Steroid responses in sepsis: some novel thinking that may provide new insight.

abstract：:The definition of what constitutes a 'normal' adrenal response to critical illness is unclear. Consequently, published studies have used a variety of biochemical criteria to define 'adrenal insufficiency'. These criteria have been based on the baseline cortisol level or the increment in cortisol following corticotropi...

journal_title：Critical care (London, England)

authors： Marik PE

更新日期：2006-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the critically ill and is associated with adverse outcomes. Although there are plausible benefits from conversion and maintenance of sinus rhythm (the so-called 'rhythm-control' strategy), recent randomized trials have failed to demonstrate th...

journal_title：Critical care (London, England)

authors： Lim HS,Hamaad A,Lip GY

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:Data on prehospital and trauma-room fluid management of multiple trauma patients with pelvic disruptions are rarely reported. Present trauma algorithms recommend early hemorrhage control and massive fluid resuscitation. By matching the German Pelvic Injury Register (PIR) with the TraumaRegister DGU (TR) fo...

journal_title：Critical care (London, England)

authors： Burkhardt M,Nienaber U,Pizanis A,Maegele M,Culemann U,Bouillon B,Flohé S,Pohlemann T,Paffrath T,TraumaRegister DGU.,German Pelvic Injury Register of the Deutsche Gesellschaft für Unfallchirurgie.

更新日期：2012-08-22 00:00:00

abstract：INTRODUCTION:Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness, even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. The ...

journal_title：Critical care (London, England)

authors： Pérez-Bárcena J,Llompart-Pou JA,Homar J,Abadal JM,Raurich JM,Frontera G,Brell M,Ibáñez J,Ibáñez J

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Patients in intensive care units (ICUs) often receive sedation for prolonged periods. In order to better understand the impact of sub-optimal sedation practice on outcomes, we performed a systematic review, including observational studies and controlled trials which were conducted in sedated patients in th...

journal_title：Critical care (London, England)

authors： Jackson DL,Proudfoot CW,Cann KF,Walsh T

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Procalcitonin (PCT) has been proposed as a marker of infection in critically ill patients; its level is related to the severity of infection. We evaluated the value of PCT as a marker of bacterial infection for emergency department patients. METHODS:This prospective observational study consecutively enrol...

journal_title：Critical care (London, England)

authors： Chan YL,Tseng CP,Tsay PK,Chang SS,Chiu TF,Chen JC

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:As a result of drug sequestration and increased volume of distribution, the extracorporeal membrane oxygenation (ECMO) procedure might lead to a decrease in drug concentrations during a patient's treatment. The aim of this study was to evaluate sedative, antibiotic and immunosuppressive drug loss in ECMO c...

journal_title：Critical care (London, England)

authors： Lemaitre F,Hasni N,Leprince P,Corvol E,Belhabib G,Fillâtre P,Luyt CE,Leven C,Farinotti R,Fernandez C,Combes A

更新日期：2015-02-12 00:00:00

abstract：INTRODUCTION:Myocardial dysfunction is a well-known complication in septic shock but its characteristics and frequency remains elusive. Here, we evaluate global longitudinal peak strain (GLPS) of the left ventricle as a diagnostic and prognostic tool in septic shock. METHODS:Fifty adult patients with septic shock admi...

journal_title：Critical care (London, England)

authors： De Geer L,Engvall J,Oscarsson A

更新日期：2015-03-26 00:00:00

abstract：INTRODUCTION:Severe hypoglycemia (blood glucose concentration (BG) < 40 mg/dL) is independently associated with an increased risk of mortality in critically ill patients. The association of milder hypoglycemia (BG < 70 mg/dL) with mortality is less clear. METHODS:Prospectively collected data from two observational coh...

journal_title：Critical care (London, England)

authors： Krinsley JS,Schultz MJ,Spronk PE,Harmsen RE,van Braam Houckgeest F,van der Sluijs JP,Mélot C,Preiser JC

更新日期：2011-07-25 00:00:00

abstract：BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...

journal_title：Critical care (London, England)

authors： Cepkova M,Brady S,Sapru A,Matthay MA,Church G

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Dysbiosis of intestinal microbiota likely plays an important role in the development of gut-derived infections, making it a potential therapeutic target against sepsis. However, experience with fecal microbiota transplantation (FMT) in the treatment of sepsis and knowledge of the underlying mechanisms are ...

