Recombinant human activated protein C resets thrombin generation in patients with severe sepsis - a case control study.

abstract：:Severe sepsis and septic shock are among the leading causes of mortality in the intensive care unit. Over a decade ago, early goal-directed therapy (EGDT) emerged as a novel approach for reducing sepsis mortality and was incorporated into guidelines published by the international Surviving Sepsis Campaign. In addition...

journal_title：Critical care (London, England)

authors： Gupta RG,Hartigan SM,Kashiouris MG,Sessler CN,Bearman GM

更新日期：2015-08-28 00:00:00

abstract：:Severe sepsis is more and more frequent, especially because of an increased rate of immunocompromised patients. Despite the improvement in the overall prognosis of HIV/AIDS patients and the improvement of global ICU care, the prognosis of HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. This situ...

journal_title：Critical care (London, England)

authors： Timsit JF

更新日期：2005-01-01 00:00:00

abstract：: ...

journal_title：Critical care (London, England)

authors： Virk HS,Wiersinga WJ

更新日期：2019-02-13 00:00:00

abstract：:Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Aboab J,Mansart A,Annane D

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Early identification of predictors for a poor long-term outcome in patients who survive the initial phase of out-of-hospital cardiac arrest (OHCA) may facilitate future clinical research, the process of care and information provided to relatives. The aim of this study was to determine the association between...

journal_title：Critical care (London, England)

authors： Martinell L,Nielsen N,Herlitz J,Karlsson T,Horn J,Wise MP,Undén J,Rylander C

更新日期：2017-04-13 00:00:00

abstract：:Using biomarkers as a guide to tailor the duration of antibiotic treatment in respiratory infections is an attractive hypothesis assessed in several studies. Recent work aiming to summarize the evidence assessed the effect of a procalcitonin (PCT)-guided antibiotic treatment on outcomes in acute lower respiratory trac...

journal_title：Critical care (London, England)

authors： Lisboa T,Salluh J,Povoa P

更新日期：2018-01-27 00:00:00

abstract：INTRODUCTION:The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patients. Unfortunately, processes such as gene transcription and drug metabolism are dynamic in the cr...

journal_title：Critical care (London, England)

authors： Celi LA,Hinske LC,Alterovitz G,Szolovits P

更新日期：2008-01-01 00:00:00

abstract：:The present review introduces the notion of statistical power and the hazard of under-powered studies. The problem of how to calculate an ideal sample size is also discussed within the context of factors that affect power, and specific methods for the calculation of sample size are presented for two common scenarios, ...

journal_title：Critical care (London, England)

authors： Whitley E,Ball J

更新日期：2002-08-01 00:00:00

abstract：INTRODUCTION:Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-mobility group box 1 (HMGB1). In the current study we sought to determine the functional role o...

journal_title：Critical care (London, England)

authors： Achouiti A,van der Meer AJ,Florquin S,Yang H,Tracey KJ,van 't Veer C,de Vos AF,van der Poll T

更新日期：2013-12-16 00:00:00

abstract：:Great variability exists in data collection and coding of variables in studies on traumatic brain injury (TBI). This confounds comparison of results and analysis of data across studies. The difficulties in performing a meta-analysis of individual patient data were recently illustrated in the IMPACT project (Internatio...

journal_title：Critical care (London, England)

authors： Maas AI

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Sedation overuse is frequent and possibly associated with poor outcomes in the intensive care unit (ICU) patients. However, the association of early oversedation with clinical outcomes has not been thoroughly evaluated. The aim of this study was to assess the association of early sedation strategies with o...

journal_title：Critical care (London, England)

authors： Tanaka LM,Azevedo LC,Park M,Schettino G,Nassar AP,Réa-Neto A,Tannous L,de Souza-Dantas VC,Torelly A,Lisboa T,Piras C,Carvalho FB,Maia Mde O,Giannini FP,Machado FR,Dal-Pizzol F,de Carvalho AG,dos Santos RB,Tierno PF,

