Abstract:
:A progressive rise of oxidative stress due to altered reduction-oxidation (redox) homeostasis appears to be one of the hallmarks of the processes that regulate gene transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signaling messengers for the evolution and perpetuation of the inflammatory process that is often associated with the condition of oxidative stress, which involves genetic regulation. Changes in the pattern of gene expression through reactive oxygen species/reactive nitrogen species-sensitive regulatory transcription factors are crucial components of the machinery that determines cellular responses to oxidative/redox conditions. The present review describes the basic components of the intracellular oxidative/redox control machinery and its crucial regulation of oxygen-sensitive and redox-sensitive transcription factors within the context of lung injury. Particularly, the review discusses mechanical ventilation and NF-kappaB-mediated lung injury, ischemia-reperfusion and transplantation, compromised host defense and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lung injury. Changes in the pattern of gene expression through regulatory transcription factors are therefore crucial components of the machinery that determines cellular responses to oxidative/redox stress.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Haddad JJdoi
10.1186/cc1840keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
47-54issue
1eissn
1364-8535issn
1466-609Xjournal_volume
7pub_type
杂志文章,评审相关文献
CRITICAL CARE文献大全abstract:BACKGROUND:In patients intubated for mechanical ventilation, prolonged diaphragm inactivity could lead to weakness and poor outcome. Time to resume a minimal diaphragm activity may be related to sedation practice and patient severity. METHODS:Prospective observational study in critically ill patients. Diaphragm electr...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03435-y
更新日期:2021-01-11 00:00:00
abstract:INTRODUCTION:Sepsis is the leading cause of acute kidney injury (AKI) in critical patients. The optimal timing of initiating renal replacement therapy (RRT) in septic AKI patients remains controversial. The objective of this study is to determine the impact of early or late initiation of RRT, as defined using the simpl...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10252
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:The overall prognosis of critically ill patients with cancer has improved during the past decade. The aim of this study was to identify early prognostic factors of intensive care unit (ICU) mortality in patients with cancer. METHODS:We designed a prospective, consecutive, observational study over a one-ye...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5721
更新日期:2007-01-01 00:00:00
abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-017-1639-8
更新日期:2017-03-21 00:00:00
abstract::The past 15 years have seen major advances in our understanding of severity assessment in community-acquired pneumonia (CAP). Prognostic tools have been promoted to guide all major management decisions in CAP, including admission to the critical care unit. Several recent studies, including the study by Renaud and coll...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc7889
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5037
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Our understanding of septic acute kidney injury (AKI) remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore, we dynamically assessed renal haemodynamic, microvascular and metabolic responses to, and ultrastructural sequelae of, sepsis in...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7164
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Frequency-dependent acceleration of relaxation (FDAR) ensures appropriate ventricular filling at high heart rates and results from accelerated sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) activity independent of calcium removal from the cell. Because lipopolysaccharide (LPS) challenge may indu...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7712
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Hyperbilirubinaemia is a common occurrence in patients who are admitted to intensive care units (ICUs) after major surgery, and it is associated with high mortality. We investigated the incidence of hyperbilirubinaemia after two major types of thoracic surgery: open-heart surgery and oesophagectomy. In order...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc691
更新日期:2000-01-01 00:00:00
abstract::Emergency departments (EDs) face several challenges in maintaining consistent quality care in the face of steadily increasing public demand. Improvements in the survival rate of critically ill patients in the ED are directly related to the advancement of early recognition and treatment. Frequent episodes of overcrowdi...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0692-9
更新日期:2014-12-08 00:00:00
abstract::With imprecise definitions, inexact measurement tools, and flawed study execution, our clinical science often lags behind bedside experience and simply documents what appear to be the apparent faults or validity of ongoing practices. These impressions are later confirmed, modified, or overturned by the results of the ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-017-1904-x
更新日期:2017-12-28 00:00:00
abstract::Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care, Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neur...
