HIF-1 modulates longevity and healthspan in a temperature-dependent manner.

abstract：:Aging is associated with a large number of both phenotypic and molecular changes, but for most of these, it is not known whether these changes are detrimental, neutral, or protective. We have identified a conserved Caenorhabditis elegans GATA transcription factor/MTA-1 homolog egr-1 (lin-40) that extends lifespan and ...

journal_title：Aging cell

authors： Zimmerman SM,Kim SK

更新日期：2014-04-01 00:00:00

abstract：:Ubiquitously reduced signaling via Methuselah (MTH), a G-protein-coupled receptor (GPCR) required for neurosecretion, has previously been reported to extend life and enhance stress resistance in flies. Whether these effects are due to reduced MTH signalling in specific tissues remains unknown. We determined that reduc...

journal_title：Aging cell

authors： Gimenez LE,Ghildyal P,Fischer KE,Hu H,Ja WW,Eaton BA,Wu Y,Austad SN,Ranjan R

更新日期：2013-02-01 00:00:00

abstract：:The transcription of ribosomal RNA genes (rDNA) is subject to epigenetic regulation, as it is abrogated by the methylation of CpG dinucleotides within their promoter region. Here, we investigated, through Sequenom platform, the age-related methylation status of the CpG island falling into the rDNA promoter in 472 bloo...

journal_title：Aging cell

authors： D'Aquila P,Montesanto A,Mandalà M,Garasto S,Mari V,Corsonello A,Bellizzi D,Passarino G

更新日期：2017-10-01 00:00:00

abstract：:Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...

journal_title：Aging cell

authors： Zhang B,Podolskiy DI,Mariotti M,Seravalli J,Gladyshev VN

更新日期：2020-05-01 00:00:00

abstract：:The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more ...

journal_title：Aging cell

authors： Fridovich I

更新日期：2004-02-01 00:00:00

abstract：:Downregulation of insulin-like growth factor (IGF) pathways prolongs lifespan in various species, including mammals. Still, the cellular mechanisms by which IGF signaling controls the aging trajectory of individual organs are largely unknown. Here, we asked whether suppression of IGF-I receptor (IGF-1R) in adult stem ...

journal_title：Aging cell

authors： Chaker Z,Aïd S,Berry H,Holzenberger M

更新日期：2015-10-01 00:00:00

abstract：:One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To inves...

journal_title：Aging cell

authors： Ye X,Linton JM,Schork NJ,Buck LB,Petrascheck M

更新日期：2014-04-01 00:00:00

abstract：:A huge amount of evidence has implicated amyloid beta (A beta) peptides and other derivatives of the amyloid precursor protein (beta APP) as central to the pathogenesis of Alzheimer's disease (AD). It is also widely recognized that age is the most important risk factor for AD and that the innate immune system plays a ...

journal_title：Aging cell

authors： Blasko I,Stampfer-Kountchev M,Robatscher P,Veerhuis R,Eikelenboom P,Grubeck-Loebenstein B

更新日期：2004-08-01 00:00:00

abstract：:Age-associated changes in apoptotic rates have been observed in a number of different tissues. While the implications of these findings remain unclear, a better understanding of how apoptosis is regulated may further our understanding of the aging process. The role of the JNK pathway in apoptosis has been highly contr...

journal_title：Aging cell

authors： Lin A,Dibling B

更新日期：2002-12-01 00:00:00

abstract：:Dietary restriction (DR) increases lifespan and attenuates age-related phenotypes in many organisms; however, the effect of DR on longevity of individuals in genetically heterogeneous populations is not well characterized. Here, we describe a large-scale effort to define molecular mechanisms that underlie genotype-spe...

journal_title：Aging cell

authors： Schleit J,Johnson SC,Bennett CF,Simko M,Trongtham N,Castanza A,Hsieh EJ,Moller RM,Wasko BM,Delaney JR,Sutphin GL,Carr D,Murakami CJ,Tocchi A,Xian B,Chen W,Yu T,Goswami S,Higgins S,Holmberg M,Jeong KS,Kim JR,Kl

