Prognostic indicators in patients presenting with acute cardiogenic pulmonary edema treated with CPAP: it's not the acid that matters, it's back to basics.


:Several prognostic markers have been identified for patients admitted with acute cardiogenic pulmonary edema. Most of the markers are based on clinical risk scores. Unlike hypercapnic respiratory failure, acidosis is not an adverse predictor in these patients. Hemodynamic variables that assess pathophysiological mechanisms may be more helpful to guide appropriate management.


Crit Care


Schlosshan D,Elliott M




Has Abstract


2010-01-01 00:00:00














  • Automatic detection of ventilatory modes during invasive mechanical ventilation.

    abstract:BACKGROUND:Expert systems can help alleviate problems related to the shortage of human resources in critical care, offering expert advice in complex situations. Expert systems use contextual information to provide advice to staff. In mechanical ventilation, it is crucial for an expert system to be able to determine the...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Murias G,Montanyà J,Chacón E,Estruga A,Subirà C,Fernández R,Sales B,de Haro C,López-Aguilar J,Lucangelo U,Villar J,Kacmarek RM,Blanch L

    更新日期:2016-08-14 00:00:00

  • Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial.

    abstract:BACKGROUND:Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for head injury, the effects of progesterone on neurologic outcome of acute TBI patients remain unclear. The ai...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Xiao G,Wei J,Yan W,Wang W,Lu Z

    更新日期:2008-01-01 00:00:00

  • Respiratory support withdrawal in intensive care units: families, physicians and nurses views on two hypothetical clinical scenarios.

    abstract:INTRODUCTION:Evidence suggests that dying patients' physical and emotional suffering is inadequately treated in intensive care units. Although there are recommendations regarding decisions to forgo life-sustaining therapy, deciding on withdrawal of life support is difficult, and it is also difficult to decide who shoul...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Fumis RR,Deheinzelin D

    更新日期:2010-01-01 00:00:00

  • Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas.

    abstract::The use of extracorporeal cardiopulmonary resuscitation (ECPR) to restore circulation during cardiac arrest is a time-critical, resource-intensive intervention of unproven efficacy. The current COVID-19 pandemic has brought additional complexity and significant barriers to the ongoing provision and implementation of E...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Worku E,Gill D,Brodie D,Lorusso R,Combes A,Shekar K

    更新日期:2020-07-27 00:00:00

  • Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevance.

    abstract:INTRODUCTION:Previous studies have shown through theoretical analyses that the ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2) varies with the FiO2 level. The aim of the present study was to evaluate the relevance of this variation both theoretically and experimen...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Karbing DS,Kjaergaard S,Smith BW,Espersen K,Allerød C,Andreassen S,Rees SE

    更新日期:2007-01-01 00:00:00

  • The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study.

    abstract:INTRODUCTION:Diabetes mellitus (DM) is one of the most common chronic co-morbid medical conditions in the USA and is frequently present in patients with sepsis. Previous studies reported that people with DM and severe sepsis are less likely to develop acute lung injury (ALI). We sought to determine whether organ dysfun...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Esper AM,Moss M,Martin GS

    更新日期:2009-01-01 00:00:00

  • Pre-emptive antibiotic therapy to reduce ventilator-associated pneumonia: "thinking outside the box".

    abstract::Mechanically ventilated, intubated patients are at increased risk for tracheal colonization with bacterial pathogens that may progress to heavy bacterial colonization, ventilator-associated tracheobronchitis (VAT), and/or ventilator-associated pneumonia (VAP). Previous studies report that 10 to 30 % of patients with V...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Craven DE,Hudcova J,Lei Y,Craven KA,Waqas A

    更新日期:2016-09-29 00:00:00

  • A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients.

    abstract:INTRODUCTION:Following trauma, patients may suffer an overwhelming pro-inflammatory response and immune paralysis resulting in infection and multiple organ failure (MOF). Various potentially immunomodulative interventions have been tested. The objective of this study is to systematically review the randomized controlle...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Spruijt NE,Visser T,Leenen LP

    更新日期:2010-01-01 00:00:00

  • Evidence-based review of the use of the pulmonary artery catheter: impact data and complications.

    abstract::The pulmonary artery catheter (PAC) was introduced in 1971 for the assessment of heart function at the bedside. Since then it has generated much enthusiasm and controversy regarding the benefits and potential harms caused by this invasive form of hemodynamic monitoring. This review discusses all clinical studies condu...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Hadian M,Pinsky MR