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:Critically ill patients in the intensive care unit (ICU) are at high risk for developing Clostridioides difficile infections (CDI). Risk factors predicting their mortality or standardized treatment recommendations have not been defined for this cohort. Our goal is to determine outcome and mortality associate...

journal_title：Critical care (London, England)

authors： Manthey CF,Dranova D,Christner M,Drolz A,Kluge S,Lohse AW,Fuhrmann V

更新日期：2019-12-09 00:00:00

abstract：INTRODUCTION:Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage t...

journal_title：Critical care (London, England)

authors： Ranucci M,Carlucci C,Isgrò G,Boncilli A,De Benedetti D,De la Torre T,Brozzi S,Frigiola A

更新日期：2009-01-01 00:00:00

abstract：:The previous review in this series introduced the notion of data description and outlined some of the more common summary measures used to describe a dataset. However, a dataset is typically only of interest for the information it provides regarding the population from which it was drawn. The present review focuses on...

journal_title：Critical care (London, England)

authors： Whitley E,Ball J

更新日期：2002-04-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to identify and characterize the most highly cited clinical research articles published on sepsis. METHODS:A comprehensive list of citation classics in sepsis was generated by searching the database of Web of Science-Expanded (1970 to present) using keywords 'sepsis' or 'se...

journal_title：Critical care (London, England)

authors： Tao T,Zhao X,Lou J,Bo L,Wang F,Li J,Deng X

更新日期：2012-06-26 00:00:00

abstract：INTRODUCTION:Acute kidney injury (AKI) is a frequent complication after cardiac surgery with cardiopulmonary bypass in infants. Renal near-infrared spectroscopy (NIRS) is used to evaluate regional oximetry in a non-invasive continuous real-time fashion, and reflects tissue perfusion. The aim of this study was to evalua...

journal_title：Critical care (London, England)

authors： Ruf B,Bonelli V,Balling G,Hörer J,Nagdyman N,Braun SL,Ewert P,Reiter K

更新日期：2015-01-29 00:00:00

abstract：:BACKGROUND: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. RESULTS: A portable, battery-powered blood analyzer was used on patients in life threatening conditions to determine pH, pCO2, pO2, sodium, potassium and ionized c...

journal_title：Critical care (London, England)

authors： Prause G,Ratzenhofer-Komenda B,Offner A,Lauda P,Voit H,Pojer H

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Recent evidence suggests a link between excess lipid peroxidation and specific organ failures in sepsis. No study has been performed in sepsis by multidrug-resistant (MDR) Gram-negative bacteria. METHODS:Lethal sepsis was induced in rats by the intraperitoneal injection of one MDR isolate of Pseudomonas a...

journal_title：Critical care (London, England)

authors： Toufekoula C,Papadakis V,Tsaganos T,Routsi C,Orfanos SE,Kotanidou A,Carrer DP,Raftogiannis M,Baziaka F,Giamarellos-Bourboulis EJ

更新日期：2013-01-16 00:00:00

abstract：INTRODUCTION:Data on prehospital and trauma-room fluid management of multiple trauma patients with pelvic disruptions are rarely reported. Present trauma algorithms recommend early hemorrhage control and massive fluid resuscitation. By matching the German Pelvic Injury Register (PIR) with the TraumaRegister DGU (TR) fo...

journal_title：Critical care (London, England)

authors： Burkhardt M,Nienaber U,Pizanis A,Maegele M,Culemann U,Bouillon B,Flohé S,Pohlemann T,Paffrath T,TraumaRegister DGU.,German Pelvic Injury Register of the Deutsche Gesellschaft für Unfallchirurgie.