更新日期：2013-12-01 00:00:00

abstract：:The ING family of tumor suppressor proteins affects cell growth, apoptosis and response to DNA damage by modulating chromatin structure through association with different HAT and HDAC complexes. The major splicing isoforms of the ING1 locus are ING1a and INGlb. While INGlb plays a role in inducing apoptosis, the funct...

journal_title：Aging cell

authors： Soliman MA,Berardi P,Pastyryeva S,Bonnefin P,Feng X,Colina A,Young D,Riabowol K

更新日期：2008-12-01 00:00:00

abstract：:The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approac...

journal_title：Aging cell

authors： van den Akker EB,Passtoors WM,Jansen R,van Zwet EW,Goeman JJ,Hulsman M,Emilsson V,Perola M,Willemsen G,Penninx BW,Heijmans BT,Maier AB,Boomsma DI,Kok JN,Slagboom PE,Reinders MJ,Beekman M

更新日期：2014-04-01 00:00:00

abstract：:The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a genome protective barrier and mechanotransduction interface between the cytoplasm and the nucleus. The NE is mainly composed of a nuclear lamina and a double membrane connected at specific points where the nuclear pore complex...

journal_title：Aging cell

authors： Martins F,Sousa J,Pereira CD,da Cruz E Silva OAB,Rebelo S

更新日期：2020-05-01 00:00:00

abstract：:Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generations of telomerase-def...

journal_title：Aging cell

authors： García-Beccaria M,Martínez P,Flores JM,Blasco MA

更新日期：2014-10-01 00:00:00

abstract：:The epidermis of the skin, acting as the primary physical barrier between self and environment, is a dynamic tissue whose maintenance is critical to the survival of an organism. Like most other tissues and organs, the epidermis is maintained and repaired by a population of resident somatic stem cells. The epidermal st...

journal_title：Aging cell

authors： Stern MM,Bickenbach JR

更新日期：2007-08-01 00:00:00

abstract：:Wnt signaling is a major and highly conserved developmental pathway that guides many important events during embryonic and larval development. In adulthood, misregulation of Wnt signaling has been implicated in tumorigenesis and various age-related diseases. These effects occur through highly complicated cell-to-cell ...

journal_title：Aging cell

authors： Lezzerini M,Budovskaya Y

更新日期：2014-02-01 00:00:00

abstract：:Histone acetyltransferases (HATs) are important enzymes that transfer acetyl groups onto histones and thereby regulate both gene expression and chromosomal structures. Previous work has shown that the activation of sirtuins, which are histone deacetylases, can extend lifespan. This suggests that inhibiting HATs may ha...

journal_title：Aging cell

authors： Huang B,Zhong D,Zhu J,An Y,Gao M,Zhu S,Dang W,Wang X,Yang B,Xie Z

更新日期：2020-04-01 00:00:00

abstract：:The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here, we describe the rationale for identification and validation of a new class of d...

journal_title：Aging cell

authors： Zhu Y,Tchkonia T,Pirtskhalava T,Gower AC,Ding H,Giorgadze N,Palmer AK,Ikeno Y,Hubbard GB,Lenburg M,O'Hara SP,LaRusso NF,Miller JD,Roos CM,Verzosa GC,LeBrasseur NK,Wren JD,Farr JN,Khosla S,Stout MB,McGowan SJ,Fuh

更新日期：2015-08-01 00:00:00

abstract：:Dietary restriction is arguably the most promising nonpharmacological intervention to extend human life and health span. Yet, only few genetic regulators mediating the cellular response to dietary restriction are known, and the question remains which other regulatory factors are involved. Here, we measured at the geno...

journal_title：Aging cell

authors： Campos SE,Avelar-Rivas JA,Garay E,Juárez-Reyes A,DeLuna A

更新日期：2018-06-01 00:00:00

abstract：:Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy to slow aging. However, recent evidence indicates that adding metformin to exercise antagonizes the exercise-induced improvement in insulin sensitivity and car...

journal_title：Aging cell

authors： Konopka AR,Laurin JL,Schoenberg HM,Reid JJ,Castor WM,Wolff CA,Musci RV,Safairad OD,Linden MA,Biela LM,Bailey SM,Hamilton KL,Miller BF

