Year in review 2009: Critical Care--metabolism.


:Novel insights into the metabolic alterations of critical illness were published in Critical Care in 2009. The association between early hypoglycaemia/high glycemic variability and poor outcome was confirmed. Improvements in the understanding of the pathophysiological mechanisms of stress hyperglycemia and potential progress in the bedside management of glucose control were presented. With regard to enteral nutrition, some alterations of gastrointestinal physiology were better delineated. The relationship between the achievement of nutritional goals and outcomes was further investigated. Finally, understanding of some critical-illness-related endocrine and neuromuscular disorders improved through new experimental and clinical findings.


Crit Care


Huberlant V,Preiser JC




Has Abstract


2010-01-01 00:00:00














  • Still a man's world, but why?

    abstract::Women are generally under-represented in many academic medical settings. Through a brief commentary on this issue, the present article discusses possible explanations for this under-representation as well as potential solutions. Issues examined include women in leadership positions, attrition out of academic medicine,...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Weinacker A,Stapleton RD

    更新日期:2013-01-29 00:00:00

  • Clinical review: the management of hypertensive crises.

    abstract::Hypertension is an extremely common clinical problem, affecting approximately 50 million people in the USA and approximately 1 billion individuals worldwide. Approximately 1% of these patients will develop acute elevations in blood pressure at some point in their lifetime. A number of terms have been applied to severe...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Varon J,Marik PE

    更新日期:2003-10-01 00:00:00

  • Bench-to-bedside review: human subjects research--are more standards needed?

    abstract::There are many controversial issues surrounding ethics in study design and conduct of human subjects research. In this review we briefly touch on the origin of ethics in clinical research and how the current regulations and standards came into practice. We then discuss current controversies regarding informed consent,...

    journal_title:Critical care (London, England)

    pub_type: 历史文章,杂志文章,评审


    authors: Huang DT,Hadian M

    更新日期:2006-01-01 00:00:00

  • Urinalysis and pre-renal acute kidney injury: time to move on.

    abstract::Urinary indices are classically believed to allow differentiation of transient (or pre-renal) acute kidney injury (AKI) from persistent (or acute tubular necrosis) AKI. However, the data validating urinalysis in critically ill patients are weak. In the previous issue of Critical Care, Pons and colleagues demonstrate i...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Schneider AG,Bellomo R

    更新日期:2013-05-07 00:00:00

  • Rapid response systems: are they really effective?

    abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at Further information about the Annual Update in Intensive Care a...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Sandroni C,D'Arrigo S,Antonelli M

    更新日期:2015-03-16 00:00:00

  • Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: results of an experimental study in adult sheep.

    abstract:INTRODUCTION:Extracorporeal lung assist, an extreme resource in patients with acute respiratory failure (ARF), is expanding its indications since knowledge about ventilator-induced lung injury has increased and protective ventilation has become the standard in ARF. METHODS:A prospective study on seven adult sheep was ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Livigni S,Maio M,Ferretti E,Longobardo A,Potenza R,Rivalta L,Selvaggi P,Vergano M,Bertolini G

    更新日期:2006-01-01 00:00:00

  • Inter-hospital transport of critically ill patients; expect surprises.

    abstract:INTRODUCTION:Inter-hospital transport of critically ill patients is increasing. When performed by specialized retrieval teams there are less adverse events compared to transport by ambulance. These transports are performed with technical equipment also used in an Intensive Care Unit (ICU). As a consequence technical pr...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Droogh JM,Smit M,Hut J,de Vos R,Ligtenberg JJ,Zijlstra JG

    更新日期:2012-02-12 00:00:00

  • Bench-to-bedside review: Therapeutic options and issues in the management of ventilator-associated bacterial pneumonia.

    abstract::Despite progress in the diagnosis, prevention and therapy for hospital-acquired infections, ventilator-associated pneumonia (VAP) continues to complicate the course of a significant proportion of patients receiving mechanical ventilation. Mortality rates among patients with VAP have been reported to be as high as 72%,...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Rello J

    更新日期:2005-06-01 00:00:00

  • Antiepileptic drugs in critically ill patients.

    abstract:BACKGROUND:The incidence of seizures in intensive care units ranges from 3.3% to 34%. It is therefore often necessary to initiate or continue anticonvulsant drugs in this setting. When a new anticonvulsant is initiated, drug factors, such as onset of action and side effects, and patient factors, such as age, renal, and...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Farrokh S,Tahsili-Fahadan P,Ritzl EK,Lewin JJ 3rd,Mirski MA

    更新日期:2018-06-07 00:00:00

  • Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis.

    abstract:INTRODUCTION:Deregulated apoptosis and overshooting neutrophil functions contribute to immune and organ dysfunction in sepsis and multiple organ failure (MOF). In the present study, we determined the role of soluble Fas (sFas) in the regulation of posttraumatic neutrophil extrinsic apoptosis and the development of seps...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Paunel-Görgülü A,Flohé S,Scholz M,Windolf J,Lögters T

    更新日期:2011-01-01 00:00:00

  • Shock subtypes by left ventricular ejection fraction following out-of-hospital cardiac arrest.

