A French multicenter randomised trial comparing two dose-regimens of prothrombin complex concentrates in urgent anticoagulation reversal.

abstract：INTRODUCTION:Sepsis, severe sepsis and septic shock are common conditions with high mortality. Their early diagnosis in the Emergency Department (ED) is one of the keys to improving survival. Procalcitonin (PCT) has been used as a biomarker in septic patients but has limited specificity and can be elevated in other sce...

journal_title：Critical care (London, England)

authors： Ulla M,Pizzolato E,Lucchiari M,Loiacono M,Soardo F,Forno D,Morello F,Lupia E,Moiraghi C,Mengozzi G,Battista S

更新日期：2013-07-30 00:00:00

abstract：:Chloride is the principal anion in the extracellular fluid and is the second main contributor to plasma tonicity. Its concentration is frequently abnormal in intensive care unit patients, often as a consequence of fluid therapy. Yet chloride has received less attention than any other ion in the critical care literatur...

journal_title：Critical care (London, England)

authors： Yunos NM,Bellomo R,Story D,Kellum J

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Timely administration of appropriate antibiotic therapy has been shown to improve outcome in hospital-acquired pneumonia (HAP). Empirical treatment guidelines tailored to local ecology have been advocated in antibiotic stewardship programs. We compared a local ecology based algorithm (LEBA) to a surveillan...

journal_title：Critical care (London, England)

authors： De Bus L,Saerens L,Gadeyne B,Boelens J,Claeys G,De Waele JJ,Benoit DD,Decruyenaere J,Depuydt PO

更新日期：2014-07-15 00:00:00

abstract：INTRODUCTION:Multiple organ dysfunction syndrome (MODS) is a common complication of sepsis in mechanically ventilated patients with acute respiratory distress syndrome, but the links between mechanical ventilation and MODS are unclear. Our goal was to determine whether a minimally injurious mechanical ventilation strat...

journal_title：Critical care (London, England)

authors： O'Mahony DS,Liles WC,Altemeier WA,Dhanireddy S,Frevert CW,Liggitt D,Martin TR,Matute-Bello G

更新日期：2006-01-01 00:00:00

abstract：:The forced oscillation technique (FOT) is a method for non-invasively assessing respiratory mechanics that is applicable both in paralysed and non-paralysed patients. As the FOT requires a minimal modification of the conventional ventilation setting and does not interfere with the ventilation protocol, the technique i...

journal_title：Critical care (London, England)

authors： Navajas D,Farré R

更新日期：2001-01-01 00:00:00

abstract：:A crucial determinant for the success of intensive insulin therapy in critically ill patients is the frequent and accurate measurement of blood glucose values with immediate feedback of results. In general, therefore, this is achieved by point-of-care testing, raising the question of the best way of monitoring blood g...

journal_title：Critical care (London, England)

authors： Brunkhorst FM,Wahl HG

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patients. Unfortunately, processes such as gene transcription and drug metabolism are dynamic in the cr...

journal_title：Critical care (London, England)

authors： Celi LA,Hinske LC,Alterovitz G,Szolovits P

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:It is recognized that administration of insulin with glucose decreases catabolic response in sepsis. The aim of the present study was to compare the effects of two levels of insulinaemia on glucose metabolism and energy expenditure in septic patients and volunteers. METHODS:Glucose uptake, oxidation and s...

journal_title：Critical care (London, England)

authors： Rusavy Z,Sramek V,Lacigova S,Novak I,Tesinsky P,Macdonald IA

更新日期：2004-08-01 00:00:00

abstract：:Antithrombotic prophylaxis in critically ill patients frequently fails. Venous thromboembolism is associated with adverse clinical outcomes, including a prolonged intensive care unit stay and death. A potential mechanism by which critically ill patients may be predisposed to antithrombotic failure is the inability to ...

journal_title：Critical care (London, England)

authors： Crowther M,Lim W

更新日期：2006-01-01 00:00:00

abstract：:Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and prevent propagation of thrombin generation and formation of microvascular thrombosis. Furthermore, it may simu...

journal_title：Critical care (London, England)

authors： Levi M,van der Poll T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Critical illness following head injury is associated with a hypermetabolic state but there are insufficient epidemiological data describing acute nutrition delivery to this group of patients. Furthermore, there is little information describing relationships between nutrition and clinical outcomes in this pop...