更新日期：2019-02-01 00:00:00

abstract：:The discovery of biomarkers able to predict biological age of individuals is a crucial goal in aging research. Recently, researchers' attention has turn toward epigenetic markers of aging. Using the Illumina Infinium HumanMethylation450 BeadChip on whole blood DNA from a small cohort of 64 subjects of different ages, ...

journal_title：Aging cell

authors： Garagnani P,Bacalini MG,Pirazzini C,Gori D,Giuliani C,Mari D,Di Blasio AM,Gentilini D,Vitale G,Collino S,Rezzi S,Castellani G,Capri M,Salvioli S,Franceschi C

更新日期：2012-12-01 00:00:00

abstract：:This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases esp...

journal_title：Aging cell

authors： Conover CA

更新日期：2010-12-01 00:00:00

abstract：:Sequence variations in a variety of pro- or anti-inflammatory cytokine genes have been found to influence successful aging and longevity. Because of the role played by the transforming growth factor beta1 (TGF-beta1) cytokine in inflammation and regulation of immune responses, the variability of the TGF-beta1 gene may...

journal_title：Aging cell

authors： Carrieri G,Marzi E,Olivieri F,Marchegiani F,Cavallone L,Cardelli M,Giovagnetti S,Stecconi R,Molendini C,Trapassi C,De Benedictis G,Kletsas D,Franceschi C

更新日期：2004-12-01 00:00:00

abstract：:Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the unknown etiol...

journal_title：Aging cell

authors： Kreienkamp R,Billon C,Bedia-Diaz G,Albert CJ,Toth Z,Butler AA,McBride-Gagyi S,Ford DA,Baldan A,Burris TP,Gonzalo S

更新日期：2019-02-01 00:00:00

abstract：:Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood-brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model o...

journal_title：Aging cell

authors： Elhaik Goldman S,Goez D,Last D,Naor S,Liraz Zaltsman S,Sharvit-Ginon I,Atrakchi-Baranes D,Shemesh C,Twitto-Greenberg R,Tsach S,Lotan R,Leikin-Frenkel A,Shish A,Mardor Y,Schnaider Beeri M,Cooper I

更新日期：2018-10-01 00:00:00

abstract：:Werner syndrome (WS) is an autosomal recessive disorder, the hallmarks of which are premature aging and early onset of neoplastic diseases (Orren, 2006; Bohr, 2008). The gene, whose mutation underlies the WS phenotype, is called WRN. The protein encoded by the WRN gene, WRNp, has DNA helicase activity (Gray et al., 19...

journal_title：Aging cell

authors： Smith JA,Ndoye AM,Geary K,Lisanti MP,Igoucheva O,Daniel R

更新日期：2010-08-01 00:00:00

abstract：:The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amy...

journal_title：Aging cell

authors： Schultz N,Brännström K,Byman E,Moussaud S,Nielsen HM,Netherlands Brain Bank.,Olofsson A,Wennström M

更新日期：2018-06-01 00:00:00

abstract：:The aim of this study was to investigate changes in astrocyte density, morphology, proliferation and apoptosis occurring in the central nervous system during physiological aging. Astrocytes in retinal whole-mount preparations from Wistar rats aged 3 (young adult) to 25 months (aged) were investigated qualitatively and...

journal_title：Aging cell

authors： Mansour H,Chamberlain CG,Weible MW 2nd,Hughes S,Chu Y,Chan-Ling T

更新日期：2008-08-01 00:00:00

abstract：:Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotyp...

journal_title：Aging cell

authors： Umehara T,Kawai T,Kawashima I,Tanaka K,Okuda S,Kitasaka H,Richards JS,Shimada M

更新日期：2017-12-01 00:00:00

abstract：:The mitochondrial theory of aging is based around the idea of a vicious cycle, in which somatic mutation of mtDNA engenders respiratory chain dysfunction, enhancing the production of DNA-damaging oxygen radicals. In turn, this is proposed to result in the accumulation of further mtDNA mutations. Finally, a bioenergeti...

journal_title：Aging cell

authors： Jacobs HT

更新日期：2003-02-01 00:00:00