Abstract:
:Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. These studies have led to advances in fields as diverse as endocrinology, immunology, and oncology. A variation on the technique, heterochronic parabiosis, whereby two animals of different ages are joined to test for systemic regulators of aspects of aging or age-related diseases also has almost a century-long scientific history. In this review, we focus on the history of heterochronic parabiosis, methodological considerations and caveats, and the major advances that have emerged from those studies, including recent advances in our understanding of stem cell aging.
journal_name
Aging Celljournal_title
Aging cellauthors
Conboy MJ,Conboy IM,Rando TAdoi
10.1111/acel.12065subject
Has Abstractpub_date
2013-06-01 00:00:00pages
525-30issue
3eissn
1474-9718issn
1474-9726journal_volume
12pub_type
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