Abstract:
:Urinary indices are classically believed to allow differentiation of transient (or pre-renal) acute kidney injury (AKI) from persistent (or acute tubular necrosis) AKI. However, the data validating urinalysis in critically ill patients are weak. In the previous issue of Critical Care, Pons and colleagues demonstrate in a multicenter observational study that sodium and urea excretion fractions as well as urinary over plasma ratios performed poorly as diagnostic tests to separate such entities. This study confirms the limited diagnostic and prognostic ability of urine testing. Together with other studies, this study raises more fundamental questions about the value, meaning and pathophysiologic validity of the pre-renal AKI paradigm and suggests that AKI (like all other forms of organ injury) is a continuum of injury that cannot be neatly divided into functional (pre-renal or transient) or structural (acute tubular necrosis or persistent).
journal_name
Crit Carejournal_title
Critical care (London, England)authors
Schneider AG,Bellomo Rdoi
10.1186/cc12676subject
Has Abstractpub_date
2013-05-07 00:00:00pages
141issue
3eissn
1364-8535issn
1466-609Xpii
cc12676journal_volume
17pub_type
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