Bench-to-bedside review: the initial hemodynamic resuscitation of the septic patient according to Surviving Sepsis Campaign guidelines--does one size fit all?

abstract：:Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Aboab J,Mansart A,Annane D

更新日期：2009-01-01 00:00:00

abstract：:Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI among ICU patients is estimated at 0.4-4% and has severe impact on morbidity and mortality. An estimated 10-20%...

journal_title：Critical care (London, England)

authors： Prechter F,Katzer K,Bauer M,Stallmach A

更新日期：2017-10-22 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Bassetti M,Bandera A,Gori A

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:Delivery of bronchodilators with a metered-dose inhaler (MDI) and a spacer device in mechanically ventilated patients has become a widespread practice. However, except for the short-acting beta2-agonist salbutamol, the duration of action of other bronchodilators, including long-acting beta2-agonists, deliv...

journal_title：Critical care (London, England)

authors： Malliotakis P,Linardakis M,Gavriilidis G,Georgopoulos D

更新日期：2008-01-01 00:00:00

abstract：:Acute pancreatitis is an inflammatory disease process which may present with clinical manifestations ranging from benign self-limited disease to overwhelming sepsis. The ability to predict outcome would be helpful in developing treatment plans, and possibly in stratifying patients for clinical trials. ...

journal_title：Critical care (London, England)

authors： Rotstein OD

更新日期：2014-10-20 00:00:00

abstract：INTRODUCTION:Prothrombin complex concentrates (PCC) are haemostatic blood preparations indicated for urgent anticoagulation reversal, though the optimal dose for effective reversal is still under debate. The latest generation of PCCs include four coagulation factors, the so-called 4-factor PCC. The aim of this study wa...

journal_title：Critical care (London, England)

authors： Kerebel D,Joly LM,Honnart D,Schmidt J,Galanaud D,Negrier C,Kursten F,Coriat P,Lex206 Investigator Group.

更新日期：2013-01-10 00:00:00

abstract：:In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest...

journal_title：Critical care (London, England)

authors： Walker PF,Buehner MF,Wood LA,Boyer NL,Driscoll IR,Lundy JB,Cancio LC,Chung KK

更新日期：2015-10-28 00:00:00

abstract：INTRODUCTION:It is unknown whether the reported short-term reduction in cardiac arrests associated with the introduction of the medical emergency team (MET) system can be sustained. METHOD:We conducted a prospective, controlled before-and-after examination of the effect of a MET system on the long-term incidence of ca...

journal_title：Critical care (London, England)

authors： Jones D,Bellomo R,Bates S,Warrillow S,Goldsmith D,Hart G,Opdam H,Gutteridge G

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Patients with sepsis often demonstrate severely impaired immune responses. The hallmark of this state of immunoparalysis is monocytic deactivation characterized by decreased human leukocyte antigen (HLA)-DR expression and reduced production of proinflammatory cytokines. Recently, diminished numbers of dend...

journal_title：Critical care (London, England)

authors： Poehlmann H,Schefold JC,Zuckermann-Becker H,Volk HD,Meisel C

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill patients remains an understudied area. Previous studies have identified that acute tubular necrosis (ATN) is not the only driver of sepsis-AKI. The focus of this study was to identify additional candidate processes that may driv...

journal_title：Critical care (London, England)

authors： Aslan A,van den Heuvel MC,Stegeman CA,Popa ER,Leliveld AM,Molema G,Zijlstra JG,Moser J,van Meurs M

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Distinguishing the predominant shock subtype with widely available clinical metrics may have prognosti...

journal_title：Critical care (London, England)

authors： Anderson RJ,Jinadasa SP,Hsu L,Ghafouri TB,Tyagi S,Joshua J,Mueller A,Talmor D,Sell RE,Beitler JR

更新日期：2018-06-15 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Jonkman AH,de Vries HJ,Heunks LMA

更新日期：2020-03-24 00:00:00

abstract：:There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework fo...

journal_title：Critical care (London, England)

authors： Kempker JA,Wang HE,Martin GS

更新日期：2018-05-06 00:00:00

abstract：:Tight glycemic control has engendered large numbers of investigations, with conflicting results. The world has largely embraced intensive insulin as a practice, but applies this therapy with great variability in the manner of glucose control and measurement. The present commentary reviews what we actually know with ce...

journal_title：Critical care (London, England)

authors： Nasraway SA Jr,Rattan R

更新日期：2010-01-01 00:00:00

abstract：:Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this ...

journal_title：Critical care (London, England)

authors： Venkataraman R,Subramanian S,Kellum JA

更新日期：2003-04-01 00:00:00

abstract：INTRODUCTION:Mobilisation of patients in the intensive care unit (ICU) is an area of growing research. Currently, there is little data on baseline mobilisation practises and the barriers to them for patients of all admission diagnoses. METHODS:The objectives of the study were to (1) quantify and benchmark baseline lev...

journal_title：Critical care (London, England)

authors： Harrold ME,Salisbury LG,Webb SA,Allison GT,Australia and Scotland ICU Physiotherapy Collaboration.