journal_title：Critical care (London, England)

authors： Chapple LA,Chapman MJ,Lange K,Deane AM,Heyland DK

更新日期：2016-01-07 00:00:00

abstract：BACKGROUND:Sepsis remains a complex medical problem and a major challenge in healthcare. Diagnostics and outcome predictions are focused on physiological parameters with less consideration given to patients' medical background. Given the aging population, not only are diseases becoming increasingly prevalent but occur ...

journal_title：Critical care (London, England)

authors： Zador Z,Landry A,Cusimano MD,Geifman N

更新日期：2019-07-08 00:00:00

abstract：INTRODUCTION:Our aims were to assess risk factors, clinical features, management and outcomes in critically ill patients in whom Aspergillus spp. were isolated from respiratory secretions, using a database from a study designed to assess fungal infections. METHODS:A multicentre prospective study was conducted over a 9...

journal_title：Critical care (London, England)

authors： Garnacho-Montero J,Amaya-Villar R,Ortiz-Leyba C,León C,Alvarez-Lerma F,Nolla-Salas J,Iruretagoyena JR,Barcenilla F

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Patients admitted to the intensive care unit often develop hyperglycaemia, but the underlying mechanisms have not been fully described. The incretin effect is reduced in patients with type 2 diabetes. Type 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resis...

journal_title：Critical care (London, England)

authors： Nielsen ST,Janum S,Krogh-Madsen R,Solomon TP,Møller K

更新日期：2015-11-16 00:00:00

abstract：:Glucocorticoid use in sepsis is controversial. In contrast to other extracellular signaling molecules, glucocorticoid receptors (GRs) are intra-cytoplasmic. Several GR isoforms have been identified. A study in Critical Care Forum suggests that sepsis alters the abundance of the dominant negative GRβ. Here we discuss G...

journal_title：Critical care (London, England)

authors： Deutschman CS

更新日期：2013-06-27 00:00:00

abstract：:Climate change and environmental stewardship are phrases that have been defining the past few decades and promoting change in our societies. The sensitivities of intensive care as a specialty make the process of greening an intensive care unit a challenge, but not one that is insurmountable. This paper discusses oppor...

journal_title：Critical care (London, England)

authors： Chapman M,Chapman A

更新日期：2011-01-01 00:00:00

abstract：:Recent interest in transfusion management of trauma patients has heightened expectation in the role of blood component therapy in improving patient outcome. Optimal transfusion support in supplementation with fibrinogen has not been defined by high-quality evidence. Current evidence comes mainly from case series and u...

journal_title：Critical care (London, England)

authors： Stanworth SJ,Hunt BJ

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Transthoracic echocardiography (TTE) is a useful tool for minimally invasive hemodynamic monitoring in the ICU. Dynamic indices (such as the inferior vena cava distensibility index (dIVC)) can be used to predict fluid responsiveness in mechanically ventilated patients. Although quantitative use of the dIVC...

journal_title：Critical care (London, England)

authors： Duwat A,Zogheib E,Guinot P,Levy F,Trojette F,Diouf M,Slama M,Dupont H

更新日期：2014-01-14 00:00:00

abstract：INTRODUCTION:Sepsis is the leading cause of acute kidney injury (AKI) in critical patients. The optimal timing of initiating renal replacement therapy (RRT) in septic AKI patients remains controversial. The objective of this study is to determine the impact of early or late initiation of RRT, as defined using the simpl...

journal_title：Critical care (London, England)

authors： Chou YH,Huang TM,Wu VC,Wang CY,Shiao CC,Lai CF,Tsai HB,Chao CT,Young GH,Wang WJ,Kao TW,Lin SL,Han YY,Chou A,Lin TH,Yang YW,Chen YM,Tsai PR,Lin YF,Huang JW,Chiang WC,Chou NK,Ko WJ,Wu KD,Tsai TJ,NSARF Stud

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Data on the incidence of a hypercoagulable state in trauma, as measured by thromboelastometry (ROTEM), is limited and the prognostic value of hypercoagulability after trauma on outcome is unclear. We aimed to determine the incidence of hypercoagulability after trauma, and to assess whether early hypercoagu...

journal_title：Critical care (London, England)

authors： Müller MC,Balvers K,Binnekade JM,Curry N,Stanworth S,Gaarder C,Kolstadbraaten KM,Rourke C,Brohi K,Goslings JC,Juffermans NP

