当前位置： SCI文献检索 > CRITICAL CARE期刊下所有文献 > Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective.

Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective.

Abstract：

:Sepsis represents a dysregulated host response to infection, the extent of which determines the severity of organ dysfunction and subsequent outcome. All trialled immunomodulatory strategies to date have resulted in either outright failure or inconsistent degrees of success. Intravenous immunoglobulin (IVIg) therapy falls into the latter category with opinion still divided as to its utility. This article provides a narrative review of the biological rationale for using IVIg in sepsis. A literature search was conducted using the PubMed database (1966 to February 2011). The strategy included the following text terms and combinations of these: IVIg, intravenous immune globulin, intravenous immunoglobulin, immunoglobulin, immunoglobulin therapy, pentaglobin, sepsis, inflammation, immune modulation, apoptosis. Preclinical and extrapolated clinical data of IVIg therapy in sepsis suggests improved bacterial clearance, inhibitory effects upon upstream mediators of the host response (for example, the nuclear factor kappa B (NF-κB) transcription factor), scavenging of downstream inflammatory mediators (for example, cytokines), direct anti-inflammatory effects mediated via Fcγ receptors, and a potential ability to attenuate lymphocyte apoptosis and thus sepsis-related immunosuppression. Characterizing the trajectory of change in immunoglobulin levels during sepsis, understanding mechanisms contributing to these changes, and undertaking IVIg dose-finding studies should be performed prior to further large-scale interventional trials to enhance the likelihood of a successful outcome.

journal_name

Crit Care

journal_title

Critical care (London, England)

authors

Shankar-Hari M,Spencer J,Sewell WA,Rowan KM,Singer M

doi

10.1186/cc10597

subject

Has Abstract

pub_date

2012-12-12 00:00:00

pages

206

issue

2

eissn

1364-8535

issn

1466-609X

pii

cc10597

journal_volume

16

pub_type

杂志文章,评审

相关文献

CRITICAL CARE文献大全
  • Sepsis is a preventable public health problem.

    abstract：:There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework fo...

    journal_title：Critical care (London, England)

    pub_type： 信件

    doi：10.1186/s13054-018-2048-3

    authors： Kempker JA,Wang HE,Martin GS

    更新日期：2018-05-06 00:00:00

  • The global burden of sepsis: barriers and potential solutions.

    abstract：:Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/s13054-018-2157-z

    authors： Rudd KE,Kissoon N,Limmathurotsakul D,Bory S,Mutahunga B,Seymour CW,Angus DC,West TE

    更新日期：2018-09-23 00:00:00

  • A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion.

    abstract：INTRODUCTION:Although activation of A3 adenosine receptors attenuates reperfusion lung injury and associated apoptosis, the signaling pathway that mediates this protection remains unclear. Adenosine agonists activate mitogen-activated protein kinases, and these kinases have been implicated in ischemia/reperfusion injur...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc4893

    authors： Matot I,Weiniger CF,Zeira E,Galun E,Joshi BV,Jacobson KA

    更新日期：2006-01-01 00:00:00

  • Early predictors of poor outcome after out-of-hospital cardiac arrest.

    abstract：BACKGROUND:Early identification of predictors for a poor long-term outcome in patients who survive the initial phase of out-of-hospital cardiac arrest (OHCA) may facilitate future clinical research, the process of care and information provided to relatives. The aim of this study was to determine the association between...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-017-1677-2

    authors： Martinell L,Nielsen N,Herlitz J,Karlsson T,Horn J,Wise MP,Undén J,Rylander C

    更新日期：2017-04-13 00:00:00

  • A systematic review of the impact of sedation practice in the ICU on resource use, costs and patient safety.

    abstract：INTRODUCTION:Patients in intensive care units (ICUs) often receive sedation for prolonged periods. In order to better understand the impact of sub-optimal sedation practice on outcomes, we performed a systematic review, including observational studies and controlled trials which were conducted in sedated patients in th...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc8956

    authors： Jackson DL,Proudfoot CW,Cann KF,Walsh T

    更新日期：2010-01-01 00:00:00

  • Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas.

    abstract：:The use of extracorporeal cardiopulmonary resuscitation (ECPR) to restore circulation during cardiac arrest is a time-critical, resource-intensive intervention of unproven efficacy. The current COVID-19 pandemic has brought additional complexity and significant barriers to the ongoing provision and implementation of E...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-020-03172-2

    authors： Worku E,Gill D,Brodie D,Lorusso R,Combes A,Shekar K

    更新日期：2020-07-27 00:00:00

  • Heart-kidney crosstalk and role of humoral signaling in critical illness.

