Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet.

abstract：:Skin hair follicles (HF) contain bulge stem cells (SC) that regenerate HFs during hair cycles, and repair skin epithelia following injury. As natural aging is associated with decreased skin repair capacity in humans, we have investigated the impact of age on human scalp HF bulge cell number and function. Here, we isol...

journal_title：Aging cell

authors： Rittié L,Stoll SW,Kang S,Voorhees JJ,Fisher GJ

更新日期：2009-12-01 00:00:00

abstract：:Neuropeptide Y (NPY) is an orexigenic peptide that plays an essential role in caloric restriction (CR)-mediated lifespan extension. However, the mechanisms underlying the NPY-mediated effects in CR are poorly defined. Here, we report that NPY deficiency in male mice during CR increases mortality in association with li...

journal_title：Aging cell

authors： Park S,Komatsu T,Kim SE,Tanaka K,Hayashi H,Mori R,Shimokawa I

更新日期：2017-04-01 00:00:00

abstract：:Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death rate, which is thought to reflect the rate of age-related damage accumulation....

journal_title：Aging cell

authors： Valenzano DR,Terzibasi E,Cattaneo A,Domenici L,Cellerino A

更新日期：2006-06-01 00:00:00

abstract：:Maternal age-related decline in oocyte quality is associated with meiotic defects, but the underlying mechanisms remain to be explored. Histone deacetylase 3 (HDAC3) has been shown to govern multiple cellular events via deacetylating diverse substrates. We previously found that HDAC3 could promote meiotic apparatus as...

journal_title：Aging cell

authors： He Y,Li X,Gao M,Liu H,Gu L

更新日期：2019-12-01 00:00:00

abstract：:The deleterious reactive carbonyls released upon oxidation of polyunsaturated fatty acids in biological membranes are believed to foster cellular aging. Comparative studies in mammals and birds have shown that the susceptibility to peroxidation of membrane lipids peroxidation index (PI) is negatively correlated with l...

journal_title：Aging cell

authors： Munro D,Blier PU

更新日期：2012-10-01 00:00:00

abstract：:H(2)O(2) is a major reactive oxygen species produced by mitochondria that is implicated to be important in aging and pathogenesis of diseases such as diabetes; however, the cellular and physiological roles of mitochondrial H(2)O(2) remain poorly understood. Peroxiredoxin 3 (Prdx3/Prx3) is a thioredoxin peroxidase loca...

journal_title：Aging cell

authors： Chen L,Na R,Gu M,Salmon AB,Liu Y,Liang H,Qi W,Van Remmen H,Richardson A,Ran Q

更新日期：2008-12-01 00:00:00

abstract：:The progressively increasing frailty, morbidity and mortality of aging organisms coincides with, and may be causally related to, their waning ability to adapt to environmental perturbations. Transcriptional responses to challenges, such as oxidative stress or pathogens, diminish with age. This effect is manifest in th...

journal_title：Aging cell

authors： Cheng Y,Pitoniak A,Wang J,Bohmann D

更新日期：2021-01-20 00:00:00

abstract：:Aging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefit...

journal_title：Aging cell

authors： Crane JD,MacNeil LG,Lally JS,Ford RJ,Bujak AL,Brar IK,Kemp BE,Raha S,Steinberg GR,Tarnopolsky MA

更新日期：2015-08-01 00:00:00

abstract：:This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases esp...

journal_title：Aging cell

authors： Conover CA

更新日期：2010-12-01 00:00:00

abstract：:Translation of RNA to protein is essential for life. It should perhaps not be surprising, therefore, that appropriate regulation of translation plays a key role in determining longevity. This Hot Topic article discusses papers published in the last year related to the importance of translation and its regulation by si...

journal_title：Aging cell

authors： Kaeberlein M,Kennedy BK

更新日期：2007-12-01 00:00:00

abstract：:The 'rate of living' theory predicts that longevity should be inversely correlated with the rate of mitochondrial respiration. However, recent studies in a number of model organisms, including mice, have reported that interventions that retard the aging process are, in fact, associated with an increase in mitochondria...

