Effects of aging and gender on the spatial organization of nuclei in single human skeletal muscle cells.

abstract：:Summary We address the problem of establishing a survival schedule for wild populations. A demographic key identity is established, leading to a method whereby age-specific survival and mortality can be deduced from a marked cohort life table established for individuals that are randomly sampled at unknown age and mar...

journal_title：Aging cell

authors： Müller HG,Wang JL,Carey JR,Caswell-Chen EP,Chen C,Papadopoulos N,Yao F

更新日期：2004-06-01 00:00:00

abstract：:Oestrogenic compounds have been postulated as neuroprotective agents. This prompted us to investigate their mechanism action in neurons in primary culture. Cells were pretreated with physiological concentrations of 17-beta estradiol (0.2 nm) or with nutritionally relevant concentrations of genistein (0.5 microm), and ...

journal_title：Aging cell

authors： Vallés SL,Borrás C,Gambini J,Furriol J,Ortega A,Sastre J,Pallardó FV,Viña J

更新日期：2008-01-01 00:00:00

abstract：:Aging is inevitably accompanied by gradual and irreversible innate endothelial dysfunction. In this study, we tested the hypothesis that accentuation of glucose metabolism via the aldose reductase (AR) pathway contributes to age-related vascular dysfunction. AR protein and activity levels were significantly increased ...

journal_title：Aging cell

authors： Hallam KM,Li Q,Ananthakrishnan R,Kalea A,Zou YS,Vedantham S,Schmidt AM,Yan SF,Ramasamy R

更新日期：2010-10-01 00:00:00

abstract：:Upon oxidative challenge the genome accumulates adducts and breaks that activate the DNA damage response to repair, arrest, or eliminate the damaged cell. Thus, reactive oxygen species (ROS) generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, few studies determined the mutation...

journal_title：Aging cell

authors： Beltrami E,Ruggiero A,Busuttil R,Migliaccio E,Pelicci PG,Vijg J,Giorgio M

更新日期：2013-04-01 00:00:00

abstract：:Impaired osteoblast function is involved in osteoporosis, and microRNA (miRNA) dysregulation may cause abnormal osteoblast osteogenic activity. However, the influence of miRNA on osteoblast activity and the underlying mechanisms remain elusive. In this study, miR-103-3p was found to be negatively correlated with bone ...

journal_title：Aging cell

authors： Sun Z,Wang H,Wang Y,Yuan G,Yu X,Jiang H,Wu Q,Yang B,Hu Z,Shi F,Cao X,Zhang S,Guo T,Zhao J

更新日期：2021-01-13 00:00:00

abstract：:We used DNA microarrays to identify panels of transcriptional markers of aging that are differentially expressed in young (5 month) and old (25 month) mice of multiple inbred strains (129sv, BALB/c, CBA, DBA, B6, C3H and B6C3F(1)). In the heart, age-related changes of five genes were studied throughout the mouse lifes...

journal_title：Aging cell

authors： Park SK,Kim K,Page GP,Allison DB,Weindruch R,Prolla TA

更新日期：2009-08-01 00:00:00

abstract：:Sequence variations in a variety of pro- or anti-inflammatory cytokine genes have been found to influence successful aging and longevity. Because of the role played by the transforming growth factor beta1 (TGF-beta1) cytokine in inflammation and regulation of immune responses, the variability of the TGF-beta1 gene may...

journal_title：Aging cell

authors： Carrieri G,Marzi E,Olivieri F,Marchegiani F,Cavallone L,Cardelli M,Giovagnetti S,Stecconi R,Molendini C,Trapassi C,De Benedictis G,Kletsas D,Franceschi C

更新日期：2004-12-01 00:00:00

abstract：:Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A variation on the technique, heteroch...

journal_title：Aging cell

authors： Conboy MJ,Conboy IM,Rando TA

更新日期：2013-06-01 00:00:00

abstract：:Cross-sectional studies have repeatedly suggested peripheral blood monocyte telomere length as a biomarker of aging. To test this suggestion in a large population-based follow-up study of the oldest old, we measured telomere length at baseline in 598 participants of the Leiden 85-plus Study (mean age at baseline 89.8 ...