    abstract：:Organ failure in the heart or kidney can initiate various complex metabolic, cell-mediated and humoral pathways affecting distant organs, contributing to the high therapeutic costs and significantly higher morbidity and mortality. The universal outreach of cells in an injured state has myriad consequences to distant o...

    journal_title：Critical care (London, England)

    pub_type： 信件,评审

    doi：10.1186/cc13177

    authors： Virzì G,Day S,de Cal M,Vescovo G,Ronco C

    更新日期：2014-01-06 00:00:00

  • First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1.

    abstract：:The great majority of infections caused by the pandemic variant of the influenza virus (nvH1N1) are self-limited, but a small percentage of patients develop severe symptoms requiring hospitalization. Bermejo-Martin and colleagues have presented a pilot study describing the differences in the early immune response for ...

    journal_title：Critical care (London, England)

    pub_type： 评论,信件

    doi：10.1186/cc8846

    authors： de Castro IF,Guzmán-Fulgencio M,García-Alvarez M,Resino S

    更新日期：2010-01-01 00:00:00

  • N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report.

    abstract：BACKGROUND:N-acetylcysteine (NAC) has been shown to improve splanchnic blood flow in experimental studies. This report evaluates the effects of NAC on liver perfusion and lactate signal intensities in the liver tissue of septic shock patients using proton magnetic resonance imaging and spectroscopy. Furthermore, the mo...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc2426

    authors： Hein OV,Ohring R,Schilling A,Oellerich M,Armstrong VW,Kox WJ,Spies C

    更新日期：2004-04-01 00:00:00

  • Using an expiratory resistor, arterial pulse pressure variations predict fluid responsiveness during spontaneous breathing: an experimental porcine study.

    abstract：INTRODUCTION:Fluid responsiveness prediction is difficult in spontaneously breathing patients. Because the swings in intrathoracic pressure are minor during spontaneous breathing, dynamic parameters like pulse pressure variation (PPV) and systolic pressure variation (SPV) are usually small. We hypothesized that during ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc7760

    authors： Dahl MK,Vistisen ST,Koefoed-Nielsen J,Larsson A

    更新日期：2009-01-01 00:00:00

  • Relationship between acid-base status and inflammation in the critically ill.

    abstract：INTRODUCTION:There is a complex interplay between changes in acid-base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid-base status on admission to intensive care. METHODS:We conducted a prospective cohort study in a 13-bed ICU in a tertiary-car...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc13993

    authors： Zampieri FG,Kellum JA,Park M,Ranzani OT,Barbeiro HV,de Souza HP,da Cruz Neto LM,da Silva FP

    更新日期：2014-07-17 00:00:00

  • Reliability of standard pupillometry practice in neurocritical care: an observational, double-blinded study.

    abstract：BACKGROUND:In critical care units, pupil examination is an important clinical parameter for patient monitoring. Current practice is to use a penlight to observe the pupillary light reflex. The result seems to be a subjective measurement, with low precision and reproducibility. Several quantitative pupillometer devices ...

    journal_title：Critical care (London, England)

    pub_type： 临床试验,杂志文章

    doi：10.1186/s13054-016-1239-z

    authors： Couret D,Boumaza D,Grisotto C,Triglia T,Pellegrini L,Ocquidant P,Bruder NJ,Velly LJ

    更新日期：2016-03-13 00:00:00

  • Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review.

    abstract：BACKGROUND:Microcirculatory perfusion disturbances are associated with increased morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Technological advancements made it possible to monitor sublingual microcirculatory perfusion over time. The goal of this review is to provide...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-020-02948-w

    authors： den Os MM,van den Brom CE,van Leeuwen ALI,Dekker NAM

    更新日期：2020-05-13 00:00:00

  • Clinical review: the management of hypertensive crises.

    abstract：:Hypertension is an extremely common clinical problem, affecting approximately 50 million people in the USA and approximately 1 billion individuals worldwide. Approximately 1% of these patients will develop acute elevations in blood pressure at some point in their lifetime. A number of terms have been applied to severe...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc2351

    authors： Varon J,Marik PE

    更新日期：2003-10-01 00:00:00

  • Measuring the anticoagulant effect of low molecular weight heparins in the critically ill.

