Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship.

abstract：INTRODUCTION:Partial pressure of end-tidal carbon dioxide (PetCO2) during cardiopulmonary resuscitation (CPR) correlates with cardiac output and consequently has a prognostic value in CPR. In our previous study we confirmed that initial PetCO2 value was significantly higher in asphyxial arrest than in ventricular fibri...

journal_title：Critical care (London, England)

authors： Lah K,Križmarić M,Grmec S

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Thrombomodulin, which is expressed solely on monocytes, along with tissue factor (TF), takes part in coagulation and inflammation. Circulating blood monocytes can be divided into 3 major subtypes on the basis of their receptor phenotype: classical (CD14brightCD16negative, CMs), inflammatory (CD14brightCD16...

journal_title：Critical care (London, England)

authors： Hwang SM,Kim JE,Han KS,Kim HK

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Evidence suggests that dying patients' physical and emotional suffering is inadequately treated in intensive care units. Although there are recommendations regarding decisions to forgo life-sustaining therapy, deciding on withdrawal of life support is difficult, and it is also difficult to decide who shoul...

journal_title：Critical care (London, England)

authors： Fumis RR,Deheinzelin D

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar space. We previously found that endothelial progenitor cell (EPC) exosomes prevent endothelial dysf...

journal_title：Critical care (London, England)

authors： Zhou Y,Li P,Goodwin AJ,Cook JA,Halushka PV,Chang E,Zingarelli B,Fan H

更新日期：2019-02-13 00:00:00

abstract：INTRODUCTION:Blood transfusion in the perioperative period has frequently been associated with an excess of nosocomial infections. Whilst transfused whole blood induces specific host immune alteration that may predispose to nosocomial infections, the immunomodulating properties associated with leukodepleted blood remai...

journal_title：Critical care (London, England)

authors： Fragkou PC,Torrance HD,Pearse RM,Ackland GL,Prowle JR,Owen HC,Hinds CJ,O'Dwyer MJ

更新日期：2014-10-01 00:00:00

abstract：:In the previous issue of Critical Care, Ma and colleagues perform a meta-analysis of five randomized, clinical trials of endothelin antagonists in patients with aneurysmal subarachnoid hemorrhage. There are four trials using clazosentan and one trial with TAK-044. These studies show that endothelin plays an important ...

journal_title：Critical care (London, England)

authors： Macdonald RL

更新日期：2012-11-09 00:00:00

abstract：INTRODUCTION:Frequency-dependent acceleration of relaxation (FDAR) ensures appropriate ventricular filling at high heart rates and results from accelerated sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) activity independent of calcium removal from the cell. Because lipopolysaccharide (LPS) challenge may indu...

journal_title：Critical care (London, England)

authors： Joulin O,Marechaux S,Hassoun S,Montaigne D,Lancel S,Neviere R

更新日期：2009-01-01 00:00:00

abstract：:The early recognition and management of sepsis remain the greatest challenges in the field of critical care medicine. Endothelial injury is one of the hallmarks of sepsis, leading to capillary leak, microcirculatory dysfunction, organ failure, and eventual death in many critically ill patients. The angiogenic growth f...

journal_title：Critical care (London, England)

authors： Giuliano JS Jr,Wheeler DS

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management and the use of adjunct therapy in routine clinical practice for patients fulfilling the Berlin definition of ARDS in mainland China....

journal_title：Critical care (London, England)

authors： Huang X,Zhang R,Fan G,Wu D,Lu H,Wang D,Deng W,Sun T,Xing L,Liu S,Wang S,Cai Y,Tian Y,Zhang Y,Xia J,Zhan Q,CHARDSnet group.