    abstract:BACKGROUND:Post-resuscitation hemodynamic instability following out-of-hospital cardiac arrest (OHCA) may occur from myocardial dysfunction underlying cardiogenic shock and/or inflammation-mediated distributive shock. Distinguishing the predominant shock subtype with widely available clinical metrics may have prognosti...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Anderson RJ,Jinadasa SP,Hsu L,Ghafouri TB,Tyagi S,Joshua J,Mueller A,Talmor D,Sell RE,Beitler JR

    更新日期:2018-06-15 00:00:00

  • Presence of Candida cell wall derived polysaccharides in the sera of intensive care unit patients: relation with candidaemia and Candida colonisation.

    abstract:INTRODUCTION:Prompt diagnosis of candidaemia and invasive candidosis is crucial to the early initiation of antifungal therapy. The poor sensitivity of blood cultures (BCs) has led to the development of fungal glycan tests as a diagnostic adjunct. We analysed the performance of tests for the detection of circulating β-D...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Poissy J,Sendid B,Damiens S,Ichi Ishibashi K,François N,Kauv M,Favory R,Mathieu D,Poulain D

    更新日期:2014-06-29 00:00:00

  • How the relationships between general practitioners and intensivists can be improved: the general practitioners' point of view.

    abstract:INTRODUCTION:The present study assessed the opinion of general practitioners (GPs) concerning their relationships with intensivists. METHODS:An anonymous questionnaire was mailed to 7,239 GPs. GPs were asked about their professional activities, postgraduate intensive care unit (ICU) training, the rate of patient admit...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Etesse B,Jaber S,Mura T,Leone M,Constantin JM,Michelet P,Zoric L,Capdevila X,Malavielle F,Allaouchiche B,Orban JC,Fabbro-Peray P,Lefrant JY,AzuRéa Group.

    更新日期:2010-01-01 00:00:00

  • Cell-free DNA and outcome in sepsis.

    abstract::Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condi...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Rhodes A,Cecconi M

    更新日期:2012-11-08 00:00:00

  • Bench-to-bedside review: Burn-induced cerebral inflammation--a neglected entity?

    abstract::Severe burn injury remains a major burden on patients and healthcare systems. Following severe burns, the injured tissues mount a local inflammatory response aiming to restore homeostasis. With excessive burn load, the immune response becomes disproportionate and patients may develop an overshooting systemic inflammat...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Flierl MA,Stahel PF,Touban BM,Beauchamp KM,Morgan SJ,Smith WR,Ipaktchi KR

    更新日期:2009-01-01 00:00:00

  • Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia.

    abstract::This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2019. Other selected articles can be found online at . Further information about the Annual Update in Intensive Care and Emergency Medicine is available...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,评审


    authors: Cillóniz C,Dominedò C,Torres A

    更新日期:2019-03-09 00:00:00

  • Hyperbilirubinaemia after major thoracic surgery: comparison between open-heart surgery and oesophagectomy.

    abstract:BACKGROUND:Hyperbilirubinaemia is a common occurrence in patients who are admitted to intensive care units (ICUs) after major surgery, and it is associated with high mortality. We investigated the incidence of hyperbilirubinaemia after two major types of thoracic surgery: open-heart surgery and oesophagectomy. In order...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Hosotsubo KK,Nishimura M,Nishimura S

    更新日期:2000-01-01 00:00:00

  • Feasibility of optical coherence tomography angiography to assess changes in retinal microcirculation in ovine haemorrhagic shock.

    abstract:BACKGROUND:This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of haemorrhagic shock. METHODS:Haemorrhagic shock was induced in five healthy, anaesthetized sheep by ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Alnawaiseh M,Ertmer C,Seidel L,Arnemann PH,Lahme L,Kampmeier TG,Rehberg SW,Heiduschka P,Eter N,Hessler M

    更新日期:2018-05-29 00:00:00

  • Mild hypoglycemia is independently associated with increased mortality in the critically ill.

    abstract:INTRODUCTION:Severe hypoglycemia (blood glucose concentration (BG) < 40 mg/dL) is independently associated with an increased risk of mortality in critically ill patients. The association of milder hypoglycemia (BG < 70 mg/dL) with mortality is less clear. METHODS:Prospectively collected data from two observational coh...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Krinsley JS,Schultz MJ,Spronk PE,Harmsen RE,van Braam Houckgeest F,van der Sluijs JP,Mélot C,Preiser JC

    更新日期:2011-07-25 00:00:00

  • Imposed work of breathing during high-frequency oscillatory ventilation: a bench study.

    abstract:INTRODUCTION:The ventilator and the endotracheal tube impose additional workload in mechanically ventilated patients breathing spontaneously. The total work of breathing (WOB) includes elastic and resistive work. In a bench test we assessed the imposed WOB using 3100 A/3100 B SensorMedics high-frequency oscillatory ven...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: van Heerde M,van Genderingen HR,Leenhoven T,Roubik K,Plötz FB,Markhorst DG

    更新日期:2006-02-01 00:00:00

  • Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey.

