Abstract:
:Storage time and residual leukocytes in red blood cell (RBC) units may be deleterious by increasing the accumulation of leukocyte-derived cytokines and by raising the adhesion of RBCs to endothelium. Leukodepleted RBC transfusion may reduce the incidence of infection and organ dysfunction. However, the influence of leukodepletion on microcirculation remains not well defined in ICU patients. In this context, an original study in a previous issue of Critical Care emphasizes the microcirculatory effects of transfusion of leukodepleted RBCs (post-storage leukoreduction) or nonleukodepleted RBCs in septic patients. This study suggests a positive rheological impact of leukodepleted RBCs in septic patients with an increase in sublingual microvascular flow and perfused vessel density. Given the variability in the microvascular response to RBC transfusion in individual patients, there is a need for monitoring the microcirculation to guide transfusion in patients with sepsis rather than deciding to transfuse RBCs according to an arbitrary hemoglobin level. Further studies to identify the microvascular response to RBC transfusion in ICU patients are warranted.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Tanaka S,Harrois A,Duranteau Jdoi
10.1186/cc13811subject
Has Abstractpub_date
2014-04-01 00:00:00pages
128issue
2eissn
1364-8535issn
1466-609Xpii
cc13811journal_volume
18pub_type
评论,杂志文章相关文献
CRITICAL CARE文献大全abstract:BACKGROUND:The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of shock than traditional vital signs alone. In previous literature, use of the reverse shock index (rSI), taken as SBP divided by HR, is recommended instead of SI for hospital...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-018-2014-0
更新日期:2018-04-11 00:00:00
abstract:INTRODUCTION:Uncalibrated arterial pulse power analysis has been recently introduced for continuous monitoring of cardiac index (CI). The aim of the present study was to compare the accuracy of arterial pulse power analysis with intermittent transpulmonary thermodilution (TPTD) before and after cardiopulmonary bypass (...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10065
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Lung protective ventilation requires low tidal volume and suitable positive end-expiratory pressure (PEEP). To date, few methods have been accepted for clinical use to set the appropriate PEEP. The aim of this study was to test the feasibility of PEEP titration guided by ventilation homogeneity using the g...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8860
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Identification of bacterial infections is crucial if treatment is to be initiated early and antibiotics used rationally. The primary objective of this study was to test the efficiency of procalcitonin (PCT) in identifying bacterial/parasitic episodes among febrile adult patients presenting to an emergency ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5926
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular reactivity and their ability to predict outcome in critically ill patients using thenar near-infrared ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1500-5
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARD...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-018-2158-y
更新日期:2018-10-27 00:00:00
abstract::The encouraging results of recent clinical trials on therapy of severe sepsis and septic shock are paralleled by ongoing studies on the epidemiology of sepsis and infection in intensive care unit patients all over the world. The development of network-based systems for assessing morbidity and mortality in intensive ca...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2175
更新日期:2003-10-01 00:00:00
abstract::The epidemiology of severe acute renal failure has dramatically changed in the past decade. Its leading cause is sepsis and the syndrome develops mostly in the intensive care unit as part of multiple organ dysfunction syndrome. After the significant improvements obtained from the mid 1970s to the mid 1990s, the past d...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc4843
更新日期:2006-02-01 00:00:00
abstract:INTRODUCTION:The effect of sepsis on epidermal wound healing has not been previously studied. It was hypothesised that epidermal wound healing is disturbed in severe sepsis. METHODS:Blister wounds were induced in 35 patients with severe sepsis and in 15 healthy controls. The healing of the wounds was followed up by me...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7932
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Staphylococcus (S.) aureus has emerged as an important cause of necrotizing pneumonia. Lung injury during S. aureus pneumonia may be enhanced by local release of damage associated molecular patterns such as high-mobility group box 1 (HMGB1). In the current study we sought to determine the functional role o...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13162
更新日期:2013-12-16 00:00:00
abstract:INTRODUCTION:Patients admitted to intensive care following surgery for faecal peritonitis present particular challenges in terms of clinical management and risk assessment. Collaborating surgical and intensive care teams need shared perspectives on prognosis. We aimed to determine the relationship between dynamic asses...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-015-0931-8
更新日期:2015-05-05 00:00:00
abstract::Carbon dioxide has been monitored in the body using a variety of technologies with a multitude of applications. The monitoring of this common physiologic variable in medicine is an illustrative example of the different levels of evidence that are required before any new health technology should establish itself in cli...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2916
更新日期:2004-08-01 00:00:00
abstract::A new randomised controlled trial suggested that plasma exchange hastened removal from the ventilator in mechanically ventilated children with Guillain-Barré syndrome compared with intravenous immunoglobulin. Two larger trials in adults showed the opposite result. ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10312
