An overview of harms associated with beta-lactam antimicrobials: where do the carbapenems fit in?

abstract：:Even more than in previous disasters, Katrina has proven itself to be a testing ground for a plethora of new technologies. Although not all of these technologies did immediately save lives, in this regard a number of them exhibited considerable potential for the future, and hence there is a need to include them in fut...

journal_title：Critical care (London, England)

authors： Leitl E

更新日期：2006-02-01 00:00:00

abstract：:Activation of nuclear factor kappa-B (NF-κB) results in its translocation from the cytoplasm to the nucleus and binding to the promoters of a large number of genes, including those encoding proinflammatory cytokines and other mediators that can contribute to organ system dysfunction in severe infection. While inhibiti...

journal_title：Critical care (London, England)

authors： Abraham E

更新日期：2013-06-11 00:00:00

abstract：INTRODUCTION:Fluid responsiveness prediction is difficult in spontaneously breathing patients. Because the swings in intrathoracic pressure are minor during spontaneous breathing, dynamic parameters like pulse pressure variation (PPV) and systolic pressure variation (SPV) are usually small. We hypothesized that during ...

journal_title：Critical care (London, England)

authors： Dahl MK,Vistisen ST,Koefoed-Nielsen J,Larsson A

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Intensive care units (ICUs) face financial, bed management, and staffing constraints. Detailed data covering all aspects of patients' journeys into and through intensive care are now collected and stored in electronic health records: machine learning has been used to analyse such data in order to provide dec...

journal_title：Critical care (London, England)

authors： Shillan D,Sterne JAC,Champneys A,Gibbison B

更新日期：2019-08-22 00:00:00

abstract：INTRODUCTION:Data on the incidence of a hypercoagulable state in trauma, as measured by thromboelastometry (ROTEM), is limited and the prognostic value of hypercoagulability after trauma on outcome is unclear. We aimed to determine the incidence of hypercoagulability after trauma, and to assess whether early hypercoagu...

journal_title：Critical care (London, England)

authors： Müller MC,Balvers K,Binnekade JM,Curry N,Stanworth S,Gaarder C,Kolstadbraaten KM,Rourke C,Brohi K,Goslings JC,Juffermans NP

更新日期：2014-12-25 00:00:00

abstract：BACKGROUND:Hypoxia is common during daily nursing procedures (DNPs) routinely performed on mechanically ventilated patients. The impact of automated ventilation on the incidence and severity of blood oxygen desaturation during DNPs remains unknown. METHODS:A prospective randomized controlled crossover trial was carrie...

journal_title：Critical care (London, England)

authors： Chelly J,Mazerand S,Jochmans S,Weyer CM,Pourcine F,Ellrodt O,Thieulot-Rolin N,Serbource-Goguel J,Sy O,Vong LVP,Monchi M

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Atrial fibrillation occurs frequently in patients following cardiac surgery and can be a cause of increased morbidity and mortality. The use of dexmedetomidine to prevent atrial fibrillation is unclear. The present study was designed to evaluate the effect of dexmedetomidine sedation on the incidence of atri...

journal_title：Critical care (London, England)

authors： Liu X,Zhang K,Wang W,Xie G,Fang X

更新日期：2016-09-21 00:00:00

abstract：INTRODUCTION:Early multimodal treatment of severe sepsis, including the use of drotrecogin alfa (activated) (DrotAA) when indicated, is considered essential for optimum outcome. However, predicting which infected patients will progress to severe sepsis and the need for aggressive intervention continues to be problemati...

journal_title：Critical care (London, England)

authors： Hodder RV,Hall R,Russell JA,Fisher HN,Lee B

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Prothrombin complex concentrates (PCC) are haemostatic blood preparations indicated for urgent anticoagulation reversal, though the optimal dose for effective reversal is still under debate. The latest generation of PCCs include four coagulation factors, the so-called 4-factor PCC. The aim of this study wa...

journal_title：Critical care (London, England)

authors： Kerebel D,Joly LM,Honnart D,Schmidt J,Galanaud D,Negrier C,Kursten F,Coriat P,Lex206 Investigator Group.