journal_title：Aging cell

authors： Bahadorani S,Cho J,Lo T,Contreras H,Lawal HO,Krantz DE,Bradley TJ,Walker DW

更新日期：2010-04-01 00:00:00

abstract：:The skeletal muscle fibre is a syncitium where each myonucleus regulates the gene products in a finite volume of the cytoplasm, i.e., the myonuclear domain (MND). We analysed aging- and gender-related effects on myonuclei organization and the MND size in single muscle fibres from six young (21-31 years) and nine old m...

journal_title：Aging cell

authors： Cristea A,Qaisar R,Edlund PK,Lindblad J,Bengtsson E,Larsson L

更新日期：2010-10-01 00:00:00

abstract：:SARS-CoV-2 is a novel betacoronavirus which infects the lower respiratory tract and can cause coronavirus disease 2019 (COVID-19), a complex respiratory distress syndrome. Epidemiological data show that COVID-19 has a rising mortality particularly in individuals with advanced age. Identifying a functional association ...

journal_title：Aging cell

authors： Nehme J,Borghesan M,Mackedenski S,Bird TG,Demaria M

更新日期：2020-10-01 00:00:00

abstract：:Little is known about the types and numbers of mutations that may accumulate in normal human cells with age. Such information would require obtaining enough DNA from a single cell to accurately carry out reliable analysis despite extensive amplification; and complete genomic coverage under these circumstances is diffi...

journal_title：Aging cell

authors： Hsieh JC,Van Den Berg D,Kang H,Hsieh CL,Lieber MR

更新日期：2013-04-01 00:00:00

abstract：:Methionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where ...

journal_title：Aging cell

authors： Aledo JC,Li Y,de Magalhães JP,Ruíz-Camacho M,Pérez-Claros JA

更新日期：2011-04-01 00:00:00

abstract：:Most mammalian cells when placed in culture will undergo a limited number of cell divisions before entering an unresponsive non-proliferating state termed senescence. However, several pathways that are activated singly or in concert can allow cells to bypass senescence at least for limited periods. These include the t...

journal_title：Aging cell

authors： Miura T,Mattson MP,Rao MS

更新日期：2004-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting both the hippocampus and the cerebral cortex. Reduced synaptic density that occurs early in the disease process seems to be partially due to the overactivation of N-methyl-d-aspartate receptors (NMDARs) leading to excitotoxicity. Recently, ...

journal_title：Aging cell

authors： Costa RO,Lacor PN,Ferreira IL,Resende R,Auberson YP,Klein WL,Oliveira CR,Rego AC,Pereira CM

更新日期：2012-10-01 00:00:00

abstract：:In many tissues, mammalian aging is associated with a decline in the replicative and functional capacity of somatic stem cells and other self-renewing compartments. Understanding the basis of this decline is a major goal of aging research. In particular, therapeutic approaches to ameliorate or reverse the age-associat...

journal_title：Aging cell

authors： Sharpless NE

更新日期：2010-08-01 00:00:00

abstract：:Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has r...

journal_title：Aging cell

authors： Mendenhall A,Driscoll M,Brent R

更新日期：2016-02-01 00:00:00

abstract：:Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancem...

journal_title：Aging cell

authors： Liu YL,Lu WC,Brummel TJ,Yuh CH,Lin PT,Kao TY,Li FY,Liao PC,Benzer S,Wang HD

更新日期：2009-08-01 00:00:00

abstract：:One goal of aging research is to find drugs that delay the onset of age-associated disease. Studies in invertebrates, particularly Caenorhabditis elegans, have uncovered numerous genes involved in aging, many conserved in mammals. However, which of these encode proteins suitable for drug targeting is unknown. To inves...

journal_title：Aging cell

authors： Ye X,Linton JM,Schork NJ,Buck LB,Petrascheck M

更新日期：2014-04-01 00:00:00

abstract：:Impairments of dendritic trees and spines have been found in many neurodegenerative diseases, including Alzheimer's disease (AD), in which the deficits of melatonin signal pathway were reported. Melatonin receptor 2 (MT2) is widely expressed in the hippocampus and mediates the biological functions of melatonin. It is ...

