Abstract:
:In this work we report that carnitines, in particular acetyl-l-carnitine (ALC), are able to prolong the chronological aging of yeast cells during the stationary phase. Lifespan extension is significantly reduced in yca1 mutants as well in rho(0) strains, suggesting that the protective effects pass through the Yca1 caspase and mitochondrial functions. ALC can also prevent apoptosis in pro-apoptotic mutants, pointing to the importance of mitochondrial functions in regulating yeast apoptosis and aging. We also demonstrate that ALC attenuates mitochondrial fission in aged yeast cells, indicating a correlation between its protective effect and this process. Our findings suggest that ALC, used as therapeutic for stroke, myocardial infarction and neurodegenerative diseases, besides the well-known anti-oxidant effects, might exert protective effects also acting on mitochondrial morphology.
journal_name
Aging Celljournal_title
Aging cellauthors
Palermo V,Falcone C,Calvani M,Mazzoni Cdoi
10.1111/j.1474-9726.2010.00587.xsubject
Has Abstractpub_date
2010-08-01 00:00:00pages
570-9issue
4eissn
1474-9718issn
1474-9726pii
ACE587journal_volume
9pub_type
杂志文章相关文献
AGING CELL文献大全abstract::Ubiquitously reduced signaling via Methuselah (MTH), a G-protein-coupled receptor (GPCR) required for neurosecretion, has previously been reported to extend life and enhance stress resistance in flies. Whether these effects are due to reduced MTH signalling in specific tissues remains unknown. We determined that reduc...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12027
更新日期:2013-02-01 00:00:00
abstract::Although the link between altered stem cell properties and tissue aging has been recognized, the molecular and cellular processes of tendon aging have not been elucidated. As tendons contain stem/progenitor cells (TSPC), we investigated whether the molecular and cellular attributes of TSPC alter during tendon aging an...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12124
更新日期:2013-12-01 00:00:00
abstract::Maternal age-related decline in oocyte quality is associated with meiotic defects, but the underlying mechanisms remain to be explored. Histone deacetylase 3 (HDAC3) has been shown to govern multiple cellular events via deacetylating diverse substrates. We previously found that HDAC3 could promote meiotic apparatus as...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13036
更新日期:2019-12-01 00:00:00
abstract::Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mu...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/j.1474-9726.2010.00608.x
更新日期:2010-10-01 00:00:00
abstract::Fibrosis is a hallmark of aging tissues which often leads to altered architecture and function. The ovary is the first organ to show overt signs of aging, including increased fibrosis in the ovarian stroma. How this fibrosis affects ovarian biomechanics and the underlying mechanisms are unknown. Using instrumental ind...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13259
更新日期:2020-11-01 00:00:00
abstract::Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life-history traits and transcriptomes of 14 Drosophila species d...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12740
更新日期:2018-08-01 00:00:00
abstract::Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isol...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2009.00526.x
更新日期:2009-12-01 00:00:00
abstract::Epidemiological studies of human longevity found two interesting features, robust advantage of female lifespan and consistent reduction of lifespan variation. To help understand the genetic aspects of these phenomena, the current study examined sex differences and variation of longevity using previously published mous...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13263
更新日期:2020-11-01 00:00:00
abstract::Growth hormone receptor knockout (GHRKO) mice are remarkably long-lived and have improved glucose homeostasis along with altered energy metabolism which manifests through decreased respiratory quotient (RQ) and increased oxygen consumption (VO2 ). Short-term exposure of these animals to increased environmental tempera...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13123
更新日期:2020-05-01 00:00:00
abstract::This annual review focuses on invertebrate model organisms, which shed light on new mechanisms in aging and provide excellent systems for in-depth analysis. This year, the first quantitative estimate of evolutionary conservation of genetic effects on lifespan has pointed to the key importance of genes involved in prot...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1111/j.1474-9726.2008.00415.x
更新日期:2008-10-01 00:00:00
abstract::Neurogenesis, which may contribute to the ability of the adult brain to function normally and adapt to disease, nevertheless declines with advancing age. Adult neurogenesis can be enhanced by administration of growth factors, but whether the aged brain remains responsive to these factors is unknown. We compared the ef...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1046/j.1474-9728.2003.00046.x
更新日期:2003-06-01 00:00:00
abstract::The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide...
journal_title:Aging cell
pub_type: 杂志文章,meta分析
doi:10.1111/acel.12490
更新日期:2016-10-01 00:00:00
abstract::Age-associated changes in apoptotic rates have been observed in a number of different tissues. While the implications of these findings remain unclear, a better understanding of how apoptosis is regulated may further our understanding of the aging process. The role of the JNK pathway in apoptosis has been highly contr...