journal_title：Critical care (London, England)

authors： Li Q,Wang C,Tang C,He Q,Zhao X,Li N,Li J

更新日期：2015-02-09 00:00:00

abstract：BACKGROUND:(1,3)-β-D-Glucan has been widely used in clinical practice for the diagnosis of invasive Candida infections. However, such serum biomarker showed potential to guide antimicrobial therapy in order to reduce the duration of empirical antifungal treatment in critically ill septic patients with suspected invasiv...

journal_title：Critical care (London, England)

authors： De Pascale G,Posteraro B,D'Arrigo S,Spinazzola G,Gaspari R,Bello G,Montini LM,Cutuli SL,Grieco DL,Di Gravio V,De Angelis G,Torelli R,De Carolis E,Tumbarello M,Sanguinetti M,Antonelli M

更新日期：2020-09-05 00:00:00

abstract：INTRODUCTION:A paucity of literature exists regarding delays in transfer out of the intensive care unit. We sought to analyze the incidence, causes, and costs of delayed transfer from a surgical intensive care unit (SICU). METHODS:An IRB-approved prospective observational study was conducted from January 24, 2010, to ...

journal_title：Critical care (London, England)

authors： Johnson DW,Schmidt UH,Bittner EA,Christensen B,Levi R,Pino RM

更新日期：2013-07-04 00:00:00

abstract：INTRODUCTION:Ultrasound of the lung and quantification of B lines was recently introduced as a novel tool to detect overhydration. In the present study, we aimed to evaluate a four-region protocol of lung ultrasound to determine the pulmonary fluid status in ventilated patients in the intensive care unit. METHODS:Fift...

journal_title：Critical care (London, England)

authors： Enghard P,Rademacher S,Nee J,Hasper D,Engert U,Jörres A,Kruse JM

更新日期：2015-02-06 00:00:00

abstract：INTRODUCTION:Sepsis-induced immunosuppression may result in death. The mechanisms of immune suppression include loss of macrophage and monocyte expression of the major histocompatibility complex, increased anti-inflammatory cytokine expression and decreased expression of proinflammatory cytokines. In this study, we sou...

journal_title：Critical care (London, England)

authors： Wu HP,Shih CC,Lin CY,Hua CC,Chuang DY

更新日期：2011-01-01 00:00:00

abstract：:There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments and intensive care units but also as one that is addressed as public health issue with population- and systems-based solutions. We offer a conceptual framework fo...

journal_title：Critical care (London, England)

authors： Kempker JA,Wang HE,Martin GS

更新日期：2018-05-06 00:00:00

abstract：INTRODUCTION:Lymphocyte apoptosis has been suggested to play a central role in sepsis pathophysiology, and studies in animal models demonstrated that blocking this pathway improves outcome. However, no routine biomarkers of apoptosis are so far available in patients. Thus, the aim of our study was to assess the differe...

journal_title：Critical care (London, England)

authors： Turrel-Davin F,Guignant C,Lepape A,Mougin B,Monneret G,Venet F

更新日期：2010-01-01 00:00:00

abstract：:Great white sharks are responsible for about 10 cases of death annually worldwide, as compared with millions of deaths caused by sepsis. However, the basic principles of avoiding shark attacks and fighting sepsis seem to be similar: avoidance, attention, and speed, if necessary. The present review discusses the curren...

journal_title：Critical care (London, England)

authors： Westphal M,Kampmeier T

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life...

journal_title：Critical care (London, England)

authors： Vuylsteke A,Vincent JL,de La Garanderie DP,Anderson FA,Emery L,Wyman A,Rushton-Smith S,Gore JM,Euro-STAT Investigators.

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. METHODS:Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 ser...

journal_title：Critical care (London, England)

authors： van den Boogaard M,Ramakers BP,van Alfen N,van der Werf SP,Fick WF,Hoedemaekers CW,Verbeek MM,Schoonhoven L,van der Hoeven JG,Pickkers P

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Dextrose may be used during cardiac arrest resuscitation to prevent or reverse hypoglycemia. However, the incidence of dextrose administration during cardiac arrest and the association of dextrose administration with survival and other outcomes are unknown. METHODS:We used the Get With The Guidelines®-Res...

journal_title：Critical care (London, England)

authors： Peng TJ,Andersen LW,Saindon BZ,Giberson TA,Kim WY,Berg K,Novack V,Donnino MW,American Heart Association’s Get With The Guidelines®-Resuscitation Investigators.

