Abstract:
INTRODUCTION:Severe acute pancreatitis (SAP) requiring admission to a critical care unit is associated with high mortality and long lengths of stay. We describe the case mix, outcome, and activity of admissions with SAP who were identified from a high-quality clinical database. METHODS:We conducted a secondary analysis of the ICNARC (Intensive Care National Audit & Research Centre) Case Mix Programme Database of 219,468 admissions to 159 adult, general critical care units in England, Wales, and Northern Ireland for the period of 1995 to 2003 to identify admissions with SAP. The ability of the modified Glasgow criteria to discriminate hospital survivors from non-survivors was compared to that of the Acute Physiology and Chronic Health Evaluation (APACHE) II score and a number of individual physiological parameters. RESULTS:A total of 2,677 admissions with SAP were identified (1.2% of all admissions). Mortality for these admissions was 31% in the critical care unit and 42% in hospital. The median length of stay in the critical care unit was 3.8 days and was similar for survivors and non-survivors. Increasing numbers of modified Glasgow criteria were associated with increasing hospital mortality, but better discrimination was provided by the APACHE II score and by several physiological parameters. CONCLUSION:SAP requiring critical care is associated with high mortality and long length of stay. The modified Glasgow criteria represent a simple measure of severity but were not designed to predict hospital mortality. It may be possible to develop a specific model for risk prediction in patients with SAP requiring critical care.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Harrison DA,D'Amico G,Singer Mdoi
10.1186/cc5682subject
Has Abstractpub_date
2007-01-01 00:00:00pages
S1eissn
1364-8535issn
1466-609Xpii
cc5682journal_volume
11 Suppl 1pub_type
杂志文章相关文献
CRITICAL CARE文献大全abstract::The diagnosis of patients presenting to the emergency department with acute heart failure (AHF) is challenging due to the similarity of AHF symptoms to other conditions such as chronic obstructive pulmonary disease and pneumonia. Additionally, because AHF is most common in an older population, the presentation of coex...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-015-1114-3
更新日期:2015-11-10 00:00:00
abstract::Sepsis represents a dysregulated host response to infection, the extent of which determines the severity of organ dysfunction and subsequent outcome. All trialled immunomodulatory strategies to date have resulted in either outright failure or inconsistent degrees of success. Intravenous immunoglobulin (IVIg) therapy f...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc10597
更新日期:2012-12-12 00:00:00
abstract:INTRODUCTION:Multiple organ dysfunction syndrome (MODS) is a common complication of sepsis in mechanically ventilated patients with acute respiratory distress syndrome, but the links between mechanical ventilation and MODS are unclear. Our goal was to determine whether a minimally injurious mechanical ventilation strat...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5050
更新日期:2006-01-01 00:00:00
abstract::Considerable progress has been made recently in the understanding of how best to accomplish safe and effective ventilation of patients with acute lung injury. Mechanical and nonmechanical factors contribute to causation of ventilator-associated lung injury. Intervention timing helps determine the therapeutic efficacy ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc14722
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:In critical care units, pupil examination is an important clinical parameter for patient monitoring. Current practice is to use a penlight to observe the pupillary light reflex. The result seems to be a subjective measurement, with low precision and reproducibility. Several quantitative pupillometer devices ...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/s13054-016-1239-z
更新日期:2016-03-13 00:00:00
abstract::Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3007
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to perform a descriptive, content-based analysis on the different forms of documentation for in-flight medical emergencies that are currently provided in the emergency medical kits on board commercial airlines. METHODS:Passenger airlines in the World Airline Directory were co...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11238
更新日期:2012-12-12 00:00:00
abstract::Prediction of ventilation weaning outcome in children is important, as unsuccessful extubation increases both morbidity and mortality. Adult weaning criteria are poor predictors of weaning outcome in children for several possible reasons: the length of mechanical ventilation is generally much shorter, and the weaning ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc3950
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Coagulation can be visualised using whole blood coagulation analyses such as thromboelastometry and platelet aggregation tests; however, the role of temperature in the analyses is ambiguous. The aim was to examine whether temperature influences the whole blood coagulation tests. METHODS:We included 40 patie...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1302-9
更新日期:2016-04-30 00:00:00
abstract::In the previous issue of Critical Care, Meybohm and colleagues provide evidence to support hypothermia as a kind of therapeutic option for patients suffering cardiac arrest. Although anesthetics had been used to induce hypothermia, sevoflurane post-conditioning fails to confer additional anti-inflammatory effects afte...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc8923
更新日期:2010-01-01 00:00:00
