Bench-to-bedside review: fulfilling promises of the Human Genome Project.


:Since most common diseases have been shown to be influenced by inherited variations in our genes, completion of the Human Genome Project and mapping of the human genome single-nucleotide polymorphisms will have a tremendous impact on our approach to medicine. New developments in genotyping techniques and bioinformatics, enabling detection of single-nucleotide polymorphisms, already provide physicians and scientists with tools that change our understanding of human biology. In the near future, studies will relate genetic polymorphisms to features of critical illnesses, increased susceptibility to common diseases, and altered response to therapy. Novel insights into the contribution of genetic factors to critical illnesses and advances in pharmacogenomics will be used to select the most effective therapeutic agent and the optimal dosage required to elicit the expected drug response for a given individual. Implementation of genetic criteria for patient selection and individual assessment of the risks and benefits of treatment emerges as a major challenge to the pharmaceutical industry.


Crit Care


Chiche JD,Cariou A,Mira JP





Has Abstract


2002-06-01 00:00:00












  • Eubaric hyperoxia: controversies in the management of acute traumatic brain injury.

    abstract::Controversy exists on the role of hyperoxia in major trauma with brain injury. Hyperoxia on arterial blood gas has been associated with acute lung injury and pulmonary complications, impacting clinical outcome. The hyperoxia could be reflective of the physiological interventions following major systemic trauma. Despit...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Narotam PK

    更新日期:2013-10-16 00:00:00

  • Ethics roundtable debate: withdrawal of tube feeding in a patient with persistent vegetative state where the patients wishes are unclear and there is family dissension.

    abstract::The decision to withdraw or withhold life supporting treatment in moribund patients is difficult under any circumstances. When the patient becomes incompetent to clarify their wishes regarding continued maintenance in long-term facilities, surrogates sometimes cannot agree, further clouding the issue. We examine a cas...

    journal_title:Critical care (London, England)

    pub_type: 社论


    authors: Buckley T,Crippen D,DeWitt AL,Fisher M,Liolios A,Scheetz CL,Whetstine LM

    更新日期:2004-04-01 00:00:00

  • Bench-to-bedside review: Bacterial virulence and subversion of host defences.

    abstract::Bacterial pathogens possess an array of specific mechanisms that confer virulence and the capacity to avoid host defence mechanisms. Mechanisms of virulence are often mediated by the subversion of normal aspects of host biology. In this way the pathogen modifies host function so as to promote the pathogen's survival o...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Webb SA,Kahler CM

    更新日期:2008-01-01 00:00:00

  • Intraoperative milrinone versus dobutamine in cardiac surgery patients: a retrospective cohort study on mortality.

    abstract:BACKGROUND:Several choices of inotropic therapy are available and used in relation to cardiac surgery. Comparisons are necessary to select optimal therapy. In Denmark, dobutamine and milrinone are the two inotropic agents most commonly used to treat post-bypass low cardiac output syndrome. This study compares all-cause...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Nielsen DV,Torp-Pedersen C,Skals RK,Gerds TA,Karaliunaite Z,Jakobsen CJ

    更新日期:2018-02-26 00:00:00

  • Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions.

    abstract:INTRODUCTION:Metabolic acidosis during hemorrhagic shock is common and conventionally considered to be due to hyperlactatemia. There is increasing awareness, however, that other nonlactate, unmeasured anions contribute to this type of acidosis. METHODS:Eleven anesthetized dogs were hemorrhaged to a mean arterial press...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Bruegger D,Kemming GI,Jacob M,Meisner FG,Wojtczyk CJ,Packert KB,Keipert PE,Faithfull NS,Habler OP,Becker BF,Rehm M

    更新日期:2007-01-01 00:00:00

  • Association between kidney intracapsular pressure and ultrasound elastography.

    abstract:BACKGROUND:Kidney congestion is a common pathophysiologic pathway of acute kidney injury (AKI) in sepsis and heart failure. There is no noninvasive tool to measure kidney intracapsular pressure (KIP) directly. METHODS:We evaluated the correlation of KIP with kidney elasticity measured by ultrasound surface wave elasto...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Kashani KB,Mao SA,Safadi S,Amiot BP,Glorioso JM,Lieske JC,Nyberg SL,Zhang X

    更新日期:2017-10-19 00:00:00

  • Early postoperative serum S100 beta levels predict ongoing brain damage after meningioma surgery: a prospective observational study.

    abstract:INTRODUCTION:Elevated serum levels of S100beta, an astrocyte-derived protein, correlate with unfavourable neurological outcomes following cardiac surgery, neurotrauma, and resuscitation. This study evaluated whether pre-/postoperative serum S100beta levels correlate with unfavourable clinical and radiological findings ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Einav S,Shoshan Y,Ovadia H,Matot I,Hersch M,Itshayek E

    更新日期:2006-01-01 00:00:00

  • Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury.

    abstract:BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Cepkova M,Brady S,Sapru A,Matthay MA,Church G

    更新日期:2006-01-01 00:00:00

  • Our favorite unproven ideas for future critical care.

