Reducing mortality in sepsis: new directions.

abstract：:Ventilator-induced lung injury (VILI) consists of tissue damage and a biological response resulting from the application of inappropriate mechanical forces to the lung parenchyma. The current paradigm attributes VILI to overstretching due to very high-volume ventilation (volutrauma) and cyclic changes in aeration due ...

journal_title：Critical care (London, England)

authors： Albaiceta GM,Blanch L

更新日期：2011-04-07 00:00:00

abstract：INTRODUCTION:To investigate the effects of G-CSF or GM-CSF therapy in non-neutropenic patients with sepsis. METHODS:A systematic literature search of Medline, Embase and Cochrane Central Register of Controlled Trials was conducted using specific search terms. A manual review of references was also performed. Eligible ...

journal_title：Critical care (London, England)

authors： Bo L,Wang F,Zhu J,Li J,Deng X

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Neutrophil gelatinase-associated lipocalin (NGAL) is a promising novel biomarker that correlates with the severity and outcome of acute kidney injury (AKI). However, its prognostic utility during the late course of AKI, especially in patients that require renal replacement therapy (RRT) remains unknown. Th...

journal_title：Critical care (London, England)

authors： Kümpers P,Hafer C,Lukasz A,Lichtinghagen R,Brand K,Fliser D,Faulhaber-Walter R,Kielstein JT

更新日期：2010-01-01 00:00:00

abstract：:Those involved in the airway management of COVID-19 patients are particularly at risk. Here, we describe a practical, stepwise protocol for safe in-hospital airway management in patients with suspected or confirmed COVID-19 infection. ...

journal_title：Critical care (London, England)

authors： Sullivan EH,Gibson LE,Berra L,Chang MG,Bittner EA

更新日期：2020-06-05 00:00:00

abstract：:Even more than in previous disasters, Katrina has proven itself to be a testing ground for a plethora of new technologies. Although not all of these technologies did immediately save lives, in this regard a number of them exhibited considerable potential for the future, and hence there is a need to include them in fut...

journal_title：Critical care (London, England)

authors： Leitl E

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (iNO) is a rescue therapy for severe hypoxemia in patients with acute respiratory distress syndrome (ARDS). Pooled data from clinical trials have signaled a renal safety warning for iNO therapy, but the significance of these findings in daily clinical practice is unclear. We used primary...

journal_title：Critical care (London, England)

authors： Ruan SY,Wu HY,Lin HH,Wu HD,Yu CJ,Lai MS

更新日期：2016-11-30 00:00:00

abstract：: ...

journal_title：Critical care (London, England)

authors： Virk HS,Wiersinga WJ

更新日期：2019-02-13 00:00:00

abstract：INTRODUCTION:Sepsis, severe sepsis and septic shock are common conditions with high mortality. Their early diagnosis in the Emergency Department (ED) is one of the keys to improving survival. Procalcitonin (PCT) has been used as a biomarker in septic patients but has limited specificity and can be elevated in other sce...

journal_title：Critical care (London, England)

authors： Ulla M,Pizzolato E,Lucchiari M,Loiacono M,Soardo F,Forno D,Morello F,Lupia E,Moiraghi C,Mengozzi G,Battista S

更新日期：2013-07-30 00:00:00

abstract：INTRODUCTION:It has been unclear if mechanical cardiopulmonary resuscitation (CPR) is a viable alternative to manual CPR. We aimed to compare resuscitation outcomes before and after switching from manual CPR to load-distributing band (LDB) CPR in a multi-center emergency department (ED) trial. METHODS:We conducted a p...

journal_title：Critical care (London, England)

authors： Hock Ong ME,Fook-Chong S,Annathurai A,Ang SH,Tiah L,Yong KL,Koh ZX,Yap S,Sultana P

更新日期：2012-08-03 00:00:00

abstract：INTRODUCTION:Abdominal compartment syndrome has been described in patients with severe acute pancreatitis, but its clinical impact remains unclear. We therefore studied patient factors associated with the development of intra-abdominal hypertension (IAH), the incidence of organ failure associated with IAH, and the effe...

journal_title：Critical care (London, England)

authors： De Waele JJ,Hoste E,Blot SI,Decruyenaere J,Colardyn F

更新日期：2005-08-01 00:00:00

abstract：:Burns are a prevalent and burdensome critical care problem. The priorities of specialized facilities focus on stabilizing the patient, preventing infection, and optimizing functional recovery. Research on burns has generated sustained interest over the past few decades, and several important advancements have resulted...

