Abstract:
:The rate of oxygen consumption by certain tissues is impaired when mice or rats are injected with lipopolysaccharide. A similar change in the rate of oxygen consumption is observed when Caco-2 human enterocyte-like cells are incubated in vitro with cytomix, a cocktail of cytokines containing tumor necrosis factor, IL-1beta, and IFN-gamma. The decrease in the rate of oxygen consumption is not due to a change in oxygen delivery (e.g. on the basis of diminished microvascular perfusion), but rather to an acquired intrinsic defect in cellular respiration, a phenomenon that we have termed 'cytopathic hypoxia'. A number of different biochemical mechanisms have been postulated to account for cytopathic hypoxia in sepsis, including reversible inhibition of cytochrome a,a3 by nitric oxide, and irreversible inhibition of one or more mitochondrial respiratory complexes by peroxynitrite. Recently, however, our laboratory has obtained data to suggest that the most important mechanism underlying the development of cytopathic hypoxia is depletion of cellular stores of nicotinamide adenine dinucleotide (NAD+/NADH) as a result of activation of the enzyme, poly(ADP-ribose) polymerase-1. If cytopathic hypoxia is important in the pathophysiology of established sepsis and multiorgan dysfunction syndrome, then efforts in the future will need to focus on pharmacological interventions designed to preserve normal mitochondrial function and energy production in sepsis.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Fink MPdoi
10.1186/cc1824keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
491-9issue
6eissn
1364-8535issn
1466-609Xjournal_volume
6pub_type
杂志文章,评审相关文献
CRITICAL CARE文献大全abstract:INTRODUCTION:Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays, however, have several limitations. A surge of interest exists in the use of point-of-care tests to diagnose hypo- and hypercoagulability in sepsis. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched from 1 Janu...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13721
更新日期:2014-02-10 00:00:00
abstract::Critical care medicine in China has made great advances in recent decades. This has led to an unavoidable issue: end-of-life ethics. With advances in medical technology and therapeutics allowing the seemingly limitless maintenance of life, the exact time of death of an individual patient is often determined by the dec...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13140
更新日期:2013-12-04 00:00:00
abstract:BACKGROUND:Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiological data describing acute nutrition delivery to this group of patients. Furthermore, there is little information describing relationships between nutrition and clinical outcomes in this pop...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1177-1
更新日期:2016-01-07 00:00:00
abstract:INTRODUCTION:Patients admitted to the intensive care unit often develop hyperglycaemia, but the underlying mechanisms have not been fully described. The incretin effect is reduced in patients with type 2 diabetes. Type 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resis...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1118-z
更新日期:2015-11-16 00:00:00
abstract::Hydrogen sulfide (H2S), a gas with the characteristic odor of rotten eggs, is known for its toxicity and as an environmental hazard, inhibition of mitochondrial respiration resulting from blockade of cytochrome c oxidase being the main toxic mechanism. Recently, however, H2S has been recognized as a signaling molecule...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7700
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Mobilisation of patients in the intensive care unit (ICU) is an area of growing research. Currently, there is little data on baseline mobilisation practises and the barriers to them for patients of all admission diagnoses. METHODS:The objectives of the study were to (1) quantify and benchmark baseline lev...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-015-1033-3
更新日期:2015-09-14 00:00:00
abstract:INTRODUCTION:Glial fibrillary acidic protein (GFAP) may serve as a serum marker of traumatic brain injury (TBI) that can be used to monitor biochemical changes in patients and gauge the response to treatment. However, the temporal profile of serum GFAP in the acute period of brain injury and the associated utility for ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1081-8
更新日期:2015-10-12 00:00:00
abstract:BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5037
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Identification of bacterial infections is crucial if treatment is to be initiated early and antibiotics used rationally. The primary objective of this study was to test the efficiency of procalcitonin (PCT) in identifying bacterial/parasitic episodes among febrile adult patients presenting to an emergency ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5926
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Little is known about mortality rates following general surgical procedures in the United Kingdom. Deaths are most common in the 'high-risk' surgical population consisting mainly of older patients, with coexisting medical disease, who undergo major surgery. Only limited data are presently available to desc...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4928
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Ultrasound of the lung and quantification of B lines was recently introduced as a novel tool to detect overhydration. In the present study, we aimed to evaluate a four-region protocol of lung ultrasound to determine the pulmonary fluid status in ventilated patients in the intensive care unit. METHODS:Fift...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-0756-5
更新日期:2015-02-06 00:00:00
abstract:BACKGROUND:Patients with COVID-19 (COVID) may develop acute respiratory distress syndrome with or without sepsis, coagulopathy and visceral damage. While chest CT scans are routinely performed in the initial assessment of patients with severe pulmonary forms, thymus involvement and reactivation have not been investigat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03440-1
更新日期:2021-01-04 00:00:00
abstract:INTRODUCTION:The ventilator and the endotracheal tube impose additional workload in mechanically ventilated patients breathing spontaneously. The total work of breathing (WOB) includes elastic and resistive work. In a bench test we assessed the imposed WOB using 3100 A/3100 B SensorMedics high-frequency oscillatory ven...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3988
