Endotoxemia-induced inflammation and the effect on the human brain.

abstract：INTRODUCTION:This prospective, randomized, controlled, experimental animal study looks at the effects of recombinant human activated protein C (rhAPC) on global hemodynamics and microcirculation in ovine acute lung injury (ALI) and septic shock, resulting from smoke inhalation injury. METHODS:Twenty-one sheep (37 ± 2 ...

journal_title：Critical care (London, England)

authors： Maybauer MO,Maybauer DM,Fraser JF,Szabo C,Westphal M,Kiss L,Horvath EM,Nakano Y,Herndon DN,Traber LD,Traber DL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The aim of the present study was to investigate the relationship between the blood IL-6 level, the blood glucose level, and glucose control in septic patients. METHODS:This retrospective observational study in a general ICU of a university hospital included a total of 153 patients with sepsis, severe seps...

journal_title：Critical care (London, England)

authors： Nakamura M,Oda S,Sadahiro T,Watanabe E,Abe R,Nakada TA,Morita Y,Hirasawa H

更新日期：2012-12-12 00:00:00

abstract：BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) is a rare though often fatal hyperinflammatory syndrome mimicking sepsis in the critically ill. Diagnosis relies on the HLH-2004 criteria and HScore, both of which have been developed in pediatric or adult non-critically ill patients, respectively. Therefore, we aimed...

journal_title：Critical care (London, England)

authors： Knaak C,Nyvlt P,Schuster FS,Spies C,Heeren P,Schenk T,Balzer F,La Rosée P,Janka G,Brunkhorst FM,Keh D,Lachmann G

更新日期：2020-05-24 00:00:00

abstract：INTRODUCTION:Patients with acute-on-chronic liver failure show an aggravated hyperdynamic circulation. We evaluated, in a controlled manner, potential changes in systemic haemodynamics induced by the molecular adsorbent recirculating system (MARS) and the Prometheus system liver detoxification devices in a group of pat...

journal_title：Critical care (London, England)

authors： Laleman W,Wilmer A,Evenepoel P,Elst IV,Zeegers M,Zaman Z,Verslype C,Fevery J,Nevens F

更新日期：2006-01-01 00:00:00

abstract：:Urinary indices are classically believed to allow differentiation of transient (or pre-renal) acute kidney injury (AKI) from persistent (or acute tubular necrosis) AKI. However, the data validating urinalysis in critically ill patients are weak. In the previous issue of Critical Care, Pons and colleagues demonstrate i...

journal_title：Critical care (London, England)

authors： Schneider AG,Bellomo R

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:Critically ill patients in the intensive care unit (ICU) are at high risk for developing Clostridioides difficile infections (CDI). Risk factors predicting their mortality or standardized treatment recommendations have not been defined for this cohort. Our goal is to determine outcome and mortality associate...

journal_title：Critical care (London, England)

authors： Manthey CF,Dranova D,Christner M,Drolz A,Kluge S,Lohse AW,Fuhrmann V

更新日期：2019-12-09 00:00:00

abstract：INTRODUCTION:Contrast-enhanced ultrasound (CEUS) is a new technique that might enable portable and non-invasive organ perfusion quantification at the bedside. However, it has not yet been tested in critically ill patients. We sought to establish CEUS's feasibility, safety, reproducibility and potential diagnostic value...

journal_title：Critical care (London, England)

authors： Schneider AG,Goodwin MD,Schelleman A,Bailey M,Johnson L,Bellomo R

更新日期：2013-07-12 00:00:00

abstract：INTRODUCTION:Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with changes in pulmonary and systemic inflammation and coagulation occurring in patients who do not meet t...

journal_title：Critical care (London, England)

authors： Tuinman PR,Vlaar AP,Cornet AD,Hofstra JJ,Levi M,Meijers JC,Beishuizen A,Schultz MJ,Groeneveld AJ,Juffermans NP

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly adopted for the treatment of cardiogenic shock (CS). However, a marker of successful weaning remains largely unknown. Our hypothesis was that successful weaning is associated with sustained microcirculatory function during ECMO flow ...

journal_title：Critical care (London, England)

authors： Akin S,Dos Reis Miranda D,Caliskan K,Soliman OI,Guven G,Struijs A,van Thiel RJ,Jewbali LS,Lima A,Gommers D,Zijlstra F,Ince C