journal_title：Critical care (London, England)

authors： Rowan MP,Cancio LC,Elster EA,Burmeister DM,Rose LF,Natesan S,Chan RK,Christy RJ,Chung KK

更新日期：2015-06-12 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is common among intensive care unit (ICU) patients. AKI is highly heterogeneous, with variable links to poor outcomes. Current approaches to classify AKI severity and identify patients at highest risk for poor outcomes focus on the maximum change in serum creatinine (SCr) values. Ho...

journal_title：Critical care (London, England)

authors： Bhatraju PK,Mukherjee P,Robinson-Cohen C,O'Keefe GE,Frank AJ,Christie JD,Meyer NJ,Liu KD,Matthay MA,Calfee CS,Christiani DC,Himmelfarb J,Wurfel MM

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...

journal_title：Critical care (London, England)

authors： Wu CP,Xu YJ,Wang TG,Ku SC,Chan DC,Lee JJ,Wei YC,Hsiao TY,Chen CC

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:There is growing interest in patient outcomes following critical illness, with an increasing number and different types of studies conducted, and a need for synthesis of existing findings to help inform the field. For this purpose we conducted a systematic review of qualitative studies evaluating patient out...

journal_title：Critical care (London, England)

authors： Hashem MD,Nallagangula A,Nalamalapu S,Nunna K,Nausran U,Robinson KA,Dinglas VD,Needham DM,Eakin MN

更新日期：2016-10-26 00:00:00

abstract：:The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach - Safe, Effective Gluco...

journal_title：Critical care (London, England)

authors： Krinsley JS,Preiser JC

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Recombinant human activated protein C (rhAPC) is the first drug for which a reduction of mortality in severe sepsis has been demonstrated. However, the mechanism by which this reduction in mortality is achieved is still not clearly defined. The aim of the present study was to evaluate the dynamics of the a...

journal_title：Critical care (London, England)

authors： de Pont AC,Bakhtiari K,Hutten BA,de Jonge E,Vroom MB,Meijers JC,Büller HR,Levi M

更新日期：2005-10-05 00:00:00

abstract：INTRODUCTION:Monitoring of hemodynamic and volumetric parameters after severe burns is of critical importance. Pulmonary artery catheters, however, have been associated with many risks. Our aim was to show the feasibility of continuous monitoring with minimally invasive transpulmonary thermodilution (TPTD) in severely ...

journal_title：Critical care (London, England)

authors： Branski LK,Herndon DN,Byrd JF,Kinsky MP,Lee JO,Fagan SP,Jeschke MG

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Admission blood glucose (BG) level is a predictor of mortality in patients with ST-segment elevation myocardial infarction (STEMI). However, limited data are available relating admission BG to mortality in patients with STEMI complicated by cardiogenic shock, and it is not known whether diabetic status has...

journal_title：Critical care (London, England)

authors： Yang JH,Song PS,Song YB,Hahn JY,Choi SH,Choi JH,Lee SH,Jeong MH,Kim YJ,Gwon HC

更新日期：2013-10-03 00:00:00

abstract：INTRODUCTION:Tight glucose control therapy (TGC) has been implemented to control hyperglycemia in ICU patients. TGC may also influence serum potassium concentrations. We therefore investigated the influence of TGC on both serum glucose and serum potassium concentrations and associated mortality. METHOD:We performed a ...

journal_title：Critical care (London, England)

authors： Uijtendaal EV,Zwart-van Rijkom JE,de Lange DW,Lalmohamed A,van Solinge WW,Egberts TC

更新日期：2015-06-22 00:00:00

abstract：INTRODUCTION:The purpose of this study was to perform a descriptive, content-based analysis on the different forms of documentation for in-flight medical emergencies that are currently provided in the emergency medical kits on board commercial airlines. METHODS:Passenger airlines in the World Airline Directory were co...

journal_title：Critical care (London, England)

authors： Sand M,Morrosch S,Sand D,Altmeyer P,Bechara FG

更新日期：2012-12-12 00:00:00

abstract：INTRODUCTION:The choice of invasive systemic haemodynamic monitoring in critically ill patients remains controversial as no multicentre comparative clinical data exist. Accordingly, we sought to study and compare the features and outcomes of patients who receive haemodynamic monitoring with either the pulmonary artery ...

journal_title：Critical care (London, England)

authors： Uchino S,Bellomo R,Morimatsu H,Sugihara M,French C,Stephens D,Wendon J,Honore P,Mulder J,Turner A,PAC\/PiCCO Use and Likelihood of Success Evaluation PULSE Study Group.

