Point-of-care testing in the overcrowded emergency department--can it make a difference?

abstract：INTRODUCTION:Abdominal distension is common in critical illness. There is a growing recognition that intra-abdominal hypertension (IAH) may complicate nonsurgical critical illness as well as after abdominal surgery. However, the pathophysiological basis of the injury to the intestinal mucosal barrier and its influence ...

journal_title：Critical care (London, England)

authors： Cheng J,Wei Z,Liu X,Li X,Yuan Z,Zheng J,Chen X,Xiao G,Li X

更新日期：2013-12-09 00:00:00

abstract：INTRODUCTION:Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possib...

journal_title：Critical care (London, England)

authors： Yang R,Zou X,Koskinen ML,Tenhunen J

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and patient severity. METHODS:Prospective observational study in critically ill patients. Diaphragm electr...

journal_title：Critical care (London, England)

authors： Sklar MC,Madotto F,Jonkman A,Rauseo M,Soliman I,Damiani LF,Telias I,Dubo S,Chen L,Rittayamai N,Chen GQ,Goligher EC,Dres M,Coudroy R,Pham T,Artigas RM,Friedrich JO,Sinderby C,Heunks L,Brochard L

更新日期：2021-01-11 00:00:00

abstract：INTRODUCTION:Procalcitonin (PCT) has been proposed as a marker of infection in critically ill patients; its level is related to the severity of infection. We evaluated the value of PCT as a marker of bacterial infection for emergency department patients. METHODS:This prospective observational study consecutively enrol...

journal_title：Critical care (London, England)

authors： Chan YL,Tseng CP,Tsay PK,Chang SS,Chiu TF,Chen JC

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Although activation of A3 adenosine receptors attenuates reperfusion lung injury and associated apoptosis, the signaling pathway that mediates this protection remains unclear. Adenosine agonists activate mitogen-activated protein kinases, and these kinases have been implicated in ischemia/reperfusion injur...

journal_title：Critical care (London, England)

authors： Matot I,Weiniger CF,Zeira E,Galun E,Joshi BV,Jacobson KA

更新日期：2006-01-01 00:00:00

abstract：:Storage time and residual leukocytes in red blood cell (RBC) units may be deleterious by increasing the accumulation of leukocyte-derived cytokines and by raising the adhesion of RBCs to endothelium. Leukodepleted RBC transfusion may reduce the incidence of infection and organ dysfunction. However, the influence of le...

journal_title：Critical care (London, England)

authors： Tanaka S,Harrois A,Duranteau J

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Respiratory viruses are increasingly recognized as significant etiologies of pneumonia among hospitalized patients. Advanced technologies using multiplex molecular assays and polymerase-chain reaction increase the ability to identify viral pathogens and may ultimately impact antibacterial use. METHOD:This...

journal_title：Critical care (London, England)

authors： Crotty MP,Meyers S,Hampton N,Bledsoe S,Ritchie DJ,Buller RS,Storch GA,Kollef MH,Micek ST

更新日期：2015-11-18 00:00:00

abstract：:Acute pancreatitis results from a sequence of events that involve the systemic inflammatory response. Activated C has multiple anti-inflammatory activities and may attenuate the degree of pancreatic injury and systemic organ dysfunction when infused early in pancreatitis. ...

journal_title：Critical care (London, England)

authors： Kirschenbaum L,Astiz M

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Ventilator-associated pneumonia (VAP) remains a common hazardous complication in mechanically ventilated patients and is associated with increased morbidity and mortality. We undertook a systematic review and meta-analysis of randomized controlled trials to assess the effect of toothbrushing as a component...

journal_title：Critical care (London, England)

authors： Gu WJ,Gong YZ,Pan L,Ni YX,Liu JC

更新日期：2012-10-12 00:00:00

abstract：INTRODUCTION:Early multimodal treatment of severe sepsis, including the use of drotrecogin alfa (activated) (DrotAA) when indicated, is considered essential for optimum outcome. However, predicting which infected patients will progress to severe sepsis and the need for aggressive intervention continues to be problemati...

journal_title：Critical care (London, England)

authors： Hodder RV,Hall R,Russell JA,Fisher HN,Lee B

更新日期：2009-01-01 00:00:00

abstract：:Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cerebral herniation. Decompressive craniectomy (DC) is a surgical technique aiming to open the "closed box" repres...

journal_title：Critical care (London, England)

authors： Beez T,Munoz-Bendix C,Steiger HJ,Beseoglu K

更新日期：2019-06-07 00:00:00

abstract：INTRODUCTION:The present study examined the median survival, life expectancies, and cumulative incidence rate (CIR) of patients undergoing prolonged mechanical ventilation (PMV) stratified by different underlying diseases. METHODS:According to the National Health Insurance Research Database of Taiwan, there were 8,906...

journal_title：Critical care (London, England)

authors： Hung MC,Lu HM,Chen L,Hu FC,Chan SY,Yan YH,Fan PS,Lin MS,Chen CR,Kuo LC,Yu CJ,Wang JD

更新日期：2011-01-01 00:00:00

abstract：:Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condi...

journal_title：Critical care (London, England)

authors： Rhodes A,Cecconi M

更新日期：2012-11-08 00:00:00

abstract：:Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Aboab J,Mansart A,Annane D