    abstract:BACKGROUND:The aim of this study, conducted in 2006, was to find out whether changes in sedation management in German intensive care units took place in comparison with our survey from 2002. METHODS:We conducted a follow-up survey with a descriptive and comparative cross-sectional multi-center design. A postal survey ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Martin J,Franck M,Sigel S,Weiss M,Spies C

    更新日期:2007-01-01 00:00:00

  • The 21st International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium, 20-23 March 2001.

    abstract::The 21st International Symposium on Intensive Care and Emergency Medicine was dominated by the results of recent clinical trials in sepsis and acute respiratory distress syndrome (ARDS). The promise of extracorporeal liver replacement therapy and noninvasive ventilation were other areas of interest. Ethical issues als...

    journal_title:Critical care (London, England)



    authors: Ball J,Venn R

    更新日期:2001-01-01 00:00:00

  • Effect of glomerular filtration rate impairment on diagnostic performance of neutrophil gelatinase-associated lipocalin and B-type natriuretic peptide as markers of acute cardiac and renal failure in chronic kidney disease patients.

    abstract:INTRODUCTION:Cardio-renal syndromes are characterized by the impairment of cardiac and renal functions. Plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL), and plasma B-type natriuretic peptide (BNP) are markers of acute kidney injury (AKI) and heart failure (HF), respectively. METHODS:GFR (99mTc-DTP...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Donadio C

    更新日期:2014-02-28 00:00:00

  • Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival.

    abstract:INTRODUCTION:Severe sepsis is the leading cause of mortality in critically ill patients. Abnormal concentrations of inflammatory mediators appear to be involved in the pathogenesis of sepsis. Based on the humoral theory of sepsis, a potential therapeutic approach involves high-volume haemofiltration (HVHF), which has e...

    journal_title:Critical care (London, England)

    pub_type: 临床试验,杂志文章


    authors: Ratanarat R,Brendolan A,Piccinni P,Dan M,Salvatori G,Ricci Z,Ronco C

    更新日期:2005-08-01 00:00:00

  • Prolonged refractory status epilepticus following acute traumatic brain injury: a case report of excellent neurological recovery.

    abstract:INTRODUCTION:Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality. METHODS:This case report describes a 20 year old previously healthy woman who suffered a severe TBI as a result of a motor vehicle collision and...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Peets AD,Berthiaume LR,Bagshaw SM,Federico P,Doig CJ,Zygun DA

    更新日期:2005-01-01 00:00:00

  • Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.

    abstract:BACKGROUND:Acute kidney injury (AKI) is common among intensive care unit (ICU) patients. AKI is highly heterogeneous, with variable links to poor outcomes. Current approaches to classify AKI severity and identify patients at highest risk for poor outcomes focus on the maximum change in serum creatinine (SCr) values. Ho...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章,多中心研究


    authors: Bhatraju PK,Mukherjee P,Robinson-Cohen C,O'Keefe GE,Frank AJ,Christie JD,Meyer NJ,Liu KD,Matthay MA,Calfee CS,Christiani DC,Himmelfarb J,Wurfel MM

    更新日期:2016-11-17 00:00:00

  • PEEP titration guided by ventilation homogeneity: a feasibility study using electrical impedance tomography.

    abstract:INTRODUCTION:Lung protective ventilation requires low tidal volume and suitable positive end-expiratory pressure (PEEP). To date, few methods have been accepted for clinical use to set the appropriate PEEP. The aim of this study was to test the feasibility of PEEP titration guided by ventilation homogeneity using the g...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Zhao Z,Steinmann D,Frerichs I,Guttmann J,Möller K

    更新日期:2010-01-01 00:00:00

  • Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study.

    abstract:INTRODUCTION:Veno-venous extracorporeal membrane oxygenation (vvECMO) can be a life-saving therapy in patients with severe acute lung failure refractory to conventional therapy. Nevertheless, vvECMO is a procedure associated with high costs and resource utilization. The aim of this study was to assess published models ...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Enger T,Philipp A,Videm V,Lubnow M,Wahba A,Fischer M,Schmid C,Bein T,Müller T

    更新日期:2014-04-09 00:00:00

  • Impact of transpulmonary thermodilution-based cardiac contractility and extravascular lung water measurements on clinical outcome of patients with Takotsubo cardiomyopathy after subarachnoid hemorrhage: a retrospective observational study.

    abstract:INTRODUCTION:Takotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcome have not been studied. The purpose of this study was to investigate the TCM-induced cardiac function by transpulmonary thermodilution and its imp...

    journal_title:Critical care (London, England)

    pub_type: 杂志文章


    authors: Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

    更新日期:2014-08-12 00:00:00

  • Broadening our perspectives on ICU delirium risk factors.

    abstract::ICU delirium is associated with poor patient outcome. Risk factor stratification is essential to the understanding, prevention and treatment of this disorder. Alcohol consumption, smoking and prior cognitive impairment appear strongly correlated with delirium risk. Several potentially modifiable associations deserve p...

    journal_title:Critical care (London, England)

    pub_type: 评论,杂志文章


    authors: Skrobik Y

    更新日期:2009-01-01 00:00:00