Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study.

abstract：INTRODUCTION:Intravenous fluid administration is an essential component of sepsis management, but a positive fluid balance has been associated with worse prognosis. We analyzed whether a positive fluid balance and its persistence over time was an independent prognostic factor in septic patients. METHODS:We prospective...

journal_title：Critical care (London, England)

authors： Acheampong A,Vincent JL

更新日期：2015-06-15 00:00:00

abstract：INTRODUCTION:This prospective study aimed to assess whether use of the subxiphoid acoustic window in transthoracic echocardiography (TTE) can be an accurate alternative in the absence of an apical view to assess hemodynamic parameters. METHODS:This prospective study took place in a teaching hospital medical ICU. Over ...

journal_title：Critical care (London, England)

authors： Maizel J,Salhi A,Tribouilloy C,Massy ZA,Choukroun G,Slama M

更新日期：2013-09-03 00:00:00

abstract：INTRODUCTION:Passive leg raising (PLR) is a simple reversible maneuver that mimics rapid fluid loading and increases cardiac preload. The effects of this endogenous volume expansion on stroke volume enable the testing of fluid responsiveness with accuracy in spontaneously breathing patients. However, this maneuver requ...

journal_title：Critical care (London, England)

authors： Biais M,Vidil L,Sarrabay P,Cottenceau V,Revel P,Sztark F

更新日期：2009-01-01 00:00:00

abstract：:The rationale for the provision of nitrogen from proteins given via the enteral route or from intravenous amino acids is to boost the synthesis of muscle proteins, and thereby to limit the severity of intensive care unit-acquired weakness by the prevention of muscle loss. However, the optimal timing for supplemental n...

journal_title：Critical care (London, England)

authors： Preiser JC

更新日期：2018-10-25 00:00:00

abstract：INTRODUCTION:Serum concentrations of adhesion molecules may be connected to the pathogenesis of secondary brain injury after spontaneous intracerebral hemorrhage (ICH). This study posits the hypothesis that levels of adhesion molecules substantially increase after ICH and are decreased thereafter, and that they can pre...

journal_title：Critical care (London, England)

authors： Wang HC,Lin WC,Lin YJ,Rau CS,Lee TH,Chang WN,Tsai NW,Cheng BC,Kung CT,Lu CH

更新日期：2011-01-01 00:00:00

abstract：:Primary or secondary infection of necrotized areas by enteral bacteria is considered a primary cause of mortality in patients with severe acute pancreatitis (SAP). Indeed, 20-30% of patients die during the course of the disease from multiple organ dysfunction after infection. This is why strategies such as antibiotic ...

journal_title：Critical care (London, England)

authors： Gerlach H

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:V(2)-receptor (V(2)R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-line therapy with the selective V(2)R-antagonist (Propionyl(1)-D-Tyr(Et)(2)-Val(4)-Abu(6)-Arg...

journal_title：Critical care (London, England)

authors： Rehberg S,Ertmer C,Lange M,Morelli A,Whorton E,Dünser M,Strohhäcker AK,Lipke E,Kampmeier TG,Van Aken H,Traber DL,Westphal M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant therapy may delay RRT for other patients. The furosemide stress test (FST) has been shown to predict ...

journal_title：Critical care (London, England)

authors： Lumlertgul N,Peerapornratana S,Trakarnvanich T,Pongsittisak W,Surasit K,Chuasuwan A,Tankee P,Tiranathanagul K,Praditpornsilpa K,Tungsanga K,Eiam-Ong S,Kellum JA,Srisawat N,FST Study Group.

更新日期：2018-04-19 00:00:00

abstract：INTRODUCTION:There is a complex interplay between changes in acid-base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid-base status on admission to intensive care. METHODS:We conducted a prospective cohort study in a 13-bed ICU in a tertiary-car...

journal_title：Critical care (London, England)

authors： Zampieri FG,Kellum JA,Park M,Ranzani OT,Barbeiro HV,de Souza HP,da Cruz Neto LM,da Silva FP

更新日期：2014-07-17 00:00:00

abstract：:Many advances in medicine have been achieved through challenging established dogma with revolutionary thought and novel practices. Each and every specialty is reinvigorated by regular re-evaluation of processes and practices in the light of new evidence and fresh conceptualization. Challenge can galvanize fresh thinki...