更新日期：2020-08-20 00:00:00

abstract：:Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform. It is important to interpret the results of such studies in view of our limited ability to diagnose and quantify brain dysfunction and to consider our limited understanding of th...

journal_title：Critical care (London, England)

authors： Steiner LA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Serum concentrations of adhesion molecules may be connected to the pathogenesis of secondary brain injury after spontaneous intracerebral hemorrhage (ICH). This study posits the hypothesis that levels of adhesion molecules substantially increase after ICH and are decreased thereafter, and that they can pre...

journal_title：Critical care (London, England)

authors： Wang HC,Lin WC,Lin YJ,Rau CS,Lee TH,Chang WN,Tsai NW,Cheng BC,Kung CT,Lu CH

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The analysis of flow and pressure waveforms generated by ventilators can be useful in the optimization of patient-ventilator interactions, notably in chronic obstructive pulmonary disease (COPD) patients. To date, however, a real clinical benefit of this approach has not been proven. METHODS:The aim of th...

journal_title：Critical care (London, England)

authors： Di Marco F,Centanni S,Bellone A,Messinesi G,Pesci A,Scala R,Perren A,Nava S

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possible to monitor sublingual microcirculatory perfusion over time. The goal of this review is to provide...

journal_title：Critical care (London, England)

authors： den Os MM,van den Brom CE,van Leeuwen ALI,Dekker NAM

更新日期：2020-05-13 00:00:00

abstract：INTRODUCTION:Patients admitted to intensive care following surgery for faecal peritonitis present particular challenges in terms of clinical management and risk assessment. Collaborating surgical and intensive care teams need shared perspectives on prognosis. We aimed to determine the relationship between dynamic asses...

journal_title：Critical care (London, England)

authors： Tridente A,Clarke GM,Walden A,Gordon AC,Hutton P,Chiche JD,Holloway PA,Mills GH,Bion J,Stüber F,Garrard C,Hinds C,GenOSept Investigators.

更新日期：2015-05-05 00:00:00

abstract：INTRODUCTION:Between 1 and 31% of patients suffering out-of-hospital cardiac arrest (OHCA) survive to discharge from hospital. International studies have shown that the level of care provided by the admitting hospital determines survival for patients suffering from OHCA. These data may only be partially transferable to...

journal_title：Critical care (London, England)

authors： Wnent J,Seewald S,Heringlake M,Lemke H,Brauer K,Lefering R,Fischer M,Jantzen T,Bein B,Messelken M,Gräsner JT

更新日期：2012-09-12 00:00:00

abstract：:Adverse events affect approximately 3% to 12% of hospitalized patients. At least a third, but as many as half, of such events are considered preventable. Detection of these events requires investments of time and money. A report in a recent issue of Critical Care used the medical emergency team activation as a trigger...

journal_title：Critical care (London, England)

authors： Amaral AC,Shojania KG

更新日期：2009-01-01 00:00:00

abstract：:The recent bus crash in Switzerland involving many children provides several lessons for the pre-hospital care community. The use of multiple helicopters that are capable of flying at night and that carry advanced medical pre-hospital teams undoubtedly saved lives following the tragedy. We describe the medical respons...

journal_title：Critical care (London, England)

authors： Lyon RM,Sanders J

更新日期：2012-07-11 00:00:00

abstract：INTRODUCTION:In intensive care unit patients we assessed, using bispectral index (BIS) monitoring, whether the addition of magnesium sulphate infusion could decrease the sufentanil infusion required to maintain sedation. PATIENTS AND METHODS:A total of 30 adult patients who were expected to require mechanical ventilat...

journal_title：Critical care (London, England)

authors： Memiş D,Turan A,Karamanlioglu B,Oguzhan N,Pamukçu Z

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Herpes simplex virus (HSV) is frequently detected in the respiratory tract of mechanically ventilated patients. The aim of this study was to assess current evidence to determine whether antiviral therapy is associated with better outcomes in these patients. METHODS:MEDLINE, ISI Web of Science, Cochrane Data...

journal_title：Critical care (London, England)

authors： Hagel S,Scherag A,Schuierer L,Hoffmann R,Luyt CE,Pletz MW,Kesselmeier M,Weis S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failure, and high short-term mortality rates. Hemodynamic dysfunction and activation of endogenous vasoconstrictor systems are thought to contribute to the pathogenesis of ACLF. We explored...

journal_title：Critical care (London, England)

authors： Kerbert AJC,Verspaget HW,Navarro ÀA,Jalan R,Solà E,Benten D,Durand F,Ginès P,van der Reijden JJ,van Hoek B,Coenraad MJ,CANONIC Study Investigators of the EASL-CLIF Consortium.