更新日期：2014-12-25 00:00:00

abstract：BACKGROUND:Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier function and the association with microcircula...

journal_title：Critical care (London, England)

authors： Dekker NAM,van Leeuwen ALI,van Strien WWJ,Majolée J,Szulcek R,Vonk ABA,Hordijk PL,Boer C,van den Brom CE

更新日期：2019-04-11 00:00:00

abstract：:Malignant stroke occurs in a subgroup of patients suffering from ischemic cerebral infarction and is characterized by neurological deterioration due to progressive edema, raised intracranial pressure, and cerebral herniation. Decompressive craniectomy (DC) is a surgical technique aiming to open the "closed box" repres...

journal_title：Critical care (London, England)

authors： Beez T,Munoz-Bendix C,Steiger HJ,Beseoglu K

更新日期：2019-06-07 00:00:00

abstract：INTRODUCTION:Extracorporeal lung assist, an extreme resource in patients with acute respiratory failure (ARF), is expanding its indications since knowledge about ventilator-induced lung injury has increased and protective ventilation has become the standard in ARF. METHODS:A prospective study on seven adult sheep was ...

journal_title：Critical care (London, England)

authors： Livigni S,Maio M,Ferretti E,Longobardo A,Potenza R,Rivalta L,Selvaggi P,Vergano M,Bertolini G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the clinical usefulness of open lung biopsy (OLB) in patients undergoing mechanical ventilation for diffuse pulmonary infiltrates of unknown etiology. METHODS:This was a 10-year retrospective study in a 10-bed medical intensive care unit. The medical records of 36 v...

journal_title：Critical care (London, England)

authors： Lim SY,Suh GY,Choi JC,Koh WJ,Lim SY,Han J,Lee KS,Shim YM,Chung MP,Kim H,Kwon OJ

更新日期：2007-01-01 00:00:00

abstract：:Body cell mass (BCM) is the metabolically active cell mass involved in O₂ consumption, CO₂ production and energy expenditure. BCM measurement has been suggested as a tool for the evaluation of nutritional status. Since BCM is closely related to energy expenditure, it could also represent a good reference value for the...

journal_title：Critical care (London, England)

authors： Fiaccadori E,Morabito S,Cabassi A,Regolisti G

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Evidence suggests that dying patients' physical and emotional suffering is inadequately treated in intensive care units. Although there are recommendations regarding decisions to forgo life-sustaining therapy, deciding on withdrawal of life support is difficult, and it is also difficult to decide who shoul...

journal_title：Critical care (London, England)

authors： Fumis RR,Deheinzelin D

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of shock than traditional vital signs alone. In previous literature, use of the reverse shock index (rSI), taken as SBP divided by HR, is recommended instead of SI for hospital...

journal_title：Critical care (London, England)

authors： Kimura A,Tanaka N

更新日期：2018-04-11 00:00:00

abstract：INTRODUCTION:This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as...

journal_title：Critical care (London, England)

authors： Mattingley JS,Holets SR,Oeckler RA,Stroetz RW,Buck CF,Hubmayr RD

更新日期：2011-01-01 00:00:00

abstract：:Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is an increasingly adopted life-saving mechanical circulatory support for a number of potentially reversible or treatable cardiac diseases. It is also started as a bridge-to-transplantation/ventricular assist device in the case of unrecoverable cardiac or ca...

journal_title：Critical care (London, England)

authors： Bonicolini E,Martucci G,Simons J,Raffa GM,Spina C,Coco VL,Arcadipane A,Pilato M,Lorusso R

更新日期：2019-07-30 00:00:00

abstract：BACKGROUND:Intensive care medicine is a relatively young discipline that has rapidly grown into a full-fledged medical subspecialty. Intensivists are responsible for managing an ever-increasing number of patients with complex, life-threatening diseases. Several factors may influence their performance, including age, tr...

journal_title：Critical care (London, England)

authors： Castro R,Nin N,Ríos F,Alegría L,Estenssoro E,Murias G,Friedman G,Jibaja M,Ospina-Tascon G,Hurtado J,Marín MDC,Machado FR,Cavalcanti AB,Dubin A,Azevedo L,Cecconi M,Bakker J,Hernandez G,Latin-American Intensive Care Net

更新日期：2018-02-21 00:00:00