journal_title：Critical care (London, England)

authors： Singer M,Matthay MA

更新日期：2011-07-26 00:00:00

abstract：INTRODUCTION:Delayed patient admission to the intensive care unit (ICU) due to lack of bed availability is a common problem, but the effect on patient outcome is not fully known. METHODS:A retrospective study was performed using departmental computerised records to determine the effect of delayed ICU admission and tem...

journal_title：Critical care (London, England)

authors： O'Callaghan DJ,Jayia P,Vaughan-Huxley E,Gribbon M,Templeton M,Skipworth JR,Gordon AC

更新日期：2012-10-01 00:00:00

abstract：:Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and prevent propagation of thrombin generation and formation of microvascular thrombosis. Furthermore, it may simu...

journal_title：Critical care (London, England)

authors： Levi M,van der Poll T

更新日期：2007-01-01 00:00:00

abstract：:Care of the critically ill patient is becoming increasingly complex. Protocols, which standardize care of patients with similar diseases, represent a potential solution to managing multiple simultaneous problems in critically ill patients. In this article, we examine the advantages and disadvantages to care protocoliz...

journal_title：Critical care (London, England)

authors： Chang SY,Sevransky J,Martin GS

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The safety of perioperative hyperoxia is currently unclear. Previous studies in patients undergoing coronary artery bypass surgery suggest reduced myocardial damage when avoiding extreme perioperative hyperoxia (>400 mmHg). In this study we investigated whether an oxygenation strategy from moderate hyperoxia...

journal_title：Critical care (London, England)

authors： Smit B,Smulders YM,de Waard MC,Boer C,Vonk AB,Veerhoek D,Kamminga S,de Grooth HJ,García-Vallejo JJ,Musters RJ,Girbes AR,Oudemans-van Straaten HM,Spoelstra-de Man AM

更新日期：2016-03-10 00:00:00

abstract：:Over the last years, there was an increase in the number and severity of Clostridium difficile infections (CDI) in all medical settings, including the intensive care unit (ICU). The current prevalence of CDI among ICU patients is estimated at 0.4-4% and has severe impact on morbidity and mortality. An estimated 10-20%...

journal_title：Critical care (London, England)

authors： Prechter F,Katzer K,Bauer M,Stallmach A

更新日期：2017-10-22 00:00:00

abstract：INTRODUCTION:Despite experimental evidence, clinical demonstration of acute state of oxidative stress and inflammation during post-cardiac arrest syndrome is lacking. Plasma level of thioredoxin (TRX), a redox-active protein induced under conditions of oxidative stress and inflammation, is increased in various critical...

journal_title：Critical care (London, England)

authors： Mongardon N,Lemiale V,Borderie D,Burke-Gaffney A,Perbet S,Marin N,Charpentier J,Pène F,Chiche JD,Mira JP,Cariou A

更新日期：2013-01-29 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Jonkman AH,de Vries HJ,Heunks LMA

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:The objective of this study was to evaluate the effects of two different mean arterial blood pressure (MAP) targets on needs for resuscitation, organ dysfunction, mitochondrial respiration and inflammatory response in a long-term model of fecal peritonitis. METHODS:Twenty-four anesthetized and mechanicall...

journal_title：Critical care (London, England)

authors： Corrêa TD,Vuda M,Takala J,Djafarzadeh S,Silva E,Jakob SM

更新日期：2013-01-30 00:00:00

abstract：:Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condi...

journal_title：Critical care (London, England)

authors： Rhodes A,Cecconi M

更新日期：2012-11-08 00:00:00

abstract：INTRODUCTION:It is recognized that administration of insulin with glucose decreases catabolic response in sepsis. The aim of the present study was to compare the effects of two levels of insulinaemia on glucose metabolism and energy expenditure in septic patients and volunteers. METHODS:Glucose uptake, oxidation and s...

journal_title：Critical care (London, England)

authors： Rusavy Z,Sramek V,Lacigova S,Novak I,Tesinsky P,Macdonald IA

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Prior retrospective cross-sectional work has associated antimicrobials with a non-specific phrase: encephalopathy without seizures. The purpose of this study is to determine whether different classes of antimicrobials have differential associations with the daily risk of delirium after critical illness is ad...