journal_title：Aging cell

authors： Tang H,Ma M,Wu Y,Deng MF,Hu F,Almansoub HAMM,Huang HZ,Wang DQ,Zhou LT,Wei N,Man H,Lu Y,Liu D,Zhu LQ

更新日期：2019-04-01 00:00:00

abstract：:During aging, decreases in energy expenditure and locomotor activity lead to body weight and fat gain. Aging is also associated with decreases in muscle strength and endurance leading to functional decline. Here, we show that lifelong deletion of ghrelin prevents development of obesity associated with aging by modulat...

journal_title：Aging cell

authors： Guillory B,Chen JA,Patel S,Luo J,Splenser A,Mody A,Ding M,Baghaie S,Anderson B,Iankova B,Halder T,Hernandez Y,Garcia JM

更新日期：2017-08-01 00:00:00

abstract：:Studies in the nematode Caenorhabditis elegans have been instrumental in defining genetic pathways that are involved in modulating lifespan. Multiple processes such as endocrine signaling, nutritional sensing and mitochondrial function play a role in determining lifespan in the worm and these mechanisms appear to be c...

journal_title：Aging cell

authors： Gill MS

更新日期：2006-02-01 00:00:00

abstract：:The hypoxia-inducible factor HIF-1 has recently been identified as an important modifier of longevity in the roundworm Caenorhabditis elegans. Studies have reported that HIF-1 can function as both a positive and negative regulator of life span, and several disparate models have been proposed for the role of HIF in agi...

journal_title：Aging cell

authors： Leiser SF,Begun A,Kaeberlein M

更新日期：2011-04-01 00:00:00

abstract：:Aging is associated with a progressive loss of tissue and metabolic homeostasis. This loss can be delayed by single-gene perturbations, increasing lifespan. How such perturbations affect metabolic and proteostatic networks to extend lifespan remains unclear. Here, we address this question by comprehensively characteri...

journal_title：Aging cell

authors： Wang L,Davis SS,Borch Jensen M,Rodriguez-Fernandez IA,Apaydin C,Juhasz G,Gibson BW,Schilling B,Ramanathan A,Ghaemmaghami S,Jasper H

更新日期：2019-06-01 00:00:00

abstract：:Deficits in learning and memory accompanied by age-related neurodegenerative diseases are closely related to the impairment of synaptic plasticity. In this study, we investigated the role of thiol redox status in the modulation of the N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) in CA1 ...

journal_title：Aging cell

authors： Yang YJ,Wu PF,Long LH,Yu DF,Wu WN,Hu ZL,Fu H,Xie N,Jin Y,Ni L,Wang JZ,Wang F,Chen JG

更新日期：2010-10-01 00:00:00

abstract：:Oestrogenic compounds have been postulated as neuroprotective agents. This prompted us to investigate their mechanism action in neurons in primary culture. Cells were pretreated with physiological concentrations of 17-beta estradiol (0.2 nm) or with nutritionally relevant concentrations of genistein (0.5 microm), and ...

journal_title：Aging cell

authors： Vallés SL,Borrás C,Gambini J,Furriol J,Ortega A,Sastre J,Pallardó FV,Viña J

更新日期：2008-01-01 00:00:00

abstract：:Aging is associated with increased vulnerability to inflammatory challenge. However, the effects of altered inflammatory response on the metabolic status of tissues or organs are not well documented. In this study, we present evidence demonstrating that lipopolysaccharide (LPS)-induced upregulation of the inflammasome...

journal_title：Aging cell

authors： Chung KW,Lee EK,Kim DH,An HJ,Kim ND,Im DS,Lee J,Yu BP,Chung HY

更新日期：2015-08-01 00:00:00

abstract：:Recent studies demonstrate that aging exacerbates hypertension-induced cognitive decline, but the specific age-related mechanisms remain elusive. Cerebral microhemorrhages (CMHs) are associated with rupture of small intracerebral vessels and are thought to progressively impair neuronal function. To determine whether a...

journal_title：Aging cell

authors： Toth P,Tarantini S,Springo Z,Tucsek Z,Gautam T,Giles CB,Wren JD,Koller A,Sonntag WE,Csiszar A,Ungvari Z

更新日期：2015-06-01 00:00:00