更新日期:2006-02-01 00:00:00
abstract:INTRODUCTION:Critical illness is commonly complicated by hyperglycaemia caused by mediators of stress and inflammation. Severity of disease is the main risk factor for development of hyperglycaemia, but not all severely ill develop hyperglycemia and some do even in mild disease. We hypothesised that acute disease only ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9101
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Patients admitted to intensive care following surgery for faecal peritonitis present particular challenges in terms of clinical management and risk assessment. Collaborating surgical and intensive care teams need shared perspectives on prognosis. We aimed to determine the relationship between dynamic asses...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-015-0931-8
更新日期:2015-05-05 00:00:00
abstract:BACKGROUND:Early survival following severe injury has been improved with refined resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among this fragile group of patients leading to prolonged hospital stay and late mortality. MODS after trauma is widely attributed to dysregulated inflammation ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1341-2
更新日期:2016-06-07 00:00:00
abstract:INTRODUCTION:Timely administration of appropriate antibiotic therapy has been shown to improve outcome in hospital-acquired pneumonia (HAP). Empirical treatment guidelines tailored to local ecology have been advocated in antibiotic stewardship programs. We compared a local ecology based algorithm (LEBA) to a surveillan...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13990
更新日期:2014-07-15 00:00:00
abstract:INTRODUCTION:Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality. METHODS:This case report describes a 20 year old previously healthy woman who suffered a severe TBI as a result of a motor vehicle collision and...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3884
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Current concepts of the pathophysiology of acute pancreatitis suggest that disease progression from acinar injury to systemic illness involves a complex interplay between cellular and soluble inflammatory mediators and endothelial beds. To date, there is no specific pharmacologic intervention for acute pan...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3777
更新日期:2005-08-01 00:00:00
abstract:INTRODUCTION:To determine whether single nucleotide polymorphisms (SNPs) in FAS and related genes are associated with acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS). METHODS:We studied 401 (Caucasian N = 310 and African-American N = 91) patients aged ≥ 13 years with ALI who enrol...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1084-5
更新日期:2015-10-19 00:00:00
abstract::Organ donation offers opportunities for people in critical care units to help save the lives of other patients. It is not always easy, however, to handle the transition from treating a patient to preserving a potential donor, and organ donation consistently provokes ethical questions in critical care units. What do we...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9379
更新日期:2011-01-24 00:00:00
abstract:INTRODUCTION:Ventilator-associated pneumonia (VAP) remains a common hazardous complication in mechanically ventilated patients and is associated with increased morbidity and mortality. We undertook a systematic review and meta-analysis of randomized controlled trials to assess the effect of toothbrushing as a component...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/cc11675
更新日期:2012-10-12 00:00:00
abstract:BACKGROUND:The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood beca...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-018-2025-x
更新日期:2018-04-25 00:00:00
abstract:INTRODUCTION:Elevated serum levels of S100beta, an astrocyte-derived protein, correlate with unfavourable neurological outcomes following cardiac surgery, neurotrauma, and resuscitation. This study evaluated whether pre-/postoperative serum S100beta levels correlate with unfavourable clinical and radiological findings ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5058
更新日期:2006-01-01 00:00:00
abstract::Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide polymorphisms will have a tremendous impact on our approach to medicine. New developments in genotyping techniques and bioinformatic...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc1491
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failure, and high short-term mortality rates. Hemodynamic dysfunction and activation of endogenous vasoconstrictor systems are thought to contribute to the pathogenesis of ACLF. We explored...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1894-8
更新日期:2017-12-21 00:00:00
abstract:INTRODUCTION:The objective of this study was to identify and characterize the most highly cited clinical research articles published on sepsis. METHODS:A comprehensive list of citation classics in sepsis was generated by searching the database of Web of Science-Expanded (1970 to present) using keywords 'sepsis' or 'se...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11401
更新日期:2012-06-26 00:00:00
abstract:INTRODUCTION:Evidence suggests that dying patients' physical and emotional suffering is inadequately treated in intensive care units. Although there are recommendations regarding decisions to forgo life-sustaining therapy, deciding on withdrawal of life support is difficult, and it is also difficult to decide who shoul...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc9390
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Appropriate care for patients with tracheostomies in hospital settings is an important issue. Each year more than 7000 patients receive tracheostomies in Australia and New Zealand alone. Many of these tracheostomy patients commence their care in the intensive care unit (ICU) and once stabilised are then tr...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8159
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary to account for pathophysiological changes or renal replacement therapy. Extracorporeal membrane oxygenation (ECMO) is increasingly bei...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03397-1
更新日期:2020-11-25 00:00:00