Abstract:
INTRODUCTION:Critical illness is commonly complicated by hyperglycaemia caused by mediators of stress and inflammation. Severity of disease is the main risk factor for development of hyperglycaemia, but not all severely ill develop hyperglycemia and some do even in mild disease. We hypothesised that acute disease only exposes a latent disturbance of glucose metabolism which puts those patients at higher risk for developing diabetes. METHODS:Medical patients with no history of impaired glucose metabolism or other endocrine disorder admitted to an intensive care unit between July 1998 and June 2004 were considered for inclusion. Glucose was measured at least two times a day, and patients were divided into the hyperglycaemia group (glucose ≥7.8 mmol/l) and normoglycaemia group. An oral glucose tolerance test was performed within six weeks after discharge to disclose patients with unknown diabetes or pre-diabetes who were excluded. Patients treated with corticosteroids and those terminally ill were also excluded from the follow-up which lasted for a minimum of five years with annual oral glucose tolerance tests. RESULTS:A five-year follow-up was completed for 398 patients in the normoglycaemia group, of which 14 (3.5%) developed type 2 diabetes. In the hyperglycaemia group 193 patients finished follow-up and 33 (17.1%) developed type 2 diabetes. The relative risk for type 2 diabetes during five years after the acute illness was 5.6 (95% confidence interval (CI) 3.1 to 10.2). CONCLUSIONS:Patients with hyperglycaemia during acute illness who are not diagnosed with diabetes before or during the hospitalization should be considered a population at increased risk for developing diabetes. They should, therefore, be followed-up, in order to be timely diagnosed and treated.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Gornik I,Vujaklija-Brajkovic A,Renar IP,Gasparovic Vdoi
10.1186/cc9101subject
Has Abstractpub_date
2010-01-01 00:00:00pages
R130issue
4eissn
1364-8535issn
1466-609Xpii
cc9101journal_volume
14pub_type
杂志文章相关文献
CRITICAL CARE文献大全abstract:INTRODUCTION:In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tr...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc6791
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays, however, have several limitations. A surge of interest exists in the use of point-of-care tests to diagnose hypo- and hypercoagulability in sepsis. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched from 1 Janu...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13721
更新日期:2014-02-10 00:00:00
abstract:BACKGROUND:Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China. METHODS:This cross-sectional multicenter study included crit...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03439-8
更新日期:2021-01-05 00:00:00
abstract::Patients in ICUs frequently require tracheostomy for long-term ventilator support, and the percutaneous dilatational tracheostomy (PDT) method is preferred over surgical tracheostomy. The use of ultrasound (US) imaging to guide ICU procedures and interventions has recently emerged as a simple and noninvasive tool. The...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-015-0942-5
更新日期:2015-05-18 00:00:00
abstract:INTRODUCTION:Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric emptying (GE) and ab...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8021
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, drug factors, such as onset of action and side effects, and patient factors, such as age, renal, and...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-018-2066-1
更新日期:2018-06-07 00:00:00
abstract:INTRODUCTION:Sepsis is characterized by systemic microvascular dysfunction. Endothelial progenitor cells (EPCs) are critically involved in maintaining vascular homeostasis under both physiological and pathological conditions. The aim of the present study was to analyze the endothelial progenitor cell system in patients...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10100
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:There has been dramatic improvement in survival for patients with HIV/AIDS; however, some studies on patients with HIV/AIDS and serious illness have reported continued low rates of intensive care. The purpose of this study was to examine patterns of care and outcomes for patients with severe sepsis and HIV...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3811
更新日期:2005-01-01 00:00:00
abstract::Heart rate variability in the frequency domain can now be obtained at the bedside in the ICU. Promising data suggest that it may help to characterize a patient response to a spontaneous breathing trial. Refinement of the analysis could even help to predict the outcome of extubation or at least help to detect early pat...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13807
更新日期:2014-03-31 00:00:00
abstract:BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the HLH-2004 criteria and HScore, both of which have been developed in pediatric or adult non-critically ill patients, respectively. Therefore, we aimed...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-02941-3
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:The aim of life-support measures in brain-dead donors is to preserve the functional value of their organs. In renal transplantation, serum creatinine level is one of the criteria for graft harvest. The aim of this study was to assess the impact of intensive care on donor renal function through two criteria: ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6120
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness, even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. The ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc6999
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:To determine whether subjecting patients to 100 ml of additional dead space after a 120-minute weaning trial could predict readiness for extubation. METHODS:This was a prospective, non-randomised pilot study in an intensive care unit at a university hospital with 14 beds. It included all non-tracheostomis...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc7783
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Current concepts of the pathophysiology of acute pancreatitis suggest that disease progression from acinar injury to systemic illness involves a complex interplay between cellular and soluble inflammatory mediators and endothelial beds. To date, there is no specific pharmacologic intervention for acute pan...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3777