    更新日期:2006-01-01 00:00:00

  • The dynamic pattern of end-tidal carbon dioxide during cardiopulmonary resuscitation: difference between asphyxial cardiac arrest and ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest.

    abstract:INTRODUCTION:Partial pressure of end-tidal carbon dioxide (PetCO2) during cardiopulmonary resuscitation (CPR) correlates with cardiac output and consequently has a prognostic value in CPR. In our previous study we confirmed that initial PetCO2 value was significantly higher in asphyxial arrest than in ventricular fibri...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Lah K,Križmarić M,Grmec S

    更新日期:2011-01-01 00:00:00

  • A regional trauma system to optimize the pre-hospital triage of trauma patients.

    abstract:INTRODUCTION:Pre-hospital triage is a key element in a trauma system that aims to admit patients to the most suitable trauma center, and may decrease intra-hospital mortality. We evaluated the performance of a pre-hospital procedure in a regional trauma system through measurements of the quality of pre-hospital medical...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Bouzat P,Ageron FX,Brun J,Levrat A,Berthet M,Rancurel E,Thouret JM,Thony F,Arvieux C,Payen JF,TRENAU group.

    更新日期:2015-03-18 00:00:00

  • Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis.

    abstract:BACKGROUND:The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown. METHODS:In this work, an antibiotic cocktail was used to ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Li M,Li C,Wu X,Chen T,Ren L,Xu B,Cao J

    更新日期:2020-05-27 00:00:00

  • Neurological manifestations of COVID-19: a systematic review.

    abstract:INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Nepal G,Rehrig JH,Shrestha GS,Shing YK,Yadav JK,Ojha R,Pokhrel G,Tu ZL,Huang DY

    更新日期:2020-07-13 00:00:00

  • Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review.

    abstract:INTRODUCTION:To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU). METHODS:Medline, EMBASE and other databases were searched for English-language articles with the major objective of ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Minne L,Abu-Hanna A,de Jonge E

    更新日期:2008-01-01 00:00:00

  • Community-acquired polymicrobial pneumonia in the intensive care unit: aetiology and prognosis.

    abstract:INTRODUCTION:The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. The aim of the present study was to describe the prevalence, clinical characteristics and outcomes of severe CAP of polymicrobial aetiology in pati...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Cillóniz C,Ewig S,Ferrer M,Polverino E,Gabarrús A,Puig de la Bellacasa J,Mensa J,Torres A

    更新日期:2011-01-01 00:00:00

  • Neuromonitoring of delirium with quantitative pupillometry in sedated mechanically ventilated critically ill patients.

    abstract:BACKGROUND:Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk o...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Favre E,Bernini A,Morelli P,Pasquier J,Miroz JP,Abed-Maillard S,Ben-Hamouda N,Oddo M

    更新日期:2020-02-24 00:00:00

  • Heart-kidney crosstalk and role of humoral signaling in critical illness.

    abstract::Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant o...

    journal_title:Critical care (London, England)

    pub_type: 信件,评审


    authors: Virzì G,Day S,de Cal M,Vescovo G,Ronco C

    更新日期:2014-01-06 00:00:00

  • Thromboelastometry and organ failure in trauma patients: a prospective cohort study.

    abstract:INTRODUCTION:Data on the incidence of a hypercoagulable state in trauma, as measured by thromboelastometry (ROTEM), is limited and the prognostic value of hypercoagulability after trauma on outcome is unclear. We aimed to determine the incidence of hypercoagulability after trauma, and to assess whether early hypercoagu...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Müller MC,Balvers K,Binnekade JM,Curry N,Stanworth S,Gaarder C,Kolstadbraaten KM,Rourke C,Brohi K,Goslings JC,Juffermans NP

    更新日期:2014-12-25 00:00:00

  • Statistics review 2: samples and populations.

    abstract::The previous review in this series introduced the notion of data description and outlined some of the more common summary measures used to describe a dataset. However, a dataset is typically only of interest for the information it provides regarding the population from which it was drawn. The present review focuses on...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Whitley E,Ball J

    更新日期:2002-04-01 00:00:00

  • Multimorbidity states associated with higher mortality rates in organ dysfunction and sepsis: a data-driven analysis in critical care.

    abstract:BACKGROUND:Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients' medical background. Given the aging population, not only are diseases becoming increasingly prevalent but occur ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Zador Z,Landry A,Cusimano MD,Geifman N

    更新日期:2019-07-08 00:00:00

  • Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort.

    abstract:INTRODUCTION:Patients admitted to intensive care following surgery for faecal peritonitis present particular challenges in terms of clinical management and risk assessment. Collaborating surgical and intensive care teams need shared perspectives on prognosis. We aimed to determine the relationship between dynamic asses...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Tridente A,Clarke GM,Walden A,Gordon AC,Hutton P,Chiche JD,Holloway PA,Mills GH,Bion J,Stüber F,Garrard C,Hinds C,GenOSept Investigators.

