Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension.

abstract：:H(2)O(2) is a major reactive oxygen species produced by mitochondria that is implicated to be important in aging and pathogenesis of diseases such as diabetes; however, the cellular and physiological roles of mitochondrial H(2)O(2) remain poorly understood. Peroxiredoxin 3 (Prdx3/Prx3) is a thioredoxin peroxidase loca...

journal_title：Aging cell

authors： Chen L,Na R,Gu M,Salmon AB,Liu Y,Liang H,Qi W,Van Remmen H,Richardson A,Ran Q

更新日期：2008-12-01 00:00:00

abstract：:Oestrogenic compounds have been postulated as neuroprotective agents. This prompted us to investigate their mechanism action in neurons in primary culture. Cells were pretreated with physiological concentrations of 17-beta estradiol (0.2 nm) or with nutritionally relevant concentrations of genistein (0.5 microm), and ...

journal_title：Aging cell

authors： Vallés SL,Borrás C,Gambini J,Furriol J,Ortega A,Sastre J,Pallardó FV,Viña J

更新日期：2008-01-01 00:00:00

abstract：:We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear. In the present study, we identified distinct contributions of lung endothelial cells (Ec) and ep...

journal_title：Aging cell

authors： Kim SJ,Shan P,Hwangbo C,Zhang Y,Min JN,Zhang X,Ardito T,Li A,Peng T,Sauler M,Lee PJ

更新日期：2019-06-01 00:00:00

abstract：:Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...

journal_title：Aging cell

authors： Zhang B,Podolskiy DI,Mariotti M,Seravalli J,Gladyshev VN

更新日期：2020-05-01 00:00:00

abstract：:Despite its medical, social, and economic significance, understanding what primarily causes aging, that is, the mechanisms of the aging process, remains a fundamental and fascinating problem in biology. Accumulating evidence indicates that a small RNA-based gene regulatory machinery, the Piwi-piRNA pathway, represents...

journal_title：Aging cell

authors： Sturm Á,Perczel A,Ivics Z,Vellai T

更新日期：2017-10-01 00:00:00

abstract：:Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline ...

journal_title：Aging cell

authors： Tarantini S,Valcarcel-Ares NM,Yabluchanskiy A,Fulop GA,Hertelendy P,Gautam T,Farkas E,Perz A,Rabinovitch PS,Sonntag WE,Csiszar A,Ungvari Z

更新日期：2018-04-01 00:00:00

abstract：:Aberrant neural progenitor cell (NPC) proliferation and self-renewal have been linked to age-related neurodegeneration and neurodegenerative disorders including Alzheimer's disease (AD). Rhizoma Acori tatarinowii is a traditional Chinese herbal medicine against cognitive decline. In this study, we found that the extra...

journal_title：Aging cell

authors： Mao J,Huang S,Liu S,Feng XL,Yu M,Liu J,Sun YE,Chen G,Yu Y,Zhao J,Pei G

更新日期：2015-10-01 00:00:00

abstract：:Adequate energy stores are essential for survival, and sophisticated neuroendocrine mechanisms evolved to stimulate foraging in response to nutrient deprivation. Food search behavior is usually investigated in young animals, and it is not known how aging alters this behavior. To address this question in Drosophila mel...

journal_title：Aging cell

authors： Egenriether SM,Chow ES,Krauth N,Giebultowicz JM

更新日期：2015-10-01 00:00:00

abstract：:Cockayne syndrome (CS) is a rare hereditary multisystem disease characterized by neurological and development impairment, and premature aging. Cockayne syndrome cells are hypersensitive to oxidative stress, but the molecular mechanisms involved remain unresolved. Here we provide the first evidence that primary fibrobl...

journal_title：Aging cell

authors： Pascucci B,Lemma T,Iorio E,Giovannini S,Vaz B,Iavarone I,Calcagnile A,Narciso L,Degan P,Podo F,Roginskya V,Janjic BM,Van Houten B,Stefanini M,Dogliotti E,D'Errico M

更新日期：2012-06-01 00:00:00

abstract：:Mitochondrial malfunction is a universal and critical step in the pathogenesis of many neurodegenerative diseases including prion diseases. Dynamin-like protein 1 (DLP1) is one of the key regulators of mitochondrial fission. In this study, we investigated the role of DLP1 in mitochondrial fragmentation and dysfunction...

journal_title：Aging cell

authors： Li C,Wang D,Wu W,Yang W,Ali Shah SZ,Zhao Y,Duan Y,Wang L,Zhou X,Zhao D,Yang L