journal_title:Aging cell
pub_type: 杂志文章,评审
doi:10.1046/j.1474-9728.2002.00014.x
更新日期:2002-12-01 00:00:00
abstract::Dietary restriction (DR) extends lifespan in multiple species from various taxa. This effect can arise via two distinct but not mutually exclusive ways: a change in aging rate and/or vulnerability to the aging process (i.e. initial mortality rate). When DR affects vulnerability, this lowers mortality instantly, wherea...
journal_title:Aging cell
pub_type: 杂志文章,meta分析
doi:10.1111/acel.12061
更新日期:2013-06-01 00:00:00
abstract::Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processe...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12919
更新日期:2019-06-01 00:00:00
abstract::Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.13119
更新日期:2020-05-01 00:00:00
abstract::The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...
journal_title:Aging cell
pub_type: 杂志文章,meta分析
doi:10.1111/acel.12160
更新日期:2014-04-01 00:00:00
abstract::The aim of this study was to determine the mechanism underlying the association between one-carbon metabolism and DNA methylation during chronic degenerative joint disorder, osteoarthritis (OA). Articular chondrocytes were isolated from human OA cartilage and normal cartilage biopsied, and the degree of cartilage degr...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12363
更新日期:2015-10-01 00:00:00
abstract::While age-related insulin resistance and hyperinsulinemia are usually considered to be secondary to changes in muscle, the liver also plays a key role in whole-body insulin handling and its role in age-related changes in insulin homeostasis is largely unknown. Here, we show that patent pores called 'fenestrations' are...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12481
更新日期:2016-08-01 00:00:00
abstract::Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells represent a promising therapeutic tool for many diseases, including aged tissues and organs at high risk of failure. However, the intrinsic self-renewal and pluripotency of ES and iPS cells make them tumorigenic, and hence, the risk of tumor developmen...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2011.00754.x
更新日期:2012-02-01 00:00:00
abstract::Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long-term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high-fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12883
更新日期:2019-04-01 00:00:00
abstract::Despite its medical, social, and economic significance, understanding what primarily causes aging, that is, the mechanisms of the aging process, remains a fundamental and fascinating problem in biology. Accumulating evidence indicates that a small RNA-based gene regulatory machinery, the Piwi-piRNA pathway, represents...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12630
更新日期:2017-10-01 00:00:00
abstract::Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12731
更新日期:2018-04-01 00:00:00
abstract::Brain mitochondrial function has been posited to decline with aging. In order to test this hypothesis, cortical and striatal mitochondria were isolated from Fischer 344 rats at 2, 5, 11, 24 and 33 months of age. Mitochondrial membrane potential remained stable through 24 months, declining slightly in mitochondria from...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2005.00156.x
更新日期:2005-06-01 00:00:00
abstract::Endothelial oxidative stress develops with aging and reactive oxygen species impair endothelium-dependent relaxation (EDR) by decreasing nitric oxide (NO) availability. Endothelial KCa 3.1, which contributes to EDR, is upregulated by H2 O2 . We investigated whether KCa 3.1 upregulation compensates for diminished EDR t...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12502
更新日期:2016-10-01 00:00:00
abstract::Aging is associated with a large number of both phenotypic and molecular changes, but for most of these, it is not known whether these changes are detrimental, neutral, or protective. We have identified a conserved Caenorhabditis elegans GATA transcription factor/MTA-1 homolog egr-1 (lin-40) that extends lifespan and ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/acel.12179
更新日期:2014-04-01 00:00:00
abstract::The aim of this study was to investigate changes in astrocyte density, morphology, proliferation and apoptosis occurring in the central nervous system during physiological aging. Astrocytes in retinal whole-mount preparations from Wistar rats aged 3 (young adult) to 25 months (aged) were investigated qualitatively and...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2008.00402.x
更新日期:2008-08-01 00:00:00
abstract::In many tissues, mammalian aging is associated with a decline in the replicative and functional capacity of somatic stem cells and other self-renewing compartments. Understanding the basis of this decline is a major goal of aging research. In particular, therapeutic approaches to ameliorate or reverse the age-associat...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2010.00592.x
更新日期:2010-08-01 00:00:00
abstract::The epidermis of the skin, acting as the primary physical barrier between self and environment, is a dynamic tissue whose maintenance is critical to the survival of an organism. Like most other tissues and organs, the epidermis is maintained and repaired by a population of resident somatic stem cells. The epidermal st...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2007.00318.x
更新日期:2007-08-01 00:00:00
abstract::Aging is inevitably accompanied by gradual and irreversible innate endothelial dysfunction. In this study, we tested the hypothesis that accentuation of glucose metabolism via the aldose reductase (AR) pathway contributes to age-related vascular dysfunction. AR protein and activity levels were significantly increased ...
journal_title:Aging cell
pub_type: 杂志文章
doi:10.1111/j.1474-9726.2010.00606.x
更新日期:2010-10-01 00:00:00