Abstract:
:Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this network have been unsuccessful. For these reasons, the ideal immunomodulating strategy would be one that restores immunologic stability rather than blindly inhibiting or stimulating one or another component of this complex network. Hence, the recent focus of immunomodulatory therapy in sepsis has shifted to nonspecific methods of influencing the entire inflammatory response without suppressing it. Here, we discuss the various modalities of extracorporeal blood purification, the existing evidence, and future prospects.
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Venkataraman R,Subramanian S,Kellum JAdoi
10.1186/cc1889keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
139-45issue
2eissn
1364-8535issn
1466-609Xjournal_volume
7pub_type
杂志文章,评审相关文献
CRITICAL CARE文献大全abstract::The present review introduces the notion of statistical power and the hazard of under-powered studies. The problem of how to calculate an ideal sample size is also discussed within the context of factors that affect power, and specific methods for the calculation of sample size are presented for two common scenarios, ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc1521
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION:Recently, a non-invasive, continuous ventricular stroke volume monitoring system using skin electrodes has been developed. In contrast to impedance-based methods, the new technique (ventricular field recognition) enables measurement of changes in ventricular volume. A prototype using this new method was bu...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc10306
更新日期:2011-07-11 00:00:00
abstract:BACKGROUND:Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular reactivity and their ability to predict outcome in critically ill patients using thenar near-infrared ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-016-1500-5
更新日期:2016-10-01 00:00:00
abstract::The Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock recommend that the initial hemodynamic resuscitation be done according to the protocol used by Rivers and colleagues in their well-known early goal-directed therapy (EGDT) study. However, it may well be that their patients we...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6979
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Our objective was to evaluate the impact of gastric versus post-pyloric feeding on the incidence of pneumonia, caloric intake, intensive care unit (ICU) length of stay (LOS), and mortality in critically ill and injured ICU patients. METHOD:Data sources were Medline, Embase, Healthstar, citation review of re...
journal_title:Critical care (London, England)
pub_type: 杂志文章,meta分析,评审
doi:10.1186/cc2190
更新日期:2003-06-01 00:00:00
abstract:INTRODUCTION:Acute respiratory distress syndrome (ARDS) has heterogeneous etiologies, rapid progressive change and a high mortality rate. To improve the outcome of ARDS, accurate diagnosis is essential to the application of effective early treatment. The present study investigated the clinical effects and safety of ope...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4981
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Hypoxia is common during daily nursing procedures (DNPs) routinely performed on mechanically ventilated patients. The impact of automated ventilation on the incidence and severity of blood oxygen desaturation during DNPs remains unknown. METHODS:A prospective randomized controlled crossover trial was carrie...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03155-3
更新日期:2020-07-22 00:00:00
abstract:INTRODUCTION:The aetiology of lower respiratory tract infections in young children admitted to the paediatric intensive care unit (PICU) is often difficult to establish. However, most infections are believed to be caused by respiratory viruses. A diagnostic study was performed to compare conventional viral tests with t...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc4895
更新日期:2006-01-01 00:00:00
abstract::Owing to an increasing focus on the rising cost of medical care in the United States, bending the cost curve has become the central tenet of healthcare reform. The exact definition of this phrase, however, remains elusive. In order to affect change in the cost and quality of healthcare, the importance of comparative e...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc9045
更新日期:2010-01-01 00:00:00
abstract::Central venous oxygen saturation (ScvO2) >70% or mixed venous oxygen saturation (SvO2) >65% is recommended for both septic and non-septic patients. Although it is the task of experts to suggest clear and simple guidelines, there is a risk of reducing critical care to these simple recommendations. This article reviews ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-014-0579-9
更新日期:2014-11-10 00:00:00
abstract:INTRODUCTION:Abdominal compartment syndrome has been described in patients with severe acute pancreatitis, but its clinical impact remains unclear. We therefore studied patient factors associated with the development of intra-abdominal hypertension (IAH), the incidence of organ failure associated with IAH, and the effe...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3754
更新日期:2005-08-01 00:00:00
abstract::Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc2879
更新日期:2004-12-01 00:00:00
abstract::Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known a...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc12700
更新日期:2013-08-27 00:00:00
abstract:BACKGROUND:Patients with infective endocarditis (IE) have an elevated risk of renal dysfunction because of extensive systemic inflammation and use of nephrotoxic antibiotics. In this randomized, placebo-controlled trial, we investigated whether perioperative sodium bicarbonate administration could attenuate postoperati...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-016-1591-z
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry is an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility in patients at risk o...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-2796-8
更新日期:2020-02-24 00:00:00
abstract:OBJECTIVES:To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management and the use of adjunct therapy in routine clinical practice for patients fulfilling the Berlin definition of ARDS in mainland China....