更新日期：2018-02-01 00:00:00

abstract：:Incidence of intracerebral hemorrhage (ICH) and brain iron accumulation increases with age. Excess iron accumulation in brain tissues post-ICH induces oxidative stress and neuronal damage. However, the mechanisms underlying iron deregulation in ICH, especially in the aged ICH model have not been well elucidated. Ferro...

journal_title：Aging cell

authors： Bao WD,Zhou XT,Zhou LT,Wang F,Yin X,Lu Y,Zhu LQ,Liu D

更新日期：2020-11-01 00:00:00

abstract：:We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in...

journal_title：Aging cell

authors： Sutphin GL,Backer G,Sheehan S,Bean S,Corban C,Liu T,Peters MJ,van Meurs JBJ,Murabito JM,Johnson AD,Korstanje R,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group.

更新日期：2017-08-01 00:00:00

abstract：:Older adults universally suffer from sarcopenia and approximately 60-70% are diabetic or prediabetic. Nonetheless, the mechanisms underlying these aging-related metabolic disorders are unknown. NFκB has been implicated in the pathogenesis of several aging-related pathologies including sarcopenia and type 2 diabetes an...

journal_title：Aging cell

authors： Zhang N,Valentine JM,Zhou Y,Li ME,Zhang Y,Bhattacharya A,Walsh ME,Fischer KE,Austad SN,Osmulski P,Gaczynska M,Shoelson SE,Van Remmen H,Chen HI,Chen Y,Liang H,Musi N

更新日期：2017-08-01 00:00:00

abstract：:The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...

journal_title：Aging cell

authors： van den Akker EB,Passtoors WM,Jansen R,van Zwet EW,Goeman JJ,Hulsman M,Emilsson V,Perola M,Willemsen G,Penninx BW,Heijmans BT,Maier AB,Boomsma DI,Kok JN,Slagboom PE,Reinders MJ,Beekman M

更新日期：2014-04-01 00:00:00

abstract：:Adipose tissue inflammation and dysfunction are associated with obesity-related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the development of dia...

journal_title：Aging cell

authors： Palmer AK,Xu M,Zhu Y,Pirtskhalava T,Weivoda MM,Hachfeld CM,Prata LG,van Dijk TH,Verkade E,Casaclang-Verzosa G,Johnson KO,Cubro H,Doornebal EJ,Ogrodnik M,Jurk D,Jensen MD,Chini EN,Miller JD,Matveyenko A,Stout MB,Sc

更新日期：2019-06-01 00:00:00

abstract：:Neuropeptide Y (NPY) is an orexigenic peptide that plays an essential role in caloric restriction (CR)-mediated lifespan extension. However, the mechanisms underlying the NPY-mediated effects in CR are poorly defined. Here, we report that NPY deficiency in male mice during CR increases mortality in association with li...

journal_title：Aging cell

authors： Park S,Komatsu T,Kim SE,Tanaka K,Hayashi H,Mori R,Shimokawa I

更新日期：2017-04-01 00:00:00

abstract：:Sequence variations in a variety of pro- or anti-inflammatory cytokine genes have been found to influence successful aging and longevity. Because of the role played by the transforming growth factor beta1 (TGF-beta1) cytokine in inflammation and regulation of immune responses, the variability of the TGF-beta1 gene may...

journal_title：Aging cell

authors： Carrieri G,Marzi E,Olivieri F,Marchegiani F,Cavallone L,Cardelli M,Giovagnetti S,Stecconi R,Molendini C,Trapassi C,De Benedictis G,Kletsas D,Franceschi C

更新日期：2004-12-01 00:00:00

abstract：:During aging, decreases in energy expenditure and locomotor activity lead to body weight and fat gain. Aging is also associated with decreases in muscle strength and endurance leading to functional decline. Here, we show that lifelong deletion of ghrelin prevents development of obesity associated with aging by modulat...

journal_title：Aging cell

authors： Guillory B,Chen JA,Patel S,Luo J,Splenser A,Mody A,Ding M,Baghaie S,Anderson B,Iankova B,Halder T,Hernandez Y,Garcia JM

更新日期：2017-08-01 00:00:00

abstract：:The 'rate of living' theory predicts that longevity should be inversely correlated with the rate of mitochondrial respiration. However, recent studies in a number of model organisms, including mice, have reported that interventions that retard the aging process are, in fact, associated with an increase in mitochondria...

journal_title：Aging cell

authors： Bahadorani S,Cho J,Lo T,Contreras H,Lawal HO,Krantz DE,Bradley TJ,Walker DW