更新日期：2013-01-10 00:00:00

abstract：INTRODUCTION:Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytosis, and bioavailabili...

journal_title：Critical care (London, England)

authors： Davis JS,Yeo TW,Piera KA,Woodberry T,Celermajer DS,Stephens DP,Anstey NM

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Acute respiratory failure (ARF) remains a common hazardous complication in immunocompromised patients and is associated with increased mortality rates when endotracheal intubation is needed. We aimed to evaluate the effect of early noninvasive ventilation (NIV) compared with oxygen therapy alone in this pati...

journal_title：Critical care (London, England)

authors： Huang HB,Xu B,Liu GY,Lin JD,Du B

更新日期：2017-01-07 00:00:00

abstract：INTRODUCTION:Frequency-dependent acceleration of relaxation (FDAR) ensures appropriate ventricular filling at high heart rates and results from accelerated sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) activity independent of calcium removal from the cell. Because lipopolysaccharide (LPS) challenge may indu...

journal_title：Critical care (London, England)

authors： Joulin O,Marechaux S,Hassoun S,Montaigne D,Lancel S,Neviere R

更新日期：2009-01-01 00:00:00

abstract：:Urinary indices are classically believed to allow differentiation of transient (or pre-renal) acute kidney injury (AKI) from persistent (or acute tubular necrosis) AKI. However, the data validating urinalysis in critically ill patients are weak. In the previous issue of Critical Care, Pons and colleagues demonstrate i...

journal_title：Critical care (London, England)

authors： Schneider AG,Bellomo R

更新日期：2013-05-07 00:00:00

abstract：:An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organ...

journal_title：Critical care (London, England)

authors： Ni W,Yang X,Yang D,Bao J,Li R,Xiao Y,Hou C,Wang H,Liu J,Yang D,Xu Y,Cao Z,Gao Z

更新日期：2020-07-13 00:00:00

abstract：INTRODUCTION:As a result of drug sequestration and increased volume of distribution, the extracorporeal membrane oxygenation (ECMO) procedure might lead to a decrease in drug concentrations during a patient's treatment. The aim of this study was to evaluate sedative, antibiotic and immunosuppressive drug loss in ECMO c...

journal_title：Critical care (London, England)

authors： Lemaitre F,Hasni N,Leprince P,Corvol E,Belhabib G,Fillâtre P,Luyt CE,Leven C,Farinotti R,Fernandez C,Combes A

更新日期：2015-02-12 00:00:00

abstract：INTRODUCTION:Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life...

journal_title：Critical care (London, England)

authors： Vuylsteke A,Vincent JL,de La Garanderie DP,Anderson FA,Emery L,Wyman A,Rushton-Smith S,Gore JM,Euro-STAT Investigators.

更新日期：2011-01-01 00:00:00

abstract：: ...

journal_title：Critical care (London, England)

authors： Virk HS,Wiersinga WJ

更新日期：2019-02-13 00:00:00

abstract：:The majority of intensive care practitioners, until comparatively recently, was content to discharge surviving patients to the care of referring primary specialty colleagues who would undertake subsequent inpatient and outpatient care. With the exception of mortality statistics from clinical studies, the practitioners...

journal_title：Critical care (London, England)

authors： Broomhead LR,Brett SJ

更新日期：2002-10-01 00:00:00

abstract：:Assessment of vasomotor tone is essential in defining appropriate resuscitation strategies for the hypotensive patient. Although changes in mean arterial pressure to cardiac output define arterial resistance, resistance is only one component of vasomotor tone. Compliance is the other component. The reciprocal of compl...

journal_title：Critical care (London, England)

authors： Pinsky MR

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The goal of the current study was to investigate the effect of aging on the development of endothelial dysfunction in a murine model of sepsis, and to compare it with the effect of genetic deficiency of the endothelial isoform of nitric oxide synthase (eNOS). METHODS:Cecal ligation and puncture (CLP) was ...

journal_title：Critical care (London, England)

authors： Coletta C,Módis K,Oláh G,Brunyánszki A,Herzig DS,Sherwood ER,Ungvári Z,Szabo C