    abstract::The future of critical care medicine will be shaped not only by the evidence-validated foundations of science, but also by innovations based on unproven and, in many cases, untested concepts and thoughtful visions of scientists and clinicians familiar with the complex problems actually faced in clinical practice. Clin...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Marini JJ,Vincent JL,Wischmeyer P,Singer M,Gattinoni L,Ince C,Gan TJ

    更新日期:2013-01-01 00:00:00

  • Prognostic value of admission blood glucose level in patients with and without diabetes mellitus who sustain ST segment elevation myocardial infarction complicated by cardiogenic shock.

    abstract:INTRODUCTION:Admission blood glucose (BG) level is a predictor of mortality in patients with ST-segment elevation myocardial infarction (STEMI). However, limited data are available relating admission BG to mortality in patients with STEMI complicated by cardiogenic shock, and it is not known whether diabetic status has...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Yang JH,Song PS,Song YB,Hahn JY,Choi SH,Choi JH,Lee SH,Jeong MH,Kim YJ,Gwon HC

    更新日期:2013-10-03 00:00:00

  • Open the intensive care unit doors to HIV-infected patients with sepsis.

    abstract::Severe sepsis is more and more frequent, especially because of an increased rate of immunocompromised patients. Despite the improvement in the overall prognosis of HIV/AIDS patients and the improvement of global ICU care, the prognosis of HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. This situ...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Timsit JF

    更新日期:2005-01-01 00:00:00

  • Effect of perioperative sodium bicarbonate administration on renal function following cardiac surgery for infective endocarditis: a randomized, placebo-controlled trial.

    abstract:BACKGROUND:Patients with infective endocarditis (IE) have an elevated risk of renal dysfunction because of extensive systemic inflammation and use of nephrotoxic antibiotics. In this randomized, placebo-controlled trial, we investigated whether perioperative sodium bicarbonate administration could attenuate postoperati...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Cho JS,Soh S,Shim JK,Kang S,Choi H,Kwak YL

    更新日期:2017-01-05 00:00:00

  • Whole blood thromboelastometry: another Knight at the Roundtable?

    abstract::Thromboelastography and thromboelastometry represent viscoelastic diagnostic methodologies with promising application to diseases of altered coagulation. Their use in trauma-induced coagulopathy as a means of assessing the real-time status of the patient's functional coagulation profile in addition to its impact on ef...

    journal_title:Critical care (London, England)

    pub_type: 评论,社论


    authors: Bluth MH,Kashuk JL

    更新日期:2011-01-01 00:00:00

  • Alveolar microstrain and the dark side of the lung.

    abstract::Mechanical ventilation associated lung injury (VALI) negatively impacts the outcomes of critically ill patients. Research during the past two decades has led to a better understanding of key physiologic mechanisms of injury, yet uncertainty over the topographical distribution of these mechanisms continues to fuel cont...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章,评审


    authors: Oeckler RA,Hubmayr RD

    更新日期:2007-01-01 00:00:00

  • A pilot study of a new test to predict extubation failure.

    abstract:INTRODUCTION:To determine whether subjecting patients to 100 ml of additional dead space after a 120-minute weaning trial could predict readiness for extubation. METHODS:This was a prospective, non-randomised pilot study in an intensive care unit at a university hospital with 14 beds. It included all non-tracheostomis...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章


    authors: Solsona JF,Díaz Y,Vázquez A,Pilar Gracia M,Zapatero A,Marrugat J

    更新日期:2009-01-01 00:00:00

  • Bench-to-bedside review: the initial hemodynamic resuscitation of the septic patient according to Surviving Sepsis Campaign guidelines--does one size fit all?

    abstract::The Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock recommend that the initial hemodynamic resuscitation be done according to the protocol used by Rivers and colleagues in their well-known early goal-directed therapy (EGDT) study. However, it may well be that their patients we...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Perel A

    更新日期:2008-01-01 00:00:00

  • Information technology issues during and after Katrina and usefulness of the Internet: how we mobilized and utilized digital communications systems.

    abstract::Even more than in previous disasters, Katrina has proven itself to be a testing ground for a plethora of new technologies. Although not all of these technologies did immediately save lives, in this regard a number of them exhibited considerable potential for the future, and hence there is a need to include them in fut...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Leitl E

    更新日期:2006-02-01 00:00:00

  • Feasibility and reliability of an automated controller of inspired oxygen concentration during mechanical ventilation.

    abstract:INTRODUCTION:Hypoxemia and high fractions of inspired oxygen (FiO2) are concerns in critically ill patients. An automated FiO2 controller based on continuous oxygen saturation (SpO2) measurement was tested. Two different SpO2-FiO2 feedback open loops, designed to react differently based on the level of hypoxemia, were ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Saihi K,Richard JC,Gonin X,Krüger T,Dojat M,Brochard L

    更新日期:2014-02-19 00:00:00

  • Rapid response systems: are they really effective?

    abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at Further information about the Annual Update in Intensive Care a...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Sandroni C,D'Arrigo S,Antonelli M