更新日期：2010-04-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model o...

journal_title：Aging cell

authors： Elhaik Goldman S,Goez D,Last D,Naor S,Liraz Zaltsman S,Sharvit-Ginon I,Atrakchi-Baranes D,Shemesh C,Twitto-Greenberg R,Tsach S,Lotan R,Leikin-Frenkel A,Shish A,Mardor Y,Schnaider Beeri M,Cooper I

更新日期：2018-10-01 00:00:00

abstract：:Methionine restriction (MetR) extends lifespan across different species and exerts beneficial effects on metabolic health and inflammatory responses. In contrast, certain cancer cells exhibit methionine auxotrophy that can be exploited for therapeutic treatment, as decreasing dietary methionine selectively suppresses ...

journal_title：Aging cell

authors： Parkhitko AA,Jouandin P,Mohr SE,Perrimon N

更新日期：2019-12-01 00:00:00

abstract：:The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (gamma-H2A.X) at either un...

journal_title：Aging cell

authors： Wang C,Jurk D,Maddick M,Nelson G,Martin-Ruiz C,von Zglinicki T

更新日期：2009-06-01 00:00:00

abstract：:Extending lifespan by lowering ambient temperature in the habitat has been shown in a variety of organisms. Its mechanism, however, remains elusive. In this study, we examined the survivorship and the aging process of the annual fish (Nothobranchius rachovii) reared under high (30 degrees C), moderate (25 degrees C) a...

journal_title：Aging cell

authors： Hsu CY,Chiu YC

更新日期：2009-12-01 00:00:00

abstract：:Deficits in learning and memory accompanied by age-related neurodegenerative diseases are closely related to the impairment of synaptic plasticity. In this study, we investigated the role of thiol redox status in the modulation of the N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) in CA1 ...

journal_title：Aging cell

authors： Yang YJ,Wu PF,Long LH,Yu DF,Wu WN,Hu ZL,Fu H,Xie N,Jin Y,Ni L,Wang JZ,Wang F,Chen JG

更新日期：2010-10-01 00:00:00

abstract：:Chromatin structure affects the accessibility of DNA to transcription, repair, and replication. Changes in chromatin structure occur during development, but less is known about changes during aging. We examined the state of chromatin structure and its effect on gene expression during aging in Drosophila at the whole g...

journal_title：Aging cell

authors： Wood JG,Hillenmeyer S,Lawrence C,Chang C,Hosier S,Lightfoot W,Mukherjee E,Jiang N,Schorl C,Brodsky AS,Neretti N,Helfand SL

更新日期：2010-12-01 00:00:00

abstract：:The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation init...

journal_title：Aging cell

authors： Rousakis A,Vlassis A,Vlanti A,Patera S,Thireos G,Syntichaki P

更新日期：2013-10-01 00:00:00

abstract：:Cellular senescence is a cellular program that prevents the proliferation of cells at risk of neoplastic transformation. On the other hand, age-related accumulation of senescent cells promotes aging at least partially due to the senescence-associated secretory phenotype, whereby cells secrete high levels of inflammato...

journal_title：Aging cell

authors： Takasugi M

更新日期：2018-04-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is the most common type of HF in older adults. Although no pharmacological therapy has yet improved survival in HFpEF, exercise training (ExT) has emerged as the most effective intervention to improving functional outcomes in this age-related disease. The molecula...

journal_title：Aging cell

authors： Roh JD,Houstis N,Yu A,Chang B,Yeri A,Li H,Hobson R,Lerchenmüller C,Vujic A,Chaudhari V,Damilano F,Platt C,Zlotoff D,Lee RT,Shah R,Jerosch-Herold M,Rosenzweig A

更新日期：2020-06-01 00:00:00

abstract：:Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of cal...

journal_title：Aging cell

authors： García-Matas S,Paul RK,Molina-Martínez P,Palacios H,Gutierrez VM,Corpas R,Pallas M,Cristòfol R,de Cabo R,Sanfeliu C

更新日期：2015-06-01 00:00:00

abstract：:Although it is known that the expression and activity of sirtuin 1 (Sirt1) decrease in the aged kidney, the role of interaction between Sirt1 and hypoxia-inducible factor (HIF)-1α is largely unknown. In this study, we investigated whether HIF-1α could be a deacetylation target of Sirt1 and the effect of their interact...

journal_title：Aging cell

authors： Ryu DR,Yu MR,Kong KH,Kim H,Kwon SH,Jeon JS,Han DC,Noh H

更新日期：2019-04-01 00:00:00