更新日期：2017-12-21 00:00:00

abstract：BACKGROUND:Providing supplemental amino acids to ICU patients during a 3-h period results in improved whole-body net protein balance, without an increase in amino acid oxidation. The primary objective was to investigate if a 24-h intravenous amino acid infusion in critically ill patients has a sustained effect on whole...

journal_title：Critical care (London, England)

authors： Sundström Rehal M,Liebau F,Tjäder I,Norberg Å,Rooyackers O,Wernerman J

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of shock than traditional vital signs alone. In previous literature, use of the reverse shock index (rSI), taken as SBP divided by HR, is recommended instead of SI for hospital...

journal_title：Critical care (London, England)

authors： Kimura A,Tanaka N

更新日期：2018-04-11 00:00:00

abstract：:A relative immunosuppression is observed in patients after sepsis, trauma, burns, or any severe insults. It is currently proposed that selected patients will benefit from treatment aimed at boosting their immune systems. However, the host immune response needs to be considered in context with pathogen-type, timing,and...

journal_title：Critical care (London, England)

authors： Cavaillon JM,Eisen D,Annane D

更新日期：2014-03-24 00:00:00

abstract：BACKGROUND:Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin ...

journal_title：Critical care (London, England)

authors： Lundberg OHM,Lengquist M,Spångfors M,Annborn M,Bergmann D,Schulte J,Levin H,Melander O,Frigyesi A,Friberg H

更新日期：2020-11-04 00:00:00

abstract：INTRODUCTION:Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytosis, and bioavailabili...

journal_title：Critical care (London, England)

authors： Davis JS,Yeo TW,Piera KA,Woodberry T,Celermajer DS,Stephens DP,Anstey NM

更新日期：2010-01-01 00:00:00

abstract：:Carbon dioxide is a waste product of aerobic cellular respiration in all aerobic life forms. PaCO2 represents the balance between the carbon dioxide produced and that eliminated. Hypocapnia remains a common - and generally underappreciated - component of many disease states, including early asthma, high-altitude pulmo...

journal_title：Critical care (London, England)

authors： Curley G,Laffey JG,Kavanagh BP

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Delivery of bronchodilators with a metered-dose inhaler (MDI) and a spacer device in mechanically ventilated patients has become a widespread practice. However, except for the short-acting beta2-agonist salbutamol, the duration of action of other bronchodilators, including long-acting beta2-agonists, deliv...

journal_title：Critical care (London, England)

authors： Malliotakis P,Linardakis M,Gavriilidis G,Georgopoulos D

更新日期：2008-01-01 00:00:00

abstract：:Thromboelastography and thromboelastometry represent viscoelastic diagnostic methodologies with promising application to diseases of altered coagulation. Their use in trauma-induced coagulopathy as a means of assessing the real-time status of the patient's functional coagulation profile in addition to its impact on ef...

journal_title：Critical care (London, England)

authors： Bluth MH,Kashuk JL

更新日期：2011-01-01 00:00:00

abstract：:Urgent cardiac ultrasound examination in the critical care setting is clinically useful. Application of goal-directed echocardiography in this setting is quite distinct from typical exploratory diagnostic comprehensive echocardiography, because the urgent critical care setting mandates a goal-directed approach. Goal-d...

journal_title：Critical care (London, England)

authors： Walley PE,Walley KR,Goodgame B,Punjabi V,Sirounis D

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS:We used a unique ICU model where rats wer...

journal_title：Critical care (London, England)

authors： Llano-Diez M,Cheng AJ,Jonsson W,Ivarsson N,Westerblad H,Sun V,Cacciani N,Larsson L,Bruton J

更新日期：2016-08-10 00:00:00