journal_title：Aging cell

authors： Martin-Ruiz CM,Gussekloo J,van Heemst D,von Zglinicki T,Westendorp RG

更新日期：2005-12-01 00:00:00

abstract：:Sarcopenia, the loss of skeletal muscle mass and function during aging, is a major contributor to disability and frailty in the elderly. Previous studies found a protective effect of reduced histone deacetylase activity in models of neurogenic muscle atrophy. Because loss of muscle mass during aging is associated with...

journal_title：Aging cell

authors： Walsh ME,Bhattacharya A,Sataranatarajan K,Qaisar R,Sloane L,Rahman MM,Kinter M,Van Remmen H

更新日期：2015-12-01 00:00:00

abstract：:Inhibition of mammalian target of rapamycin, mTOR, extends lifespan and reduces age-related disease. It is not known what role mTOR plays in the arterial aging phenotype or if mTOR inhibition by dietary rapamycin ameliorates age-related arterial dysfunction. To explore this, young (3.8 ± 0.6 months) and old (30.3 ± 0....

journal_title：Aging cell

authors： Lesniewski LA,Seals DR,Walker AE,Henson GD,Blimline MW,Trott DW,Bosshardt GC,LaRocca TJ,Lawson BR,Zigler MC,Donato AJ

更新日期：2017-02-01 00:00:00

abstract：:The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation init...

journal_title：Aging cell

authors： Rousakis A,Vlassis A,Vlanti A,Patera S,Thireos G,Syntichaki P

更新日期：2013-10-01 00:00:00

abstract：:Neurogenesis, which may contribute to the ability of the adult brain to function normally and adapt to disease, nevertheless declines with advancing age. Adult neurogenesis can be enhanced by administration of growth factors, but whether the aged brain remains responsive to these factors is unknown. We compared the ef...

journal_title：Aging cell

authors： Jin K,Sun Y,Xie L,Batteur S,Mao XO,Smelick C,Logvinova A,Greenberg DA

更新日期：2003-06-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions occur sporadically in zygotic and somatic tissues and reach their highest concentration in substantia nigra. Previously, we noted the increase of the adenosine monophosphate (AMP)-activated protein kinase (AMPK) transcript by microarray in multiple cells and tissues bearing deletion...

journal_title：Aging cell

authors： Prigione A,Cortopassi G

更新日期：2007-10-01 00:00:00

abstract：:Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators ...

journal_title：Aging cell

authors： Pan KZ,Palter JE,Rogers AN,Olsen A,Chen D,Lithgow GJ,Kapahi P

更新日期：2007-02-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is regarded as one of the serious risk factors for age-related cognitive impairment; however, a causal link between these two diseases has so far not been established. It was recently discovered that, apart from high D-glucose levels, T2DM patients also display abnormally high concentra...

journal_title：Aging cell

authors： Wei Y,Han C,Wang Y,Wu B,Su T,Liu Y,He R

更新日期：2015-10-01 00:00:00

abstract：:Cellular senescence is a cellular program that prevents the proliferation of cells at risk of neoplastic transformation. On the other hand, age-related accumulation of senescent cells promotes aging at least partially due to the senescence-associated secretory phenotype, whereby cells secrete high levels of inflammato...

journal_title：Aging cell

authors： Takasugi M

更新日期：2018-04-01 00:00:00

abstract：:Cellular senescence is a state of permanent cell cycle arrest activated in response to damaging stimuli. Many hallmarks associated with senescent cells are measured by quantitative real-time PCR (qPCR). As the selection of stable reference genes for interpretation of qPCR data is often overlooked, we performed a syste...

journal_title：Aging cell

authors： Hernandez-Segura A,Rubingh R,Demaria M

更新日期：2019-04-01 00:00:00

abstract：:Amyloid-β 1-42 accumulation is the major pathogenetic event in Alzheimer's disease (AD), believed to be responsible for synaptic dysfunction and neuronal cell death. However, the physiologic activity of Aβ peptides remains elusive: Aβ might not only play a toxic role, but also act as a functional signaling intermediat...