    更新日期:2015-03-16 00:00:00

  • Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.

    abstract:INTRODUCTION:Despite recent modifications, the clinical definition of the acute respiratory distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. This study was designed to test the hypothesis that a biomarker panel would be useful for biologic confirmation of the clinical diagn...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Ware LB,Koyama T,Zhao Z,Janz DR,Wickersham N,Bernard GR,May AK,Calfee CS,Matthay MA

    更新日期:2013-10-24 00:00:00

  • Procalcitonin as a marker of bacterial infection in the emergency department: an observational study.

    abstract:INTRODUCTION:Procalcitonin (PCT) has been proposed as a marker of infection in critically ill patients; its level is related to the severity of infection. We evaluated the value of PCT as a marker of bacterial infection for emergency department patients. METHODS:This prospective observational study consecutively enrol...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chan YL,Tseng CP,Tsay PK,Chang SS,Chiu TF,Chen JC

    更新日期:2004-02-01 00:00:00

  • Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial.

    abstract:BACKGROUND:There is increasing interest in the timely administration of concentrated sources of fibrinogen to patients with major traumatic bleeding. Following evaluation of early cryoprecipitate in the CRYOSTAT 1 trial, we explored the use of fibrinogen concentrate, which may have advantages of more rapid administrati...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Curry N,Foley C,Wong H,Mora A,Curnow E,Zarankaite A,Hodge R,Hopkins V,Deary A,Ray J,Moss P,Reed MJ,Kellett S,Davenport R,Stanworth S

    更新日期:2018-06-18 00:00:00

  • Mechanical ventilation with high tidal volume induces inflammation in patients without lung disease.

    abstract:INTRODUCTION:Mechanical ventilation (MV) with high tidal volumes may induce or aggravate lung injury in critical ill patients. We compared the effects of a protective versus a conventional ventilatory strategy, on systemic and lung production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in patien...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Pinheiro de Oliveira R,Hetzel MP,dos Anjos Silva M,Dallegrave D,Friedman G

    更新日期:2010-01-01 00:00:00

  • Drotrecogin alfa (recombinant human activated protein C) in severe acute pancreatitis.

    abstract:INTRODUCTION:Current concepts of the pathophysiology of acute pancreatitis suggest that disease progression from acinar injury to systemic illness involves a complex interplay between cellular and soluble inflammatory mediators and endothelial beds. To date, there is no specific pharmacologic intervention for acute pan...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Jamdar S,Siriwardena AK

    更新日期:2005-08-01 00:00:00

  • Neuromonitoring of delirium with quantitative pupillometry in sedated mechanically ventilated critically ill patients.

    abstract:BACKGROUND:Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk o...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Favre E,Bernini A,Morelli P,Pasquier J,Miroz JP,Abed-Maillard S,Ben-Hamouda N,Oddo M

    更新日期:2020-02-24 00:00:00

  • Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19.

    abstract::An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Ni W,Yang X,Yang D,Bao J,Li R,Xiao Y,Hou C,Wang H,Liu J,Yang D,Xu Y,Cao Z,Gao Z

    更新日期:2020-07-13 00:00:00

  • Remifentanil for analgesia-based sedation in the intensive care unit.

    abstract::Providing effective analgesia and adequate sedation is a generally accepted goal of intensive care medicine. Due to its rapid, organ independent and predictable metabolism the short acting opioid remifentanil might be particularly useful for analgesia-based sedation in the intensive care unit (ICU). This hypothesis wa...

    journal_title:Critical care (London, England)

    pub_type: 评论,社论


    authors: Kuhlen R,Putensen C

    更新日期:2004-02-01 00:00:00

  • Early use of imipenem/cilastatin and vancomycin followed by de-escalation versus conventional antimicrobials without de-escalation for patients with hospital-acquired pneumonia in a medical ICU: a randomized clinical trial.

    abstract:INTRODUCTION:Although early use of broad-spectrum antimicrobials in critically ill patients may increase antimicrobial adequacy, uncontrolled use of these agents may select for more-resistant organisms. This study investigated the effects of early use of broad-spectrum antimicrobials in critically ill patients with hos...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Kim JW,Chung J,Choi SH,Jang HJ,Hong SB,Lim CM,Koh Y

    更新日期:2012-02-15 00:00:00

  • Retrospective cohort study of hospital variation in airway management during in-hospital cardiac arrest and the association with patient survival: insights from Get With The Guidelines-Resuscitation.

    abstract:IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Bradley SM,Zhou Y,Ramachandran SK,Engoren M,Donnino M,Girotra S

    更新日期:2019-05-06 00:00:00

  • Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsis?

    abstract::The multicenter study conducted by Lorente and coworkers published in the previous issue of Critical Care demonstrates that matrix metalloproteinase (MMP)-9 and MMP-10 and their inhibitor tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are promising novel biomarkers to predict severity and outcome of sepsis. I...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Hoffmann U,Brueckmann M,Borggrefe M

    更新日期:2009-01-01 00:00:00