abstract::The rapid response system concept is one of the first patient-centered and organizational-wide systems aimed at preventing deaths and serious adverse events. It has been strongly argued that we need a benchmark that reflects the care of a deteriorating patient across the organization using a 'score to door time'; that...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc10477
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemo...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11661
更新日期:2012-10-02 00:00:00
abstract::BACKGROUND: The present study was undertaken to examine the feasibility of venous oxygen measurements in the inferior vena cava (IVC) via a catheter through the umbilical vein. This may serve as a proxy for mixed venous oxygenation and the complications of right atrial cannulation can be avoided at the same time. It h...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc126
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Intravenous fluid administration is an essential component of sepsis management, but a positive fluid balance has been associated with worse prognosis. We analyzed whether a positive fluid balance and its persistence over time was an independent prognostic factor in septic patients. METHODS:We prospective...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-0970-1
更新日期:2015-06-15 00:00:00
abstract:INTRODUCTION:Sedation is widely used in intensive care unit (ICU) patients to limit the risk of pulmonary barotrauma and to decrease oxygen needs. However, adverse effects of cc5128sedation have not been fully evaluated; in particular, effects of benzodiazepine and opiates on microcirculation have not been extensively ...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc5128
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS:We used a unique ICU model where rats wer...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1417-z
更新日期:2016-08-10 00:00:00
abstract:INTRODUCTION:Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays, however, have several limitations. A surge of interest exists in the use of point-of-care tests to diagnose hypo- and hypercoagulability in sepsis. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched from 1 Janu...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc13721
更新日期:2014-02-10 00:00:00
abstract:BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-019-2623-2
更新日期:2019-11-09 00:00:00
abstract::Certain noble gases, though inert, exhibit remarkable biological properties. Notably, xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care, Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neur...
journal_title:Critical care (London, England)
pub_type: 评论,信件
doi:10.1186/cc8847
更新日期:2010-01-01 00:00:00
abstract::Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmen...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc5142
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Recent data have suggested that patient admission during intensive care unit (ICU) morning bedside rounds is associated with less favorable outcome. We undertook the present study to explore the association between morning round-time ICU admissions and hospital mortality in a large Canadian health region. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc11329
更新日期:2012-05-03 00:00:00
abstract:INTRODUCTION:Thrombomodulin, which is expressed solely on monocytes, along with tissue factor (TF), takes part in coagulation and inflammation. Circulating blood monocytes can be divided into 3 major subtypes on the basis of their receptor phenotype: classical (CD14brightCD16negative, CMs), inflammatory (CD14brightCD16...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10139
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Hypoxia is common during daily nursing procedures (DNPs) routinely performed on mechanically ventilated patients. The impact of automated ventilation on the incidence and severity of blood oxygen desaturation during DNPs remains unknown. METHODS:A prospective randomized controlled crossover trial was carrie...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03155-3
更新日期:2020-07-22 00:00:00
abstract:INTRODUCTION:Curricular content is often based on the personal opinions of a small number of individuals. Although convenient, such curricula may not meet the needs of the target learner, the program or the institution. Using an objective method to ensure content validity of a curriculum can alleviate this issue. METH...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7087
更新日期:2008-01-01 00:00:00
abstract::Body cell mass (BCM) is the metabolically active cell mass involved in O₂ consumption, CO₂ production and energy expenditure. BCM measurement has been suggested as a tool for the evaluation of nutritional status. Since BCM is closely related to energy expenditure, it could also represent a good reference value for the...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc13852
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infecti...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1303-8
更新日期:2016-05-07 00:00:00
abstract:BACKGROUND:The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This ...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc1043
更新日期:2001-10-01 00:00:00
abstract:INTRODUCTION:Functional assessment of arterial load by dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has recently been shown to predict the arterial pressure response to volume expansion (VE) in hypotensive, preload-dependent patients....
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-014-0626-6
更新日期:2014-11-19 00:00:00
abstract:: ...
journal_title:Critical care (London, England)
pub_type: 评论,信件
doi:10.1186/s13054-018-2297-1
更新日期:2019-01-09 00:00:00
abstract:: ...
journal_title:Critical care (London, England)
pub_type: 社论
doi:10.1186/s13054-018-2203-x
更新日期:2018-11-03 00:00:00