Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.

abstract：:Skin-derived precursors (SKPs) are embryonic neural crest- or somite-derived multipotent progenitor cells with properties of dermal stem cells. Although a large number of studies deal with their differentiation ability and potential applications in tissue damage repair, only a few studies have concentrated on the regu...

journal_title：Aging cell

authors： Liu S,Liu S,Wang X,Zhou J,Cao Y,Wang F,Duan E

更新日期：2011-08-01 00:00:00

abstract：:Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotyp...

journal_title：Aging cell

authors： Umehara T,Kawai T,Kawashima I,Tanaka K,Okuda S,Kitasaka H,Richards JS,Shimada M

更新日期：2017-12-01 00:00:00

abstract：:Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to vaccines in the aging population. The dysfunctions of adaptive B and T cells are well documented, but the effect of aging on innate immunity remains incompletely understo...

journal_title：Aging cell

authors： Metcalf TU,Cubas RA,Ghneim K,Cartwright MJ,Grevenynghe JV,Richner JM,Olagnier DP,Wilkinson PA,Cameron MJ,Park BS,Hiscott JB,Diamond MS,Wertheimer AM,Nikolich-Zugich J,Haddad EK

更新日期：2015-06-01 00:00:00

abstract：:Methionine residues in proteins react readily with reactive oxygen species making them particularly sensitive to oxidation. However, because oxidized methionine can be reduced back in a catalyzed reaction, it has been suggested that methionine residues act as oxidant scavengers, protecting not only the proteins where ...

journal_title：Aging cell

authors： Aledo JC,Li Y,de Magalhães JP,Ruíz-Camacho M,Pérez-Claros JA

更新日期：2011-04-01 00:00:00

abstract：:The susceptibility of human CD4+ and CD8+ T cells to senesce differs, with CD8+ T cells acquiring an immunosenescent phenotype faster than the CD4+ T cell compartment. We show here that it is the inherent difference in mitochondrial content that drives this phenotype, with senescent human CD4+ T cells displaying a hig...

journal_title：Aging cell

authors： Callender LA,Carroll EC,Bober EA,Akbar AN,Solito E,Henson SM

更新日期：2020-02-01 00:00:00

abstract：:Aging involves coordinated yet distinct changes in organs and systems throughout life, including changes in essential trace elements. However, how aging affects tissue element composition (ionome) and how these changes lead to dysfunction and disease remain unclear. Here, we quantified changes in the ionome across eig...

journal_title：Aging cell

authors： Zhang B,Podolskiy DI,Mariotti M,Seravalli J,Gladyshev VN

更新日期：2020-05-01 00:00:00

abstract：:Impairments of dendritic trees and spines have been found in many neurodegenerative diseases, including Alzheimer's disease (AD), in which the deficits of melatonin signal pathway were reported. Melatonin receptor 2 (MT2) is widely expressed in the hippocampus and mediates the biological functions of melatonin. It is ...

journal_title：Aging cell

authors： Tang H,Ma M,Wu Y,Deng MF,Hu F,Almansoub HAMM,Huang HZ,Wang DQ,Zhou LT,Wei N,Man H,Lu Y,Liu D,Zhu LQ

更新日期：2019-04-01 00:00:00

abstract：:Telomerase, which maintains the ends of chromosomes, consists of two core components, the telomerase reverse transcriptase (TERT) and the telomerase RNA (TERC). Haploinsufficiency for TERC or TERT leads to progressive telomere shortening and autosomal dominant dyskeratosis congenita (DC). The clinical manifestations o...

journal_title：Aging cell

authors： Du HY,Idol R,Robledo S,Ivanovich J,An P,Londono-Vallejo A,Wilson DB,Mason PJ,Bessler M

更新日期：2007-10-01 00:00:00

abstract：:The mitochondrial theory of aging is based around the idea of a vicious cycle, in which somatic mutation of mtDNA engenders respiratory chain dysfunction, enhancing the production of DNA-damaging oxygen radicals. In turn, this is proposed to result in the accumulation of further mtDNA mutations. Finally, a bioenergeti...

journal_title：Aging cell

authors： Jacobs HT

更新日期：2003-02-01 00:00:00

abstract：:Little is known about how diet and energy metabolism interact in determination of lifespan under ad libitum feeding. From 12 weeks of age until death, male and female wild-type (WT) and transgenic (TG) mice with increased skeletal muscle mitochondrial uncoupling (HSA-mUCP1 mice) were fed one of three different semisyn...