更新日期：2017-10-26 00:00:00

abstract：INTRODUCTION:Dynamic predictors of fluid responsiveness, namely systolic pressure variation, pulse pressure variation, stroke volume variation and pleth variability index have been shown to be useful to identify in advance patients who will respond to a fluid load by a significant increase in stroke volume and cardiac ...

journal_title：Critical care (London, England)

authors： Benes J,Giglio M,Brienza N,Michard F

更新日期：2014-10-28 00:00:00

abstract：:The definition of what constitutes a 'normal' adrenal response to critical illness is unclear. Consequently, published studies have used a variety of biochemical criteria to define 'adrenal insufficiency'. These criteria have been based on the baseline cortisol level or the increment in cortisol following corticotropi...

journal_title：Critical care (London, England)

authors： Marik PE

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Uncalibrated arterial pulse power analysis has been recently introduced for continuous monitoring of cardiac index (CI). The aim of the present study was to compare the accuracy of arterial pulse power analysis with intermittent transpulmonary thermodilution (TPTD) before and after cardiopulmonary bypass (...

journal_title：Critical care (London, England)

authors： Broch O,Renner J,Höcker J,Gruenewald M,Meybohm P,Schöttler J,Steinfath M,Bein B

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar-capillary barrier resulting in accumulation of proteinaceous edema and increased inflammatory cells in the alveolar space. We previously found that endothelial progenitor cell (EPC) exosomes prevent endothelial dysf...

journal_title：Critical care (London, England)

authors： Zhou Y,Li P,Goodwin AJ,Cook JA,Halushka PV,Chang E,Zingarelli B,Fan H

更新日期：2019-02-13 00:00:00

abstract：:Base deficit has frequently been utilized as an informal adjunct in the initial evaluation of trauma patients to assess the extent of their physiologic derangements. However, the current Advanced Trauma Life Support (ATLS) classification system for hypovolemic shock does not include base-deficit measurements and relie...

journal_title：Critical care (London, England)

authors： Privette AR,Dicker RA

更新日期：2013-03-13 00:00:00

abstract：INTRODUCTION:The objective of this study was to identify and characterize the most highly cited clinical research articles published on sepsis. METHODS:A comprehensive list of citation classics in sepsis was generated by searching the database of Web of Science-Expanded (1970 to present) using keywords 'sepsis' or 'se...

journal_title：Critical care (London, England)

authors： Tao T,Zhao X,Lou J,Bo L,Wang F,Li J,Deng X

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:The short-term and long-term consequences of the most frequent painful procedures performed in the ICU are unclear. This study aimed to identify the risk factors associated with pain-related discomfort perceived by critically ill patients during the whole ICU stay as self-reported by patients at the end of t...

journal_title：Critical care (London, England)

authors： Kalfon P,Boucekine M,Estagnasie P,Geantot MA,Berric A,Simon G,Floccard B,Signouret T,Fromentin M,Nyunga M,Audibert J,Ben Salah A,Mauchien B,Sossou A,Venot M,Robert R,Follin A,Renault A,Garrouste-Orgeas M,Collange O

更新日期：2020-12-07 00:00:00

abstract：:In a group of postoperative patients, Taniguchi and coworkers compared the effect of a computerized system for weaning against 'manual care'. The computerized system involved automatic adjustments to the level of pressure support to achieve a target respiratory rate. Manual care involved adjustments to the level of pr...

journal_title：Critical care (London, England)

authors： Adigüzel N,Güngör G,Tobin MJ

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Intensive insulin treatment of critically ill patients was seen as a promising method of treatment, though recent studies showed that reducing the blood glucose level below 6 mmol/l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The ...

journal_title：Critical care (London, England)

authors： Žuran I,Poredos P,Skale R,Voga G,Gabrscek L,Pareznik R

更新日期：2009-01-01 00:00:00

abstract：:During the past 50 years, caring for the critically ill has become increasingly complex and the need for an intensivist has become more evident. Management by intensivists has become a quality indicator for many ICUs. Numerous small studies have demonstrated the beneficial effect of intensivists on outcomes in the cri...