更新日期：2012-08-22 00:00:00

abstract：INTRODUCTION:Sepsis is a serious medical condition that requires rapidly administered, appropriate antibiotic treatment. Conventional methods take three or more days for final pathogen identification and antimicrobial susceptibility testing. We organized a prospective observational multicenter study in three study site...

journal_title：Critical care (London, England)

authors： Yanagihara K,Kitagawa Y,Tomonaga M,Tsukasaki K,Kohno S,Seki M,Sugimoto H,Shimazu T,Tasaki O,Matsushima A,Ikeda Y,Okamoto S,Aikawa N,Hori S,Obara H,Ishizaka A,Hasegawa N,Takeda J,Kamihira S,Sugahara K,Asari S,Mur

更新日期：2010-01-01 00:00:00

abstract：:There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework fo...

journal_title：Critical care (London, England)

authors： Kempker JA,Wang HE,Martin GS

更新日期：2018-05-06 00:00:00

abstract：INTRODUCTION:To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive care units (ICUs). METHODS:Prospective, multicenter, observational cohort study in ICUs from 14 French general (non-academic) and university teaching hospitals. Al...

journal_title：Critical care (London, England)

authors： Quenot JP,Binquet C,Kara F,Martinet O,Ganster F,Navellou JC,Castelain V,Barraud D,Cousson J,Louis G,Perez P,Kuteifan K,Noirot A,Badie J,Mezher C,Lessire H,Pavon A

更新日期：2013-04-25 00:00:00

abstract：:Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmen...

journal_title：Critical care (London, England)

authors： Grocott M,Montgomery H,Vercueil A

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Early multimodal treatment of severe sepsis, including the use of drotrecogin alfa (activated) (DrotAA) when indicated, is considered essential for optimum outcome. However, predicting which infected patients will progress to severe sepsis and the need for aggressive intervention continues to be problemati...

journal_title：Critical care (London, England)

authors： Hodder RV,Hall R,Russell JA,Fisher HN,Lee B

更新日期：2009-01-01 00:00:00

abstract：:Recent interest in transfusion management of trauma patients has heightened expectation in the role of blood component therapy in improving patient outcome. Optimal transfusion support in supplementation with fibrinogen has not been defined by high-quality evidence. Current evidence comes mainly from case series and u...

journal_title：Critical care (London, England)

authors： Stanworth SJ,Hunt BJ

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The current shortage of accurate and readily available, validated biomarkers of disease severity in sepsis is an important limitation when attempting to stratify patients into homogeneous groups, in order to study pathogenesis or develop therapeutic interventions. The aim of the present study was to determ...

journal_title：Critical care (London, England)

authors： Bozza FA,Salluh JI,Japiassu AM,Soares M,Assis EF,Gomes RN,Bozza MT,Castro-Faria-Neto HC,Bozza PT

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Mechanical ventilation (MV) with high tidal volumes may induce or aggravate lung injury in critical ill patients. We compared the effects of a protective versus a conventional ventilatory strategy, on systemic and lung production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in patien...

journal_title：Critical care (London, England)

authors： Pinheiro de Oliveira R,Hetzel MP,dos Anjos Silva M,Dallegrave D,Friedman G

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Many patients experience 'relocation stress' when they are transferred from an intensive care unit (ICU) to step-down (high dependency) or general ward care, and much has been written about the psychological causes. This qualitative analysis of in-depth, narrative interviews with former ICU patients explor...

journal_title：Critical care (London, England)

authors： Field K,Prinjha S,Rowan K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the quality of life of critical care survivors. However, data on its burden are conflicting. Therefore, this s...

journal_title：Critical care (London, England)

authors： Righy C,Rosa RG,da Silva RTA,Kochhann R,Migliavaca CB,Robinson CC,Teche SP,Teixeira C,Bozza FA,Falavigna M

更新日期：2019-06-11 00:00:00

abstract：:Cardiogenic shock is a lethal condition. Physicians are searching for hemodynamic markers which could help risk-stratification of patients in this picture. Torgersen and coworkers present an hourly time integral of the cardiac power index and cardiac index drops to predict outcomes in the setting of cardiogenic shock....

journal_title：Critical care (London, England)

authors： Yilmaz MB,Mebazaa A

更新日期：2009-01-01 00:00:00