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03112-0
更新日期:2020-08-20 00:00:00
abstract:INTRODUCTION:There is a complex interplay between changes in acid-base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid-base status on admission to intensive care. METHODS:We conducted a prospective cohort study in a 13-bed ICU in a tertiary-car...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13993
更新日期:2014-07-17 00:00:00
abstract:INTRODUCTION:Following trauma, patients may suffer an overwhelming pro-inflammatory response and immune paralysis resulting in infection and multiple organ failure (MOF). Various potentially immunomodulative interventions have been tested. The objective of this study is to systematically review the randomized controlle...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9218
更新日期:2010-01-01 00:00:00
abstract::In sepsis, inflammation and thrombosis are both the cause and the result of interactions between circulating (for example, leukocytes and platelets), endothelial and smooth muscle cells. Microparticles are proinflammatory and procoagulant fragments originating from plasma membrane generated after cellular activation a...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc9231
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:The study objectives were to evaluate septic shock-induced alterations in skeletal muscle hemoglobin oxygenation saturation (StO2) using near-infrared spectroscopy (NIRS) and forearm skin blood flow velocity using laser Doppler (LD) to determine the relationship of macroperfusion and microperfusion paramet...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8004
更新日期:2009-01-01 00:00:00
abstract::An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/s13054-020-03120-0
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:There is increasing interest in the timely administration of concentrated sources of fibrinogen to patients with major traumatic bleeding. Following evaluation of early cryoprecipitate in the CRYOSTAT 1 trial, we explored the use of fibrinogen concentrate, which may have advantages of more rapid administrati...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13054-018-2086-x
更新日期:2018-06-18 00:00:00
abstract:BACKGROUND:Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China. METHODS:This cross-sectional multicenter study included crit...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-020-03439-8
更新日期:2021-01-05 00:00:00
abstract:INTRODUCTION:Extracorporeal lung assist, an extreme resource in patients with acute respiratory failure (ARF), is expanding its indications since knowledge about ventilator-induced lung injury has increased and protective ventilation has become the standard in ARF. METHODS:A prospective study on seven adult sheep was ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5082
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Timely administration of appropriate antibiotic therapy has been shown to improve outcome in hospital-acquired pneumonia (HAP). Empirical treatment guidelines tailored to local ecology have been advocated in antibiotic stewardship programs. We compared a local ecology based algorithm (LEBA) to a surveillan...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc13990
更新日期:2014-07-15 00:00:00
abstract:INTRODUCTION:The FloTrac/Vigileo (Edwards Lifesciences, Irvine, CA, USA) allows pulse pressure-derived cardiac output measurement without external calibration. Software modifications were performed in order to eliminate initially observed deficits. The aim of this study was to assess changes in cardiac output determine...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7739
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Fractalkine is a chemokine implicated as a mediator in a variety of inflammatory conditions. Knowledge of fractalkine release in patients presenting with infection to the Intensive Care Unit (ICU) is highly limited. The primary objective of this study was to establish whether plasma fractalkine levels are ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/s13054-015-1125-0
更新日期:2015-11-25 00:00:00
abstract:INTRODUCTION:Delayed patient admission to the intensive care unit (ICU) due to lack of bed availability is a common problem, but the effect on patient outcome is not fully known. METHODS:A retrospective study was performed using departmental computerised records to determine the effect of delayed ICU admission and tem...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc11650
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxia (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate hyperoxia...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13054-016-1240-6
更新日期:2016-03-10 00:00:00
abstract:INTRODUCTION:Prevalence of iron deficiency (ID) at intensive care (ICU) admission is around 25 to 40%. Blood losses are important during ICU stay, leading to iron losses, but prevalence of ID at ICU discharge is unknown. ID has been associated with fatigue and muscular weakness, and may thus impair post-ICU rehabilitat...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/s13054-014-0542-9
更新日期:2014-09-30 00:00:00