更新日期:2011-07-28 00:00:00
abstract::Lobar atelectasis is a common problem caused by a variety of mechanisms including resorption atelectasis due to airway obstruction, passive atelectasis from hypoventilation, compressive atelectsis from abdominal distension and adhesive atelectasis due to increased surface tension. However, evidence-based studies on th...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3766
更新日期:2005-08-01 00:00:00
abstract:INTRODUCTION:Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness, even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. The ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc6999
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Simvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of this research was to report on mortality and cost-effectiveness of simvastatin in patients with ARDS at...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13054-017-1695-0
更新日期:2017-05-17 00:00:00
abstract:INTRODUCTION:Intensive insulin treatment of critically ill patients was seen as a promising method of treatment, though recent studies showed that reducing the blood glucose level below 6 mmol/l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc8202
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possib...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11149
更新日期:2012-01-16 00:00:00
abstract:INTRODUCTION:Critical illness is commonly complicated by hyperglycaemia caused by mediators of stress and inflammation. Severity of disease is the main risk factor for development of hyperglycaemia, but not all severely ill develop hyperglycemia and some do even in mild disease. We hypothesised that acute disease only ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9101
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Severe acute pancreatitis (SAP) requiring admission to a critical care unit is associated with high mortality and long lengths of stay. We describe the case mix, outcome, and activity of admissions with SAP who were identified from a high-quality clinical database. METHODS:We conducted a secondary analysi...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5682
更新日期:2007-01-01 00:00:00
abstract::Respiratory tract obstruction due to a blood clot may result in life threatening ventilatory impairment. Ball valve blood clot obstructions of the airways are rare. A ball valve blood clot acts as a one-way valve, allowing (near) normal air entry into the airways, but (completely) blocking expiration. In a near fatal ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2903
更新日期:2004-10-01 00:00:00
abstract:INTRODUCTION:Appropriate care for patients with tracheostomies in hospital settings is an important issue. Each year more than 7000 patients receive tracheostomies in Australia and New Zealand alone. Many of these tracheostomy patients commence their care in the intensive care unit (ICU) and once stabilised are then tr...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8159
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tr...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc6791
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The performance of N-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) to predict clinical outcomes in ICU patients is unimpressive. We aimed to assess the prognostic value of NT-proBNP, CRP or the combination of both in unselected medical ICU patients. METHODS:A total of 576...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc10004
更新日期:2011-01-01 00:00:00
abstract::Recent studies challenge the utility of central venous pressure monitoring as a surrogate for cardiac preload. Starting with Starling's original studies on the regulation of cardiac output, this review traces the history of the experiments that elucidated the role of central venous pressure in circulatory physiology. ...
journal_title:Critical care (London, England)
pub_type: 历史文章,杂志文章,评审
doi:10.1186/s13054-015-0776-1
更新日期:2015-02-16 00:00:00
abstract::The decision to transfuse a hospitalized patient must balance the known risks of transfusion with the need to provide adequate tissue oxygenation and the appropriate utilization of blood as a scarce resource. The minimum tolerated hemoglobin level is not well established, and considerable variation exists in intensivi...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2846
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Our objective was to evaluate the impact of gastric versus post-pyloric feeding on the incidence of pneumonia, caloric intake, intensive care unit (ICU) length of stay (LOS), and mortality in critically ill and injured ICU patients. METHOD:Data sources were Medline, Embase, Healthstar, citation review of re...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/cc2190
更新日期:2003-06-01 00:00:00
abstract::SARS (severe acute respiratory syndrome) proved an enormous physical and emotional challenge to frontline health care workers throughout the world in late 2002 through to mid 2003. A large percentage of patients (many being health care workers themselves) became critically ill. Unfortunately, clinicians caring for the...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2452
更新日期:2004-04-01 00:00:00
abstract:INTRODUCTION:Improved methods to optimize drug dosing in the critically ill are urgently needed. Traditional prescribing culture involves recognition of factors that mandate dose reduction (such as renal impairment), although optimizing drug exposure, through more frequent or augmented dosing, represents an evolving st...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc12544
更新日期:2013-02-28 00:00:00
abstract:BACKGROUND:This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of haemorrhagic shock. METHODS:Haemorrhagic shock was induced in five healthy, anaesthetized sheep by ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2056-3
更新日期:2018-05-29 00:00:00