journal_title：Aging cell

authors： Keipert S,Voigt A,Klaus S

更新日期：2011-02-01 00:00:00

abstract：:A partial reduction in food intake has been found to increase lifespan in many different organisms. We report here a new dietary restriction regimen in the nematode Caenorhabditis elegans, based on the standard agar plate lifespan assay, in which adult worms are maintained in the absence of a bacterial food source. Th...

journal_title：Aging cell

authors： Kaeberlein TL,Smith ED,Tsuchiya M,Welton KL,Thomas JH,Fields S,Kennedy BK,Kaeberlein M

更新日期：2006-12-01 00:00:00

abstract：:Most mammalian cells when placed in culture will undergo a limited number of cell divisions before entering an unresponsive non-proliferating state termed senescence. However, several pathways that are activated singly or in concert can allow cells to bypass senescence at least for limited periods. These include the t...

journal_title：Aging cell

authors： Miura T,Mattson MP,Rao MS

更新日期：2004-12-01 00:00:00

abstract：:The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (gamma-H2A.X) at either un...

journal_title：Aging cell

authors： Wang C,Jurk D,Maddick M,Nelson G,Martin-Ruiz C,von Zglinicki T

更新日期：2009-06-01 00:00:00

abstract：:The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation init...

journal_title：Aging cell

authors： Rousakis A,Vlassis A,Vlanti A,Patera S,Thireos G,Syntichaki P

更新日期：2013-10-01 00:00:00

abstract：:Caloric restriction (CR) can delay onset of several age-related pathophysiologies and extend lifespan in various species, including rodents. CR also induces metabolic remodeling involved in activation of lipid metabolism, enhancement of mitochondrial biogenesis, and reduction of oxidative stress in white adipose tissu...

journal_title：Aging cell

authors： Fujii N,Narita T,Okita N,Kobayashi M,Furuta Y,Chujo Y,Sakai M,Yamada A,Takeda K,Konishi T,Sudo Y,Shimokawa I,Higami Y

更新日期：2017-06-01 00:00:00

abstract：:Mitochondrial dysfunction plays a key pathogenic role in aging skeletal muscle resulting in significant healthcare costs in the developed world. However, there is no pharmacologic treatment to rapidly reverse mitochondrial deficits in the elderly. Here, we demonstrate that a single treatment with the mitochondrial-tar...

journal_title：Aging cell

authors： Siegel MP,Kruse SE,Percival JM,Goh J,White CC,Hopkins HC,Kavanagh TJ,Szeto HH,Rabinovitch PS,Marcinek DJ

更新日期：2013-10-01 00:00:00

abstract：:Pre-lamin A and progerin have been implicated in normal aging, and the pathogenesis of age-related degenerative diseases is termed 'laminopathies'. Here, we show that mature lamin A has an essential role in cellular fitness and that oxidative damage to lamin A is involved in cellular senescence. Primary human dermal f...

journal_title：Aging cell

authors： Pekovic V,Gibbs-Seymour I,Markiewicz E,Alzoghaibi F,Benham AM,Edwards R,Wenhert M,von Zglinicki T,Hutchison CJ

更新日期：2011-12-01 00:00:00

abstract：:Lactic-acid bacteria are widely recognized beneficial host associated groups of the microbiota of humans and animals. Some lactic-acid bacteria have the ability to extend the lifespan of the model animals. The mechanisms behind the probiotic effects of bacteria are not entirely understood. Recently, we reported the be...

journal_title：Aging cell

authors： Nakagawa H,Shiozaki T,Kobatake E,Hosoya T,Moriya T,Sakai F,Taru H,Miyazaki T

更新日期：2016-04-01 00:00:00

abstract：:This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases esp...

journal_title：Aging cell

authors： Conover CA

更新日期：2010-12-01 00:00:00

abstract：:The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a genome protective barrier and mechanotransduction interface between the cytoplasm and the nucleus. The NE is mainly composed of a nuclear lamina and a double membrane connected at specific points where the nuclear pore complex...