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS:We used a unique ICU model where rats wer...

journal_title：Critical care (London, England)

authors： Llano-Diez M,Cheng AJ,Jonsson W,Ivarsson N,Westerblad H,Sun V,Cacciani N,Larsson L,Bruton J

更新日期：2016-08-10 00:00:00

abstract：BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...

journal_title：Critical care (London, England)

authors： Wu CP,Xu YJ,Wang TG,Ku SC,Chan DC,Lee JJ,Wei YC,Hsiao TY,Chen CC

更新日期：2019-11-09 00:00:00

abstract：INTRODUCTION:Current concepts of the pathophysiology of acute pancreatitis suggest that disease progression from acinar injury to systemic illness involves a complex interplay between cellular and soluble inflammatory mediators and endothelial beds. To date, there is no specific pharmacologic intervention for acute pan...

journal_title：Critical care (London, England)

authors： Jamdar S,Siriwardena AK

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Hyperbilirubinaemia is a common occurrence in patients who are admitted to intensive care units (ICUs) after major surgery, and it is associated with high mortality. We investigated the incidence of hyperbilirubinaemia after two major types of thoracic surgery: open-heart surgery and oesophagectomy. In order...

journal_title：Critical care (London, England)

authors： Hosotsubo KK,Nishimura M,Nishimura S

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Candidemia is an opportunistic infection associated with high morbidity and mortality in patients hospitalized both inside and outside intensive care units (ICUs). Identification of patients at risk is crucial to ensure prompt antifungal therapy. We sought to assess risk factors for candidemia and death, bot...

journal_title：Critical care (London, England)

authors： Poissy J,Damonti L,Bignon A,Khanna N,Von Kietzell M,Boggian K,Neofytos D,Vuotto F,Coiteux V,Artru F,Zimmerli S,Pagani JL,Calandra T,Sendid B,Poulain D,van Delden C,Lamoth F,Marchetti O,Bochud PY,FUNGINOS.,Allfun F

更新日期：2020-03-18 00:00:00

abstract：:Facilitation of early spontaneous breathing activity is the most important measure to shorten weaning and avoid ventilator-induced lung injury and diaphragmatic injury in mechanically ventilated patients. However, the optimal degree of spontaneous muscle activity and ventilator support remains to be determined. Furthe...

journal_title：Critical care (London, England)

authors： Calzia E,Dembinski R

更新日期：2013-11-19 00:00:00

abstract：INTRODUCTION:The objective of the study was to describe the pharmacokinetics (PK) of fluconazole, anidulafungin, and caspofungin in critically ill patients and to compare with previously published data. We also sought to determine whether contemporary fluconazole doses achieved PK/pharmacodynamic (PD; PK/PD) targets in...

journal_title：Critical care (London, England)

authors： Sinnollareddy MG,Roberts JA,Lipman J,Akova M,Bassetti M,De Waele JJ,Kaukonen KM,Koulenti D,Martin C,Montravers P,Rello J,Rhodes A,Starr T,Wallis SC,Dimopoulos G,DALI Study authors.

更新日期：2015-02-04 00:00:00

abstract：INTRODUCTION:Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammatory cytokine expression and decreased expression of proinflammatory cytokines. In this study, we sou...

journal_title：Critical care (London, England)

authors： Wu HP,Shih CC,Lin CY,Hua CC,Chuang DY

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is a life-saving therapy in acute respiratory distress syndrome (ARDS) patients but is associated with complications and costs. Here, we validate various scores supposed to predict mortality and develop an optimized categorical model. METHODS:In a derivation cohort...

journal_title：Critical care (London, England)

authors： Hilder M,Herbstreit F,Adamzik M,Beiderlinden M,Bürschen M,Peters J,Frey UH

更新日期：2017-12-12 00:00:00

abstract：:Large numbers of patients who survive critical illness are left with significant new cognitive impairments that are often severe and remain years after hospital discharge. In the previous issue of Critical Care, Guerra and colleagues assessed risk factors for the development of dementia after an intensive care unit (I...

journal_title：Critical care (London, England)

authors： Hopkins RO

更新日期：2013-02-06 00:00:00

abstract：INTRODUCTION:Cardiac surgery using cardiopulmonary bypass in newborns, infants and small children often requires intraoperative red blood cell transfusions to prime the circuit and oxygenator and to replace blood lost during surgery. The purpose of this study was to investigate the influence of red blood cell storage t...

journal_title：Critical care (London, England)

authors： Ranucci M,Carlucci C,Isgrò G,Boncilli A,De Benedetti D,De la Torre T,Brozzi S,Frigiola A

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Delirium occurs in most ventilated patients and is independently associated with more deaths, longer stay, and higher cost. Guidelines recommend monitoring of delirium in all intensive care unit (ICU) patients, though few data exist in non-ventilated patients. The study objective was to determine the relat...

journal_title：Critical care (London, England)

authors： Thomason JW,Shintani A,Peterson JF,Pun BT,Jackson JC,Ely EW

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved. METHODS:We interrogated the Australian New Zealand Intensive Care Society Adult Patient Database to obtain data ...

journal_title：Critical care (London, England)

authors： Bagshaw SM,George C,Bellomo R,ANZICS Database Management Committee.

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Intensive insulin treatment of critically ill patients was seen as a promising method of treatment, though recent studies showed that reducing the blood glucose level below 6 mmol/l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The ...

journal_title：Critical care (London, England)

authors： Žuran I,Poredos P,Skale R,Voga G,Gabrscek L,Pareznik R

更新日期：2009-01-01 00:00:00