Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies?

abstract：:Fluid resuscitation is a cornerstone of intensive care unit patient care, but prediction of the cardiovascular response remains difficult, despite many efforts in clinical research. The concept of responders and nonresponders illustrates such a difficulty. Many techniques have been tested, from strictly non-invasive t...

journal_title：Critical care (London, England)

authors： Payen D

更新日期：2011-01-01 00:00:00

abstract：:Central venous oxygen saturation (ScvO2) >70% or mixed venous oxygen saturation (SvO2) >65% is recommended for both septic and non-septic patients. Although it is the task of experts to suggest clear and simple guidelines, there is a risk of reducing critical care to these simple recommendations. This article reviews ...

journal_title：Critical care (London, England)

authors： Squara P

更新日期：2014-11-10 00:00:00

abstract：:Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant o...

journal_title：Critical care (London, England)

authors： Virzì G,Day S,de Cal M,Vescovo G,Ronco C

更新日期：2014-01-06 00:00:00

abstract：INTRODUCTION:Patients in intensive care units (ICUs) often receive sedation for prolonged periods. In order to better understand the impact of sub-optimal sedation practice on outcomes, we performed a systematic review, including observational studies and controlled trials which were conducted in sedated patients in th...

journal_title：Critical care (London, England)

authors： Jackson DL,Proudfoot CW,Cann KF,Walsh T

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Mechanically ventilated critically ill patients frequently develop ventilator-associated pneumonia (VAP), a life-threatening complication. Proposed preventive measures against VAP include, but are not restricted to, selective decontamination of the digestive tract (SDD), selective oropharyngeal decontamina...

journal_title：Critical care (London, England)

authors： Schultz MJ,Haas LE

更新日期：2011-01-01 00:00:00

abstract：:Stridor is one of the most frequent causes of early extubation failure. The cuff-leak test may help to identify patients at risk to develop post-extubation laryngeal edema. However the discrimination power of the cuff-leak test is highly variable and can be use, at best, to detect patients at risk to develop edema but...

journal_title：Critical care (London, England)

authors： De Backer D

更新日期：2005-02-01 00:00:00

abstract：:The past 25 years have witnessed the development of improved tools with which to predict short-term and long-term outcomes after critical illness. The general paradigm for constructing the best known tools has been the logistic regression model. Recently, a variety of alternative tools, such as artificial neural netwo...

journal_title：Critical care (London, England)

authors： Clermont G

更新日期：2005-04-01 00:00:00

abstract：:Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Improvements in the understanding of the pathophysiological mechanisms of stress hyperglycemia and potential p...

journal_title：Critical care (London, England)

authors： Huberlant V,Preiser JC

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Ultrasound of the lung and quantification of B lines was recently introduced as a novel tool to detect overhydration. In the present study, we aimed to evaluate a four-region protocol of lung ultrasound to determine the pulmonary fluid status in ventilated patients in the intensive care unit. METHODS:Fift...

journal_title：Critical care (London, England)

authors： Enghard P,Rademacher S,Nee J,Hasper D,Engert U,Jörres A,Kruse JM

更新日期：2015-02-06 00:00:00

abstract：INTRODUCTION:Although early use of broad-spectrum antimicrobials in critically ill patients may increase antimicrobial adequacy, uncontrolled use of these agents may select for more-resistant organisms. This study investigated the effects of early use of broad-spectrum antimicrobials in critically ill patients with hos...

journal_title：Critical care (London, England)

authors： Kim JW,Chung J,Choi SH,Jang HJ,Hong SB,Lim CM,Koh Y

更新日期：2012-02-15 00:00:00

abstract：:There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework fo...

journal_title：Critical care (London, England)

authors： Kempker JA,Wang HE,Martin GS

更新日期：2018-05-06 00:00:00

abstract：INTRODUCTION:Fever is frequently observed in critically ill patients. An independent association of fever with increased mortality has been observed in non-neurological critically ill patients with mixed febrile etiology. The association of fever and antipyretics with mortality, however, may be different between infect...

journal_title：Critical care (London, England)

authors： Lee BH,Inui D,Suh GY,Kim JY,Kwon JY,Park J,Tada K,Tanaka K,Ietsugu K,Uehara K,Dote K,Tajimi K,Morita K,Matsuo K,Hoshino K,Hosokawa K,Lee KH,Lee KM,Takatori M,Nishimura M,Sanui M,Ito M,Egi M,Honda N,Okayama

更新日期：2012-02-28 00:00:00

abstract：INTRODUCTION:A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit (SICU). METHODS:An IRB-approved prospective observational study was conducted from January 24, 2010, to ...

journal_title：Critical care (London, England)

authors： Johnson DW,Schmidt UH,Bittner EA,Christensen B,Levi R,Pino RM

更新日期：2013-07-04 00:00:00

abstract：INTRODUCTION:Cardio-renal syndromes are characterized by the impairment of cardiac and renal functions. Plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL), and plasma B-type natriuretic peptide (BNP) are markers of acute kidney injury (AKI) and heart failure (HF), respectively. METHODS:GFR (99mTc-DTP...

journal_title：Critical care (London, England)

authors： Donadio C

更新日期：2014-02-28 00:00:00

abstract：:Three pulse contour systems for monitoring cardiac output - LiDCO Plus™, PiCCO Plus™ and FloTrac™ - were compared in postcardiac surgery patients. None of the three methods demonstrated good trending ability according to concordance analysis. Pulse contour systems remain unreliable in the haemodynamically unstable pat...

journal_title：Critical care (London, England)

authors： Critchley LA

更新日期：2011-01-19 00:00:00

abstract：INTRODUCTION:Transthoracic echocardiography (TTE) is a useful tool for minimally invasive hemodynamic monitoring in the ICU. Dynamic indices (such as the inferior vena cava distensibility index (dIVC)) can be used to predict fluid responsiveness in mechanically ventilated patients. Although quantitative use of the dIVC...