更新日期：2009-01-01 00:00:00

abstract：:Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...

journal_title：Critical care (London, England)

authors： Gerlach H

更新日期：2004-12-01 00:00:00

abstract：:A progressive rise of oxidative stress due to altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signaling messengers for the evolution and...

journal_title：Critical care (London, England)

authors： Haddad JJ

更新日期：2003-02-01 00:00:00

abstract：:Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...

journal_title：Critical care (London, England)

authors： Beck GCh,Brinkkoetter P,Hanusch C,Schulte J,van Ackern K,van der Woude FJ,Yard BA

更新日期：2004-12-01 00:00:00

abstract：:BACKGROUND: That thrombocytopenia results in increased mortality or transfusion requirements has not been confirmed by previous studies. We performed a case-control study in which 36 patients who developed severe thrombocytopenia of less than 50x109 platelets/l were carefully matched for the severity of underlying dis...

journal_title：Critical care (London, England)

authors： Stephan F,Montblanc Jd,Cheffi A,Bonnet F

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Fever is associated with a poor outcome in severely brain-injured patients, and its control is one of the therapies used in this condition. But, fever suppression may promote infection, and severely brain-injured patients are frequently exposed to infectious diseases, particularly ventilator-associated pne...

journal_title：Critical care (London, England)

authors： Launey Y,Nesseler N,Le Cousin A,Feuillet F,Garlantezec R,Mallédant Y,Seguin P

更新日期：2014-12-15 00:00:00

abstract：INTRODUCTION:Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieved is still not clearly defined. The aim of the present study was to evaluate the dynamics of the a...

journal_title：Critical care (London, England)

authors： de Pont AC,Bakhtiari K,Hutten BA,de Jonge E,Vroom MB,Meijers JC,Büller HR,Levi M

更新日期：2005-10-05 00:00:00

abstract：:Venovenous extracorporeal membrane oxygenation (vv-ECMO) has been classically employed as a rescue therapy for patients with respiratory failure not treatable with conventional mechanical ventilation alone. In recent years, however, the timing of ECMO initiation has been readdressed and ECMO is often started earlier i...

journal_title：Critical care (London, England)

authors： Langer T,Santini A,Bottino N,Crotti S,Batchinsky AI,Pesenti A,Gattinoni L

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND:Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk o...

journal_title：Critical care (London, England)

authors： Favre E,Bernini A,Morelli P,Pasquier J,Miroz JP,Abed-Maillard S,Ben-Hamouda N,Oddo M

更新日期：2020-02-24 00:00:00

abstract：INTRODUCTION:This prospective study aimed to assess whether use of the subxiphoid acoustic window in transthoracic echocardiography (TTE) can be an accurate alternative in the absence of an apical view to assess hemodynamic parameters. METHODS:This prospective study took place in a teaching hospital medical ICU. Over ...

journal_title：Critical care (London, England)

authors： Maizel J,Salhi A,Tribouilloy C,Massy ZA,Choukroun G,Slama M

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:The association between isolated admission heart rate (HR) and prognosis has been discussed, but not that between gross HR change and neurological outcome in patients with severe traumatic brain injury (TBI). In the acute phase of severe TBI, HR is influenced by several factors (e.g., pain, sympathetic activ...

journal_title：Critical care (London, England)

authors： Inoue A,Hifumi T,Kuroda Y,Nishimoto N,Kawakita K,Yamashita S,Oda Y,Dohi K,Kobata H,Suehiro E,Maekawa T,Brain Hypothermia (B-HYPO) Study Group in Japan.

更新日期：2018-12-19 00:00:00

abstract：:The pathogenesis of sepsis-induced multiple organ failure may crucially depend on the development of mitochondrial dysfunction and consequent cellular energetic failure. According to this hypothesis, interventions aimed at preventing or reversing mitochondrial damage may have major clinical relevance, although the tim...

journal_title：Critical care (London, England)

authors： Protti A,Singer M

更新日期：2006-01-01 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Jonkman AH,de Vries HJ,Heunks LMA

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients. METHODS:This retrospective observational study in a general ICU of a university hospital included a total of 153 patients with sepsis, severe seps...

journal_title：Critical care (London, England)

authors： Nakamura M,Oda S,Sadahiro T,Watanabe E,Abe R,Nakada TA,Morita Y,Hirasawa H

更新日期：2012-12-12 00:00:00

abstract：:The Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock recommend that the initial hemodynamic resuscitation be done according to the protocol used by Rivers and colleagues in their well-known early goal-directed therapy (EGDT) study. However, it may well be that their patients we...

journal_title：Critical care (London, England)

authors： Perel A

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammatory cytokine expression and decreased expression of proinflammatory cytokines. In this study, we sou...

journal_title：Critical care (London, England)

authors： Wu HP,Shih CC,Lin CY,Hua CC,Chuang DY

更新日期：2011-01-01 00:00:00

abstract：:Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known a...

journal_title：Critical care (London, England)

authors： Souza-Fonseca-Guimaraes F,Cavaillon JM,Adib-Conquy M

更新日期：2013-08-27 00:00:00