更新日期：2006-01-01 00:00:00

abstract：:Severe burn injury remains a major burden on patients and healthcare systems. Following severe burns, the injured tissues mount a local inflammatory response aiming to restore homeostasis. With excessive burn load, the immune response becomes disproportionate and patients may develop an overshooting systemic inflammat...

journal_title：Critical care (London, England)

authors： Flierl MA,Stahel PF,Touban BM,Beauchamp KM,Morgan SJ,Smith WR,Ipaktchi KR

更新日期：2009-01-01 00:00:00

abstract：:The present review introduces the notion of statistical power and the hazard of under-powered studies. The problem of how to calculate an ideal sample size is also discussed within the context of factors that affect power, and specific methods for the calculation of sample size are presented for two common scenarios, ...

journal_title：Critical care (London, England)

authors： Whitley E,Ball J

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Effective antimicrobial treatment is key to reduce mortality associated with bacterial sepsis in patients on intensive care units (ICUs). Dose adjustments are often necessary to account for pathophysiological changes or renal replacement therapy. Extracorporeal membrane oxygenation (ECMO) is increasingly bei...

journal_title：Critical care (London, England)

authors： Kühn D,Metz C,Seiler F,Wehrfritz H,Roth S,Alqudrah M,Becker A,Bracht H,Wagenpfeil S,Hoffmann M,Bals R,Hübner U,Geisel J,Lepper PM,Becker SL

更新日期：2020-11-25 00:00:00

abstract：INTRODUCTION:Due to resource limitations, few critical care interventions have been rigorously evaluated with adequately powered randomized clinical trials (RCTs). There is a need to improve the efficiency of RCTs in critical care so that more definitive high quality RCTs can be completed with the available resources. ...

journal_title：Critical care (London, England)

authors： Heyland DK,Muscedere J,Drover J,Jiang X,Day AG,Canadian Critical Care Trials Group.

更新日期：2011-01-01 00:00:00

abstract：:This review presents key publications from the research field of sepsis published in Critical Care and other relevant journals during 2013. The results of these experimental studies and clinical trials are discussed in the context of current scientific and clinical background. The discussion highlights and summarises ...

journal_title：Critical care (London, England)

authors： de Montmollin E,Annane D

更新日期：2014-10-15 00:00:00

abstract：INTRODUCTION:Leukocyte infiltration is central to the development of acute lung injury, but it is not known how mechanical ventilation strategy alters the distribution or activation of inflammatory cells. We explored how protective (vs. injurious) ventilation alters the magnitude and distribution of lung leukocyte acti...

journal_title：Critical care (London, England)

authors： de Prost N,Costa EL,Wellman T,Musch G,Tucci MR,Winkler T,Harris R,Venegas JG,Kavanagh BP,Vidal Melo MF

更新日期：2013-08-15 00:00:00

abstract：BACKGROUND:As more patients are surviving intensive care, mental health concerns in survivors have become a research priority. Among these, post-traumatic stress disorder (PTSD) can have an important impact on the quality of life of critical care survivors. However, data on its burden are conflicting. Therefore, this s...

journal_title：Critical care (London, England)

authors： Righy C,Rosa RG,da Silva RTA,Kochhann R,Migliavaca CB,Robinson CC,Teche SP,Teixeira C,Bozza FA,Falavigna M

更新日期：2019-06-11 00:00:00

abstract：PURPOSE:Measurement of central venous pressure (CVP) can be a useful clinical tool. However, the formal utility of CVP measurement in preventing mortality in septic patients has never been proven. METHODS:The Medical Information Mart for Intensive Care III (MIMIC-III) database was searched to identify septic patients ...

journal_title：Critical care (London, England)

authors： Chen H,Zhu Z,Zhao C,Guo Y,Chen D,Wei Y,Jin J

更新日期：2020-07-14 00:00:00

abstract：INTRODUCTION:Resuscitation with saline is a standard initial response to hypotension or shock of almost any cause. Saline resuscitation is thought to generate an increase in cardiac output through a preload-dependent (increased end-diastolic volume) augmentation of stroke volume. We sought to confirm this to be the mec...

journal_title：Critical care (London, England)

authors： Kumar A,Anel R,Bunnell E,Zanotti S,Habet K,Haery C,Marshall S,Cheang M,Neumann A,Ali A,Kavinsky C,Parrillo JE

更新日期：2004-06-01 00:00:00