journal_title：Critical care (London, England)

authors： Duwat A,Zogheib E,Guinot P,Levy F,Trojette F,Diouf M,Slama M,Dupont H

更新日期：2014-01-14 00:00:00

abstract：:During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small studies have demonstrated the beneficial effect of intensivists on outcomes in the cri...

journal_title：Critical care (London, England)

authors： Levy MM

更新日期：2013-10-14 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care a...

journal_title：Critical care (London, England)

authors： Pepe PE,Roppolo LP,Fowler RL

更新日期：2015-03-16 00:00:00

abstract：INTRODUCTION:In patients with acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS), recent randomised controlled trials (RCTs) showed a consistent trend of mortality reduction with prone ventilation. We updated a meta-analysis on this topic. METHODS:RCTs that compared ventilation of adult patients...

journal_title：Critical care (London, England)

authors： Abroug F,Ouanes-Besbes L,Dachraoui F,Ouanes I,Brochard L

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Fluid resuscitation is crucial in managing hemodynamically unstable patients. The last decade witnessed the use of pulse pressure variation (PPV) to predict fluid responsiveness. However, as far as we know, no systematic review and meta-analysis has been carried out to evaluate the value of PPV in predicti...

journal_title：Critical care (London, England)

authors： Yang X,Du B

更新日期：2014-11-27 00:00:00

abstract：:Prone ventilation (PV) is a ventilatory strategy that frequently improves oxygenation and lung mechanics in critical illness, yet does not consistently improve survival. While the exact physiologic mechanisms related to these benefits remain unproven, one major theoretical mechanism relates to reducing the abdominal e...

journal_title：Critical care (London, England)

authors： Kirkpatrick AW,Pelosi P,De Waele JJ,Malbrain ML,Ball CG,Meade MO,Stelfox HT,Laupland KB

更新日期：2010-01-01 00:00:00

abstract：:In a group of postoperative patients, Taniguchi and coworkers compared the effect of a computerized system for weaning against 'manual care'. The computerized system involved automatic adjustments to the level of pressure support to achieve a target respiratory rate. Manual care involved adjustments to the level of pr...

journal_title：Critical care (London, England)

authors： Adigüzel N,Güngör G,Tobin MJ

更新日期：2009-01-01 00:00:00

abstract：:Several prognostic markers have been identified for patients admitted with acute cardiogenic pulmonary edema. Most of the markers are based on clinical risk scores. Unlike hypercapnic respiratory failure, acidosis is not an adverse predictor in these patients. Hemodynamic variables that assess pathophysiological mecha...

journal_title：Critical care (London, England)

authors： Schlosshan D,Elliott M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:In order to improve assessment and outcome prediction in patients suffering from traumatic brain injury (TBI), cerebral protein levels in serum have been suggested as biomarkers of injury. However, despite much investigation, biomarkers have yet to reach broad clinical utility in TBI. This study is a 9-year ...

journal_title：Critical care (London, England)

authors： Thelin EP,Jeppsson E,Frostell A,Svensson M,Mondello S,Bellander BM,Nelson DW

更新日期：2016-09-08 00:00:00

abstract：INTRODUCTION:The purpose of this study was to perform a descriptive, content-based analysis on the different forms of documentation for in-flight medical emergencies that are currently provided in the emergency medical kits on board commercial airlines. METHODS:Passenger airlines in the World Airline Directory were co...

journal_title：Critical care (London, England)

authors： Sand M,Morrosch S,Sand D,Altmeyer P,Bechara FG

更新日期：2012-12-12 00:00:00

abstract：:The rate of oxygen consumption by certain tissues is impaired when mice or rats are injected with lipopolysaccharide. A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-...

journal_title：Critical care (London, England)

authors： Fink MP

更新日期：2002-12-01 00:00:00

abstract：:Metrics typically used to report the performance of an early warning score (EWS), such as the area under the receiver operator characteristic curve or C-statistic, are not useful for pre-implementation analyses. Because physiological deterioration has an extremely low prevalence of 0.02 per patient-day, these metrics ...

journal_title：Critical care (London, England)

authors： Romero-Brufau S,Huddleston JM,Escobar GJ,Liebow M

更新日期：2015-08-13 00:00:00

abstract：INTRODUCTION:Fever is associated with a poor outcome in severely brain-injured patients, and its control is one of the therapies used in this condition. But, fever suppression may promote infection, and severely brain-injured patients are frequently exposed to infectious diseases, particularly ventilator-associated pne...

journal_title：Critical care (London, England)

authors： Launey Y,Nesseler N,Le Cousin A,Feuillet F,Garlantezec R,Mallédant Y,Seguin P

更新日期：2014-12-15 00:00:00

abstract：:The decision to withdraw or withhold life supporting treatment in moribund patients is difficult under any circumstances. When the patient becomes incompetent to clarify their wishes regarding continued maintenance in long-term facilities, surrogates sometimes cannot agree, further clouding the issue. We examine a cas...

journal_title：Critical care (London, England)

authors： Buckley T,Crippen D,DeWitt AL,Fisher M,Liolios A,Scheetz CL,Whetstine LM

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:To determine whether single nucleotide polymorphisms (SNPs) in FAS and related genes are associated with acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS). METHODS:We studied 401 (Caucasian N = 310 and African-American N = 91) patients aged ≥ 13 years with ALI who enrol...

journal_title：Critical care (London, England)

authors： Bhatraju P,Hsu C,Mukherjee P,Glavan BJ,Burt A,Mikacenic C,Himmelfarb J,Wurfel M

更新日期：2015-10-19 00:00:00