...

journal_title：Aging cell

authors： Hernandez-Segura A,Rubingh R,Demaria M

更新日期：2019-04-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to improving functional outcomes in this age-related disease. The molecula...

journal_title：Aging cell

authors： Roh JD,Houstis N,Yu A,Chang B,Yeri A,Li H,Hobson R,Lerchenmüller C,Vujic A,Chaudhari V,Damilano F,Platt C,Zlotoff D,Lee RT,Shah R,Jerosch-Herold M,Rosenzweig A

更新日期：2020-06-01 00:00:00

abstract：:Summary We address the problem of establishing a survival schedule for wild populations. A demographic key identity is established, leading to a method whereby age-specific survival and mortality can be deduced from a marked cohort life table established for individuals that are randomly sampled at unknown age and mar...

journal_title：Aging cell

authors： Müller HG,Wang JL,Carey JR,Caswell-Chen EP,Chen C,Papadopoulos N,Yao F

更新日期：2004-06-01 00:00:00

abstract：:Aging impairs arterial function through oxidative stress and diminished nitric oxide (NO) bioavailability. Life-long caloric restriction (CR) reduces oxidative stress, but its impact on arterial aging is incompletely understood. We tested the hypothesis that life-long CR attenuates key features of arterial aging. Bloo...

journal_title：Aging cell

authors： Donato AJ,Walker AE,Magerko KA,Bramwell RC,Black AD,Henson GD,Lawson BR,Lesniewski LA,Seals DR

更新日期：2013-10-01 00:00:00

abstract：:We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear. In the present study, we identified distinct contributions of lung endothelial cells (Ec) and ep...

journal_title：Aging cell

authors： Kim SJ,Shan P,Hwangbo C,Zhang Y,Min JN,Zhang X,Ardito T,Li A,Peng T,Sauler M,Lee PJ

更新日期：2019-06-01 00:00:00

abstract：:Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a larger effect in females than males. Traditionally, this has been attributed to a stronger trade-off between LS and reproduction in females than in males that is mediated by the intake of calories. Recent studies, however, ...

journal_title：Aging cell

authors： Jensen K,McClure C,Priest NK,Hunt J

更新日期：2015-08-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is characterized by the formation of drusen, extracellular deposits associated with atrophy of the retinal pigmented epithelium (RPE), disturbance of the transepithelial barrier and photoreceptor death. Amyloid-beta (Abeta) is present in drusen but its role during AMD remains unk...

journal_title：Aging cell

authors： Bruban J,Glotin AL,Dinet V,Chalour N,Sennlaub F,Jonet L,An N,Faussat AM,Mascarelli F

更新日期：2009-04-01 00:00:00

abstract：:The level of Sirt2 protein is reduced in oocytes from aged mice, while exogenous expression of Sirt2 could ameliorate the maternal age-associated meiotic defects. To date, the underlying mechanism remains unclear. Here, we confirmed that specific depletion of Sirt2 disrupts maturational progression and spindle/chromos...

journal_title：Aging cell

authors： Qiu D,Hou X,Han L,Li X,Ge J,Wang Q

更新日期：2018-02-01 00:00:00

abstract：:Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that ha...

journal_title：Aging cell

authors： Beekman M,Blanché H,Perola M,Hervonen A,Bezrukov V,Sikora E,Flachsbart F,Christiansen L,De Craen AJ,Kirkwood TB,Rea IM,Poulain M,Robine JM,Valensin S,Stazi MA,Passarino G,Deiana L,Gonos ES,Paternoster L,Sørensen TI

更新日期：2013-04-01 00:00:00

abstract：:Maternal age-related decline in oocyte quality is associated with meiotic defects, but the underlying mechanisms remain to be explored. Histone deacetylase 3 (HDAC3) has been shown to govern multiple cellular events via deacetylating diverse substrates. We previously found that HDAC3 could promote meiotic apparatus as...

journal_title：Aging cell

authors： He Y,Li X,Gao M,Liu H,Gu L

更新日期：2019-12-01 00:00:00

abstract：:Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age-related declines in physical function. Early evidence suggests that dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) improve mitochondrial function. Here, we show that 10 weeks of dietary eicosapentaenoic acid (EPA) su...

journal_title：Aging cell

authors： Johnson ML,Lalia AZ,Dasari S,Pallauf M,Fitch M,Hellerstein MK,Lanza IR

更新日期：2015-10-01 00:00:00

abstract：:The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...