更新日期：2015-04-10 00:00:00

abstract：INTRODUCTION:Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesi...

journal_title：Critical care (London, England)

authors： Liu YY,Lee CH,Dedaj R,Zhao H,Mrabat H,Sheidlin A,Syrkina O,Huang PM,Garg HG,Hales CA,Quinn DA

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:The FloTrac/Vigileo (Edwards Lifesciences, Irvine, CA, USA) allows pulse pressure-derived cardiac output measurement without external calibration. Software modifications were performed in order to eliminate initially observed deficits. The aim of this study was to assess changes in cardiac output determine...

journal_title：Critical care (London, England)

authors： Senn A,Button D,Zollinger A,Hofer CK

更新日期：2009-01-01 00:00:00

abstract：:Large quantitaties of inflammatory mediators are released during the course of endotoxaemia. These mediators in turn can stimulate the sympathetic nervous system (SNS) to release catecholamines, which ultimately regulate inflammation-associated impairment in tissue perfusion, myocardial impairment and vasodilatation. ...

journal_title：Critical care (London, England)

authors： Beck GCh,Brinkkoetter P,Hanusch C,Schulte J,van Ackern K,van der Woude FJ,Yard BA

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:Data on the incidence of a hypercoagulable state in trauma, as measured by thromboelastometry (ROTEM), is limited and the prognostic value of hypercoagulability after trauma on outcome is unclear. We aimed to determine the incidence of hypercoagulability after trauma, and to assess whether early hypercoagu...

journal_title：Critical care (London, England)

authors： Müller MC,Balvers K,Binnekade JM,Curry N,Stanworth S,Gaarder C,Kolstadbraaten KM,Rourke C,Brohi K,Goslings JC,Juffermans NP

更新日期：2014-12-25 00:00:00

abstract：:COVID-19 has caused great devastation in the past year. Multi-organ point-of-care ultrasound (PoCUS) including lung ultrasound (LUS) and focused cardiac ultrasound (FoCUS) as a clinical adjunct has played a significant role in triaging, diagnosis and medical management of COVID-19 patients. The expert panel from 27 co...

journal_title：Critical care (London, England)

authors： Hussain A,Via G,Melniker L,Goffi A,Tavazzi G,Neri L,Villen T,Hoppmann R,Mojoli F,Noble V,Zieleskiewicz L,Blanco P,Ma IWY,Wahab MA,Alsaawi A,Al Salamah M,Balik M,Barca D,Bendjelid K,Bouhemad B,Bravo-Figueroa P,Br

更新日期：2020-12-24 00:00:00

abstract：INTRODUCTION:Metformin-associated lactic acidosis (MALA) is a classic side effect of metformin and is known to be a severe disease with a high mortality rate. The treatment of MALA with dialysis is controversial and is the subject of many case reports in the literature. We aimed to assess the prevalence of MALA in a 16...

journal_title：Critical care (London, England)

authors： Peters N,Jay N,Barraud D,Cravoisy A,Nace L,Bollaert PE,Gibot S

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Mechanically ventilated critically ill patients frequently develop ventilator-associated pneumonia (VAP), a life-threatening complication. Proposed preventive measures against VAP include, but are not restricted to, selective decontamination of the digestive tract (SDD), selective oropharyngeal decontamina...

journal_title：Critical care (London, England)

authors： Schultz MJ,Haas LE

更新日期：2011-01-01 00:00:00

abstract：:Sepsis is one of the most common conditions encountered in the intensive care unit and is the 10th leading cause of death overall in the United States. Both long-term survival and health-related quality of life are reduced in survivors of sepsis, yet there is little knowledge of the effect of sepsis-specific intervent...

journal_title：Critical care (London, England)

authors： Erickson SE,Martin GS

更新日期：2008-01-01 00:00:00

abstract：:Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Improvements in the understanding of the pathophysiological mechanisms of stress hyperglycemia and potential p...

journal_title：Critical care (London, England)

authors： Huberlant V,Preiser JC

更新日期：2010-01-01 00:00:00