    abstract：:Antithrombotic prophylaxis in critically ill patients frequently fails. Venous thromboembolism is associated with adverse clinical outcomes, including a prolonged intensive care unit stay and death. A potential mechanism by which critically ill patients may be predisposed to antithrombotic failure is the inability to ...

    journal_title：Critical care (London, England)

    pub_type： 评论,杂志文章,评审

    doi：10.1186/cc4978

    authors： Crowther M,Lim W

    更新日期：2006-01-01 00:00:00

  • Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity.

    abstract：INTRODUCTION:Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytosis, and bioavailabili...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc9020

    authors： Davis JS,Yeo TW,Piera KA,Woodberry T,Celermajer DS,Stephens DP,Anstey NM

    更新日期：2010-01-01 00:00:00

  • Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study.

    abstract：BACKGROUND:Temperature management is used with increased frequency as a tool to mitigate neurological injury. Although frequently used, little is known about the optimal cooling methods for inducing and maintaining controlled normo- and hypothermia in the intensive care unit (ICU). In this study we compared the efficac...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/cc6104

    authors： Hoedemaekers CW,Ezzahti M,Gerritsen A,van der Hoeven JG

    更新日期：2007-01-01 00:00:00

  • Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction.

    abstract：INTRODUCTION:Multiple organ dysfunction syndrome (MODS) is a common complication of sepsis in mechanically ventilated patients with acute respiratory distress syndrome, but the links between mechanical ventilation and MODS are unclear. Our goal was to determine whether a minimally injurious mechanical ventilation strat...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc5050

    authors： O'Mahony DS,Liles WC,Altemeier WA,Dhanireddy S,Frevert CW,Liggitt D,Martin TR,Matute-Bello G

    更新日期：2006-01-01 00:00:00

  • The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study.

    abstract：INTRODUCTION:To provide up-to-date information on the prognostic factors associated with 28-day mortality in a cohort of septic shock patients in intensive care units (ICUs). METHODS:Prospective, multicenter, observational cohort study in ICUs from 14 French general (non-academic) and university teaching hospitals. Al...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,多中心研究

    doi：10.1186/cc12598

    authors： Quenot JP,Binquet C,Kara F,Martinet O,Ganster F,Navellou JC,Castelain V,Barraud D,Cousson J,Louis G,Perez P,Kuteifan K,Noirot A,Badie J,Mezher C,Lessire H,Pavon A

    更新日期：2013-04-25 00:00:00

  • Glial fibrillary acidic protein as a biomarker in severe traumatic brain injury patients: a prospective cohort study.

    abstract：INTRODUCTION:Glial fibrillary acidic protein (GFAP) may serve as a serum marker of traumatic brain injury (TBI) that can be used to monitor biochemical changes in patients and gauge the response to treatment. However, the temporal profile of serum GFAP in the acute period of brain injury and the associated utility for ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-015-1081-8

    authors： Lei J,Gao G,Feng J,Jin Y,Wang C,Mao Q,Jiang J

    更新日期：2015-10-12 00:00:00

  • Refeeding syndrome influences outcome of anorexia nervosa patients in intensive care unit: an observational study.

    abstract：INTRODUCTION:Data on the epidemiology and management of anorexia nervosa (AN) in the intensive care unit (ICU) are scarce. The aim of this study was to evaluate the prevalence and associated morbidity and mortality of AN in French ICUs. METHODS:We randomly selected 30 ICUs throughout France. Thereafter, we retrospecti...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/cc9274

    authors： Vignaud M,Constantin JM,Ruivard M,Villemeyre-Plane M,Futier E,Bazin JE,Annane D,AZUREA group (AnorexieRea Study Group).