journal_title：Aging cell

authors： van den Akker EB,Passtoors WM,Jansen R,van Zwet EW,Goeman JJ,Hulsman M,Emilsson V,Perola M,Willemsen G,Penninx BW,Heijmans BT,Maier AB,Boomsma DI,Kok JN,Slagboom PE,Reinders MJ,Beekman M

更新日期：2014-04-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is regarded as one of the serious risk factors for age-related cognitive impairment; however, a causal link between these two diseases has so far not been established. It was recently discovered that, apart from high D-glucose levels, T2DM patients also display abnormally high concentra...

journal_title：Aging cell

authors： Wei Y,Han C,Wang Y,Wu B,Su T,Liu Y,He R

更新日期：2015-10-01 00:00:00

abstract：:Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here, we demonstrate that a single treatment with the mitochondrial-tar...

journal_title：Aging cell

authors： Siegel MP,Kruse SE,Percival JM,Goh J,White CC,Hopkins HC,Kavanagh TJ,Szeto HH,Rabinovitch PS,Marcinek DJ

更新日期：2013-10-01 00:00:00

abstract：:Extending lifespan by lowering ambient temperature in the habitat has been shown in a variety of organisms. Its mechanism, however, remains elusive. In this study, we examined the survivorship and the aging process of the annual fish (Nothobranchius rachovii) reared under high (30 degrees C), moderate (25 degrees C) a...

journal_title：Aging cell

authors： Hsu CY,Chiu YC

更新日期：2009-12-01 00:00:00

abstract：:The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more ...

journal_title：Aging cell

authors： Fridovich I

更新日期：2004-02-01 00:00:00

abstract：:Small body size has been associated with long life span in four stocks of mutant dwarf mice, and in two varieties of dietary restriction in rodents. In this study, small body size at ages 2-24 months was shown to be a significant predictor of life span in a genetically heterogeneous mouse population derived from four ...

journal_title：Aging cell

authors： Miller RA,Harper JM,Galecki A,Burke DT

更新日期：2002-10-01 00:00:00

abstract：:The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of the cytoplasm, i.e., the myonuclear domain (MND). We analysed aging- and gender-related effects on myonuclei organization and the MND size in single muscle fibres from six young (21-31 years) and nine old m...

journal_title：Aging cell

authors： Cristea A,Qaisar R,Edlund PK,Lindblad J,Bengtsson E,Larsson L

更新日期：2010-10-01 00:00:00

abstract：:Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging. We examined the state of chromatin structure and its effect on gene expression during aging in Drosophila at the whole g...

journal_title：Aging cell

authors： Wood JG,Hillenmeyer S,Lawrence C,Chang C,Hosier S,Lightfoot W,Mukherjee E,Jiang N,Schorl C,Brodsky AS,Neretti N,Helfand SL

更新日期：2010-12-01 00:00:00

abstract：:Age-related bone loss in mice results from a decrease in bone formation and an increase in cortical bone resorption. The former is accounted by a decrease in the number of postmitotic osteoblasts which synthesize the bone matrix and is thought to be the consequence of age-dependent changes in mesenchymal osteoblast pr...

journal_title：Aging cell

authors： Kim HN,Chang J,Shao L,Han L,Iyer S,Manolagas SC,O'Brien CA,Jilka RL,Zhou D,Almeida M

更新日期：2017-08-01 00:00:00

abstract：:Age-related thymic involution is characterized by reduction in T cell production together with ectopic adipocyte development within the hematopoietic and thymic niches. Peroxisome proliferator-activated receptor gamma (PPARgamma) is required for adipocyte development, glucose homeostasis and is a target for several in...

journal_title：Aging cell

authors： Youm YH,Yang H,Amin R,Smith SR,Leff T,Dixit VD

更新日期：2010-08-01 00:00:00

abstract：:Accumulating evidence suggests a role for microRNAs (miRNAs) in regulating various processes of mammalian postnatal development and aging. To investigate the changes in blood-based miRNA expression from preterm infants to adulthood, we compared 365 miRNA expression profiles in a screening set of preterm infants and ad...

journal_title：Aging cell

authors： Lai CY,Wu YT,Yu SL,Yu YH,Lee SY,Liu CM,Hsieh WS,Hwu HG,Chen PC,Jeng SF,Chen WJ

更新日期：2014-08-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the elderly. Previous studies found a protective effect of reduced histone deacetylase activity in models of neurogenic muscle atrophy. Because loss of muscle mass during aging is associated with...

journal_title：Aging cell

authors： Walsh ME,Bhattacharya A,Sataranatarajan K,Qaisar R,Sloane L,Rahman MM,Kinter M,Van Remmen H

更新日期：2015-12-01 00:00:00