journal_title：Aging cell

authors： Martins F,Sousa J,Pereira CD,da Cruz E Silva OAB,Rebelo S

更新日期：2020-05-01 00:00:00

abstract：:Previously, we reported that persistent DNA damage accelerates ageing of the spine, but the mechanisms behind this process are not well understood. Ataxia telangiectasia mutated (ATM) is a protein kinase involved in the DNA damage response, which controls cell fate, including cell death. To test the role of ATM in the...

journal_title：Aging cell

authors： Han Y,Zhou CM,Shen H,Tan J,Dong Q,Zhang L,McGowan SJ,Zhao J,Sowa GA,Kang JD,Niedernhofer LJ,Robbins PD,Vo NN

更新日期：2020-07-01 00:00:00

abstract：:Disturbances of neuronal Ca2+ homeostasis are considered to be important determinants of age-related cognitive impairment. Cholinergic neurons of the basal forebrain (BF) are principal targets of decline associated with aging and dementia. During the last several years, we have attempted to link these concepts in a ra...

journal_title：Aging cell

authors： Murchison D,Griffith WH

更新日期：2007-06-01 00:00:00

abstract：:In many tissues, mammalian aging is associated with a decline in the replicative and functional capacity of somatic stem cells and other self-renewing compartments. Understanding the basis of this decline is a major goal of aging research. In particular, therapeutic approaches to ameliorate or reverse the age-associat...

journal_title：Aging cell

authors： Sharpless NE

更新日期：2010-08-01 00:00:00

abstract：:The frequently quoted figure for the fractional univalent reduction of oxygen to superoxide in mitochondria is certainly too high by at least one order of magnitude. This is so because the higher number (2%) was derived from mitochondria whose cytochrome c oxidase was blocked with cyanide. Nevertheless, even the more ...

journal_title：Aging cell

authors： Fridovich I

更新日期：2004-02-01 00:00:00

abstract：:Aging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefit...

journal_title：Aging cell

authors： Crane JD,MacNeil LG,Lally JS,Ford RJ,Bujak AL,Brar IK,Kemp BE,Raha S,Steinberg GR,Tarnopolsky MA

更新日期：2015-08-01 00:00:00

abstract：:Age-associated ventriculomegaly is typically attributed to neurodegeneration; however, additional factors might initiate or contribute to progressive ventricular expansion. By directly linking postmortem human MRI sequences with histological features of periventricular tissue, we show that substantial lateral ventricl...

journal_title：Aging cell

authors： Shook BA,Lennington JB,Acabchuk RL,Halling M,Sun Y,Peters J,Wu Q,Mahajan A,Fellows DW,Conover JC

更新日期：2014-04-01 00:00:00

abstract：:Adipose tissue inflammation and dysfunction are associated with obesity-related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the development of dia...

journal_title：Aging cell

authors： Palmer AK,Xu M,Zhu Y,Pirtskhalava T,Weivoda MM,Hachfeld CM,Prata LG,van Dijk TH,Verkade E,Casaclang-Verzosa G,Johnson KO,Cubro H,Doornebal EJ,Ogrodnik M,Jurk D,Jensen MD,Chini EN,Miller JD,Matveyenko A,Stout MB,Sc

更新日期：2019-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized clinically by memory loss and cognitive decline. Protein kinase A (PKA)-CREB signaling plays a critical role in learning and memory. It is known that glucose uptake and O-GlcNAcylation are reduced in AD brain. In this study, we found that PKA catalytic subunits (PKAcs) were po...

journal_title：Aging cell

authors： Xie S,Jin N,Gu J,Shi J,Sun J,Chu D,Zhang L,Dai CL,Gu JH,Gong CX,Iqbal K,Liu F

更新日期：2016-06-01 00:00:00

abstract：:Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death rate, which is thought to reflect the rate of age-related damage accumulation....

journal_title：Aging cell

authors： Valenzano DR,Terzibasi E,Cattaneo A,Domenici L,Cellerino A

更新日期：2006-06-01 00:00:00

abstract：:Impaired insulin/IGF1 signalling has been shown to extend lifespan in model organisms ranging from yeast to mammals. Here we sought to determine the effect of targeted disruption of the insulin receptor (IR) in non-neuronal tissues of adult mice on the lifespan. We induced hemizygous (PerIRKO+/- ) or homozygous (PerIR...

journal_title：Aging cell

authors： Merry TL,Kuhlow D,Laube B,Pöhlmann D,Pfeiffer AFH,Kahn CR,Ristow M,Zarse K

更新日期：2017-08-01 00:00:00