journal_title：Critical care (London, England)

authors： Grahl JJ,Stollings JL,Rakhit S,Person AK,Wang L,Thompson JL,Pandharipande PP,Ely EW,Patel MB

更新日期：2018-12-12 00:00:00

abstract：INTRODUCTION:Our aim in this study was to assess whether the new Glasgow Coma Scale, Age, and Systolic Blood Pressure (GAP) scoring system, which is a modification of the Mechanism, Glasgow Coma Scale, Age, and Arterial Pressure (MGAP) scoring system, better predicts in-hospital mortality and can be applied more easily...

journal_title：Critical care (London, England)

authors： Kondo Y,Abe T,Kohshi K,Tokuda Y,Cook EF,Kukita I

更新日期：2011-08-10 00:00:00

abstract：:Glucocorticoid use in sepsis is controversial. In contrast to other extracellular signaling molecules, glucocorticoid receptors (GRs) are intra-cytoplasmic. Several GR isoforms have been identified. A study in Critical Care Forum suggests that sepsis alters the abundance of the dominant negative GRβ. Here we discuss G...

journal_title：Critical care (London, England)

authors： Deutschman CS

更新日期：2013-06-27 00:00:00

abstract：INTRODUCTION:Inflammation and coagulation are closely linked, and both can be triggered by endotoxin. Thrombelastometry and impedance aggregometry are of diagnostic and predictive value in critically ill patients. In this observational study we investigated the correlation of endotoxin activity with thrombelasometric a...

journal_title：Critical care (London, England)

authors： Koch A,Meesters MI,Scheller B,Boer C,Zacharowski K

更新日期：2013-09-11 00:00:00

abstract：INTRODUCTION:Sepsis is the leading cause of acute kidney injury (AKI) in critical patients. The optimal timing of initiating renal replacement therapy (RRT) in septic AKI patients remains controversial. The objective of this study is to determine the impact of early or late initiation of RRT, as defined using the simpl...

journal_title：Critical care (London, England)

authors： Chou YH,Huang TM,Wu VC,Wang CY,Shiao CC,Lai CF,Tsai HB,Chao CT,Young GH,Wang WJ,Kao TW,Lin SL,Han YY,Chou A,Lin TH,Yang YW,Chen YM,Tsai PR,Lin YF,Huang JW,Chiang WC,Chou NK,Ko WJ,Wu KD,Tsai TJ,NSARF Stud

更新日期：2011-01-01 00:00:00

abstract：:Prediction of ventilation weaning outcome in children is important, as unsuccessful extubation increases both morbidity and mortality. Adult weaning criteria are poor predictors of weaning outcome in children for several possible reasons: the length of mechanical ventilation is generally much shorter, and the weaning ...

journal_title：Critical care (London, England)

authors： Schindler MB

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possib...

journal_title：Critical care (London, England)

authors： Yang R,Zou X,Koskinen ML,Tenhunen J

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the incidence of organ failure in trauma patients treated in an intensive care unit (ICU), and to study the relationship between organ failure and long-term survival and functional status. METHODS:This is a cohort study of all adult ICU trauma patients admitted to a unive...

journal_title：Critical care (London, England)

authors： Ulvik A,Kvåle R,Wentzel-Larsen T,Flaatten H

更新日期：2007-01-01 00:00:00

abstract：:Activation of nuclear factor kappa-B (NF-κB) results in its translocation from the cytoplasm to the nucleus and binding to the promoters of a large number of genes, including those encoding proinflammatory cytokines and other mediators that can contribute to organ system dysfunction in severe infection. While inhibiti...

journal_title：Critical care (London, England)

authors： Abraham E

更新日期：2013-06-11 00:00:00

abstract：:Characteristic patterns of variation over time, namely rhythms, represent a defining feature of complex systems, one that is synonymous with life. Despite the intrinsic dynamic, interdependent and nonlinear relationships of their parts, complex biological systems exhibit robust systemic stability. Applied to critical ...

journal_title：Critical care (London, England)

authors： Seely AJ,Macklem PT

更新日期：2004-12-01 00:00:00