journal_title：Aging cell

authors： Guglielmotto M,Monteleone D,Boido M,Piras A,Giliberto L,Borghi R,Vercelli A,Fornaro M,Tabaton M,Tamagno E

更新日期：2012-10-01 00:00:00

abstract：:Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effect of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. Here, we describe a large-scale effort to define molecular mechanisms that underlie genotype-spe...

journal_title：Aging cell

authors： Schleit J,Johnson SC,Bennett CF,Simko M,Trongtham N,Castanza A,Hsieh EJ,Moller RM,Wasko BM,Delaney JR,Sutphin GL,Carr D,Murakami CJ,Tocchi A,Xian B,Chen W,Yu T,Goswami S,Higgins S,Holmberg M,Jeong KS,Kim JR,Kl

更新日期：2013-12-01 00:00:00

abstract：:With reduced thymic activity, the population of naïve T cells in humans is maintained by homeostatic proliferation throughout adult life. In young adults, naïve CD4 T cells have enormous proliferative potential and plasticity to differentiate into different lineages. Here, we explored whether naïve CD4 T-cell aging is...

journal_title：Aging cell

authors： Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ

更新日期：2019-08-01 00:00:00

abstract：:Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has r...

journal_title：Aging cell

authors： Mendenhall A,Driscoll M,Brent R

更新日期：2016-02-01 00:00:00

abstract：:Aging is associated with a progressive loss of tissue and metabolic homeostasis. This loss can be delayed by single-gene perturbations, increasing lifespan. How such perturbations affect metabolic and proteostatic networks to extend lifespan remains unclear. Here, we address this question by comprehensively characteri...

journal_title：Aging cell

authors： Wang L,Davis SS,Borch Jensen M,Rodriguez-Fernandez IA,Apaydin C,Juhasz G,Gibson BW,Schilling B,Ramanathan A,Ghaemmaghami S,Jasper H

更新日期：2019-06-01 00:00:00

abstract：:A huge amount of evidence has implicated amyloid beta (A beta) peptides and other derivatives of the amyloid precursor protein (beta APP) as central to the pathogenesis of Alzheimer's disease (AD). It is also widely recognized that age is the most important risk factor for AD and that the innate immune system plays a ...

journal_title：Aging cell

authors： Blasko I,Stampfer-Kountchev M,Robatscher P,Veerhuis R,Eikelenboom P,Grubeck-Loebenstein B

更新日期：2004-08-01 00:00:00

abstract：:In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolong the chronological aging of yeast cells during the stationary phase. Lifespan extension is significantly reduced in yca1 mutants as well in rho(0) strains, suggesting that the protective effects pass through the Yca1 cas...

journal_title：Aging cell

authors： Palermo V,Falcone C,Calvani M,Mazzoni C

更新日期：2010-08-01 00:00:00

abstract：:Modest dietary restriction extends lifespan (LS) in a diverse range of taxa and typically has a larger effect in females than males. Traditionally, this has been attributed to a stronger trade-off between LS and reproduction in females than in males that is mediated by the intake of calories. Recent studies, however, ...

journal_title：Aging cell

authors： Jensen K,McClure C,Priest NK,Hunt J

更新日期：2015-08-01 00:00:00

abstract：:We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan. This enrichment is markedly higher than published genomewide longevity screens in...

journal_title：Aging cell

authors： Sutphin GL,Backer G,Sheehan S,Bean S,Corban C,Liu T,Peters MJ,van Meurs JBJ,Murabito JM,Johnson AD,Korstanje R,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Gene Expression Working Group.

更新日期：2017-08-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a benefici...

journal_title：Aging cell

authors： Yang CC,Chen D,Lee SS,Walter L

更新日期：2011-08-01 00:00:00

abstract：:Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isol...

journal_title：Aging cell

authors： Rittié L,Stoll SW,Kang S,Voorhees JJ,Fisher GJ

更新日期：2009-12-01 00:00:00