    更新日期:2015-05-05 00:00:00

  • Recent evolution of renal replacement therapy in the critically ill patient.

    abstract::The epidemiology of severe acute renal failure has dramatically changed in the past decade. Its leading cause is sepsis and the syndrome develops mostly in the intensive care unit as part of multiple organ dysfunction syndrome. After the significant improvements obtained from the mid 1970s to the mid 1990s, the past d...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Ronco C

    更新日期:2006-02-01 00:00:00

  • Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship.

    abstract:INTRODUCTION:Respiratory viruses are increasingly recognized as significant etiologies of pneumonia among hospitalized patients. Advanced technologies using multiplex molecular assays and polymerase-chain reaction increase the ability to identify viral pathogens and may ultimately impact antibacterial use. METHOD:This...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Crotty MP,Meyers S,Hampton N,Bledsoe S,Ritchie DJ,Buller RS,Storch GA,Kollef MH,Micek ST

    更新日期:2015-11-18 00:00:00

  • Information technology issues during and after Katrina and usefulness of the Internet: how we mobilized and utilized digital communications systems.

    abstract::Even more than in previous disasters, Katrina has proven itself to be a testing ground for a plethora of new technologies. Although not all of these technologies did immediately save lives, in this regard a number of them exhibited considerable potential for the future, and hence there is a need to include them in fut...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Leitl E

    更新日期:2006-02-01 00:00:00

  • Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs.

    abstract:INTRODUCTION:Our understanding of septic acute kidney injury (AKI) remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore, we dynamically assessed renal haemodynamic, microvascular and metabolic responses to, and ultrastructural sequelae of, sepsis in...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Chvojka J,Sykora R,Krouzecky A,Radej J,Varnerova V,Karvunidis T,Hes O,Novak I,Radermacher P,Matejovic M

    更新日期:2008-01-01 00:00:00

  • Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.

    abstract::Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a systems-based approach, similar to that in acute myocardial infarction, stroke and trauma, called ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Nguyen HB,Jaehne AK,Jayaprakash N,Semler MW,Hegab S,Yataco AC,Tatem G,Salem D,Moore S,Boka K,Gill JK,Gardner-Gray J,Pflaum J,Domecq JP,Hurst G,Belsky JB,Fowkes R,Elkin RB,Simpson SQ,Falk JL,Singer DJ,Rivers EP

    更新日期:2016-07-01 00:00:00

  • Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials.

    abstract:INTRODUCTION:Due to resource limitations, few critical care interventions have been rigorously evaluated with adequately powered randomized clinical trials (RCTs). There is a need to improve the efficiency of RCTs in critical care so that more definitive high quality RCTs can be completed with the available resources. ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,随机对照试验


    authors: Heyland DK,Muscedere J,Drover J,Jiang X,Day AG,Canadian Critical Care Trials Group.

    更新日期:2011-01-01 00:00:00

  • Sizing the lung of mechanically ventilated patients.

    abstract:INTRODUCTION:This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Mattingley JS,Holets SR,Oeckler RA,Stroetz RW,Buck CF,Hubmayr RD

    更新日期:2011-01-01 00:00:00

  • Complications of regional citrate anticoagulation: accumulation or overload?

    abstract::Regional citrate anticoagulation (RCA) is now recommended over systemic heparin for continuous renal replacement therapy in patients without contraindications. Its use is likely to increase throughout the world. However, in the absence of citrate blood level monitoring, the diagnosis of citrate accumulation, the most ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Schneider AG,Journois D,Rimmelé T

    更新日期:2017-11-19 00:00:00

  • Plasma colloid osmotic pressure in healthy infants.

    abstract:BACKGROUND:The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This ...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章


    authors: Sussmane JB,de Soto M,Torbati D

    更新日期:2001-10-01 00:00:00