更新日期:2005-08-01 00:00:00
abstract::Stress hyperglycaemia is a common event in acute critical illness. There is increasing evidence that maintaining normoglycaemia and treatment with insulin (or with glucose-insulin-potassium [GIK]), even in non-diabetic persons, is helpful in limiting organ damage after myocardial infarction, stroke, traumatic brain in...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc1463
更新日期:2002-04-01 00:00:00
abstract::Circulating cell-free DNA (cf-DNA) mainly comes from apoptotic cells and can reflect the extent of cellular damage. Increased plasma levels of cf-DNA have been found in many acute disorders, including septic and clinically ill patients, and usually correlate well with clinical outcome. Acute respiratory failure, the m...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10365
更新日期:2011-01-01 00:00:00
abstract::Chloride is the principal anion in the extracellular fluid and is the second main contributor to plasma tonicity. Its concentration is frequently abnormal in intensive care unit patients, often as a consequence of fluid therapy. Yet chloride has received less attention than any other ion in the critical care literatur...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9052
更新日期:2010-01-01 00:00:00
abstract::Until relatively recently, critical illness was considered as a separate entity and the intensive care unit (ICU), often a little cut-off from other areas of the hospital, was in many cases used as a last resort for patients so severely ill that it was no longer possible to care for them on the general ward. However, ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-019-2393-x
更新日期:2019-06-14 00:00:00
abstract:INTRODUCTION:The appropriate strategy for trauma-induced coagulopathy management is under debate. We report the treatment of major trauma using mainly coagulation factor concentrates. METHODS:This retrospective analysis included trauma patients who received >or= 5 units of red blood cell concentrate within 24 hours. C...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8948
更新日期:2010-01-01 00:00:00
abstract::The recent bus crash in Switzerland involving many children provides several lessons for the pre-hospital care community. The use of multiple helicopters that are capable of flying at night and that carry advanced medical pre-hospital teams undoubtedly saved lives following the tragedy. We describe the medical respons...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11370
更新日期:2012-07-11 00:00:00
abstract:BACKGROUND:Early identification of predictors for a poor long-term outcome in patients who survive the initial phase of out-of-hospital cardiac arrest (OHCA) may facilitate future clinical research, the process of care and information provided to relatives. The aim of this study was to determine the association between...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-017-1677-2
更新日期:2017-04-13 00:00:00
abstract:INTRODUCTION:Serum concentrations of adhesion molecules may be connected to the pathogenesis of secondary brain injury after spontaneous intracerebral hemorrhage (ICH). This study posits the hypothesis that levels of adhesion molecules substantially increase after ICH and are decreased thereafter, and that they can pre...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10568
更新日期:2011-01-01 00:00:00
abstract::Characteristic patterns of variation over time, namely rhythms, represent a defining feature of complex systems, one that is synonymous with life. Despite the intrinsic dynamic, interdependent and nonlinear relationships of their parts, complex biological systems exhibit robust systemic stability. Applied to critical ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2948
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:The aetiology of lower respiratory tract infections in young children admitted to the paediatric intensive care unit (PICU) is often difficult to establish. However, most infections are believed to be caused by respiratory viruses. A diagnostic study was performed to compare conventional viral tests with t...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4895
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess the volume of gas being poorly ventilated or non-ventilated within the lungs of patients treated with mechanical ventilation and suffering from acute respiratory distress syndrome (ARDS). METHODS:A prospective, descriptive study was performed of 25 sedated and paralysed...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3058
更新日期:2005-04-01 00:00:00
abstract::High mobility group box protein 1 (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc8141
更新日期:2009-01-01 00:00:00
abstract::Sepsis, despite recent therapeutic progress, still carries unacceptably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta-adrenergic regulation of the immune function in sepsis is complex ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8026
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Recently, a non-invasive, continuous ventricular stroke volume monitoring system using skin electrodes has been developed. In contrast to impedance-based methods, the new technique (ventricular field recognition) enables measurement of changes in ventricular volume. A prototype using this new method was bu...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10306
更新日期:2011-07-11 00:00:00
abstract::Hemodynamic monitoring is a central component of intensive care. Patterns of hemodynamic variables often suggest cardiogenic, hypovolemic, obstructive, or distributive (septic) etiologies to cardiovascular insufficiency, thus defining the specific treatments required. Monitoring increases in invasiveness, as required,...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc3927
更新日期:2005-01-01 00:00:00
abstract::The decision to withdraw or withhold life supporting treatment in moribund patients is difficult under any circumstances. When the patient becomes incompetent to clarify their wishes regarding continued maintenance in long-term facilities, surrogates sometimes cannot agree, further clouding the issue. We examine a cas...
journal_title:Critical care (London, England)
pub_type: 社论
doi:10.1186/cc2451
更新日期:2004-04-01 00:00:00