更新日期：2014-09-16 00:00:00

abstract：:Severe burn injury remains a major burden on patients and healthcare systems. Following severe burns, the injured tissues mount a local inflammatory response aiming to restore homeostasis. With excessive burn load, the immune response becomes disproportionate and patients may develop an overshooting systemic inflammat...

journal_title：Critical care (London, England)

authors： Flierl MA,Stahel PF,Touban BM,Beauchamp KM,Morgan SJ,Smith WR,Ipaktchi KR

更新日期：2009-01-01 00:00:00

abstract：: ...

journal_title：Critical care (London, England)

authors： Martin CM

更新日期：2018-11-03 00:00:00

abstract：BACKGROUND:Several biological markers of lung injury are predictors of morbidity and mortality in patients with acute lung injury (ALI). The low tidal volume lung-protective ventilation strategy is associated with a significant decrease in plasma biomarker levels compared to the high tidal volume ventilation strategy. ...

journal_title：Critical care (London, England)

authors： Cepkova M,Brady S,Sapru A,Matthay MA,Church G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Crystalloids and different component colloids, used for volume resuscitation, are sometimes associated with various adverse effects. Clinical trial findings for such fluid types in different patients' conditions are conflicting. Whether the mortality benefit of balanced crystalloid than saline can be inferre...

journal_title：Critical care (London, England)

authors： Tseng CH,Chen TT,Wu MY,Chan MC,Shih MC,Tu YK

更新日期：2020-12-14 00:00:00

abstract：:The diagnosis of patients presenting to the emergency department with acute heart failure (AHF) is challenging due to the similarity of AHF symptoms to other conditions such as chronic obstructive pulmonary disease and pneumonia. Additionally, because AHF is most common in an older population, the presentation of coex...

journal_title：Critical care (London, England)

authors： Peacock WF,Cannon CM,Singer AJ,Hiestand BC

更新日期：2015-11-10 00:00:00

abstract：:Many prior studies have shown that, in critically ill patients, acute kidney injury (AKI) commonly occurs in association with sepsis and its presence portends an increased likelihood of poor outcomes. In contrast, few studies have focused specifically on the influence of AKI on the long-term risk of developing sepsis....

journal_title：Critical care (London, England)

authors： Clark E,Bagshaw SM

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:Epidemiological studies have provided inconsistent results on whether intensive care unit (ICU) discharge at night and on weekends is associated with an increased risk of mortality. This systematic review and meta-analysis aimed to determine whether ICU discharge time was associated with hospital mortality. ...

journal_title：Critical care (London, England)

authors： Yang S,Wang Z,Liu Z,Wang J,Ma L

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Little is known about mortality rates following general surgical procedures in the United Kingdom. Deaths are most common in the 'high-risk' surgical population consisting mainly of older patients, with coexisting medical disease, who undergo major surgery. Only limited data are presently available to desc...

journal_title：Critical care (London, England)

authors： Pearse RM,Harrison DA,James P,Watson D,Hinds C,Rhodes A,Grounds RM,Bennett ED

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) affects a large proportion of the critically ill and is associated with worse patient outcomes. Early identification of AKI can lead to earlier initiation of supportive therapy and better management. In this study, we evaluate the impact of computerized AKI decision support tool int...

journal_title：Critical care (London, England)

authors： Bourdeaux C,Ghosh E,Atallah L,Palanisamy K,Patel P,Thomas M,Gould T,Warburton J,Rivers J,Hadfield J

更新日期：2020-11-23 00:00:00

abstract：INTRODUCTION:The purpose of this study was to investigate whether common variants across the nuclear factor erythroid 2-like 2 (NFE2L2) gene contribute to the development of the acute respiratory distress syndrome (ARDS) in patients with severe sepsis. NFE2L2 is involved in the response to oxidative stress, and it has ...

journal_title：Critical care (London, England)

authors： Acosta-Herrera M,Pino-Yanes M,Blanco J,Ballesteros JC,Ambrós A,Corrales A,Gandía F,Subirá C,Domínguez D,Baluja A,Añón JM,Adalia R,Pérez-Méndez L,Flores C,Villar J,GRECIA and GEN-SEP networks.

更新日期：2015-06-16 00:00:00