    更新日期：2010-01-01 00:00:00

  • Clinical review: extracorporeal blood purification in severe sepsis.

    abstract：:Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc1889

    authors： Venkataraman R,Subramanian S,Kellum JA

    更新日期：2003-04-01 00:00:00

  • The desperate need for good-quality clinical trials to evaluate the optimal source and dose of fibrinogen in managing bleeding.

    abstract：:Recent interest in transfusion management of trauma patients has heightened expectation in the role of blood component therapy in improving patient outcome. Optimal transfusion support in supplementation with fibrinogen has not been defined by high-quality evidence. Current evidence comes mainly from case series and u...

    journal_title：Critical care (London, England)

    pub_type： 评论,社论

    doi：10.1186/cc10510

    authors： Stanworth SJ,Hunt BJ

    更新日期：2011-01-01 00:00:00

  • Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study.

    abstract：BACKGROUND:Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary to account for pathophysiological changes or renal replacement therapy. Extracorporeal membrane oxygenation (ECMO) is increasingly bei...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-020-03397-1

    authors： Kühn D,Metz C,Seiler F,Wehrfritz H,Roth S,Alqudrah M,Becker A,Bracht H,Wagenpfeil S,Hoffmann M,Bals R,Hübner U,Geisel J,Lepper PM,Becker SL

    更新日期：2020-11-25 00:00:00

  • Interest of low-dose hydrocortisone therapy during brain-dead organ donor resuscitation: the CORTICOME study.

    abstract：INTRODUCTION:Circulatory failure during brain death organ donor resuscitation is a problem that compromises recovery of organs. Combined administration of steroid, thyroxine and vasopressin has been proposed to optimize the management of brain deceased donors before recovery of organs. However the single administration...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,多中心研究

    doi：10.1186/cc13997

    authors： Pinsard M,Ragot S,Mertes PM,Bleichner JP,Zitouni S,Cook F,Pierrot M,Dube L,Menguy E,Lefèvre LM,Escaravage L,Dequin PF,Vignon P,Pichon N

    更新日期：2014-07-23 00:00:00

  • Usefulness of open lung biopsy in mechanically ventilated patients with undiagnosed diffuse pulmonary infiltrates: influence of comorbidities and organ dysfunction.

    abstract：BACKGROUND:The purpose of this study was to evaluate the clinical usefulness of open lung biopsy (OLB) in patients undergoing mechanical ventilation for diffuse pulmonary infiltrates of unknown etiology. METHODS:This was a 10-year retrospective study in a 10-bed medical intensive care unit. The medical records of 36 v...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/cc6106

    authors： Lim SY,Suh GY,Choi JC,Koh WJ,Lim SY,Han J,Lee KS,Shim YM,Chung MP,Kim H,Kwon OJ

    更新日期：2007-01-01 00:00:00

  • Reducing mortality in sepsis: new directions.

    abstract：:Considerable progress has been made in the past few years in the development of therapeutic interventions that can reduce mortality in sepsis. However, encouraging physicians to put the results of new studies into practice is not always simple. A roundtable was thus convened to provide guidance for clinicians on the i...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章,评审

    doi：10.1186/cc1860

    authors： Vincent JL,Abraham E,Annane D,Bernard G,Rivers E,Van den Berghe G

    更新日期：2002-12-01 00:00:00

  • Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients.

    abstract：BACKGROUND:Acute kidney injury and hyperchloremia are commonly present in critically ill septic patients. Our study goal was to evaluate the association of hyperchloremia and acute kidney injury in severe sepsis and septic shock patients. METHODS:In this retrospective cohort study in a provincial tertiary care hospita...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-016-1499-7

    authors： Suetrong B,Pisitsak C,Boyd JH,Russell JA,Walley KR

    更新日期：2016-10-06 00:00:00

  • Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness.

    abstract：BACKGROUND:Biomarkers can be of help to understand critical illness and to identify and stratify sepsis. Adrenomedullin is a vasoactive hormone, with reported prognostic and potentially therapeutic value in sepsis. The primary aim of this study was to investigate the association of circulating bioactive adrenomedullin ...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-020-03351-1

    authors： Lundberg OHM,Lengquist M,Spångfors M,Annborn M,Bergmann D,Schulte J,Levin H,Melander O,Frigyesi A,Friberg H

    更新日期：2020-11-04 00:00:00

  • Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury.

    abstract：INTRODUCTION:To determine whether single nucleotide polymorphisms (SNPs) in FAS and related genes are associated with acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS). METHODS:We studied 401 (Caucasian N = 310 and African-American N = 91) patients aged ≥ 13 years with ALI who enrol...

    journal_title：Critical care (London, England)

    pub_type： 杂志文章

    doi：10.1186/s13054-015-1084-5

    authors： Bhatraju P,Hsu C,Mukherjee P,Glavan BJ,Burt A,Mikacenic C,Himmelfarb J,Wurfel M

    更新日期：2015-10-19 00:00:00