journal_title:Critical care (London, England)
pub_type: 评论,信件
doi:10.1186/cc8847
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Extracorporeal lung assist, an extreme resource in patients with acute respiratory failure (ARF), is expanding its indications since knowledge about ventilator-induced lung injury has increased and protective ventilation has become the standard in ARF. METHODS:A prospective study on seven adult sheep was ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5082
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The respiratory variation in pulse pressure (PP) has been established as a dynamic variable of cardiac preload which indicates fluid responsiveness in mechanically ventilated patients. The impact of acute changes in cardiac performance on respiratory fluctuations in PP has not been evaluated until now. We ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5779
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Intensive care medicine is a relatively young discipline that has rapidly grown into a full-fledged medical subspecialty. Intensivists are responsible for managing an ever-increasing number of patients with complex, life-threatening diseases. Several factors may influence their performance, including age, tr...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-1956-6
更新日期:2018-02-21 00:00:00
abstract::The composition and function of intestinal microflora are emerging as integral to both health and disease. During critical illness the normal microbiota are rapidly replaced by pathogenic species as a result of both the physiologic stress itself and the use of antibiotics. In this report, the authors use fecal pH as a...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc11474
更新日期:2012-09-12 00:00:00
abstract:INTRODUCTION:Despite recent interest in measurement of central venous oxygen saturation (ScvO2), there are no published data describing the pattern of ScvO2 changes after major general surgery or any relationship with outcome. METHODS:ScvO2 and other biochemical, physiological and demographic data were prospectively m...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3888
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Unawareness of an asymmetry between the right and left internal jugular vein (IJV) and methodological pitfalls in previous studies raise concerns about such asymmetry. Hence the aim of this prospective non-interventional study was to validate the hypothesis that right IJV diameter is greater than those of ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8200
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Delayed patient admission to the intensive care unit (ICU) due to lack of bed availability is a common problem, but the effect on patient outcome is not fully known. METHODS:A retrospective study was performed using departmental computerised records to determine the effect of delayed ICU admission and tem...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11650
更新日期:2012-10-01 00:00:00
abstract::Coronavirus disease (COVID-19) is an emerging viral infection that is rapidly spreading across the globe. SARS-CoV-2 belongs to the same coronavirus class that caused respiratory illnesses such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). During the SARS and MERS outbreaks, ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03231-8
更新日期:2020-09-23 00:00:00
abstract:INTRODUCTION:In the past two decades, healthcare adopted industrial strategies for process measurement and control. In the industry model, care is taken to avoid minimal deviations from a standard. In healthcare there is scarce data to support that a similar strategy can lead to better outcomes. Briefly, when complianc...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11335
更新日期:2012-05-08 00:00:00
abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease and rapidly escalating epidemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of COVID-19 remains to be elucidated. We aimed to clarify correlation of systemic inflammation with disease s...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03255-0
更新日期:2020-08-27 00:00:00
abstract:INTRODUCTION:Procalcitonin (PCT) and C-reactive protein (CRP) are established markers of infection in the general population. In contrast, several studies reported falsely increased PCT levels in patients receiving T-cell antibodies. We evaluated the validity of these markers in patients scheduled for hemopoietic stem ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7749
更新日期:2009-01-01 00:00:00
abstract::Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2879
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:N-acetylcysteine (NAC) has been shown to improve splanchnic blood flow in experimental studies. This report evaluates the effects of NAC on liver perfusion and lactate signal intensities in the liver tissue of septic shock patients using proton magnetic resonance imaging and spectroscopy. Furthermore, the mo...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2426
更新日期:2004-04-01 00:00:00
abstract:INTRODUCTION:Patients with sepsis often demonstrate severely impaired immune responses. The hallmark of this state of immunoparalysis is monocytic deactivation characterized by decreased human leukocyte antigen (HLA)-DR expression and reduced production of proinflammatory cytokines. Recently, diminished numbers of dend...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7969
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Respiratory viruses are increasingly recognized as significant etiologies of pneumonia among hospitalized patients. Advanced technologies using multiplex molecular assays and polymerase-chain reaction increase the ability to identify viral pathogens and may ultimately impact antibacterial use. METHOD:This...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1120-5
更新日期:2015-11-18 00:00:00
abstract::Respiratory tract obstruction due to a blood clot may result in life threatening ventilatory impairment. Ball valve blood clot obstructions of the airways are rare. A ball valve blood clot acts as a one-way valve, allowing (near) normal air entry into the airways, but (completely) blocking expiration. In a near fatal ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc2903
更新日期:2004-10-01 00:00:00
abstract::The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the best known tools has been the logistic regression model. Recently, a variety of alternative tools, such as artificial neural netwo...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3507
更新日期:2005-04-01 00:00:00
abstract::Tracheal reintubation is a common event in critical care. Elmer and colleagues provide the first comparison of complication rates of initial and subsequent reintubation(s) during the same hospitalization. Their work shows an increased risk of complications associated with reintubation, in particular hypoxemia and hypo...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/s13054-015-0841-9
更新日期:2015-03-27 00:00:00