journal_title：Critical care (London, England)

authors： Levy MM

更新日期：2013-10-14 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine whether the degree of fluid responsiveness in critically ill septic patients is related to baseline mixed venous oxygen saturation (SvO2) levels. We also sought to define whether fluid responsiveness would be less likely in the presence of a high SvO2 (>70%). METHODS...

journal_title：Critical care (London, England)

authors： Velissaris D,Pierrakos C,Scolletta S,De Backer D,Vincent JL

更新日期：2011-07-26 00:00:00

abstract：:Those involved in the airway management of COVID-19 patients are particularly at risk. Here, we describe a practical, stepwise protocol for safe in-hospital airway management in patients with suspected or confirmed COVID-19 infection. ...

journal_title：Critical care (London, England)

authors： Sullivan EH,Gibson LE,Berra L,Chang MG,Bittner EA

更新日期：2020-06-05 00:00:00

abstract：INTRODUCTION:Between 1 and 31% of patients suffering out-of-hospital cardiac arrest (OHCA) survive to discharge from hospital. International studies have shown that the level of care provided by the admitting hospital determines survival for patients suffering from OHCA. These data may only be partially transferable to...

journal_title：Critical care (London, England)

authors： Wnent J,Seewald S,Heringlake M,Lemke H,Brauer K,Lefering R,Fischer M,Jantzen T,Bein B,Messelken M,Gräsner JT

更新日期：2012-09-12 00:00:00

abstract：:This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available ...

journal_title：Critical care (London, England)

authors： Bassetti M,Bandera A,Gori A

更新日期：2020-03-24 00:00:00

abstract：INTRODUCTION:The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patients. Unfortunately, processes such as gene transcription and drug metabolism are dynamic in the cr...

journal_title：Critical care (London, England)

authors： Celi LA,Hinske LC,Alterovitz G,Szolovits P

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:The purpose of the present study was to critically review the existing body of evidence on ventilation modes for infants and children up to the age of 18 years. METHODS:The PubMed and EMBASE databases were searched using the search terms 'artificial respiration', 'instrumentation', 'device', 'devices', 'm...

journal_title：Critical care (London, England)

authors： Duyndam A,Ista E,Houmes RJ,van Driel B,Reiss I,Tibboel D

更新日期：2011-01-01 00:00:00

abstract：:The US Institute of Medicine's focus on patient safety has motivated hospital administrators to facilitate a culture of safety. As a result, subcommittees of the pharmacy and therapeutics committee have emerged in many hospitals to focus on adverse events and patient safety. Antimicrobial harms have gained the attenti...

journal_title：Critical care (London, England)

authors： Owens RC Jr

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Fluid resuscitation is crucial in managing hemodynamically unstable patients. The last decade witnessed the use of pulse pressure variation (PPV) to predict fluid responsiveness. However, as far as we know, no systematic review and meta-analysis has been carried out to evaluate the value of PPV in predicti...

journal_title：Critical care (London, England)

authors： Yang X,Du B

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Omega-3 (ω-3) fatty acid (FA)-containing parenteral nutrition (PN) is associated with significant improvements in patient outcomes compared with standard PN regimens without ω-3 FA lipid emulsions. Here, we evaluate the impact of ω-3 FA-containing PN versus standard PN on clinical outcomes and costs in adult...

journal_title：Critical care (London, England)

authors： Pradelli L,Klek S,Mayer K,Omar Alsaleh AJ,Rosenthal MD,Heller AR,Muscaritoli M

更新日期：2020-11-03 00:00:00

abstract：INTRODUCTION:Due to resource limitations, few critical care interventions have been rigorously evaluated with adequately powered randomized clinical trials (RCTs). There is a need to improve the efficiency of RCTs in critical care so that more definitive high quality RCTs can be completed with the available resources. ...

journal_title：Critical care (London, England)

authors： Heyland DK,Muscedere J,Drover J,Jiang X,Day AG,Canadian Critical Care Trials Group.

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The gut is often considered as the motor of critical illness through bacterial translocation, which amplifies the inflammatory response and alters the immune status. However, systemic bacterial translocation was rarely proven and endotoxin measurement only reflects translocation of Gram-negative-derived pr...

journal_title：Critical care (London, England)

authors： Kim OY,Monsel A,Bertrand M,Cavaillon JM,Coriat P,Adib-Conquy M

更新日期：2009-01-01 00:00:00